Kuehne + Nagel – AMS Pharma Gateway

Amsterdam Airport Schiphol – CoolZone

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Pharma Gateway GxP compliant trained staff KN PharmaChain SOP / WI’s outlining all handling procedures Dedicated Pharma team “CoolZone” temperature controlled storage meeting GxP requirements & having two defined temperature zones (+2°C to +8°C & +15°C to +25°C)

KN PharmaChain: AMS Pharma Gateway Pharma Gateway Specifics

Replace picture AMS CoolZone

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Located at Amsterdam Airport Schiphol

Airside facility (direct platform access – 1st Line facility)

Close to near by sea ports of Rotterdam, Amsterdam, Moerdijk and Antwerp

Well connected to the main European highway network (E19, E35, E22, E231)

Excellent hinterland connections in and out of European markets

KN PharmaChain: AMS CoolZone Location

Schiphol Airport

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KN PharmaChain: AMS CoolZone Airside Facility

AMS CoolZone

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24/7/365 operation

GxP compliant facility & processes

Acts as cross-dock and emergency storage facility

Two defined temperature controlled storage areas

- +2ºC to +8ºC (approx 32 warehouse pallet positions)

- +15ºC to +25ºC (approx 72 warehouse pallet positions)

Temperature controlled acceptance area +15ºC to +25ºC temperature controlled portal for temporary storage and cargo acceptances purposes

Dedicated cargo loading area for active temperature controlled ULD’s

KN PharmaChain: AMS CoolZone Specifications

Definition of CoolZone: GxP Compliant Two Designated Temperature Zones

+2ºC to +8ºC & +15ºC to +25ºC Where required:

PCM and Gel pack Conditioning Areas Freezer Facilities

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1 wireless Gateway communication unit located in AMS CoolZone Sensors installed in temperature controlled areas (see pictures)

+2ºC to +8ºC +15ºC to +25ºC

Temperature mapped and monitored facility Transmitter supports up to 600 active wireless sensors per location Resident sensors can be added to extend the range of the AMS

Gateway Transmits all data to KN Login and will not interfere with existing IT

wireless infrastructures

Active wireless sensors - activates with a simple push of the button

Shipment sensor shown in picture

CareTeam proactively monitors the wireless sensor data, taking action when required

KN PharmaChain: Wireless Monitoring - AMS CoolZone Connecting Your Sensors For Seamless Data Transmission to KN Login

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Shipment Preparation

Repackaging

Relabeling

Packaging solutions

Pre-conditioning

Consolidation / deconsolidation

Cross-docking

Recall possibilities / procedures

Customs Services

Import / Export customs clearance

Fiscal Representation

VAT Deferment

KN PharmaChain: Value Added Services at AMS CoolZone Additional Options to Fully Customize Your Shipment Needs

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Replenishment

Replenishment of dry ice and batteries for active temperature controlled ULD’s

Phase Change Material and Gel packs

Gel packs and Phase Change Materials pre-cooling and exchange

Re-charging

Recharging stations for active temperature controlled ULD’s

All heating and cooling types

KN PharmaChain: Value Added Services at AMS CoolZone Additional Options to Fully Customize Your Shipment Needs

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KN PharmaChain Road is a specialized and dedicated road network product for the Pharmaceutical and Healthcare industry

AMS CoolZone connected to KN PharmaChain road network Temperature mapped trucks with wireless tracking and tracing

Wireless tracking and tracing (transmitter - mobile unit) is located on the truck´s dashboard for GPS & GPRS connection (temperature monitoring)

Dedicated conditioned trucks for pre- and on-carriage Owned equipment includes Mono/Bi-Thermo and double stack trucks Offering daily departures across Europe and beyond from AMS CoolZone Express deliveries and pickups

Additional services include: re-icing / gel-pack replenishment

Truck temperature control process

Kuehne + Nagel also uses a selected number of highly qualified subcontractors for temperature controlled trucking services

KN PharmaChain: AMS CoolZone KN PharmaChain Road

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AMS CoolZone staff (performing VAL’s, shipment preparation) Fully trained & GxP compliant

Operational Service Desk Pharma desk - Netherlands CareTeam (Global - 24/7)

QSHE Manager Airfreight Facility/QSHE Manager In-line with WHO regulations/GDP Policy

KN PharmaChain: AMS CoolZone Your Dedicated NL Pharma Team

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Security cameras (CCTV) 24/7/365 controlled access high security Restricted access Dedicated staff (key card access)

Special panel finishing (walls) Temperature controlled areas built with special panel finishing for hygienic solution Backup generator Refrigeration and heating system – redundant solution and back-up generator Pre Chamber Provides a temperature buffer between the cargo handling and storage area

KN PharmaChain: AMS CoolZone Security features / other

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“Kuehne + Nagel is committed to offering environmentally

sound, sustainable and innovative supply chain solutions

that continually reduce our impact on the environment”

Green AMS CoolZone features include:

Energy efficient lighting (automatic sensors)

CO² monitored facility

PVC Strip curtains – saves energy, keep rooms better insulated

100% recyclable panels (CFC free)

The refrigerant used has an ODP value of zero

Hermetic compressors – energy efficient, noise reduction

KN PharmaChain: AMS CoolZone Environmentally friendly features

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Why Kuehne + Nagel – AMS CoolZone? Your Dedicated Partner

Contract Manufacturing

Integrated Logistics Service Provider (Sea, Air, Road and Rail, Contract Logistics)

Secured solutions for Pharmaceutical & Healthcare goods

Focus on Pharmaceutical & Healthcare solutions (dedicated facility)

Dedicated range of Pharmaceutical & Healthcare value added services

Strong IT Management and temperature monitoring solutions

Dedicated Key Account Management / Pharmaceutical & Healthcare Team

Global Coverage & Network (1000 offices worldwide)

In-house Customs department / Insurance (Nacora)

AMS CoolZone located in heart of European consumer belt and excellent transport connections

Local NL QSHE is well connected and aligned to our Global QSHE (SGI) team

Thank you for your attention