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The Power of Fasting or Why Less is More We will review: §Energy metabolism basics §Insulin §Growth and Reproduction Times of Plenty Philip Myron MDCM, FRCPC October 4, 2019
The Power of Fasting orWhy Less is More
We will review:§Energy metabolism basics§Insulin§Growth and Reproduction Times of Plenty
Philip Myron MDCM, FRCPC October 4, 2019
The Power of Fasting orWhy Less is More
§Hormesis Times of Scarcity§Autophagy§Bad Science Bad Outcomes§Bad Science Dietary Myths§Fasting A Powerful Tool and Corrective
1980 ððð2014
• Quadrupling of number of adults with DM worldwide
• 108M in 1980è 422M in 2014• Burden growing faster in low and middle
income countries• Based on current trends global target of
holding levels to 2010 levels in 2025:< 1% males< 1% females
3 Principle Macromolecules
• Carbohydrates• Fat• Protein
Gluconeogenesis
• Takes place primarily in liver• Converts pyruvate, lactate, glycerol and amino
acids into glucose• Energy for this biochemical process from
oxidation of fat• Mammals cannot convert fat directly into
glucose
Energy Regulating Hormones
Glucose Lowering• Insulin
Glucose Raising• Glucagon• Growth hormone• Epinephrine• Norepinephrine• T4, T3• Cortisol
Hormesis
•What doesn’t kill you makes you stronger• The dose makes the poison
Figure 1
Cell Metabolism 2014 19, 181-192DOI: (10.1016/j.cmet.2013.12.008) Copyright © 2014 Elsevier Inc. Terms and Conditions
Yoshinori Ohsumi Recipient of 2016 Nobel Prize in Physiology or Medicine
