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Benefits to Attending Hear from and meet with the people shaping the pharmaceutical landscape. 2017 attendees include: VPs of Discovery, Alkermes, Astra Zeneca, LEO, Lundbeck, MSD UCB; Senior Directors from Novartis, AbbVie, J&J, Gruenthal, Pfizer, Immunocore, Novimmune, Biogen Idec Discover collaborative solutions to small molecule and large molecule drug discovery challenges. This summit brings together experts on the best discovery techniques and technology, validating novel drug targets, improving lead optimisation in different therapeutic areas including Immuno- Therapy, Autoimmune, Oncology, Inflammatory, cardiovascular and metabolic diseases Explore innovative Phenotypic screening, target based as well as RNAi screening methods Gain from two discovery and computational chemistry streams to provide insights into modern medicinal chemistry strategies, computational chemistry, FEP in structured based design, DNA coded libraries, automation, and novel approaches to drug design A stratified program ensuring tailored content Benefit from attending pre-event webinars, panel discussions and roundtable discussions on Novel Discovery Tools, Open Innovation, Artificial Intelligence, Phenotypic vs. target-based drug discovery, ADMET, Gene Editing and PROTAC Unparalleled networking opportunities. The two-day congress format combines dedicated networking breaks, pre-organised 1-2-1 meetings and our popular drinks reception. The exhibition hall and poster presentation spaces offer a relaxed and professional environment for discussion Co-located with the Microbiome Discovery & Development Congress Klaus Bæk Simonsen, Vice President, Lundbeck Markus Haeberlein, Vice President, Discovery, Alkermes, Nick Terrett ,Scientific Associate Vice Preside MSD Constance Höfer, Chief Operating Officer, Priaxon Peter Juhasz, Director, Mechanisms and Pathways, Biogen Guido Hanauer, Scient Director Translational Medicine, Takeda For booking details & registration fees please refer to the last page or visit: http://www.drugdiscovery-summit1.com/marketing Day 1 Stream 1: Drug Discovery Innovation and Strategies, Enabling Technologies Innovative Target Discovery and Discovery Models in: Metabolic and Cardiovascular Therapeutics, Cardiometabolic Drug Targets, Cancer Immunotherapy, Oncology and Neurological Diseases Strategies in Target Validation and Lead Optimization Managing Translational Informatics Data Management in Discovery Novel Drug Targets and Screening Tools Managing Complex Discovery Portfolios ADMET Drug Discovery Day 2 Stream 1: Novel Drug Target Discovery for Immuno-Therapy, Autoimmune Diseases and Oncology Discovery of T-Cell Cancer Immuno-Therapy Novel Therapies for Cancer and Emerging Targets Kinase Inhibitors: Cancer Immunotherapy Discovery, Autoimmune and Inflammatory Diseases, CNS and Neurodegenerative Disorders Cancer metabolism /cancer metabolism targets - including anti-cachexic strategies Day 1 Stream 2: Successful Phenotypic Drug Discovery: High Content Screening Techniques and Tools in High Content Technologies Phenotypic Screening Applications 3D Cell Based Screening Methods Using Model Organisms for Screening Methods Novel Approaches for Phenotypic Screening Using Patient-Derived Tumour Models for Screening Screening in Oncology and CNS Therapeutic Areas High Content Screening & Data Management Day 2 Stream 2: PART I - Open Innovation and Drug Discovery PART 2- RNAi Screening, Genomics Discovery and Gene Editing for Drug Discovery Applications for Invivo RNAi Screening Novel Applications in RNAi Screening High-Throughput Imaging and Genomics 3D Cell Culture-Based Screen siRNA Screening for Drug Target Identification Gene Editing for Drug Discovery Day 1 Stream 3: Discovery Chemistry, Medicinal and Computational Chemistry Modern Medicinal Chemistry Strategies Computational Chemistry Approaches and Drug Discovery From classical computational chemistry to data analysis and Data Integration Ligand Design Case Studies in Molecular Structure Computation, Intermolecular Behaviour, Ligand-Receptor Interaction and Modelling Modern Approaches to Structure Based Design Measuring and Predicting Drug Efficacy Fragment-Based Drug Discovery Hits to Leads and Integrating Leads from HTS Screens Day 2 Stream 3: Discovery Chemistry, Medicinal Chemistry and Drug Design: Novel Approaches Protein Kinases in Immunology and Oncology Inhibitors Discovery Strategies in Medicinal Chemistry FEP in Structure-based Discovery Peptide Discovery and Development DNA Coded Libraries Chemical Biology Targeted covalent inhibitors (TCIs) Immune Modulation PROTAC-induced BET protein degradation - therapy for castration-resistant prostate cancer Medicinal Chemistry for Autoimmune Diseases CNS Interfacing Chemistry and Biology to Advance Neuroscience Drug Discovery Metabolic and Inflammation Metabolic Profiling and Drug Target Discovery Novel Approaches to Drug Design and Development Complimentary registration to our pre-event webinars Email [email protected]
Transcript
Page 1: Benefits to Attending Discover collaborative solutions to ... · Fragment-Based Drug Discovery Hits to Leads and Integrating Leads from HTS Screens Day 2 Stream 3: Discovery Chemistry,

