ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

www.indianactsi.org

Scott C. Denne, MDAssociate Director, Indiana CTSI

April 25, 2011

Plenary Session II: “Research Highlights of the Year”

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

www.indianactsi.org

Research Inventions and Scientific Innovation (RISC) Grants

Pilot program supports research that leads to IP generation

K Basic Science Scholar AwardsCareer development supports PhD basic scientists doing translational research

Project Development Team Pilot Funding

Multidisciplinary team supports development of preliminary data for external grant submissions

Unique Pilot Funding Programs of the Indiana CTSI

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

www.indianactsi.org

Project Development Teams (PDTs)

•Multidisciplinary teams serve as “one stop shops” by providing investigators access to protocol/project development; pilot funding; biostatistics; IRB/regulatory and nursing support

•Helps investigators develop ideas/hypotheses into well-designed translational projects

•Facilitates collaboration with other investigators

•Provides access to other CTSI resources

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

www.indianactsi.org

Translational Sciences Research

Officer Clinical Sciences

(T1, T2, T3)

Imaging Sciences

(T1, T2, T3)

Pediatric Sciences

(T1, T2, T3)

Beh. & Pop. Sci

(T2, T3, T4)

Purdue(T1, T2, T3,

T4)

Notre Dame (T1, T2)

PreClinical Sciences

(T1)

Design and Biostatistics

Program

Regulatory Knowledge

Support Program

Research Recruitment

Research Education,

Training and Career

Development

Community and Health

Engagement Program

Indiana Biobank

Clinical Research

Center

Tracking and Evaluation

Indiana University

Research & Technology Corporation

CTSI HUBPDT Web Page

Investigator

Fill out PDT assistance request form

Assign to PDT(s)

Translational Technologies

and Resources Program

Other CTSI Programs with representatives on PDTs

ACCELERATING CLINICAL AND TRANSLATIONAL RESEARCH

www.indianactsi.org

PDT projects - portfolio by stage

PreclinicalSciences

PediatricSciences

BP Sciences

Purdue

Imaging

BENCH Basic Science Research

Preclinical StudiesAnimal Research

Clinical Sciences

Notre Dame

BEDSIDE

Human Clinical Research

Controlled Observational

StudiesPhase 3 Clinical

Trials

PRACTICE Clinical PracticeDelivery of CareIdentification of

New Clinical Questions and

Gaps in Care

T1Case Series

Phase 1 and 2Clinical Trials

T2Guideline Development

Meta-analysesSystematic ReviewsT3

Dissemination & Implementation ResearchHealth Systems Redesign

Applied Health ITProof of Model DrugConcept Dev Dev

4 1 3 5 6 7 8 212 9 1011 131415

16171819 20 21 2223 2425

26 2728 29 30 31 32 33 34 35 36 37 38 39 40 41 42 4344 4546 47 484950

5152

5354

55 56 57 58 59 60 61 6263 64 65 6667 6869 7071 7273 74 75 76 77 78 7981 82

83 84 85 86 87 88 89 90 91 92 93 94 95 9697 98

99100 101102 103 104

105106

107108

109 110 111112113 114 115 116117 118 119 120 121122

123

124

125

126 127 128 129 130131

132

133

134

135

136137 138

139140 141 142143 144145 146147

148 149 150

151

152 153154 155

156

157

158

159 160

161 162

163 164 165

166

167168

169

170

171

172173 174

175176 177

178

179

180 181

182183

184

185 187188 189

190

191192

193

194

195

196

197

198

199

200 201

202

80

186

203 204 205 206207

208

209

210

211

212

213214 215

216

219220

221

222

223

224

225

226 227 228229

230

231232

233 234

235

236

237 238

239

240241

242243

244

245

246

247

248

249

250251 252

253254

255

256

257

258259

250

261

262

263

264

265266

267

268269

270

271

273272

274

275 276

277

278

279

280

281282

283 284

285

286

287

288

289

290

291292

293

294 295

296

297

298 299 300 301

302

304 305

306

307

308

309

310 311

312

313

314

315

316

TRIP

317

318

319