56
Dr. Fathi Neana, MD Chief of Orthopaedics Dr. Fakhry & Dr. A. Al-Garzaie Hospital Saudi Arabia September, 28 - 2017
| Date post: | 22-Jan-2018 |
| Category: |
Health & Medicine |
| Upload: | fathi-neana |
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Dr Fathi Neana MDChief of Orthopaedics
Dr Fakhry amp Dr A Al-Garzaie HospitalSaudi Arabia
September 28 - 2017
هم بعض ال ذي عملوا لعل ليذيقهم اس ظهر الفساد في البر والبحر بما كسبت أيدي الن
الروم( 41)يرجعون Mischief has appeared on land and sea because of (the meed) that the hands of men have earned that
(Allah) may give them a taste of some of their deeds in order that they may turn back (from Evil) (Quran 3041)
Health
As defined by World Health Organization (WHO) Health is a State of complete physical mental and social well being and not merely the absence of a disease or infirmity
Health is a dynamic condition resulting from a bodys constant adjustment and adaptation in response to stresses and changes in the environment for maintaining an inner equilibrium called homeostasis
Read more httpwwwbusinessdictionarycomdefinitionhealthhtml
Human Health
DiseaseAcute
chronic
PathogenBacteria
viruses
PollutionRisksObesity
smoke
Chemicals
Types
Neurotoxines
Carcinogenes
Teratogenes
Endocrine
disruptors
Allergens
Dose ndash response Duration
Bioaccumulation
Biomagnification
Stockholm convention
LD50
PCBs (Polychlorinated biphenyls)
widely deployed as dielectric and coolant fluids in electrical apparatus carbonless copy paper and in heat transfer fluids
Because of their longevity PCBs are still widely in use
PCBs cause cancer in animals and are human carcinogenic teratogenic endocrine disruptor (thyroid) toxic to liver and nervous system
Because of PCBs environmental toxicity and classification as a persistent organic pollutant PCB production was banned by the United States Congress in 1979 and by the Stockholm Convention on Persistent Organic Pollutants in 2001
Many rivers and buildings including schools parks and other sites are contaminated with PCBs and there have been contaminations of food supplies with the substances
Bioaccumulation and BiomagnificationPCBs Polychlorinated biphenyls
Overfishing of small fish (sardines
anchovy mackerel and scads)الصيد الجائر لالسماك الصغيرة مثل السردين
Living phytoplankton amp zooplankton
absorb pollutants like lead mercury
Small fish consume the loaded living
phytoplankton amp zooplankton
Dead phytoplankton amp zooplankton
release pollutants in water again
Human health effects
Human health effects can be due to
1- Climate change
2- Pollutants
Human health effectsTop 45 diseases caused by pollution
Air pollution 1 Asthma attacks - chronic obstructive pulmonary disease ndashCOPD2 Weakening of lung function3 Pulmonary cancer4 Mesothelioma5 Pneumonia6 Bronchitis7 Emphysema8 Leukemia9 Birth defects and immune system defects10 Cardiovascular problems11 Neurobehavioral disorders12 Liver and other types of cancer13 Premature death14 Autism
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Noise pollution39 Efficiency decrease of people40 Lack of concentration41 Fatigue42 Abortion43 Blood Pressure44 Temporary or permanent deafness45 Anxiety
Light PollutionMelatonin
Radioactive contaminationIonized radiationNon ionized radiation (EMFs ndash Wi-Fi)
Thermal pollutionPharmaceuticals DrugsAlcohol SmokeMental - psychological
Water Pollution
Water Pollution
مياه عذبة
Water Pollution
bull Water pollution is the contamination of water bodies (eg lakes rivers oceans aquifers and groundwater)
bull Water pollution occurs when pollutants are discharged directly or indirectly into water bodies without adequate treatment to remove harmful compounds
bull Water pollution affects plants and organisms living in these bodies of water
bull In almost all cases the effect is damaging not only to individual species and populations but also to the natural biological communities
Water pollution is a serious issue as it is easily spread
Water pollution have a strong impact on the delicate balance in the natural ecosystem This will ultimately impact the humans and other living organisms
The effects of water pollution are different and depend on the chemicals dumped in that particular location
The effects of water pollution could be classified intobulleffects on ecosystembulleffects on animal healthbulleffects on human health
Effects of Water Pollution
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Human health effectsTop 45 diseases caused by pollution
Sources of water pollution
bull Domestic sewage
bull Industrial waste water
bull Agricultural waste water
bull Construction site storm water
bull Urban runoff storm water
bull Petroleum hydrocarbons
bull Plastics
bull Pesticides
bull Heavy metals
bull Sewage
bull Radioactive waste
bull Thermal effluents
bull Pharmaceuticals
Water Pollutants
bull Detergents
bull Chloroform
bull Food processing waste (fats and grease)
bull Insecticides and herbicides
bull Petroleum hydrocarbons (gasoline diesel fuel jet fuels and fuel oil)
bull Lubricants (motor oil)
bull From storm water runoff
bull Pharmaceuticals
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
هم بعض ال ذي عملوا لعل ليذيقهم اس ظهر الفساد في البر والبحر بما كسبت أيدي الن
الروم( 41)يرجعون Mischief has appeared on land and sea because of (the meed) that the hands of men have earned that
(Allah) may give them a taste of some of their deeds in order that they may turn back (from Evil) (Quran 3041)
Health
As defined by World Health Organization (WHO) Health is a State of complete physical mental and social well being and not merely the absence of a disease or infirmity
Health is a dynamic condition resulting from a bodys constant adjustment and adaptation in response to stresses and changes in the environment for maintaining an inner equilibrium called homeostasis
Read more httpwwwbusinessdictionarycomdefinitionhealthhtml
Human Health
DiseaseAcute
chronic
PathogenBacteria
viruses
PollutionRisksObesity
smoke
Chemicals
Types
Neurotoxines
Carcinogenes
Teratogenes
Endocrine
disruptors
Allergens
Dose ndash response Duration
Bioaccumulation
Biomagnification
Stockholm convention
LD50
PCBs (Polychlorinated biphenyls)
widely deployed as dielectric and coolant fluids in electrical apparatus carbonless copy paper and in heat transfer fluids
Because of their longevity PCBs are still widely in use
PCBs cause cancer in animals and are human carcinogenic teratogenic endocrine disruptor (thyroid) toxic to liver and nervous system
Because of PCBs environmental toxicity and classification as a persistent organic pollutant PCB production was banned by the United States Congress in 1979 and by the Stockholm Convention on Persistent Organic Pollutants in 2001
Many rivers and buildings including schools parks and other sites are contaminated with PCBs and there have been contaminations of food supplies with the substances
Bioaccumulation and BiomagnificationPCBs Polychlorinated biphenyls
Overfishing of small fish (sardines
anchovy mackerel and scads)الصيد الجائر لالسماك الصغيرة مثل السردين
Living phytoplankton amp zooplankton
absorb pollutants like lead mercury
Small fish consume the loaded living
phytoplankton amp zooplankton
Dead phytoplankton amp zooplankton
release pollutants in water again
Human health effects
Human health effects can be due to
1- Climate change
2- Pollutants
Human health effectsTop 45 diseases caused by pollution
Air pollution 1 Asthma attacks - chronic obstructive pulmonary disease ndashCOPD2 Weakening of lung function3 Pulmonary cancer4 Mesothelioma5 Pneumonia6 Bronchitis7 Emphysema8 Leukemia9 Birth defects and immune system defects10 Cardiovascular problems11 Neurobehavioral disorders12 Liver and other types of cancer13 Premature death14 Autism
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Noise pollution39 Efficiency decrease of people40 Lack of concentration41 Fatigue42 Abortion43 Blood Pressure44 Temporary or permanent deafness45 Anxiety
Light PollutionMelatonin