Benefits to Attending

Hear from and meet with the people shaping the pharmaceutical landscape. 2017 attendees include: VPs of

Discovery, Alkermes, Astra Zeneca, LEO, Lundbeck, MSD UCB; Senior Directors from Novartis, AbbVie, J&J, Gruenthal,

Pfizer, Immunocore, Novimmune, Biogen Idec

Discover collaborative solutions to small molecule and large molecule drug discovery challenges. This summit

brings together experts on the best discovery techniques and technology, validating novel drug targets, improving lead

optimisation in different therapeutic areas including Immuno-Therapy, Autoimmune, Oncology, Inflammatory,

cardiovascular and metabolic diseases

Explore innovative Phenotypic screening, target based as well as RNAi screening methods

Gain from two discovery and computational chemistry streams to provide insights into modern medicinal chemistry

strategies, computational chemistry, FEP in structured based design, DNA coded libraries, automation, and novel

approaches to drug design

A stratified program ensuring tailored content –

Benefit from attending pre-event webinars, panel discussions and roundtable discussions on Novel Discovery Tools, Open Innovation, Artificial Intelligence, Phenotypic vs. target-based drug discovery, ADMET, Gene Editing and PROTAC

Unparalleled networking opportunities. The two-day

congress format combines dedicated networking breaks, pre-organised 1-2-1 meetings and our popular drinks reception. The exhibition hall and poster presentation spaces offer a relaxed and professional environment for discussion

Co-located with the Microbiome Discovery & Development Congress

Klaus Bæk Simonsen, Vice President, Lundbeck

Markus Haeberlein, Vice President, Discovery, Alkermes,

Nick Terrett ,Scientific Associate Vice President, , MSD

Constance Höfer, Chief Operating Officer, Priaxon

Peter Juhasz, Director, Mechanisms and Pathways, Biogen

Guido Hanauer, Scientific Director Translational Medicine, Takeda

For booking details & registration fees please refer to the last page or visit:

http://www.drugdiscovery-summit1.com/marketing

Day 1 Stream 1: Drug Discovery Innovation and Strategies, Enabling Technologies

Innovative Target Discovery and Discovery Models in: Metabolic and Cardiovascular Therapeutics, Cardiometabolic Drug Targets, Cancer Immunotherapy, Oncology and Neurological Diseases

Strategies in Target Validation and Lead Optimization

Managing Translational Informatics

Data Management in Discovery

Novel Drug Targets and Screening Tools

Managing Complex Discovery Portfolios

ADMET Drug Discovery

Day 2 Stream 1: Novel Drug Target Discovery for Immuno-Therapy, Autoimmune Diseases and Oncology

Discovery of T-Cell Cancer Immuno-Therapy

Novel Therapies for Cancer and Emerging Targets

Kinase Inhibitors: Cancer Immunotherapy Discovery, Autoimmune and Inflammatory Diseases, CNS and Neurodegenerative Disorders

Cancer metabolism /cancer metabolism targets - including anti-cachexic strategies

Day 1 Stream 2: Successful Phenotypic Drug Discovery: High Content Screening

Techniques and Tools in High Content Technologies

Phenotypic Screening Applications

3D Cell Based Screening Methods

Using Model Organisms for Screening Methods

Novel Approaches for Phenotypic Screening

Using Patient-Derived Tumour Models for Screening

Screening in Oncology and CNS Therapeutic Areas

High Content Screening & Data Management

Day 2 Stream 2: PART I - Open Innovation and Drug Discovery PART 2- RNAi Screening, Genomics Discovery and Gene Editing for Drug Discovery

