Activatedprotein-C

Thrombin activatedfibrinolysis inhibitor

Fibrinolysis

Coagulation cascade: Central role of thrombin

FibrinFibrinogen

FactorXIIIa

PlateletsPropagationPropagation

FXIaFXIa

FXa/VaFXa/VaFVIIa/TFFVIIa/TFinitiationinitiation

IXa/VIIIaIXa/VIIIa

Clot formation and stabilization

Inhibition of fibrinolysisThrombin

Reactivation of coagulation

cascadeVessel wall endothelial

lining

VBWG