Radioactive contaminationIonized radiationNon ionized radiation (EMFs ndash Wi-Fi)
Thermal pollutionPharmaceuticals DrugsAlcohol SmokeMental - psychological
Water Pollution
Water Pollution
مياه عذبة
Water Pollution
bull Water pollution is the contamination of water bodies (eg lakes rivers oceans aquifers and groundwater)
bull Water pollution occurs when pollutants are discharged directly or indirectly into water bodies without adequate treatment to remove harmful compounds
bull Water pollution affects plants and organisms living in these bodies of water
bull In almost all cases the effect is damaging not only to individual species and populations but also to the natural biological communities
Water pollution is a serious issue as it is easily spread
Water pollution have a strong impact on the delicate balance in the natural ecosystem This will ultimately impact the humans and other living organisms
The effects of water pollution are different and depend on the chemicals dumped in that particular location
The effects of water pollution could be classified intobulleffects on ecosystembulleffects on animal healthbulleffects on human health
Effects of Water Pollution
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Human health effectsTop 45 diseases caused by pollution
Sources of water pollution
bull Domestic sewage
bull Industrial waste water
bull Agricultural waste water
bull Construction site storm water
bull Urban runoff storm water
bull Petroleum hydrocarbons
bull Plastics
bull Pesticides
bull Heavy metals
bull Sewage
bull Radioactive waste
bull Thermal effluents
bull Pharmaceuticals
Water Pollutants
bull Detergents
bull Chloroform
bull Food processing waste (fats and grease)
bull Insecticides and herbicides
bull Petroleum hydrocarbons (gasoline diesel fuel jet fuels and fuel oil)
bull Lubricants (motor oil)
bull From storm water runoff
bull Pharmaceuticals
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Health
As defined by World Health Organization (WHO) Health is a State of complete physical mental and social well being and not merely the absence of a disease or infirmity
Health is a dynamic condition resulting from a bodys constant adjustment and adaptation in response to stresses and changes in the environment for maintaining an inner equilibrium called homeostasis
Read more httpwwwbusinessdictionarycomdefinitionhealthhtml
Human Health
DiseaseAcute
chronic
PathogenBacteria
viruses
PollutionRisksObesity
smoke
Chemicals
Types
Neurotoxines
Carcinogenes
Teratogenes
Endocrine
disruptors
Allergens
Dose ndash response Duration
Bioaccumulation
Biomagnification
Stockholm convention
LD50
PCBs (Polychlorinated biphenyls)
widely deployed as dielectric and coolant fluids in electrical apparatus carbonless copy paper and in heat transfer fluids
Because of their longevity PCBs are still widely in use
PCBs cause cancer in animals and are human carcinogenic teratogenic endocrine disruptor (thyroid) toxic to liver and nervous system
Because of PCBs environmental toxicity and classification as a persistent organic pollutant PCB production was banned by the United States Congress in 1979 and by the Stockholm Convention on Persistent Organic Pollutants in 2001
Many rivers and buildings including schools parks and other sites are contaminated with PCBs and there have been contaminations of food supplies with the substances
Bioaccumulation and BiomagnificationPCBs Polychlorinated biphenyls
Overfishing of small fish (sardines
anchovy mackerel and scads)الصيد الجائر لالسماك الصغيرة مثل السردين
Living phytoplankton amp zooplankton
absorb pollutants like lead mercury
Small fish consume the loaded living
phytoplankton amp zooplankton
Dead phytoplankton amp zooplankton
release pollutants in water again
Human health effects
Human health effects can be due to
1- Climate change
2- Pollutants
Human health effectsTop 45 diseases caused by pollution
Air pollution 1 Asthma attacks - chronic obstructive pulmonary disease ndashCOPD2 Weakening of lung function3 Pulmonary cancer4 Mesothelioma5 Pneumonia6 Bronchitis7 Emphysema8 Leukemia9 Birth defects and immune system defects10 Cardiovascular problems11 Neurobehavioral disorders12 Liver and other types of cancer13 Premature death14 Autism
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Noise pollution39 Efficiency decrease of people40 Lack of concentration41 Fatigue42 Abortion43 Blood Pressure44 Temporary or permanent deafness45 Anxiety
Light PollutionMelatonin
Radioactive contaminationIonized radiationNon ionized radiation (EMFs ndash Wi-Fi)
Thermal pollutionPharmaceuticals DrugsAlcohol SmokeMental - psychological
Water Pollution
Water Pollution
مياه عذبة
Water Pollution
bull Water pollution is the contamination of water bodies (eg lakes rivers oceans aquifers and groundwater)
bull Water pollution occurs when pollutants are discharged directly or indirectly into water bodies without adequate treatment to remove harmful compounds
bull Water pollution affects plants and organisms living in these bodies of water
bull In almost all cases the effect is damaging not only to individual species and populations but also to the natural biological communities
Water pollution is a serious issue as it is easily spread
Water pollution have a strong impact on the delicate balance in the natural ecosystem This will ultimately impact the humans and other living organisms
The effects of water pollution are different and depend on the chemicals dumped in that particular location
The effects of water pollution could be classified intobulleffects on ecosystembulleffects on animal healthbulleffects on human health
Effects of Water Pollution
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Human health effectsTop 45 diseases caused by pollution
Sources of water pollution
bull Domestic sewage
bull Industrial waste water
bull Agricultural waste water
bull Construction site storm water
bull Urban runoff storm water
bull Petroleum hydrocarbons
bull Plastics
bull Pesticides
bull Heavy metals
bull Sewage
bull Radioactive waste
bull Thermal effluents
bull Pharmaceuticals
Water Pollutants
bull Detergents
bull Chloroform
bull Food processing waste (fats and grease)
bull Insecticides and herbicides
bull Petroleum hydrocarbons (gasoline diesel fuel jet fuels and fuel oil)
bull Lubricants (motor oil)
bull From storm water runoff
bull Pharmaceuticals
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Human Health
DiseaseAcute
chronic
PathogenBacteria
viruses
PollutionRisksObesity
smoke
Chemicals
Types
Neurotoxines
Carcinogenes
Teratogenes
Endocrine
disruptors
Allergens
Dose ndash response Duration
Bioaccumulation
Biomagnification
Stockholm convention
LD50
PCBs (Polychlorinated biphenyls)
widely deployed as dielectric and coolant fluids in electrical apparatus carbonless copy paper and in heat transfer fluids
Because of their longevity PCBs are still widely in use
PCBs cause cancer in animals and are human carcinogenic teratogenic endocrine disruptor (thyroid) toxic to liver and nervous system
Because of PCBs environmental toxicity and classification as a persistent organic pollutant PCB production was banned by the United States Congress in 1979 and by the Stockholm Convention on Persistent Organic Pollutants in 2001
Many rivers and buildings including schools parks and other sites are contaminated with PCBs and there have been contaminations of food supplies with the substances
Bioaccumulation and BiomagnificationPCBs Polychlorinated biphenyls
Overfishing of small fish (sardines
anchovy mackerel and scads)الصيد الجائر لالسماك الصغيرة مثل السردين
Living phytoplankton amp zooplankton
absorb pollutants like lead mercury
Small fish consume the loaded living
phytoplankton amp zooplankton
Dead phytoplankton amp zooplankton
release pollutants in water again
Human health effects
Human health effects can be due to
1- Climate change
2- Pollutants
Human health effectsTop 45 diseases caused by pollution