Applications for Invivo RNAi Screening

Novel Applications in RNAi Screening

High-Throughput Imaging and Genomics

3D Cell Culture-Based Screen

siRNA Screening for Drug Target Identification

Gene Editing for Drug Discovery

Day 1 Stream 3: Discovery Chemistry, Medicinal and Computational Chemistry

Modern Medicinal Chemistry Strategies

Computational Chemistry Approaches and Drug Discovery

From classical computational chemistry to data analysis and Data Integration

Ligand Design – Case Studies in Molecular Structure Computation, Intermolecular Behaviour, Ligand-Receptor Interaction and Modelling

Modern Approaches to Structure Based Design – Measuring and Predicting Drug Efficacy

Fragment-Based Drug Discovery

Hits to Leads and Integrating Leads from HTS Screens

Day 2 Stream 3: Discovery Chemistry, Medicinal Chemistry and Drug Design: Novel Approaches

Protein Kinases in Immunology and Oncology

Inhibitors Discovery Strategies in Medicinal Chemistry

FEP in Structure-based Discovery

Peptide Discovery and Development

DNA Coded Libraries

Chemical Biology

Targeted covalent inhibitors (TCIs)

Immune Modulation

PROTAC-induced BET protein degradation - therapy for castration-resistant prostate cancer

Medicinal Chemistry for Autoimmune Diseases

CNS – Interfacing Chemistry and Biology to Advance Neuroscience Drug Discovery

Metabolic and Inflammation –Metabolic Profiling and Drug Target Discovery

Novel Approaches to Drug Design and Development

Complimentary registration to our pre-event webinars Email [email protected]

Page 2: Benefits to Attending Discover collaborative solutions to ... · Fragment-Based Drug Discovery Hits to Leads and Integrating Leads from HTS Screens Day 2 Stream 3: Discovery Chemistry,

For more information please contact [email protected]

Confirmed and Reserved speakers 2017:

Markus Haeberlein, Vice President, Discovery, Alkermes, Inc

Lorenz Mayr, Vice President, Biological Reagents & Assay Development, Astra Zeneca

Nick Terrett ,Scientific Associate Vice President, European Chemistry Lead, MSD Research GmbH

Christine Rothe, Vice President, Head of Discovery & Alliance Management, Pieris

Alastair Lawson, Vice President Structural Biology, UCB

Klaus Bæk Simonsen, Vice President, Lundbeck

Chris Gibson, CEO, Recursion Pharmaceuticals

Jim Xu, Executive Director, MSD

Markus Schade, Scientific Director, Grünenthal

Garry Pairaudeau, Senior Director, Head of External Sciences, AstraZeneca

Georgia McGaughey, Senior Director, Vertex Pharmaceuticals Patrick Kleyn, Director of Drug Target Innovation, EMD Serono

Peter Juhasz, Director, Mechanisms and Pathways, Biogen

Thomas Vorherr, Director Peptide Discovery, Novartis Institutes for BioMedical Research, GDC/IDDT

Stephen J. Shuttleworth, CSO, Karus Therapeutics, Ltd.

Stevan Djuric, Senior Director, Discovery Chemistry & Technologies, Abbvie

Guido Koch, Director Strategies & Technologies in Synthesis, Novartis

Guido Hanauer, Scientific Director Translational Medicine, Takeda Pharmaceuticals

Constance Höfer, Chief Operating Officer, Priaxon

Jan Spanholtz, CSO, Glycostem Therapeutics

Andrea van Elsas, CSO, Aduro Biotech Europe

Stephane Demotz, CEO, Dorphan

Murray Robinson, President, Molquant, Inc.

