WASTE WATER TREATMENT FOR WASTE WATER TREATMENT FOR RITONAVIR PRODUCTION PLANTRITONAVIR PRODUCTION PLANT

Presented by

Wang Dong Mei

July 8, 2000

GENERAL LAYOUT OF PHARMECUTICAL GENERAL LAYOUT OF PHARMECUTICAL FACTORYFACTORY

Chemical Process Tanks

Air Emissions

Sewer Discharge

Hazardous Waste Tank

Direct Discharge

Laboratory

Storm Water

Transportation

Storage

Construction

PROBLEM STATEMENTPROBLEM STATEMENT

High concentration of biochemical oxygen demand (BOD): 9,100 mg/l

High concentration of chemical oxygen demand (COD): 85,290 mg/l

High concentration of total organic carbon (TOC): 23980 mg/l

High concentration of total nitrogen (TN): 900 mg/l

High concentration of total solid (TS): 10,480 mg/l

DESIGN OBJECTIVESDESIGN OBJECTIVES

Removal of BOD Removal of COD Removal of TOC Removal of TN Removal of TS

RATIONAL APPROACHRATIONAL APPROACH

Primary treatment:

physical unit operations Secondary treatment:

chemical and biological unit process Tertiary treatment:

combinations of physical, chemical and biological processes

PRIMARY TREATMENTPRIMARY TREATMENT

Screening: to protect pumps, valves, pipelines, and other appurtenances from damage or clogging by rags and large objects

Grit chamber: to remove grit, sand, and gravel, usually following screening

Equalization tank: equalization of flow and loadings, neutralization pH

PRIMARY TREATMENTPRIMARY TREATMENT

Influent

Screens Grit Chamber Equalization & Neutralization Tank

Primary Sediment Tank

SECONDARY TREATMENTSECONDARY TREATMENT

Flocculation and coagulation: to apply chemical mixing to increase the removal of COD

Primary sedimentation: to remove chemical precipitation, settle-able solids, and particular matter

Activated sludge: to remove BOD by microorganism degradation

Secondary sedimentation: to remove settable-able solids

SECONDARY TREATMENTSECONDARY TREATMENT

Flocculation and Coagulation Activated

Sludge Pond

Primary Sedimentation

Secondary Sedimentation

TERTIARY TREATMENTTERTIARY TREATMENT

Two-step biological nitrification/denitrification: Removal of nitrogen by using trickling filters Ammonia is converted aerobically to

nitrate(NO3-) (nitrification) in the first step

Nitrates are converted to nitrogen gas (denitrification)

TRICKLING FILTERTRICKLING FILTER

DISINFECTIONDISINFECTION

Disinfect pathogen or other organisms by applying Cl2

Chlorate contact tank

SLUDGE PROCESSINGSLUDGE PROCESSING

Sludge thickening Sludge stabilization Anaerobic sludge digestion Gas production and collection Sludge disinfection Sludge dewatering Land fill

LAYOUT OF THE PLANTLAYOUT OF THE PLANT

WATER QUALITY OF THE EFFLUENTWATER QUALITY OF THE EFFLUENT

Parameters TOC (mg/l) BOD (mg/l) COD (mg/l) TN (mg/l) TS (mg/l)Influent 23,980 9100 85290 900 10480Physico-chemical 14388 5460 426.45 765 4192Activated Sludge 2877.6 273 213.22 612 838.4Trickling Filter 575.52 54.6 42.64 61.2 167.68Standard 20 ~ 60 120 100 3000