Air pollution 1 Asthma attacks - chronic obstructive pulmonary disease ndashCOPD2 Weakening of lung function3 Pulmonary cancer4 Mesothelioma5 Pneumonia6 Bronchitis7 Emphysema8 Leukemia9 Birth defects and immune system defects10 Cardiovascular problems11 Neurobehavioral disorders12 Liver and other types of cancer13 Premature death14 Autism
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Noise pollution39 Efficiency decrease of people40 Lack of concentration41 Fatigue42 Abortion43 Blood Pressure44 Temporary or permanent deafness45 Anxiety
Light PollutionMelatonin
Radioactive contaminationIonized radiationNon ionized radiation (EMFs ndash Wi-Fi)
Thermal pollutionPharmaceuticals DrugsAlcohol SmokeMental - psychological
Water Pollution
Water Pollution
مياه عذبة
Water Pollution
bull Water pollution is the contamination of water bodies (eg lakes rivers oceans aquifers and groundwater)
bull Water pollution occurs when pollutants are discharged directly or indirectly into water bodies without adequate treatment to remove harmful compounds
bull Water pollution affects plants and organisms living in these bodies of water
bull In almost all cases the effect is damaging not only to individual species and populations but also to the natural biological communities
Water pollution is a serious issue as it is easily spread
Water pollution have a strong impact on the delicate balance in the natural ecosystem This will ultimately impact the humans and other living organisms
The effects of water pollution are different and depend on the chemicals dumped in that particular location
The effects of water pollution could be classified intobulleffects on ecosystembulleffects on animal healthbulleffects on human health
Effects of Water Pollution
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Human health effectsTop 45 diseases caused by pollution
Sources of water pollution
bull Domestic sewage
bull Industrial waste water
bull Agricultural waste water
bull Construction site storm water
bull Urban runoff storm water
bull Petroleum hydrocarbons
bull Plastics
bull Pesticides
bull Heavy metals
bull Sewage
bull Radioactive waste
bull Thermal effluents
bull Pharmaceuticals
Water Pollutants
bull Detergents
bull Chloroform
bull Food processing waste (fats and grease)
bull Insecticides and herbicides
bull Petroleum hydrocarbons (gasoline diesel fuel jet fuels and fuel oil)
bull Lubricants (motor oil)
bull From storm water runoff
bull Pharmaceuticals
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
PCBs (Polychlorinated biphenyls)
widely deployed as dielectric and coolant fluids in electrical apparatus carbonless copy paper and in heat transfer fluids
Because of their longevity PCBs are still widely in use
PCBs cause cancer in animals and are human carcinogenic teratogenic endocrine disruptor (thyroid) toxic to liver and nervous system
Because of PCBs environmental toxicity and classification as a persistent organic pollutant PCB production was banned by the United States Congress in 1979 and by the Stockholm Convention on Persistent Organic Pollutants in 2001
Many rivers and buildings including schools parks and other sites are contaminated with PCBs and there have been contaminations of food supplies with the substances
Bioaccumulation and BiomagnificationPCBs Polychlorinated biphenyls
Overfishing of small fish (sardines
anchovy mackerel and scads)الصيد الجائر لالسماك الصغيرة مثل السردين
Living phytoplankton amp zooplankton
absorb pollutants like lead mercury
Small fish consume the loaded living
phytoplankton amp zooplankton
Dead phytoplankton amp zooplankton
release pollutants in water again
Human health effects
Human health effects can be due to
1- Climate change
2- Pollutants
Human health effectsTop 45 diseases caused by pollution
Air pollution 1 Asthma attacks - chronic obstructive pulmonary disease ndashCOPD2 Weakening of lung function3 Pulmonary cancer4 Mesothelioma5 Pneumonia6 Bronchitis7 Emphysema8 Leukemia9 Birth defects and immune system defects10 Cardiovascular problems11 Neurobehavioral disorders12 Liver and other types of cancer13 Premature death14 Autism
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Noise pollution39 Efficiency decrease of people40 Lack of concentration41 Fatigue42 Abortion43 Blood Pressure44 Temporary or permanent deafness45 Anxiety
Light PollutionMelatonin
Radioactive contaminationIonized radiationNon ionized radiation (EMFs ndash Wi-Fi)
Thermal pollutionPharmaceuticals DrugsAlcohol SmokeMental - psychological
Water Pollution
Water Pollution
مياه عذبة
Water Pollution
bull Water pollution is the contamination of water bodies (eg lakes rivers oceans aquifers and groundwater)
bull Water pollution occurs when pollutants are discharged directly or indirectly into water bodies without adequate treatment to remove harmful compounds
bull Water pollution affects plants and organisms living in these bodies of water
bull In almost all cases the effect is damaging not only to individual species and populations but also to the natural biological communities
Water pollution is a serious issue as it is easily spread
Water pollution have a strong impact on the delicate balance in the natural ecosystem This will ultimately impact the humans and other living organisms
The effects of water pollution are different and depend on the chemicals dumped in that particular location
The effects of water pollution could be classified intobulleffects on ecosystembulleffects on animal healthbulleffects on human health
Effects of Water Pollution
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Human health effectsTop 45 diseases caused by pollution
Sources of water pollution
bull Domestic sewage
bull Industrial waste water
bull Agricultural waste water
bull Construction site storm water
bull Urban runoff storm water
bull Petroleum hydrocarbons
bull Plastics
bull Pesticides
bull Heavy metals
bull Sewage
bull Radioactive waste
bull Thermal effluents
bull Pharmaceuticals
Water Pollutants
bull Detergents
bull Chloroform
bull Food processing waste (fats and grease)
bull Insecticides and herbicides
bull Petroleum hydrocarbons (gasoline diesel fuel jet fuels and fuel oil)
bull Lubricants (motor oil)
bull From storm water runoff
bull Pharmaceuticals
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Bioaccumulation and BiomagnificationPCBs Polychlorinated biphenyls
Overfishing of small fish (sardines
anchovy mackerel and scads)الصيد الجائر لالسماك الصغيرة مثل السردين
Living phytoplankton amp zooplankton
absorb pollutants like lead mercury
Small fish consume the loaded living
phytoplankton amp zooplankton
Dead phytoplankton amp zooplankton
release pollutants in water again
Human health effects
Human health effects can be due to
1- Climate change
2- Pollutants
Human health effectsTop 45 diseases caused by pollution
Air pollution 1 Asthma attacks - chronic obstructive pulmonary disease ndashCOPD2 Weakening of lung function3 Pulmonary cancer4 Mesothelioma5 Pneumonia6 Bronchitis7 Emphysema8 Leukemia9 Birth defects and immune system defects10 Cardiovascular problems11 Neurobehavioral disorders12 Liver and other types of cancer13 Premature death14 Autism
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Noise pollution39 Efficiency decrease of people40 Lack of concentration41 Fatigue42 Abortion43 Blood Pressure44 Temporary or permanent deafness45 Anxiety
Light PollutionMelatonin
Radioactive contaminationIonized radiationNon ionized radiation (EMFs ndash Wi-Fi)
Thermal pollutionPharmaceuticals DrugsAlcohol SmokeMental - psychological
Water Pollution
Water Pollution
مياه عذبة
Water Pollution
bull Water pollution is the contamination of water bodies (eg lakes rivers oceans aquifers and groundwater)
bull Water pollution occurs when pollutants are discharged directly or indirectly into water bodies without adequate treatment to remove harmful compounds
bull Water pollution affects plants and organisms living in these bodies of water