Hicham Alaoui, Director, Biochemical & Cellular Pharmacology, Genentech

Frank Osterkamp, Director Chemistry & Analytics, 3B Pharmaceuticals GmbH

Matthias Frech, Director Molecular Interactions & Biophysics, Merck Serono

Jorrit Hornberg, Director, Discovery Safety, AstraZeneca

Herman van Vlijmen, Head, Computational Chemistry, Discovery Sciences EU, Janssen, Pharmaceutical Companies of Johnson & Johnson

Daniel Zwilling, Director of CNS Discovery, Circuit Therapeutics

Pierre Ducrot, Head of Chemoinformatic and Modeling, Servier

Melanie Leveridge, Head Screening, Profiling & Mechanistic Biology UK, RD Platform Technology & Science, GSK Medicines Research Centre

Brion W. Murray, Research Fellow, Senior Director, Pfizer Oncology Research Unit

Jonathan Mason, Senior Research Fellow CADD, Heptares Therapeutics & consultant Chief Scientist, Lundbeck Research

Stephen Hearty, Head of the Autoimmune Team, Immunocore

Jose Duca, Head, Computer-Aided Drug Discovery, Novartis

Nicolas Fischer, Head, Research, Novimmune

Niclas Nilsson, Head of R&D Open Innovation, LEO Pharma

Werngard Czechtizky, Head of Medicinal Chemistry, Sanofi

Ingo Muegge, Senior Research Fellow, Boehringer Ingelheim

Rod Hubbard, Professor & Senior Fellow, Vernalis

Andrew Payne, Senior Group Leader, UCB

Christian Fischer, Principal Scientist, Chemistry, MSD

Thierry Dorval, HCS – Group Leader, Biotechnology Chemical-Biology, Servier

Yolanda Chong, Principal Scientist, Johnson & Johnson

Francois Sautel, Open Innovation Leader, Institut de Recherche Pierre Fabre

Guido Zaman, Managing Director & Head of Biology, Netherlands Translational Research Center

Ton Rijnders, Scientific Director, Head of European Screening Center, Lygature

Fabio Gasparri, Head of Cell Assay Technologies, Nerviano Medical Sciences

Paul Andrews, Director of Operations, National Phenotypic Screening Centre (NPSC), School of Life Sciences, University of Dundee

Stefano Gustincich, Head Laboratory of Neurogenomics, Scuola Internazionale Superiore di Studi Avanzati

Complimentary registration to our pre-event webinars Email: [email protected] Drug Discovery Open Innovation and Outsourcing – 10th Feb 2017, 3.30 p.m. GMT

Patrick Kleyn, Director of Drug Target Innovation, EMD Serono

Garry Pairaudeau, Senior Director, Head of External Sciences, AstraZeneca

Phenotypic Screening in Drug Discovery- Novel Tools And Applications – 1st March 2017, 10.30 a.m. GMT

Paul Andrews, Director of Operations, National Phenotypic Screening Centre (NPSC), School of Life Sciences, University of Dundee

Disruptive Technologies and Artificial Intelligence in Drug Discovery– 21st March 2017, 4.00 pm GMT

Chris Gibson, CEO, Recursion Pharmaceuticals

Page 3: Benefits to Attending Discover collaborative solutions to ... · Fragment-Based Drug Discovery Hits to Leads and Integrating Leads from HTS Screens Day 2 Stream 3: Discovery Chemistry,

For more information please contact [email protected]

If you’re on Twitter, make sure to follow us @drugdiscovery1 and join the Congress conversation on #DDSummit15 Meet Senior Decision Makers 250 VPs, Directors & Senior Managers from leading pharmaceutical organisations, biotech companies and academic institutions will attend the event. Delegate job titles include:

Small Molecule Drug discovery

Target selection

R&D Phenotypic Screening Drug design

Large Molecule Drug discovery

Lead optimisation

Open Innovation Rnai Screening Microbiome Discovery

Medicinal/Discovery Chemistry

Target validation

Computational chemistry Outsourcing Immuno-oncology

Cardiovascular

Inflammatory Diseases Metabolic Diseases Oncology CNS

Discover New Solutions Formal and informal meeting opportunities offer delegates the chance to discuss key solutions with leading service providers. Services to be discussed include:

Structure Based Drug Discovery

RNai Screening Phenotypic Screening

Target-Based Screening

Fragment based screening

Fragment Based Drug Discovery

PROTAC

Computational Chemistry

Peptides Discovery and Development

Inhibitor Discovery

Chemistry Disease Models

ADC Drug Design DNA Coded Libraries

Chemical Synthesis/Automation

Microbiome Discovery & Development

Modelling and Simulation

Lead Optimisation

Imaging Technology

ADME Data Analysis/Management/ Informatics

Target Validation Cellular Screening

High Throughput Cytometry

Library Optimisation

Lead Generation

Assay Development

PK/PD Translational Science Contract Drug Discovery Research

Target Selection

2017 sponsors

Page 4: Benefits to Attending Discover collaborative solutions to ... · Fragment-Based Drug Discovery Hits to Leads and Integrating Leads from HTS Screens Day 2 Stream 3: Discovery Chemistry,

