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Systolic Heart failure treatment with
the If inhibitor ivabradine Trial
Selective heart rate reduction with
ivabradine unloads the left ventricle
in heart failure patients
www.shift-study.comReil JC, et al. J Am Coll Cardiol. 2013 Nov 19;62(21):1977-1985
Ivabradine Placebo0
10
20
30
40
50
60
70
80
Effect of HR reduction with ivabradine on stroke volume and cardiac output in patients
with systolic HF
Stroke volume, ml
Ivabradine Placebo0
500
1000
1500
2000
2500
3000
3500
4000
4500
Cardiac output, ml/min
P =0.31 P <0.01P <0.0001
www.shift-study.comReil JC, et al. J Am Coll Cardiol. 2013 Nov 19;62(21):1977-1985
Baseline
Month 8
n=275
Procoralan maintains cardiac output.Procoralan increases stroke volume.
Ivabradine has no impact on blood pressure even in the long term
www.shift-study.comReil JC, et al. J Am Coll Cardiol. 2013 Nov 19;62(21):1977-1985
Ivabradine Placebo0
10
20
30
40
50
60
70
80
90
100
Baseline
Month 8
Blo
od
pre
ssu
re (
mm
Hg
)NS NS
n=275