bull In almost all cases the effect is damaging not only to individual species and populations but also to the natural biological communities
Water pollution is a serious issue as it is easily spread
Water pollution have a strong impact on the delicate balance in the natural ecosystem This will ultimately impact the humans and other living organisms
The effects of water pollution are different and depend on the chemicals dumped in that particular location
The effects of water pollution could be classified intobulleffects on ecosystembulleffects on animal healthbulleffects on human health
Effects of Water Pollution
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Human health effectsTop 45 diseases caused by pollution
Sources of water pollution
bull Domestic sewage
bull Industrial waste water
bull Agricultural waste water
bull Construction site storm water
bull Urban runoff storm water
bull Petroleum hydrocarbons
bull Plastics
bull Pesticides
bull Heavy metals
bull Sewage
bull Radioactive waste
bull Thermal effluents
bull Pharmaceuticals
Water Pollutants
bull Detergents
bull Chloroform
bull Food processing waste (fats and grease)
bull Insecticides and herbicides
bull Petroleum hydrocarbons (gasoline diesel fuel jet fuels and fuel oil)
bull Lubricants (motor oil)
bull From storm water runoff
bull Pharmaceuticals
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Overfishing of small fish (sardines
anchovy mackerel and scads)الصيد الجائر لالسماك الصغيرة مثل السردين
Living phytoplankton amp zooplankton
absorb pollutants like lead mercury
Small fish consume the loaded living
phytoplankton amp zooplankton
Dead phytoplankton amp zooplankton
release pollutants in water again
Human health effects
Human health effects can be due to
1- Climate change
2- Pollutants
Human health effectsTop 45 diseases caused by pollution
Air pollution 1 Asthma attacks - chronic obstructive pulmonary disease ndashCOPD2 Weakening of lung function3 Pulmonary cancer4 Mesothelioma5 Pneumonia6 Bronchitis7 Emphysema8 Leukemia9 Birth defects and immune system defects10 Cardiovascular problems11 Neurobehavioral disorders12 Liver and other types of cancer13 Premature death14 Autism
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Noise pollution39 Efficiency decrease of people40 Lack of concentration41 Fatigue42 Abortion43 Blood Pressure44 Temporary or permanent deafness45 Anxiety
Light PollutionMelatonin
Radioactive contaminationIonized radiationNon ionized radiation (EMFs ndash Wi-Fi)
Thermal pollutionPharmaceuticals DrugsAlcohol SmokeMental - psychological
Water Pollution
Water Pollution
مياه عذبة
Water Pollution
bull Water pollution is the contamination of water bodies (eg lakes rivers oceans aquifers and groundwater)
bull Water pollution occurs when pollutants are discharged directly or indirectly into water bodies without adequate treatment to remove harmful compounds
bull Water pollution affects plants and organisms living in these bodies of water
bull In almost all cases the effect is damaging not only to individual species and populations but also to the natural biological communities
Water pollution is a serious issue as it is easily spread
Water pollution have a strong impact on the delicate balance in the natural ecosystem This will ultimately impact the humans and other living organisms
The effects of water pollution are different and depend on the chemicals dumped in that particular location
The effects of water pollution could be classified intobulleffects on ecosystembulleffects on animal healthbulleffects on human health
Effects of Water Pollution
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Human health effectsTop 45 diseases caused by pollution
Sources of water pollution
bull Domestic sewage
bull Industrial waste water
bull Agricultural waste water
bull Construction site storm water
bull Urban runoff storm water
bull Petroleum hydrocarbons
bull Plastics
bull Pesticides
bull Heavy metals
bull Sewage
bull Radioactive waste
bull Thermal effluents
bull Pharmaceuticals
Water Pollutants
bull Detergents
bull Chloroform
bull Food processing waste (fats and grease)
bull Insecticides and herbicides
bull Petroleum hydrocarbons (gasoline diesel fuel jet fuels and fuel oil)
bull Lubricants (motor oil)
bull From storm water runoff
bull Pharmaceuticals
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Human health effects
Human health effects can be due to
1- Climate change
2- Pollutants
Human health effectsTop 45 diseases caused by pollution
Air pollution 1 Asthma attacks - chronic obstructive pulmonary disease ndashCOPD2 Weakening of lung function3 Pulmonary cancer4 Mesothelioma5 Pneumonia6 Bronchitis7 Emphysema8 Leukemia9 Birth defects and immune system defects10 Cardiovascular problems11 Neurobehavioral disorders12 Liver and other types of cancer13 Premature death14 Autism
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Noise pollution39 Efficiency decrease of people40 Lack of concentration41 Fatigue42 Abortion43 Blood Pressure44 Temporary or permanent deafness45 Anxiety
Light PollutionMelatonin
Radioactive contaminationIonized radiationNon ionized radiation (EMFs ndash Wi-Fi)
Thermal pollutionPharmaceuticals DrugsAlcohol SmokeMental - psychological
Water Pollution
Water Pollution
مياه عذبة
Water Pollution
bull Water pollution is the contamination of water bodies (eg lakes rivers oceans aquifers and groundwater)
bull Water pollution occurs when pollutants are discharged directly or indirectly into water bodies without adequate treatment to remove harmful compounds
bull Water pollution affects plants and organisms living in these bodies of water
bull In almost all cases the effect is damaging not only to individual species and populations but also to the natural biological communities
Water pollution is a serious issue as it is easily spread
Water pollution have a strong impact on the delicate balance in the natural ecosystem This will ultimately impact the humans and other living organisms
The effects of water pollution are different and depend on the chemicals dumped in that particular location
The effects of water pollution could be classified intobulleffects on ecosystembulleffects on animal healthbulleffects on human health
Effects of Water Pollution
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Human health effectsTop 45 diseases caused by pollution
Sources of water pollution
bull Domestic sewage
bull Industrial waste water
bull Agricultural waste water
bull Construction site storm water
bull Urban runoff storm water
bull Petroleum hydrocarbons
bull Plastics
bull Pesticides
bull Heavy metals
bull Sewage
bull Radioactive waste
bull Thermal effluents
bull Pharmaceuticals
Water Pollutants
bull Detergents
bull Chloroform
bull Food processing waste (fats and grease)
bull Insecticides and herbicides
bull Petroleum hydrocarbons (gasoline diesel fuel jet fuels and fuel oil)
bull Lubricants (motor oil)
bull From storm water runoff
bull Pharmaceuticals
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Human health effectsTop 45 diseases caused by pollution
Air pollution 1 Asthma attacks - chronic obstructive pulmonary disease ndashCOPD2 Weakening of lung function3 Pulmonary cancer4 Mesothelioma5 Pneumonia6 Bronchitis7 Emphysema8 Leukemia9 Birth defects and immune system defects10 Cardiovascular problems11 Neurobehavioral disorders12 Liver and other types of cancer13 Premature death14 Autism
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Noise pollution39 Efficiency decrease of people40 Lack of concentration41 Fatigue42 Abortion43 Blood Pressure44 Temporary or permanent deafness45 Anxiety
Light PollutionMelatonin
Radioactive contaminationIonized radiationNon ionized radiation (EMFs ndash Wi-Fi)
Thermal pollutionPharmaceuticals DrugsAlcohol SmokeMental - psychological
Water Pollution
Water Pollution
مياه عذبة
Water Pollution
bull Water pollution is the contamination of water bodies (eg lakes rivers oceans aquifers and groundwater)