For more information please contact [email protected]

18th Annual Drug Discovery Summit and 4th Annual Discovery Chemistry and Drug Design Congress Day 1 – 12th June 2017

07.30 – 08.20 Registration

08.20 – 08.25 Oxford Global Welcome Address

08.25 – 08.30 Stream Chair Welcome Address: Reserved for Cellular Dynamics 08.30 – 09.00 Keynote Presentation

Drug Discovery Summit Discovery Chemistry & Drug Design Congress

Drug Discovery on Target, Strategies and Enabling Technologies

Successful Phenotypic Drug Discovery And Screening

Discovery Chemistry, Medicinal & Computational Chemistry

Stream 1 Chair: Stream 2 Chair: Stream 3 Chair: 09.00 – 09.30 Stream Keynote

Innovative Target Discovery And Discovery Models In: Cancer Immunotherapy, Oncology And Autoimmune Diseases

Patrick Kleyn, Director of Drug Target Innovation, EMD Serono

Phenotypic Drug Discovery – The Move From High Content To High Impact Screening

Various approaches for high-content screening, phenotypic drug discovery

Induced pluripotent stem cells (iPSC) AstraZeneca/KTH Secretomics Project

Lorenz Mayr, Vice President, Biological Reagents & Assay Development, Astra Zeneca

Stream Keynote Modern Medicinal Chemistry Strategies- Computational Chemistry and Synthesis

Markus Haeberlein, Vice President, Discovery, Alkermes, Inc

09.30 – 10.00 Solution Provider Presentation

Solution Provider Presentation For sponsorship opportunities please contact

[email protected]

Solution Provider Presentation

CCG

10.00 – 11.30 Morning Refreshments: Exhibition & Poster Presentation Session: One To One Meetings x4

11.30 – 12.00 Antibody-Enabled Small Molecule Drug Discovery

Alastair Lawson, VP Structural Biology, UCB

Target Discovery From Phenotypic Screens And Known Compounds With Unknown MoA Peter Juhasz, Director, Mechanisms and Pathways, Biogen

Acceleration of Drug Discovery and Development via Enabling Chemistry Technologies Steven Tevan Djuric, Distinguished Research Fellow, Senior Director, Discovery Chemistry and Technology, Abbvie

12.00 – 12.30 Solution Provider Presentation

Selvita

Solution Provider Presentation For sponsorship opportunities please contact

[email protected]

Solution Provider Presentation For sponsorship opportunities please contact

[email protected]

12.30 – 13.00 Genomics Network Analysis for Target Identification in Oncology Murray Robinson, President, Molquant, Inc.

Phenotypic Screening Models and Biosignature Screening

Yolanda Chong, Principal Scientist, Johnson & Johnson

Automation In Drug Discovery Synthesis Guido Koch, Director Strategies & Technologies in Synthesis, Novartis

Page 5: Benefits to Attending Discover collaborative solutions to ... · Fragment-Based Drug Discovery Hits to Leads and Integrating Leads from HTS Screens Day 2 Stream 3: Discovery Chemistry,

For more information please contact [email protected]

18th Annual Drug Discovery Summit and 4th Annual Discovery Chemistry and Drug Design Congress Day 1 – 12th June 2017

Drug Discovery Summit Discovery Chemistry & Drug Design Congress

Drug Innovation Strategies Successful Phenotypic Drug Discovery: High Content Screening

Discovery Chemistry, Medicinal & Computational Chemistry

13.00 – 13.30 Solution Provider Presentation For sponsorship opportunities please contact

[email protected]

Solution Provider Presentation For sponsorship opportunities please contact

[email protected]

Solution Provider Presentation For sponsorship opportunities please contact

[email protected]

13.30 – 14.30 Lunch and One to One Meetings x3

14.30 – 15.00 HTS and AI Converge to Disrupt Discovery Chris Gibson, CEO, Recursion Pharmaceuticals

High Content Screening & Data Management Thierry Dorval, HCS – Group Leader, Biotechnology Chemical-Biology, Servier

Integrating Computational Chemistry into Decision Making in Drug Design

Ingo Mügge, Senior Research Fellow, Boehringer Ingelheim Pharmaceuticals

15.00 – 15.30 Discovery Of Innovative Drugs With The Right Safety Discovery Safety as a Drug Hunting Partner

