2141350 Biological Interactions with Materials
Instructors: Dr. Niti Yongvanich, PhD course coordinator Dr. Pimpon Uttayarat, PhDTextbook: Biomaterials Science: an introduction to materials in medicine/ edited by Buddy D. Ratner, 1st or 2nd Edition, Elsevier.
Supplement Reading: Selected journal paper
Contact: [email protected]
Grading: Dr. Niti Yongvanich 60% Dr. Pimpon Uttayarat 40% (HW 10%, Exam 25%, Part 5%)
Outline
Date Topics
1/8/20011 Introduction
1/15/2011 Proteins, Cells and Tissues
1/22/2011 Host reactions to biomaterials
1/29/2011 Testing materials
2/5/2011 Polymers as biomaterials
(cardiovascular prostheses, burn dressings)
2/12/2011 Introduction and properties of materials
2/19/2011 Introduction to practical aspects of biomaterials
2/26/2011 Midterm
3/5/2011 Introduction to practical aspects of biomaterials
3/12/2011 Implants, devices, and biomaterials: Issues unique to this field
3/19/2011 Implants, devices, and biomaterials: Issues unique to this field
3/26/2011 New products and standards. Perspectives and
possibilities in Biomaterials Science
4/2/2011 New products and standards. Perspectives and
possibilities in Biomaterials Science
4/9/2011 TBA
4/16/2011 Presentation
Date Topics
Important definitions
A biomaterial is a nonviable material used in a medical device, intended to interact with biological systems. (David Williams, 1987)
• biocompatibility: the ability of a material to perform with an appropriate host response in a specific application in the way that it does not provoke rejection by the body• to replace/restore the function of the diseased or damaged tissue• to facilitate the healing with surrounding host tissue
• biomaterials include synthetic and natural materials
Table 1 Some applications of synthetic materials and modified natural materials in medicine
Biomaterials Science p.3
Autograft is a tissue transplanted from one part of the body to another in the same individual.
Tissue Engineering is an interdisciplinary field that applies the principles of engineering and life sciences toward the development of biological substitutes that restore, maintain, or improve tissue function or a whole organ. (Langer and Vacanti 1993)
• therapeutic application or diagnosis application• include the following areas: biomaterials, cells, biomolecules, engineering design, biomechanical aspect of the design and informatics
Allograft is an organ or tissue transplanted from one individual to another of the same species but different genotype.
Xenograft is an organ or tissue taken from one species to an unlike species.
Regenerative medicine is interchangeably used with tissue engineering but strictly speaking the term primarily involves the use of stem cells to restore the tissue/organ function.
Useful resource: www.ncbi.nlm.nih.gov
Example: search pubmed for fibronectin adsorption
Example: search pubmed for a paper when you know the journal title, volume and year
Garcίa et al., Mol Biol Cell, 10, 785-798, 1999.
Garcίa et al., Mol Biol Cell, 10, 785-798, 1999.
Homework due 1/15/11
Use pubmed to find a journal paper on fibronectin/collagen/vitronectin adsorption. Write a short paragraph summarizing the abstract.
The summary must include: 1.Title of the paper2.The name of the first author3.The name of journal, volume and date of publication4.The objective of the paper/experiment (1-2 sentences)5.The main finding of the paper (2-4 sentences)6.Indicate if there’s a full text link to the paper
Biomaterials SciencePart II: Materials in Medicine
Proteins, Cells and Tissues Jan 15, 2011
textbook1.Biomaterials Science: An Interdisciplinary Endeavor2.Chapter 3