bull Water pollution occurs when pollutants are discharged directly or indirectly into water bodies without adequate treatment to remove harmful compounds
bull Water pollution affects plants and organisms living in these bodies of water
bull In almost all cases the effect is damaging not only to individual species and populations but also to the natural biological communities
Water pollution is a serious issue as it is easily spread
Water pollution have a strong impact on the delicate balance in the natural ecosystem This will ultimately impact the humans and other living organisms
The effects of water pollution are different and depend on the chemicals dumped in that particular location
The effects of water pollution could be classified intobulleffects on ecosystembulleffects on animal healthbulleffects on human health
Effects of Water Pollution
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Human health effectsTop 45 diseases caused by pollution
Sources of water pollution
bull Domestic sewage
bull Industrial waste water
bull Agricultural waste water
bull Construction site storm water
bull Urban runoff storm water
bull Petroleum hydrocarbons
bull Plastics
bull Pesticides
bull Heavy metals
bull Sewage
bull Radioactive waste
bull Thermal effluents
bull Pharmaceuticals
Water Pollutants
bull Detergents
bull Chloroform
bull Food processing waste (fats and grease)
bull Insecticides and herbicides
bull Petroleum hydrocarbons (gasoline diesel fuel jet fuels and fuel oil)
bull Lubricants (motor oil)
bull From storm water runoff
bull Pharmaceuticals
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Water Pollution
Water Pollution
مياه عذبة
Water Pollution
bull Water pollution is the contamination of water bodies (eg lakes rivers oceans aquifers and groundwater)
bull Water pollution occurs when pollutants are discharged directly or indirectly into water bodies without adequate treatment to remove harmful compounds
bull Water pollution affects plants and organisms living in these bodies of water
bull In almost all cases the effect is damaging not only to individual species and populations but also to the natural biological communities
Water pollution is a serious issue as it is easily spread
Water pollution have a strong impact on the delicate balance in the natural ecosystem This will ultimately impact the humans and other living organisms
The effects of water pollution are different and depend on the chemicals dumped in that particular location
The effects of water pollution could be classified intobulleffects on ecosystembulleffects on animal healthbulleffects on human health
Effects of Water Pollution
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Human health effectsTop 45 diseases caused by pollution
Sources of water pollution
bull Domestic sewage
bull Industrial waste water
bull Agricultural waste water
bull Construction site storm water
bull Urban runoff storm water
bull Petroleum hydrocarbons
bull Plastics
bull Pesticides
bull Heavy metals
bull Sewage
bull Radioactive waste
bull Thermal effluents
bull Pharmaceuticals
Water Pollutants
bull Detergents
bull Chloroform
bull Food processing waste (fats and grease)
bull Insecticides and herbicides
bull Petroleum hydrocarbons (gasoline diesel fuel jet fuels and fuel oil)
bull Lubricants (motor oil)
bull From storm water runoff
bull Pharmaceuticals
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Water Pollution
مياه عذبة
Water Pollution
bull Water pollution is the contamination of water bodies (eg lakes rivers oceans aquifers and groundwater)
bull Water pollution occurs when pollutants are discharged directly or indirectly into water bodies without adequate treatment to remove harmful compounds
bull Water pollution affects plants and organisms living in these bodies of water
bull In almost all cases the effect is damaging not only to individual species and populations but also to the natural biological communities
Water pollution is a serious issue as it is easily spread
Water pollution have a strong impact on the delicate balance in the natural ecosystem This will ultimately impact the humans and other living organisms
The effects of water pollution are different and depend on the chemicals dumped in that particular location
The effects of water pollution could be classified intobulleffects on ecosystembulleffects on animal healthbulleffects on human health
Effects of Water Pollution
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Human health effectsTop 45 diseases caused by pollution
Sources of water pollution
bull Domestic sewage
bull Industrial waste water
bull Agricultural waste water
bull Construction site storm water
bull Urban runoff storm water
bull Petroleum hydrocarbons
bull Plastics
bull Pesticides
bull Heavy metals
bull Sewage
bull Radioactive waste
bull Thermal effluents
bull Pharmaceuticals
Water Pollutants
bull Detergents
bull Chloroform
bull Food processing waste (fats and grease)
bull Insecticides and herbicides
bull Petroleum hydrocarbons (gasoline diesel fuel jet fuels and fuel oil)
bull Lubricants (motor oil)
bull From storm water runoff
bull Pharmaceuticals
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Water Pollution
bull Water pollution is the contamination of water bodies (eg lakes rivers oceans aquifers and groundwater)
bull Water pollution occurs when pollutants are discharged directly or indirectly into water bodies without adequate treatment to remove harmful compounds
bull Water pollution affects plants and organisms living in these bodies of water
bull In almost all cases the effect is damaging not only to individual species and populations but also to the natural biological communities
Water pollution is a serious issue as it is easily spread
Water pollution have a strong impact on the delicate balance in the natural ecosystem This will ultimately impact the humans and other living organisms
The effects of water pollution are different and depend on the chemicals dumped in that particular location
The effects of water pollution could be classified intobulleffects on ecosystembulleffects on animal healthbulleffects on human health
Effects of Water Pollution
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Human health effectsTop 45 diseases caused by pollution
Sources of water pollution
bull Domestic sewage
bull Industrial waste water
bull Agricultural waste water
bull Construction site storm water
bull Urban runoff storm water
bull Petroleum hydrocarbons
bull Plastics
bull Pesticides
bull Heavy metals
bull Sewage
bull Radioactive waste
bull Thermal effluents
bull Pharmaceuticals
Water Pollutants
bull Detergents
bull Chloroform
bull Food processing waste (fats and grease)
bull Insecticides and herbicides
bull Petroleum hydrocarbons (gasoline diesel fuel jet fuels and fuel oil)
bull Lubricants (motor oil)
bull From storm water runoff
bull Pharmaceuticals
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Water pollution is a serious issue as it is easily spread
Water pollution have a strong impact on the delicate balance in the natural ecosystem This will ultimately impact the humans and other living organisms
The effects of water pollution are different and depend on the chemicals dumped in that particular location
The effects of water pollution could be classified intobulleffects on ecosystembulleffects on animal healthbulleffects on human health
Effects of Water Pollution
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Human health effectsTop 45 diseases caused by pollution
Sources of water pollution
bull Domestic sewage
bull Industrial waste water
bull Agricultural waste water
bull Construction site storm water
bull Urban runoff storm water
bull Petroleum hydrocarbons
bull Plastics
bull Pesticides
bull Heavy metals
bull Sewage
bull Radioactive waste
bull Thermal effluents
bull Pharmaceuticals
Water Pollutants
bull Detergents
bull Chloroform
bull Food processing waste (fats and grease)
bull Insecticides and herbicides
bull Petroleum hydrocarbons (gasoline diesel fuel jet fuels and fuel oil)
