Post on 31-Dec-2015
description
transcript
THE KREB’S CYCLE What Goes Around Comes Around
The Krebs Cycle What Goes Around Comes Around
Part 1: Preparation of Pyruvate
Pyruvate (3C)Acetyl – Coenzyme A
Mitochondria
Cytosol Mitochondria Outer Membrane
CO2
H
NAD+ NADH
Coenzyme A
(2C)
Acetic Acid
Transport Protein
Acetyl CoA (2C)
Oxaloacetate (4C)
CoEnzyme A
Citrate (6C)
H2O
Isocitrate (6C)
CO2
NAD+
NADH
a-Ketoglutarate (5C)
CoEnzyme A
CO2NAD+
NAD+
NADH
NADHSuccinyl- CoA
(4C)
CoEnzyme A
GTP GDP
ADPATP
FAD+FADH
H2O
Succinate
(4C)
Fumarate
(4C)
Malate
(4C)
Part 2: Kreb’s Cycle
09-12-KrebsCycle.mov
TOTALSATP =
NADH =
FADH =
CO2 =
1 X 2 = 2
4 X 2 = 8
THE KREB’S CYCLE
1 X 2 = 2
3 X 2 = 6Kreb’s Cycle Song
Slide 2
CHORUS
The Krebs Cycle
Acetyl CoA combines with oxaloacetic acidTo create a citric acid. That's how it begins.Then a water removed and added makes it isocitric acid,Which, in turn, oxidized and loses CO2.Then alpha-ketoglutaric is oxidized again,Losing carbon dioxide with an NADH spin.Then through a phosphorylationSuccinyl CoA congeals a GDP to GTP to toss back CoASH.
CHORUS:Acetyl CoA, citric acid, iso-,Alpha-ketoglutaric, succinyl CoA,Succeeded by succinic, fumaric and malic,Then oxaloacetic starts the cycle again.
Soon we see succinic acid forming a fumaric acidAs it forms an FADH2 along the way.Water washed upon fumaric makes it into acid malic.Now there's only one step left, so let's be on our way.With one more oxidation, resisting degradation,A final NADH is made and brings us to the end.Oxaloacetic acid, first and last, a simple acidThen accepts an acetyl CoA and starts again.
melody and lyrics by Lynda Jones; adapted by Do Peterson and Greg CrowtheGreg: geek vocals, keyboard Lori: lead vocals Kirk L. Van Scoyoc: banjoDo: bass, hyper-dramatic vocals, keyboard, acoustic and electric guitar, drum