Post on 23-Dec-2015
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DISCOVERY
1934 - Karl Meyer and his assistant John Palmer isolated new glykoaminoglycane from the vitreous humour of bovine eyes
vitreous humour – sklivecbovine – hovězí, kravský
STRUCTURE
-it consists of repeating disacharides units
D-N‑acetylglucosamine
-D-glucuronic acid
-the units are joined with repeating beta‑1,4 and beta‑1,3 glycosidic bonds
OCCURENCE AND PHYSIOLOGICAL IMPORTANCE
-in the skin (about 50 % of the total hyaluronan in the body)-the vitreous humour of the eye-in the synovial fluid (3‑4 mg/ml)-in the matrix around the oocyt during ovulation (~0,5 mg/ml)-in some situations rapid increase (shock incidents, wound healing, septicaemia)
synovial fluid - kloubní mazwound healing – hojení ransepticaemia – otrava krve
USE
- in the late fifties hyaluronan was applied for the first time to humans - as vitreous humour replacement during eye surgery
- hyaluronan improves properties of synovia and silences pain in joints
surgery – operace, chirurgie
joint - kloub
- for healthy and fresh skin- to improve the effectiveness of
local anaesthesia- to prevent tissue destruction- hyaluronates are widely used in
many branches of medicine like orthopaedia, surgery, ophthalmology, oncology, dermatology, gynaecology
- may have anticancer effects and can suppress tumour progression, however, the findings are rather inconsistent
suppress – potlačovattumour – nádor, otok, zduření