Date post: | 05-Aug-2015 |
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Health & Medicine |
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BBI is the leading supplier of high quality enzymes to the diagnostic and research markets
Over 50 years of enzyme expertise
Urine Test Strips
GO/GDH Biosensors
ImmunoassaysHRP/ALP
Clinical Chemistry
RNaseNucleic Acid Extraction
Kits
Chymotrypsin and Trypsin
“Our Glucose Oxidase is tried, tested and proven to perform in blood glucose
monitoring 5 BILLION times every year”
BBI’s Glucose Oxidase is the key component in over 5 billion blood glucose monitoring test strips every year
But what makes it so good?
Highest levels of activity and purity –increase speed and accuracy
Multiple high purity grades available – optimise your assay, save money
Proven performance – meeting latest FDA accuracy guidelines (+/- 15%)
Batch to batch reproducibility and consistency – essential in high volume strip production
Number 1 supplier of Glucose Oxidase
Why use our FAD-GDH?
Not affected by variations in oxygen levels
Optimised purification method - fewer contaminants, reduced backgrounds = better sensitivity
Improved performance for hospital based systems
Good stability 70% of activity remaining after 90 days at
50ºC Stable below -20ºC for at least 24 months
No additives or animal derived materials present
“Did you know we also supply an FAD dependent Glucose Dehydrogenase
(FAD-GDH)?”
FAD dependent Glucose Dehydrogenase
Better sensitivity with FAD-GDHOur FAD-GDH’s high purity leads to a lower background signal, which enables you to measure lower glucose concentration levels – resulting in better sensitivity
Our next generation FAD-GDH is ideal for customers looking to develop a product of greater accuracy to meet tightening regulatory requirements.
But what makes it so good?
Increased accuracy through improved specificity to glucose
Higher reactivity, providing a faster signal
Improved stability, enhancing reliable strip performance
Cost savings, requiring fewer units of enzyme per strip
NEW FAD-GDH – reduced xylose interference
“We offer a service and range of products
unique to the biosensor market”
Improved specificity using GLD3
GLD1 GLD3
D (+)-Glucose: 100% 100%
D (+)-Galactose: 0.41% 0.27%
D (+)-Maltose: 0.30% 0.67%
D (+)-Mannose: 4.50% 1.73%
D (+)-Xylose: 12.40% 1.60%
2-deoxy-D-glucose: 43.20% 39.8%
Specificity was measured by substituting different sugars (concentration 200mM) for glucose in the BBI FAD-GDH assay.
Highest quality enzyme labels
Use the highest quality Alkaline Phosphatase and be confident in the results
Highest activity ALP on the market: >2200 glycine U/mg protein and >7000 DEA U/mg protein
High stability: less than 10% activity lost over 48 months
Benchmarked data: showing proven performance against the competition
Highest quality enzyme labels
Be confident in achieving better and consistent HRP conjugation
High isozyme C content (available above 90%)
High activity levels ~280 U/mg with some batches achieving >300 U/mg
Highly available amino groups for clean conjugation
Planned purchase of horseradish roots gives a controlled and consistent supply
Urease for clinical chemistry and biosensorsBBI is the leading manufacturer of Urease for diagnostic applications
Proven performance in liquid and powder reagents
High purity for biosensor applications
Manufactured in high volumes to reduce costs
Batch to batch reproducibility enabling consistent formulations
Clinical Chemistry
Catalase
Cholesterol Esterase
Cholesterol Oxidase
Creatinase
Creatininase
Glucose-6-Phosphate DH
Glucose Dehydrogenase (FAD)
Glucose Oxidase
Beta Glucosidase
Beta Glucuronidase
Glutamate Dehydrogenase
Lactate Dehydrogenase
Malate Dehydrogenase
Mutarotose
Our diagnostic enzymes
Peroxidase
Phosphoenolpyruvate Carboxylase
Sarcosine Oxidase
Urease
Uricase
Xanthine Oxidase
Immunoassay
Alkaline Phosphatase
Peroxidase
Biosensor
Cholesterol Esterase
Cholesterol Oxidase
Glucose Dehydrogenase (FAD)
Glucose Oxidase
Urease
Uricase
Urine Test Strips
Glucose Oxidase
Peroxidase
BBI flagship product
“Our team has been manufacturing
chymotrypsin for over 40 years”
Over 40 years enzyme extraction experience
Large scale extraction facility
Our optimised process delivers the highest quality material
Well controlled procedure ensuring batch to batch consistency
Direct relationship with raw material suppliers offering secure supply
True bovine origin - piece of mind on origin of material
Certificate of suitability/EDQM approved raw material – we only source from BSE-free countries
Leading manufacturer of bovine chymotrypsin
Chymotrypsin – consistent, high quality material
1900180017001600150014001300
LSL
LSL 1250Target *USL *Sample Mean 1532.03Sample N 160StDev(Within) 98.1849StDev(Overall) 122.037
Process Data
Cp *CPL 0.96CPU *Cpk 0.96
Pp *PPL 0.77PPU *Ppk 0.77Cpm *
Overall Capability
Potential (Within) Capability
% < LSL 0.63% > USL *% Total 0.63
Observed Performance% < LSL 0.20% > USL *% Total 0.20
Exp. Within Performance% < LSL 1.04% > USL *% Total 1.04
Exp. Overall Performance
WithinOverall
Process Capability of Chymo (U/ mg)
Chymotrypsin – batch to batch consistency
Dec-12 Jan-13 Jan-13 Mar-13 Apr-13 May-13May-13 Jun-13 Jul-13 Aug-13 Aug-13 Oct-13 Nov-13 Jan '14 Feb '14 Feb '14 Mar '140.0
200.0
400.0
600.0
800.0
1000.0
1200.0
1400.0
1600.0
1800.0
2000.0
Chymotrypsin Activity (U/mg)
“Our bovine trypsin has been produced at the
same facility for more than 40 years by enzyme extraction experts”
Leading manufacturer of bovine trypsin
Over 40 years experience extracting pancreatic enzymes
Our optimised process delivers the highest quality material
Well controlled procedure ensuring batch to batch consistency
Direct relationship with raw material suppliers offering secure supply
True bovine origin - piece of mind on origin of material
Certificate of suitability/EDQM approved raw material – we only source from BSE-free countries
Trypsin – consistent, high quality material
450042003900360033003000
LSL
LSL 3000Target *USL *Sample Mean 3943.95Sample N 83StDev(Within) 197.744StDev(Overall) 332.217
Process Data
Cp *CPL 1.59CPU *Cpk 1.59
Pp *PPL 0.95PPU *Ppk 0.95Cpm *
Overall Capability
Potential (Within) Capability
% < LSL 0.00% > USL *% Total 0.00
Observed Performance% < LSL 0.00% > USL *% Total 0.00
Exp. Within Performance% < LSL 0.22% > USL *% Total 0.22
Exp. Overall Performance
WithinOverall
Process Capability of Trypsin (U/ mg)
Trypsin – batch to batch consistency
Jan-
13
Feb-1
3
Feb-1
3
Mar
-13
Mar
-13
Mar
-13
Apr-1
3
Apr-1
3
May
-13
May
-13
Jun-
13
Jun-
13
July-
13
July-
13
July-
13
Aug-1
3
Aug-1
3
Sept-1
3
Oct-1
3
Nov-1
3
Dec-1
3
Feb-1
4
Feb-1
4
Mar
-14
0
500
1000
1500
2000
2500
3000
3500
4000
4500
5000
Trypsin activity (U/mg)
Act
ivit
y (U
/mg
)