of 13
8/7/2019 3-d Structure Configuration & Conformation
1/13
Subho Brato Mukherjee
MSc Applied Genetics
8/7/2019 3-d Structure Configuration & Conformation
2/13
CONTENTS-y BRIEF INTRODUCTION OF BIOMOLECULES
y 3-D STRUCTURES
y CONFIGURATION
y CONFORMATION
y BIBLIOGRAPHY
8/7/2019 3-d Structure Configuration & Conformation
3/13
BIOMOLECULES
y
The chemistry of living organisms isorganized around CARBON.
CARBON CANFORM SINGLE
BOND
WITHHYDROGEN
WITHANOTHERCARBONATOM
CARBON CANFORM DOUBLE
BOND
WITH
OXYGEN
WITHANOTHERCARBONATOM
CARBON CANFORM TRIPLE
BOND
WITH
NITROGEN
WITHANOTHERCARBONATOM
8/7/2019 3-d Structure Configuration & Conformation
4/13
8/7/2019 3-d Structure Configuration & Conformation
5/13
Functional Groups determine
chemical propertiesMost biomolecules can be regarded as derivatives
of hydrocarbons, compounds with a covalentlylinked Carbon backbone to which only Hydrogen
atoms are bonded.
The Hydrogen atoms may be replaced by a varietyof functional groups to yield different families oforganic compounds.
The chemical personality of a compound can bedetermined by the chemistry of its functionalgroups and their disposition in 3 dimensional space.
8/7/2019 3-d Structure Configuration & Conformation
6/13
EXAMPLES OF FUNCTIONAL
GROUPS
CARBOXYGROUP
CARBONYLGROUP
AMINOGROUPS
HYDROXYLGROUP
ALCOHOLS AMINES
CARBOXYLIC
ACIDS
ALDEHYDES
&
KETONES
8/7/2019 3-d Structure Configuration & Conformation
7/13
3 d structure- configuration &
conformationCompounds of Carbon commonly exist as
STEREOISOMERS, different molecules in which
the order of bonding is the same, but thespatial relationship among the atoms isdifferent.
Molecular interactions between biomoleculesare invariably STEREOSPECIFIC; that is, theyrequire specific stereochemistry in theinteracting molecules.
8/7/2019 3-d Structure Configuration & Conformation
8/13
CONFIGURATION-Molecule is changed only by
breaking a bond
It refers to the fixed spatial arrangement ofatoms-Double bonds & Chiral centres
It refers to interconversion by temporarybreaking of one or more covalent bonds.
H H HOOC HC=C C=C
HOOC COOH H COOH
Maleic Acid (cis) Fumaric Acid (trans)
8/7/2019 3-d Structure Configuration & Conformation
9/13
Stereoisomers
CHIRALCARBON
DIASTEREOMER
S
ENANTI-OMER
RACEMIC
MIXTURE
8/7/2019 3-d Structure Configuration & Conformation
10/13
Biological interactions
RSSYSTEM
R(Rectus)-
Clockwise
S (Sinister)-
Anticlockwise
DLSYSTEM
DextroRotatory
LaevoRotatory
8/7/2019 3-d Structure Configuration & Conformation
11/13
CONFORMATION
o It refers to the Spatial Arrangement ofsubstituent groups , without breaking anybonds.
o The 2 main types are-
o Freely interconvertible-not possible to isolate.
More stable (predominates)Staggered
Less stable (less predominan e)E lipsed
8/7/2019 3-d Structure Configuration & Conformation
12/13
BIBLIOGRAPHY
Google.co.in----thebiggest search engine.
Satyanarayan panikar
Leninger Principles of
Biochemistry byNelson & Cox.
8/7/2019 3-d Structure Configuration & Conformation
13/13
THANK YOU !!
For paying attention..
- SUBHO
