Week1–What’sYourHormonalProfile?

AfrouzDemeri,NMD,DHMHS,IFMCP

Outline

Whyarethey? 7Hormones

HormonalImbalance

TestingGuessing

Actionplan

•  Diseases•  Roles•  ControlSystem•  HPAAxis

•  Healthyrhythm•  HighAlert•  TiredbutWired•  Burnout•  5causesof

Dysfunction

•  HormonePathway•  Sexhormones•  Thyroid•  Pregnenolone

‘Steal’•  Hierarchy

•  Blood•  DUTCH•  Casestudies

•  ToxinQuestionnaire

•  HormoneQuiz•  Top10Tests•  FillInHandout•  *12HourFast•  *Sweating•  *Sugar/Alcohol

What’sLinkedToHormones?

•  HeartDisease

•  Dementia

•  ChronicFatigue

•  Insomnia

•  Diabetes

•  Obesity

•  Mooddisorders

•  Inflammation

YourControlSystem-Cortisol

•  Cortisolisaglucocorticoid•  Maintainingvitaltasks:– Normalizesbloodsugar– EffectsBloodpressureandCardiovascularhealth– Helpstheimmunesystemwithinflammatoryresponse

– Helpsregulatemetabolismofcarbs,proteinandfats.

– Fatdistribution-especiallyaroundwaist

TheRoleofCortisol

AhormonalBalancingact

•  Hypothalamus–CEO•  Pituitary–ExecutiveAssistants•  PinealGland–Sleep•  Thyroid–Energy,Metabolism•  Ovaries/Testes–Sexhormones•  Pancreas–Bloodsugar•  Adrenal–HormoneregulationDecidingifahormonewillgetabsorbedintoacellisdeterminedbyhowmuchcortisolisinthebloodstreamatthatmoment!

HormonalPathways

TheStressResponse

•  Necessaryandadaptiveresponsethatmobilizesthebodytorespondtostressors

•  Ensuressurvivalofthespecies•  Thestressresponseisinitiatedandmaintainedbyasystemcalled:–  HypothalamicPituitaryAdrenal(HPA)axis

–  “Fight/Flight/Famine”–  Bodydoesnotdifferentiatebetweenseeingtigeroryougettingfrustratedintrafficandbeinglate

AcuteStressResponse

ChronicStressResponse

•  TheHPAAxisalways‘ON’•  Modulateswholebodyhomeostaticmechanisms:– MetabolicFunctions–  ImmuneFunctions– CardiovascularFunction– CentralNervousFunctions– GIfunctions

Outline

Whyarethey? 7Hormones

HormonalImbalance

TestingGuessing

Actionplan

•  Diseases•  Roles•  ControlSystem•  HPAAxis

•  Healthyrhythm•  HighAlert•  TiredbutWired•  Burnout•  5causesof

Dysfunction

•  HormonePathway•  Sexhormones•  Thyroid•  Pregnenolone

‘Steal’

•  Blood•  DUTCH•  Casestudies

•  ToxinQuestionnaire

•  HormoneQuiz•  Top10Tests•  FillInHandout•  *12HourFast•  *Sweating

ReviewHormoneQuiz

TOP7Hormones

•  Diseases•  Roles•  ControlSystem•  HPAAxis

•  CORTISOL•  ESRTOGEN•  PROGESTERONE•  TESTOSTERONE•  DHEA•  INSULIN•  THYROID

•  HormonePathway•  Sexhormones•  Thyroid•  Pregnenolone

‘Steal’

•  Blood•  DUTCH•  Casestudies

•  ToxinQuestionnaire

•  HormoneQuiz•  Top10Tests•  FillInHandout•  *12HourFast•  *Sweating

AdrenalDysfunction

? ? ?

Addison’sDisease Cushing’sDisease

Addison’s Cushing’s

HealthyRhythm

HealthySexHormones…But

HighAlert

TiredbutWired

Burnout

TooHigh/TooLow

5CausesofDysfunction

1.  ChronicMentalandEmotionalStress2.  FoodTriggers3.  GutImbalances4.  ToxicOverload5.  Immunedisruptionandstealthinfections6.  Lightdisruption7.  EMFs,Radiation

PhysicalExamFindings–AdrenalDysfunction

•  Low/highbloodpressure•  Achilles’tendonreflex–slow•  Slow/Rapidpulsatingpupillaryreflexes•  Skin,hairthinning,ridgednails,creasedfingertips

•  Palelineabovevermillionborder•  NerveringsaroundperipheryofIris

NerveRings

ChronicallytaxedNervousSystem

Nails

Gutstressorsshowingonskin

Outline

Whyarethey? 7Hormones

HormonalImbalance

TestingGuessing

Actionplan

•  Diseases•  Roles•  ControlSystem•  HPAAxis

•  Healthyrhythm•  HighAlert•  TiredbutWired•  Burnout•  5causesof

Dysfunction

•  HormonePathway•  Sexhormones•  Thyroid•  Pregnenolone

‘Steal’

•  Blood•  DUTCH•  Casestudies

•  ToxinQuestionnaire

•  HormoneQuiz•  Top10Tests•  FillInHandout•  *12HourFast•  *Sweating

HormonalPathways

HormonalImbalance:EstrogenDominance

HormonalImbalance:Hypothyroidism

HormonalHierarchy

•  1.LowCortisol

•  2.HighCortisol/Thyroid/Insulin/Inflammation

•  3.Estrogen/Testosterone/Progesterone/DHEA

Outline

Whyarethey? 7Hormones

HormonalImbalance

TestingGuessing

Actionplan

•  Diseases•  Roles•  ControlSystem•  HPAAxis

•  Healthyrhythm•  HighAlert•  TiredbutWired•  Burnout•  5causesof

Dysfunction

•  HormonePathway•  Sexhormones•  Thyroid•  Pregnenolone

‘Steal’

•  Blood•  DUTCH•  Casestudies

•  ToxinQuestionnaire

•  HormoneQuiz•  Top10Tests•  FillInHandout•  *12HourFast•  *Sweating

TestingOptions

•  Blood–Cortisol,Sexhormones,Thyroid

•  Driedurine–mostcomprehensive

Outline

Whyarethey? 7Hormones

HormonalImbalance

TestingGuessing

Actionplan

•  Diseases•  Roles•  ControlSystem•  HPAAxis

•  Healthyrhythm•  HighAlert•  TiredbutWired•  Burnout•  5causesof

Dysfunction

•  HormonePathway•  Sexhormones•  Thyroid•  Pregnenolone

‘Steal’

•  Blood•  DUTCH•  Casestudies

•  ToxinQuestionnaire

•  HormoneQuiz•  Top10Tests•  FillInHandout•  *12HourFast•  *Sweating•  *Sugar/Alcohol