InducesDbx1 cellsDbx2 cells

Txn of WntIgf2GLI-1PDGFRαPtc-1

Txn of MycAxinCycD1TGF-1PPARγCD44MMP-7etc.

Vertebrates Fly

DE

LTA1

DE

LTA2

DE

LTA3

DE

LTA4

JAG

GE

D1

JAG

GE

D2

CO

NTA

CT

IN

NB

3

DE

LTA

SE

RR

AT

E

LAG

2

DSL1

C. elegans

NO

TCH

NO

TCH

TA

CE

NE

XT LR

P5/6

DA

LLY

DA

LLY - LIK

E

ME

GA

LIN

HIP

NIC

D

NIC

D

NICD

CycC, cdk8MAML

HATS

Hairless

Act-Ci Cos2

SuFu

SuFu SuFu

SuFu

SuFu

RepressorComplex

Fly

Vertebrates

Hes 1/3/5PreTαHey1/Hey2MAGCNPase

CBP, RBPjk (vertebrate)Su(H) (Fly)Lag 1 (C.elegans)

+Fbw7/Sel10

Proteosomaldegradation

?

CtBP

Slimb

KIF

Slimb

Rep-Ci

Fu

Act-Ci

Act-Ci

Act-Ci

Cos2

SuFu Fu

cAMPPS1/PS2 PEN-2 APH -1

+shh -shh

Smo Ptc

Shh

SKN

GAS-1

Dhh Ihh

Cadherin

FZ

P

P PUb UbUbUb

Proteosomaldegradation

Palmitate

Cholesterol

NCT

WNT

β-catenin

β-catenin

β-catenin

β-catenin

β-catenin

α-catenin

GBP/Frat

p120

CK1

PP2A

GSK3B

PKA

PKA

CK1

5gg

GSK3B

Axin

Pygo XSox17BCC9

CtBP

GrouchoSKIP

Syn3a CIR

SMRT

CtBP

LEF/TCF

LEF/TCF

APC

WntCerberus

WIF

Dkk

Frp

AKT Dsh

naked

GLI-2GLI-1 GLI-3

Groucho

CtBP

CSL

P P P P P

CSL

CSL

P

P+

Notch pathway shh pathway

wnt/β-catenin pathway

NUCLEUS

NeurogenesisSignaling Pathways: Notch | Shh | β-catenin