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A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions Itsunari Minami, Kohei Yamada, Tomomi G. Otsuji, Takuya Yamamoto, Yan Shen, Shinya Otsuka, Shin Kadota, Nobuhiro Morone, Maneesha Barve, Yasuyuki Asai, Tatyana Tenkova-Heuser, John E. Heuser, Motonari Uesugi, Kazuhiro Aiba, Norio Nakatsuji Cell Reports Volume 2, Issue 5, Pages 1448-1460 (November 2012) DOI: 10.1016/j.celrep.2012.09.015 Copyright © 2012 The Authors Terms and Conditions
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Page 1: A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions Itsunari Minami,

A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions 

Itsunari Minami, Kohei Yamada, Tomomi G. Otsuji, Takuya Yamamoto, Yan Shen, Shinya Otsuka, Shin Kadota, Nobuhiro Morone, Maneesha Barve, Yasuyuki Asai, Tatyana Tenkova-Heuser, John E. Heuser, Motonari Uesugi, Kazuhiro Aiba, Norio Nakatsuji  

Cell Reports Volume 2, Issue 5, Pages 1448-1460 (November 2012)

DOI: 10.1016/j.celrep.2012.09.015

Copyright © 2012 The Authors Terms and Conditions

Page 2: A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions Itsunari Minami,

Figure 1

Cell Reports 2012 2, 1448-1460DOI: (10.1016/j.celrep.2012.09.015) Copyright © 2012 The Authors Terms and Conditions

Page 3: A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions Itsunari Minami,

Figure 2

Cell Reports 2012 2, 1448-1460DOI: (10.1016/j.celrep.2012.09.015) Copyright © 2012 The Authors Terms and Conditions

Page 4: A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions Itsunari Minami,

Figure 3

Cell Reports 2012 2, 1448-1460DOI: (10.1016/j.celrep.2012.09.015) Copyright © 2012 The Authors Terms and Conditions

Page 5: A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions Itsunari Minami,

Figure 4

Cell Reports 2012 2, 1448-1460DOI: (10.1016/j.celrep.2012.09.015) Copyright © 2012 The Authors Terms and Conditions

Page 6: A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions Itsunari Minami,

Figure 5

Cell Reports 2012 2, 1448-1460DOI: (10.1016/j.celrep.2012.09.015) Copyright © 2012 The Authors Terms and Conditions

Page 7: A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions Itsunari Minami,

Figure 6

Cell Reports 2012 2, 1448-1460DOI: (10.1016/j.celrep.2012.09.015) Copyright © 2012 The Authors Terms and Conditions

Page 8: A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions Itsunari Minami,

Figure S1

Cell Reports 2012 2, 1448-1460DOI: (10.1016/j.celrep.2012.09.015) Copyright © 2012 The Authors Terms and Conditions

Page 9: A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions Itsunari Minami,

Figure S2

Cell Reports 2012 2, 1448-1460DOI: (10.1016/j.celrep.2012.09.015) Copyright © 2012 The Authors Terms and Conditions

Page 10: A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions Itsunari Minami,

Figure S3

Cell Reports 2012 2, 1448-1460DOI: (10.1016/j.celrep.2012.09.015) Copyright © 2012 The Authors Terms and Conditions

Page 11: A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions Itsunari Minami,

Figure S4

Cell Reports 2012 2, 1448-1460DOI: (10.1016/j.celrep.2012.09.015) Copyright © 2012 The Authors Terms and Conditions

Page 12: A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions Itsunari Minami,

Figure S5

Cell Reports 2012 2, 1448-1460DOI: (10.1016/j.celrep.2012.09.015) Copyright © 2012 The Authors Terms and Conditions

Page 13: A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions Itsunari Minami,

Figure S6

Cell Reports 2012 2, 1448-1460DOI: (10.1016/j.celrep.2012.09.015) Copyright © 2012 The Authors Terms and Conditions

Page 14: A Small Molecule that Promotes Cardiac Differentiation of Human Pluripotent Stem Cells under Defined, Cytokine- and Xeno-free Conditions Itsunari Minami,

Cell Reports 2012 2, 1448-1460DOI: (10.1016/j.celrep.2012.09.015) Copyright © 2012 The Authors Terms and Conditions


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