Early-Mid G 1. Restriction Pt. Late G 1. S. All pathways. Click to continue. Mitogenic signals Ras. DNA Repair. DNA Damage. BRCA2. Senescence / Apoptosis. Red = inhibits cell growth. Line = inhibits next step. mdm2. ATM. CDK2. Cyclin A. myc. Click on any yellow box. - PowerPoint PPT Presentation
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X X Mitogenic signals Ras myc Cyclin D CDK4/6 Rb E2F myc p16 INK4 p14 ARF p53 p21 p27 Cyclin E CDK2 Cyclin A CDK2 DNA Replica tion ATM mdm2 PKB Master Switch E2F DNA Replication Factors Senescenc e / Apoptosis DNA Repair TGF-β TGF-β Early-Mid G 1 Restriction Pt. Late G 1 S BRCA2 BCL- 2 Bax All pathways DNA Damage Click on any yellow box Click on any yellow box Click on any yellow box Go to next pathway Previous pathway Return to main page Red = inhibits cell growth Green = increases cell growth Line = inhibits next step Arrow = leads to next step End show Click to continu e