Impact examples of early target safety assessments

Influencing chemical design to drive the discovery of candidates with the right safety

High content screening approaches in discovery safety

Jorrit Hornberg, Director, Discovery Safety, AstraZeneca

Novel Approaches For Phenotypic Screening Paul Andrews, Director of Operations, National Phenotypic Screening Centre (NPSC), School of Life Sciences, University of Dundee

Re-imagining Drug Discovery from a Computational Chemistry Perspective: New Methods on Binding Kinetics, Solvation and Dynamic Modelling

Use of first principles to advance the science of computational chemistry

Application to reverse kinetics, membrane partition and solvation

Prospective use on drug discovery projects

Paradigm change: use of dynamic modelling in early stages of drug discovery

Jose Duca, Head, Computer-Aided Drug Discovery, Novartis

15.30 – 16.30

Solution Provider Presentation For sponsorship opportunities please contact

[email protected]

Solution Provider Presentation 3D Cell Based Screening Methods

Solution Provider Presentation For sponsorship opportunities please contact

[email protected]

16.30 – 17.30 Afternoon Refreshments: Exhibition & Poster Presentation Session, One To One Meetings x4

Drug Discovery Innovation and ADME Successful Phenotypic Drug Discovery Discovery Chemistry, Medicinal & Computational Chemistry

17.30 – 18.00 Applications Of Stable Labelled Isotopes In ADMET

Joel Krauser, Director, Novartis

Phenotypic-based Drug Discovery (TBC) Donna Finch, Associate Director, MedImmune

The Revelations of GPCR Structure-Based Drug Design: Implications For All Ligand Design Including Key Role Of Waters For Potency, Selectivity And Kinetics Jonathan Mason, Senior Research Fellow & Head CADD, Heptares Therapeutics

Page 6: Benefits to Attending Discover collaborative solutions to ... · Fragment-Based Drug Discovery Hits to Leads and Integrating Leads from HTS Screens Day 2 Stream 3: Discovery Chemistry,

For more information please contact [email protected]

18.00 – 18.30 Drug Discovery For Ultra-Rare Metabolic Diseases: Overcoming The Lack Of Tools Stephane Demotz, CEO, Dorphan

Phenotypic Screening In Oncology Areas Fabio Gasparri, Head of Cell Assay Technologies, Nerviano Medical Sciences

Predictive Kinetics Pierre Ducrot, Head of Chemoinformatics and Modeling, Servier

18th Annual Drug Discovery Summit and 4th Annual Discovery Chemistry and Drug Design Congress

Day 1 – 12th June 2017

Drug Discovery Summit Discovery Chemistry & Drug Design Congress

Drug Discovery Innovation and Strategies, Enabling Technologies

Successful Phenotypic Drug Discovery: High Content Screening

Discovery Chemistry, Medicinal & Computational Chemistry

18.30 – 19.00 Broad Overview Of The Current And Future Perspectives On Screening Technologies Including perspectives on high content/phenotypic screening, label free screening and future directions

Melanie Leveridge, Head Screening, Profiling & Mechanistic Biology UK, RD Platform Technology & Science, GSK Medicines Research Centre

DNA Coded libraries - Innovative Technology For The Synthesis And Screening Of Chemical Libraries

Nils Jakob Vest Hansen, CEO, Vipergen ApS

19.00 – 19.30 ROUNDTABLE DISCUSSIONS: Topic 1: Screening Technologies – Which to choose? Moderator: Ton Rijnders, Scientific Director, Head of European Screening Center, Lygature Topic 2: Drug Discovery and Artificial Intelligence Proposed Moderator: Chris Gibson, CEO, Recursion Pharmaceuticals Topic 3: Successful Phenotypic Drug Discovery: High Content Screening Moderator: Jim Xu, Executive Director of Corporate Development/Strategic Planning, MSD Topic 4: Enabling Decision Making in Medicinal Chemistry Moderator: Ingo Mügge, Senior Research Fellow, Boehringer Ingelheim Pharmaceuticals Topic 5: Gene Editing in Drug Discovery Topic 6: PROTAC – Protein Degradation Moderator: Senior Representative, Merck Serono Topic 7: Open Innovation Moderator: Francois Sautel, Open Innovation Leader, Institut de Recherche Pierre Fabre Topic 8: Epigenetic Modulation in Cancer and Cardiovascular Diseases Topic 9: Translational Science of the Microbiome Moderator: Adam Baker, Head of Discovery – Microbiome and Human Health, Chr-Hansen A/S

