The Power of Fasting orWhy Less is More

We will review:§Energy metabolism basics§Insulin§Growth and Reproduction Times of Plenty

Philip Myron MDCM, FRCPC October 4, 2019

The Power of Fasting orWhy Less is More

§Hormesis Times of Scarcity§Autophagy§Bad Science Bad Outcomes§Bad Science Dietary Myths§Fasting A Powerful Tool and Corrective

1980 ððð2014

• Quadrupling of number of adults with DM worldwide

• 108M in 1980è 422M in 2014• Burden growing faster in low and middle

income countries• Based on current trends global target of

holding levels to 2010 levels in 2025:< 1% males< 1% females

3 Principle Macromolecules

• Carbohydrates• Fat• Protein

Gluconeogenesis

• Takes place primarily in liver• Converts pyruvate, lactate, glycerol and amino

acids into glucose• Energy for this biochemical process from

oxidation of fat• Mammals cannot convert fat directly into

glucose

Energy Regulating Hormones

Glucose Lowering• Insulin

Glucose Raising• Glucagon• Growth hormone• Epinephrine• Norepinephrine• T4, T3• Cortisol

Hormesis

•What doesn’t kill you makes you stronger• The dose makes the poison

Figure 1

Cell Metabolism 2014 19, 181-192DOI: (10.1016/j.cmet.2013.12.008) Copyright © 2014 Elsevier Inc. Terms and Conditions

Yoshinori Ohsumi Recipient of 2016 Nobel Prize in Physiology or Medicine