bull Lubricants (motor oil)
bull From storm water runoff
bull Pharmaceuticals
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Human health effectsTop 45 diseases caused by pollution
Sources of water pollution
bull Domestic sewage
bull Industrial waste water
bull Agricultural waste water
bull Construction site storm water
bull Urban runoff storm water
bull Petroleum hydrocarbons
bull Plastics
bull Pesticides
bull Heavy metals
bull Sewage
bull Radioactive waste
bull Thermal effluents
bull Pharmaceuticals
Water Pollutants
bull Detergents
bull Chloroform
bull Food processing waste (fats and grease)
bull Insecticides and herbicides
bull Petroleum hydrocarbons (gasoline diesel fuel jet fuels and fuel oil)
bull Lubricants (motor oil)
bull From storm water runoff
bull Pharmaceuticals
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Sources of water pollution
bull Domestic sewage
bull Industrial waste water
bull Agricultural waste water
bull Construction site storm water
bull Urban runoff storm water
bull Petroleum hydrocarbons
bull Plastics
bull Pesticides
bull Heavy metals
bull Sewage
bull Radioactive waste
bull Thermal effluents
bull Pharmaceuticals
Water Pollutants
bull Detergents
bull Chloroform
bull Food processing waste (fats and grease)
bull Insecticides and herbicides
bull Petroleum hydrocarbons (gasoline diesel fuel jet fuels and fuel oil)
bull Lubricants (motor oil)
bull From storm water runoff
bull Pharmaceuticals
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Water Pollutants
bull Detergents
bull Chloroform
bull Food processing waste (fats and grease)
bull Insecticides and herbicides
bull Petroleum hydrocarbons (gasoline diesel fuel jet fuels and fuel oil)
bull Lubricants (motor oil)
bull From storm water runoff
bull Pharmaceuticals
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Water pollution15 Typhoid16 Giardiasis17 Amoebiasis18 Ascariasis19 Hookworm20 Gastroenteritis21 Diarrhea 22 Encephalitis23 Stomach cramps and aches24 Vomiting25 Hepatitis26 Respiratory infections27 Liver damage and even cancer28 Kidney damage29 Neurological problems30 Weak sexual power31 Thyroid system disorders32 Malaria 33 Rashes on skin34 Ear aches35 Pink eyes
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Preventing Water Pollution
bull Conserve water by turning off the tap
bull Mind what you throw down your sink or toilet
bull Donrsquot throw paints and oils in water channels
bull Use environment friendly household products such as washing powder household cleaning agents etc
bull Take great care not to overuse pesticides and fertilizers
bull Donrsquot throw litter into rivers lakes or oceans
bull Help clean up any litter you see on beaches or in rivers and lakes make sure it is safe to collect the litter and put it in a nearby dustbin
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Treating Polluted Water
bull Suspended solid particles and inorganic material can be removed by the use of filters
bull Use of biological filters and processes can naturally degrade the organic waste material
bull After above two steps chemical additives are supplied
to get rid of any left-over impurities
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Soil Pollution
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Soil pollution36 Cancer37 Brain and Nerve Damage38 Kidney and Liver Disease
Human health effectsTop 45 diseases caused by pollution
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Soil Pollution
Soil contamination or soil pollution is caused by the presence of xenobiotic (human-made) chemicals or other alteration in the natural soil environment
It is typically caused bybull Industrial activitybull Agricultural chemicalsbull Improper disposal of waste
Contaminating Chemicalsbull Total petroleum hydrocarbons (TPH) bull Polynuclear aromatic hydrocarbons (PAHs)bull Pesticides and fertilizers bull Lead and Other heavy metals
bull Pharmaceuticals
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
bullDirect contact with the polluted soil may cause cancer including leukemia
bullLead in soil is especially hazardous for young children and retards brain growth
bullMercury increases the risk of damage to the kidney
bullPolluted land causes neuro muscular blockage
bullIt may depress the central nervous system of the human body
bullIt also causes headaches nausea fatigue eye irritation and skin rash
Effects of land pollution on human life
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
How to control soil pollution
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
How to control soil pollution
bull Limit the use of fertilizers and pesticides
bull Biological control methods awareness and implementation
bull The grazing must be controlled and
bull Forest management should be done properly
bull The afforestation and reforestation must take place
bull Proper preventive methods like shields should be used in areas of wind erosion and wind breaks
bull Treating wastes of industries
bull Treating nuclear waste
bull Proper disposing of plastics electronics and other garbage materials by recycling
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Pharmaceutical Pollution
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Hazard of Pharmaceutical drugsIatrogenic pollutants
1- Environmental effectsWater ndash Soil pollution
2- Human health effects
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Number of pharmaceuticals detected in surface water groundwater tap water andor drinking water
Top 10 pharmaceuticals and the number of countries
in which they have been found in the aquatic
environment
Top 10 pharmaceuticals and the number of countries in which they have been found in the aquatic environment
DiclofenacCarbamazepineIIbuprofenSulfamethoxazoleNaproxenEstrone17-β-Estradiol17-α-EthinylestradiolTrimethoprimParacetamol
05101520253035404550Source IWW 2014
Pharmaceuticals in the environment a growing problemThe Pharmaceutical Journal 19 FEB 2015 By Brian Owens
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Pharmaceuticals human health effects
Conventional Medicine Is The Leading Cause Of Death In The US
Conventional Medical stream is the Leading Cause of Death in USAPharmaceutical Drugs is the 4th Leading Cause of Death USArsquos
Iatrogenic death rate in the US (death caused by doctors andor medical treatments) is 783936 a yearThatrsquos 84059 more deaths than those caused by heart disease in 2001 and 230865 more deaths than those caused by cancer
Over a decade the scientists predict that iatrogenic deaths will total about 78 million ldquomore than all the casualties from all the wars fought by the US throughout its entire historyrdquo
The Nutrition Institute of America funded an independent review of ldquogovernment-approvedrdquo medicine that was published in 2006 Professors Gary Null and Dorothy Smith along with doctors Carolyn Dean Martin Feldman and Debora Rasio titled the report ldquoDeath by MedicinerdquoThe researchers found that Americarsquos leading cause of death isnrsquot heart disease or cancer its conventional medicine
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Russell Blaylock MD 100000 Americans die each year from side effects of pharmaceutical drugs as prescribed by their doctors
You might believe that heart disease and cancer are the leading killers in this country
According to statistical research published by the Life Extension Foundation
Our conventional American medical system causes an astronomical 783936 deaths per year
That makes mainstream medicine the actual leading cause of death and injury in the United States
The Big Drug Lie
Russell Blaylock MD practiced conventional medicine as a board-certified neurosurgeon for nearly 30 years After watching both his parents die from neurodegenerative disorders that could not be helped by mainstream treatment he began to research safe and
effective natural cures
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
