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© 2015 HORIBA, Ltd. All rights reserved. 1 © 2009 HORIBA Medical All rights reserved.
© 2015 HORIBA, Ltd. All rights reserved. 1 © 2009 HORIBA Medical All rights reserved.
© 2015 HORIBA, Ltd. All rights reserved. 2 © 2015 HORIBA, Ltd. All rights reserved. 2
AMR and combined FBC/CRP solutions Tools to fight a critical health issue: Antimicrobial resistance
25th January 2017
Horiba Medical
© 2015 HORIBA, Ltd. All rights reserved. 3
2010 Antibiotics Prescription 2010 Antibiotics Resistance
Near
Patient
Testing
Solutions
Limited
antibiotic
Resistance
Areas
Source :Surveillance of antimicrobial consumption in Europe, 2010 Surveillance reports - 04 Mar 2013
POCT / Near patient Solution to ATB Resistance
© 2015 HORIBA, Ltd. All rights reserved. 4
HORIBA Near patient Solutions : Microsemi CRP & Pentra MS CRP
Leader in CRP Solutions
© 2015 HORIBA, Ltd. All rights reserved. 5
Unique HORIBA Medical + CBC solutions
Pentra MS
EDTA Capillary whole
blood 18μL
EDTA Capillary whole
blood 35μL
3 to 4 mins
5diff
3diff
© 2015 HORIBA, Ltd. All rights reserved. 6
Absorbance
Cell size
EOS
LIC
MON
NEU
LYM ALY
RBC 溶血
ＳＴＥＰ１: Hemolytic reaction
Anti ＣＲＰ Anti-body sensitized latex
Antigen-antibody complex reaction
＋
ＣＲＰ antigen
Lyse Rea.
ＳＴＥＰ２: Antigen-antibody complex reaction
WBC 5Diff CRP
WBC -Impedance method CRP - Latex Immunoturbidimetry : with hematocrit correction C Differential - Combination of impedance method, staining technology, light transmission
Unique HORIBA Medical CRP + CBC solutions
© 2015 HORIBA, Ltd. All rights reserved. 7
Infection
CRP + FBC Indication for Use Infection Screening
WBC
Time (hours)
-Rapid Kinetics
-High Amplitude Variation
-6 hours post–infection Synthesis
-18 hours Short half-life
-Rapid decrease if efficient ATB
© 2015 HORIBA, Ltd. All rights reserved. 8
CRP at the POCT - FDA approval
FDA ‘Experience’with Clinical Trials for Immune Biomarkers of Infection & Sepsis Steven Gitterman, FDA October 16, 2015
© 2015 HORIBA, Ltd. All rights reserved. 9
Source : Holland National College of General Practitioners Guidelines
Infection Type Screening
© 2015 HORIBA, Ltd. All rights reserved. 10
Primary Care Screening Immediate decision with a single tube, no centrifugation
© 2015 HORIBA, Ltd. All rights reserved. 11
Primary Care Screening Immediate decision with a single tube, no centrifugation
© 2015 HORIBA, Ltd. All rights reserved. 12
Study 1 – Paediatric ED
© 2015 HORIBA, Ltd. All rights reserved. 13
Study 2 – Paediatric ED
• Multi-site Study – Oxford AHSN • John Radcliffe • Wexham Park • Stoke Mandeville
• Part 1 – Instrument evaluation • Comparative data with laboratory instruments
• FBC • CRP
• Part 2 – Operational evaluation • ED placement/training • Feedback • Health economics
© 2015 HORIBA, Ltd. All rights reserved. 14
Danke Большое спасибо
Grazie
اشُكْر
Σας ευχαριστούμε
감사합니다
Obrigado
谢谢
ขอบคณุครบั
ありがとうございました
धन्यवाद
நன்ற
Cảm ơn
Dziękuję
Tack ska ni ha
Thank you
Merci
