A/Prof Kerrie McDonald

k.mcdonald@unsw.edu.au

Cure Brain Cancer – Neuro-Oncology Group

Personalising treatment for

Glioblastoma patients

Glioblastoma

Never Stand Still Medicine Personalised treatment

Affects all ages

Affects both men and women

No preventative screening measures

No effective treatment strategy

Personalised Treatment

Never Stand Still Medicine Personalised treatment

Dynamic Biobanking

Never Stand Still Medicine Pipeline

Biobanking: Pre-clinical Models

Never Stand Still Medicine Case Study

Case Study 1

• Headaches and nausea for a week

• MRI revealed cystic mass in the temporal lobe

• Gross total resection April 2015

• Ki67 >30%

• Negative for amplification of EGFR, PDGFRA

• Negative for PTEN loss

• INI preserved

• IDH1 wildtype

• MGMT unmethylated

• Chromosomal CGH/ SNP Microarray

• Amplification 2p in 3 discrete sites including MYCN

• Copy Number gains of 1q and 7q

MP Rage before surgery

Whole Genome Sequencing

Never Stand Still Medicine Case Study

• TSC 1

• TP53

• CIC

T1 saggittal with gadolinium 3/9/15

at relapse

Treatment

Never Stand Still Medicine Case Study

Treatment

Never Stand Still Medicine Case Study

Treatment

Never Stand Still Medicine Case Study

• Treated with sirolimus

• Stable tumour response for 4-6 weeks

• Excellent quality of life

• Passed away after a 9 month battle

We need new treatments: Immunotherapy

Never Stand Still Medicine Case Study

(1) Tetanus-diphtheria vaccine

CMV

(2) CMV-PEPTIDE

CMV CMV Peptide + GM-CSF

Toxin released

Thank you!!

Never Stand Still Medicine Acknowledgements

Prof Charlie Teo Dr Mustafa Khasraw All of the patients and their families

Dr Jacob Fairhall Dr Raj Reddy

Dr Liz Hovey