1- Why many FDA-approved prescription drugs Later pulled from the market
2- Why many drugs is prohibited inside the manufacturing country and still in use in other countries
3- Why the true long term frustrating side effects is not mentioned in the drug information provided by industry funded trials
According to the FDA a drug is removed from the market when its risks outweigh its benefits A drug is usually taken off the market because of safety issues with the drug that cannot be corrected such as when it is discovered that the drug can cause serious side effects that were not known at the time of approvalldquoThe FDA also takes into account the number of people taking a drug being considered for removal so as to not harm those patients
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Vioxx (Rofecoxib)
Use NSAID (pain relief)Manufacturer Merck
Cause for recallincreased risk of heart attack and stroke linked to about 27785 heart attacks or sudden cardiac deaths between May 20 1999 and 2003
Ads for Vioxx features Olympic gold medalists Dorothy Hamill and Bruce Jenner Vioxx was prescribed to more than 20 million people
on the market for53 YEARSMay 20 1999 to Sep 30 2004
Baycol (Cerivastatin)
Use Cholesterol reductionManufacturer Bayer AG
Cause for recallrhabdomyolysis (breakdown of muscle fibers that results in myoglobin being released into the bloodstream) which led to kidney failure 52 deaths (31 in the US) worldwide 385 nonfatal cases with most requiring hospitalization 12 of the deaths were related to taking this drug in combination with gemfibrozil (Lopid)
on the market for3 YEARS1998 to Aug 2001
Very big List of withdrawn drugs
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Bayer (Cerivastatin) Baycol or Lipobay
RhabdomyolysisMuscle PainSocial WithdrawalWeaknessCancerMuscle ProblemsTirednessGI ProblemsLeg PainKidney Failure
Baycol (Lipobay) vs Lipitor
Pfizer(Atorvastatin Calcium)Lipitor
Muscle PainTirednessWeight LossWeaknessDepressionWeight GainCrampingJoint PainLeg PainHeadaches
cerivastatin lovastatin pravastatin simvastatin atorvastatin and fluvastatin
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Disappointing frustrating long term results By the most widely spread and popular drugs world over
Ibuprufen (NSAIDs)a popular domestic and over the counter analgesic and antipyreticfor adults and childrenIbuprofen has been rated as the safest conventional NSAID
Bisphosphonates (Bone anti resorptive)
Statins (Cholesterol lowering)The top 50 prescription drugs filled in the USJun 16 2016 | Consumers Drugs Healthcare Professionals Industry News |
1- Atorvastatin Calcium(generic of Lipitor)
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
The effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite as
Ibufenac(Ibuprofen)
Withdrawn 1968
UKHepatotoxicity jaundice [3]
The generic Ibuprofen is manufactured by 62 companies has 138 Brands of Generics of Ibuprofen listed New generics are constantly being updated
For what it is prescribed Ibuprofen and Indomethacin are Chondrodestructivesby harming of Collagen metabolism in OA treatmentCelecoxib Diclofenc (1977) Aspirin are safer
Rheumatology InternationalAugust 2012 Volume 32 Issue 8 pp 2401ndash2405| Cite asThe effects of NSAIDs on types I II and III collagen metabolism in a rat osteoarthritis model
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
BisphosphonatesBone anti resorptive agent
For what it is prescribed
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
BisphosphonatesWhat is our aim
Bone BMDor
Fracture risk
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
RA OsteoporosisOn Bisphosphonates
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
SHORT-TERMUPPER GIT ADVERSE EFFECTSACUTE PHASE REACTIONSEVERE MUSCULOSKELETAL PAINHYPOCALCEMIAESOPHAGEAL CANCER WITH ORAL FORMOCULAR INFLAMMATION
LONG -TERM OSTEONECROSIS OF THE JAWATRIAL FIBRILLATIONSEVERE SUPPRESSION OF BONE TURNOVERSUBTROCHANTERIC FEMORAL FRACTURES
Adverse effects of bisphosphonate therapy
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Cell MetabolismVolume 23 Issue 3 Pages 479-491
March 2016)Ligand Activation of ERRα by
Cholesterol Mediates Statin and Bisphosphonate Effects
BisphosphonatesStatins
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
ERRa is the oldest orphan nuclear receptor Combining affinity chromatography with tissue lipidomics Wei et al identify cholesterol as an endogenous ERRa agonist ERRa mediates the effects of cholesterol on osteoclasts macrophages and myocytes as well as the pharmacological effects of statins and bisphosphonates on bone resorption and skeletal remodeling
Cell MetabolismVolume 23 Issue 3 Pages 479-491 March 2016)
Ligand Activation of ERRα by Cholesterol Mediates Statin and Bisphosphonate Effects
Cholesterol is a Ligand for estrogen-related receptors (ERRα)1- Increase OsteoclastogenesisBone resorption2- Reduce macrophage cytokines Anti inflammatory3- Increase myogenesisRepair regeneration4- Reduce myotoxicityRhabdomyolysis
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Harumi Okuyama
Professor Harumi OkuyamaNagoya City University Japan
Harumi Okuyama graduated from the University of Tokyo Graduate School of Pharmaceutical Sciences PhD degree granted in 1968 Served as Professor of biochemistry at Nagoya City University and at Kinjo GakuinUniversity Japan and as a visiting professor at Baylor College of Medicine University of Illinois at Chicago USA Dalian Medical University Dalian University China and Toyama University Japan Major interest is lipid nutritional biochemistry The first president of the Japan Society for Lipid Nutrition Data recorded August 21 2016
Expert commentaryFew cardiology specialists around the world have accepted that there is no clinical evidence for lsquothe lower the better hypothesisrsquoThe majority of clinicians still appear to accept the results of meta-analysis of reports including those published before 2004 when new penal regulations on the clinical trials came into effect in the EU that is statins are effective in lowering LDL-C levels and thereby preventing CHD incidence
Our group and others [2ndash4] only adopt the conclusions of papers reported after 2004 by scientists essentially free of conflict of interest that statins are ineffective in preventing CHD Severe and often irreversible adverse effects of statins and their pharmacological mechanisms have been discussed in this study indicating that the applicability of statins should be severely restricted
Clinicians should not rely on drug information provided by industry-funded trials or should they trust study abstracts of clinical publications which frequently do not provide the full picture and present many deceptions Nondrug company-funded sources of information are likely to be much more useful and less biased
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Statins Stimulate Atherosclerosis and Heart Failure Pharmacological Mechanisms
Expert Review of Clinical PharmacologyMarch 2015 Vol 8 No 2 pp 189ndash199 - Published online 06 Feb 2015
Harumi Okuyama Peter H Langsjoen Tomohito Hamazaki Yoichi Ogushi Rokuro Hama TetsuyukiKobayashi Hajime Uchino
AbstractIn contrast to the current belief that cholesterol reduction with statins decreases atherosclerosis We present a perspective that statins may cause coronary artery calcification and can function as mitochondrial toxins that impair muscle function in the heart and blood vessels through the depletion of coenzyme Q10 and lsquoheme Arsquo and thereby ATP generation
Statins inhibit the synthesis of vitamin K2 the cofactor for matrix Gla-protein activation which in turn protects arteries from calcification
Statins inhibit the biosynthesis of selenium containing proteins one of which is glutathione peroxidase serving to suppress peroxidative stress An impairment of selenoprotein biosynthesis may be a factor in congestive heart failure reminiscent of the dilated cardiomyopathies seen with selenium deficiency