19.30 Networking Drinks

Page 7: Benefits to Attending Discover collaborative solutions to ... · Fragment-Based Drug Discovery Hits to Leads and Integrating Leads from HTS Screens Day 2 Stream 3: Discovery Chemistry,

For more information please contact [email protected]

17th Annual Drug Discovery Summit and 4th Annual Discovery Chemistry and Drug Design Congress Day 2 – 13th June 2017

Stream Chair

08.00 – 08.30 Drug Discovery Summit Keynote Presentation How To Improve Productivity In R+D Guido Hanauer, Scientific Director Translational Medicine, TAKEDA Pharmaceuticals

Discovery Chemistry & Drug Design Congress Keynote Presentation Modalities beyond the ‘rule of 5’ – will we ever make them drug-like? Nick Terrett ,Scientific Associate Vice President, European Chemistry Lead, MSD Research GmbH

Drug Discovery Summit Discovery Chemistry & Drug Design Congress

Drug Target Discovery For Immuno-Therapy, Autoimmune Diseases And Oncology

Open Innovation and Outsourcing Computation and Medicinal Chemistry and Drug Design: Novel Approaches

Stream 1 Chair: Stream Chair Stream Chair

08.30 – 09.00 Tumor-Localized Costimulatory T-cell Engagement Christine Rothe, Vice President, Head of Discovery & Alliance Management, Pieris

Open Collaboration To Enhance Target Innovation – Translating Novel Biology Into Leads For Drug Discovery

Share our experience of opening up our lead generation capabilities and scientific expertise to help academic drug discovery

The strategies and tactics we employ in Open Innovation partnerships at AstraZeneca

Key success factors and impactful case examples

Garry Pairaudeau, Senior Director, Head of External Sciences, AstraZeneca

Leveraging New Computational and Visualization Techniques to Impact Drug Discovery

Georgia McGaughey, Senior Director, Vertex Pharmaceuticals

09.00 – 09.30 Solution Provider Presentation For sponsorship opportunities please contact

[email protected]

Solution Provider Presentation For sponsorship opportunities please contact

[email protected]

Solution Provider Presentation For sponsorship opportunities please contact

[email protected]

09.30 – 10.00 Solution Provider Presentation For sponsorship opportunities please contact

[email protected]

Solution Provider Presentation For sponsorship opportunities please contact

[email protected]

Solution Provider Presentation For sponsorship opportunities please contact

[email protected]

10.00 – 11.20 Morning Refreshments, Exhibition & Poster Presentation Session, One To One Meetings x4

11.20 – 11.50 Strategy And Tactics For The Discovery Of Kinase Inhibitors For CNS Targets - A Lundbeck Perspective Klaus Bæk Simonsen, Vice President, Lundbeck

Creating Partnerships through Open Innovation initiatives

Open Innovation offers great chances in enhancing drug discovery:

How to drive innovation through initiation of intercompany collaborations with biotech companies, startups and academic groups. Tools and case studies.

Francois Sautel, Open Innovation Leader, Institut de Recherche Pierre Fabre

Prospective Applications of Free Energy Perturbation Calculations in Drug Discovery Herman van Vlijmen, Head, Computational Chemistry, Discovery Sciences EU, Janssen, Pharmaceutical Companies of Johnson & Johnson

Page 8: Benefits to Attending Discover collaborative solutions to ... · Fragment-Based Drug Discovery Hits to Leads and Integrating Leads from HTS Screens Day 2 Stream 3: Discovery Chemistry,

For more information please contact [email protected]

17th Annual Drug Discovery Summit and 4th Annual Discovery Chemistry and Drug Design Congress

Day 2 – 13th June 2017

Drug Discovery Summit Discovery Chemistry & Drug Design Congress

Drug Target Discovery For Immuno-Therapy, Autoimmune Diseases And Oncology

Open Innovation and Outsourcing Medicinal Chemistry and Drug Design: Novel Approaches

