Systolic Heart failure treatment with

the If inhibitor ivabradine Trial

Selective heart rate reduction with

ivabradine unloads the left ventricle

in heart failure patients

www.shift-study.comReil JC, et al. J Am Coll Cardiol. 2013 Nov 19;62(21):1977-1985

Ivabradine Placebo0

10

20

30

40

50

60

70

80

Effect of HR reduction with ivabradine on stroke volume and cardiac output in patients

with systolic HF

Stroke volume, ml

Ivabradine Placebo0

500

1000

1500

2000

2500

3000

3500

4000

4500

Cardiac output, ml/min

P =0.31 P <0.01P <0.0001

www.shift-study.comReil JC, et al. J Am Coll Cardiol. 2013 Nov 19;62(21):1977-1985

Baseline

Month 8

n=275

Procoralan maintains cardiac output.Procoralan increases stroke volume.

Ivabradine has no impact on blood pressure even in the long term

www.shift-study.comReil JC, et al. J Am Coll Cardiol. 2013 Nov 19;62(21):1977-1985

Ivabradine Placebo0

10

20

30

40

50

60

70

80

90

100

Baseline

Month 8

Blo

od

pre

ssu

re (

mm

Hg

)NS NS

n=275