Thus the epidemic of heart failure and atherosclerosis that plagues the modern world may paradoxically be aggravated by the pervasive use of statin drugs We propose that current statin treatment guidelines be critically reevaluated
Keywords atherosclerosis ATP generation coenzyme Q10 heart failure mitochondrial toxin selenoprotein statin statin cardiomyopathy vitamin K2
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Dr Dwight LundellsConfession
a heart surgeon with 25 years experience
having done more than 5000 open-heart
surgeries -gtgt Life style change
the human body cannot process nor was it
designed to consume foods packed with
sugars and soaked in omega-6 oilsldquo
Thats because the low-fat high-simple-carb
diet is actively destroying the walls of our
blood vessels by causing chronic
inflammation
We add lack of exercise and stress
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Prescribing statins is a multibillion-dollar business
Pfizerrsquos Lipitor went on sale in 1997 and became the best-
selling drug in the history of prescription pharmaceuticals Sales surpassed $125 billion during the life of its patent
Crestor is now the top-selling statin It generated $52 billion in revenue in 2013
These drugs are very effective in lowering cholesterol Lipitor 40-80 mg a day and Crestor 20-40 mg can drop LDL-cholesterol levels gt50 percent
Nevertheless the prevalence of heart disease has not dropped with the advent of these cholesterol-lowing statin drugs
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
The Money Game or Gain1- Change a number or definition create a patient
A lot of money can be made from healthy people who believe they are sickThe social construction of illness is being replaced by the corporate construction of diseaseRay Moynihan journalist Iona Heath general practitioner David Henry professor of clinical pharmacology BMJ 2002324886-891
Change a number or definition create a patientThe number of people with at least one of four major medical conditions has increased dramatically in the past decade because of changes in the definitions of disease
The new definitions ultimately label 75 of the adult US population as diseased according to calculations by two Dartmouth Medical School researchers
Suddenly sick A special report by Susan Kelleher and Duff Wilson middot June 26 - June 30 2005 httpseattletimesnwsourcecomnewshealthsuddenlysicksickdefinitions26html
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Diagnosis Old Definition New definition People under
Old
People under New
increase Year
Diabetes Fasting Sugargt 140mgdl
Fasting gt 126mgdl
117 M 17 M 14 1997
Hypertension BP gt 160100 BPgt 14090 387 M 135 M 35 1997
Cholesterol gt 250mgdl gt 200mgdl 495 M 426 M 86 1998
Obesity(BMI)
BMIgt 27kgmsup2 BMIgt 25kgmsup2 706 M 305 M 43 1998
Prehypertension
Nil 12080 to13989
Nil 45 M - 2003
New definitions Change a number create a patient
Source ldquoChanging Disease Definitions Implications for Disease PrevalencerdquoDr Lisa Schwartz and Steven Woloshin Effective Clinical Practice MarchApril 1999
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
The double standard
1- Absolute Risk (True)To minimize the side effects
2- Relative Risk (Myth)To magnify the benefit
The Money Game or Gain2- Absolute Risk (True) vs Relative Risk (Myth)
لى ال ذين إذا اكتالوا ع (1)ويل ل لمطف فين
زنوهم (2)الن اس يستوفون وإذا كالوهم أو و
(3)يخسرون سورة المطففين
Woe to those that deal in fraudThose who when they have to receive by measure from men
exact full measureBut when they have to give by
measure or weight to men give less than dueAl ndash Mutaffifin
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Drugs 200464 Suppl 243-60Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations in the Anglo-
Scandinavian Cardiac Outcomes Trial--Lipid Lowering Arm (ASCOT-LLA) a multicentre randomised controlled trial
Sever PS1 Dahloumlf B Poulter NR Wedel H Beevers G Caulfield M Collins R KjeldsenSE Kristinsson A McInnes GT Mehlsen J Nieminen M OBrien E Ostergren J ASCOT
Investigators
Figure 2 Relative risk of 36 percent with actual absolute risk in the Lipitor study
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Combating Heart Disease Statins Supplements Stem Cells Hyperbaric Oxygen
By Donald W Miller Jr MD
July 14 2016
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Lipitor
bull Reduction of risk of heart attack
bull people who take statins get diabetes
Absolute Risk
bull 11 bull (19 - 3)
bull 6 bull 8 - 2
Relative Risk
bull 36bull (11 divide 3)
bull 75 bull (6 divide 8)
19 of people taking Lipitor suffered a heart attack Compared to 3 of the placebo groupAbsolute risk 3-19= 11Relative riskrdquo reduction calculated this way 3 ndash 19 = 11 and 11 divided by 3 = 36
8 of people who take statins get diabetes compared with 2 in the placebo groupAbsolute risk 8-2= 6Relative risk 8 ndash 2 = 6 and 6 divided by 8 equals 75
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
The Diabetes World Summit 2016
Bayer the maker of one-time rival statin
Baycol paid $1 billion in 2005 to settle about 3000 cases alleging the drug caused rhabdomyolysis a disease that breaks down muscle tissue Baycol was pulled from the market in 2001 after being linked to 31 deaths
Pfizer confronts surge of lawsuits
over LipitorPublished 643 AM ET Fri 8 Aug 2014ReutersPharmaceutical giant Pfizer is facing a mounting wave of lawsuits by women who allege that the company knew about possible serious side effects of its blockbuster anti-cholesterol drug Lipitor but never properly warned the publicIn the past five months a Reuters review of federal court filings shows lawsuits by US women who say that taking Lipitor gave them type-2 diabetes have shot up from 56 to almost 1000
In your relentless quest to lower your cholesterol you may be giving yourself diabetes The statins offset the cholesterol you make not eat
Statins block endogenous cholesterol production in the liver they force liver to lsquospit outrsquo the glucose that comes from eating sugary starchy foods
Normally your liver would turn that PB amp J sandwich into cholesterol but instead the glucose gets pushed back into your bloodstream
I recommend reducing cholesterol with diet exercise and healthy EFAs (essential fatty acids like fish oil chia seed oil etc) sugar levels
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
Patients on five or more drugs
1- About 20 of adult2- 30 to 70 of elderly over 65y 3- Up to 90 In nursing homes and other residential facilities
Recent study of polypharmacy89 of patients interested in stopping a medication if their physician agreed
Common Classes of medications that are good candidates for deprescribing include Anti-anxiety medications known as benzodiazepines which can contribute to cognitive impairment delirium falls (and related injuries) breathing problems and motor-vehicle accidents
Atypical antipsychotics taert ot desu nefto era hcihwatinemed ylredle eht ni dna sisohcysp
Anti-cholesterol statins which can cause muscle problems cognitive impairment and a higher risk of diabetes Statins also have a high risk for interaction with other medications and certain foods Given that the benefits of statins are long term they are not needed for elderly patients
Tricyclic antidepressants which are used for depression and dementia These are not recommended in the elderly but are often used nonetheless causing side effects or harms that can include low blood pressure (which contributes to falls and fractures) heart arrhythmias and other disturbances delirium difficulty urinating dry mouth and constipation
HealthScience alertsBreaking news on health science and the environment
Proton pump inhibitors
Mishori is a professor of family medicine and the director of the Health and Media Fellowship in the Department of Family Medicine atGeorgetown University School of Medicine
PolypharmacyThe name given to prescribing patients five or more
medications at the same time