11.50 – 12.20

Bispecific Antibody Approach Targeting An Immune

Checkpoint

Nicolas Fischer, Head, Research, Novimmune

The European Lead Factory: Results, Beneficiaries and Impact

Progress of public screening programs towards innovative drug discovery projects

Initial measures of performance of the new public compound collection

Future of the Public Private Partnership in early drug discovery

Ton Rijnders, Scientific Director, Head of European Screening Center, Lygature

Panel Discussion How to Take FEP Structure-Based Drug Design Forward In The Future

Panellists: Jonathan Mason, Senior Research Fellow & Head CADD, Heptares Therapeutics

Herman van Vlijmen, Head, Computational Chemistry, Discovery Sciences EU, Janssen, Pharmaceutical Companies of Johnson & Johnson

Jose Duca, Head, Computer-Aided Drug Discovery, Novartis

12.20 – 12.50

Drug Targets in Discovery and Development -

Autoimmune Diseases

Stephen Hearty, Head of the Autoimmune Team,

Immunocore

Use of Open Innovation As A Concrete Tool To Explore New Science And Partnerships

What can be achieved with Open Innovation in Drug Discovery

Expectations and critical change factors for implementation

A little less conversation, a little more action

Niclas Nilsson, Head of R&D Open Innovation, LEO Pharma

Large Synthetic Molecules – Opportunity & Challenge to Medicinal Chemistry Werngard Czechtizky, Head of Medicinal Chemistry, Sanofi

12.50 – 14.00 Lunch

Drug Target Discovery For Immuno-Therapy, Autoimmune Diseases And Oncology

RNAi Screening, Genomics Discovery and Gene Editing for Drug Discovery

Medicinal Chemistry and Drug Design: Novel Approaches

14.00 – 14.30

Translational Characterisation Of Seletalisib, A Novel Inhibitor Of PI3Kδ, In Immune-driven Disease Andrew Payne, Senior Group Leader, UCB

Applications For Invivo RNAi Screening In Vivo Validation Of Mutant IDH1 In Glioma: From uHTS Hits To Brain-penetrant Tool Compounds Mutations in Isocitrate Dehydrogenase (IDH) are prevalent in human glioma, in particular IDH1 R132H which is mutated in up to 80% of low grade gliomas. We have conducted a high throughput screen to identify compounds that inhibit IDH1 R132H selectively over the wild type enzyme. In this presentation we will discuss the outcome of the screen and our medicinal chemistry optimization strategy to arrive at potent, selective and orally bioavailable brain-penetrant inhibitors. We assessed the utility and potential therapeutic benefit of our optimized tool compounds in several IDH1 mutant in vivo models. These tool molecules achieved near complete inhibition of the mutant enzyme and provided significant survival benefit in a patient-derived orthotopic glioma model.

Page 9: Benefits to Attending Discover collaborative solutions to ... · Fragment-Based Drug Discovery Hits to Leads and Integrating Leads from HTS Screens Day 2 Stream 3: Discovery Chemistry,

For more information please contact [email protected]

Christian Fischer, Principal Scientist, Chemistry, MSD

17th Annual Drug Discovery Summit and 4th Annual Discovery Chemistry and Drug Design Congress

Day 2 – 13th June 2017

Drug Discovery Summit Discovery Chemistry & Drug Design Congress

Drug Target Discovery For Immuno-Therapy, Autoimmune Diseases And Oncology

Open Innovation and Outsourcing Medicinal Chemistry and Drug Design: Novel Approaches

14.30 – 15.00 Can Physiological Relevance Enhance Target

Validation and Lead Optimization? A Tale Of Two

Kinases • In vitro physiologically relevant systems such as primary

human cells, 3D tissues, and IPSC-derived cells are

increasingly being used throughout the drug discovery process

• Recent scientific advancements and emerging technologies make these systems more accessible and are thus being applied earlier and earlier in lead discovery and optimization

• Given the potential species differences in biologies between rodent and humans, these systems are now being deployed also for target discovery and validation

• Two case studies will be discussed where primary human

immune cells have been used • In the first example, the role the T cell kinase ITK plays in

Th2 cytokine regulation was investigated in primary human

Th2 cells

• The second case study will discuss how a NIK small molecule lead optimization program was accelerated using a combination of primary human B cells and primary human hepatocytes to assess whole blood potency and in vitro clearance, respectively, with the goal to estimate human dose projections early in the discovery cascade

Hicham Alaoui, Director, Biochemical & Cellular

Pharmacology, