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Transgenic Animals

Transgenic Animals

Transgenic Animals

Transgenic Animals

Transgenic Animals

“Cloning”

Transgenic Animals

Transgenic Animals

Tissue specific Expression

CFTR: Cystic Fibrosis Transmembrane Conductance Regulator

Transgenic Animals

Tissue specific Expression

Transgenic animals as organ supplier

Immunological Barriers

Hyperacute rejectionAcute vascular rejectionCellular rejectionChronic rejection

Porcine endogenous retroviruses

Humanizing the pig:

Introduction of Human Genes

Knock out of pig genes -1.3 galactosyltransferase avoid immunogenic reaction