Download - All pathways

XX

Mitogenic signals Ras

myc

Cyclin DCDK4/6

Rb

E2F

myc

p16INK4 p14ARF

p53

p21

p27Cyclin ECDK2

Cyclin ACDK2

DN

A Replicatio

n

ATMmdm2

PKB

Master Switch

E2F DNA Replication Factors

Senescence / Apoptosis

DNA Repair

TGF-β TGF-β

Early-Mid G1 Early-Mid G1

Restriction Pt.Restriction Pt.

Late G1 Late G1

SS

BRCA2

BCL-2

Bax

All pathways

DNA Damage

Click on any yellow box

Click on any yellow box

Click on any yellow box Go to next

pathwayPrevious pathwayReturn to main page

Red = inhibits cell growth

Green = increases cell growth

Line = inhibits next step

Arrow = leads to next step

End show

Click to continue

XX


myc

Cyclin DCDK4/6

Rb

E2F

myc

p16INK4 p14ARF

p53

p21

p27Cyclin ECDK2

Cyclin ACDK2

DN

A Replicatio

n

ATMmdm2

PKB

Master Switch



DNA Repair

TGF-β TGF-β



Late G1 Late G1

SS

BRCA2

BCL-2

Bax

All pathwaysAll pathways

DNA Damage

XX


myc

Cyclin DCDK4/6

Rb

E2F

Cyclin ECDK2

Cyclin ACDK2

DN

A Replicatio

n

Master Switch




Late G1 Late G1

SS

MitogenMitogen

XX

myc

Cyclin DCDK4/6

Rb

E2F

myc

p16INK4 p14ARF

p53

p21

Cyclin ECDK2

Cyclin ACDK2

DN

A Replicatio

n

Master Switch



DNA Repair



Late G1 Late G1

SS

BCL-2

Bax

mycmyc

XX

Rb

E2F

Cyclin ECDK2

Cyclin ACDK2

DN

A Replicatio

n

Master Switch




Late G1 Late G1

SS

Master SwitchMaster Switch

XX

p53

p21

Cyclin ECDK2

ATMmdm2


DNA Repair



Late G1 Late G1

SS

BRCA2

BCL-2

Bax

DNA damageDNA damage

DNA Damage

XX

p53

p21

p27Cyclin ECDK2

PKB


DNA Repair



Late G1 Late G1

SS

BCL-2

Bax

PKBPKB

XX

p16INK4

p27Cyclin ECDK2


TGF-β TGF-β



Late G1 Late G1

SS

TGF-βTGF-β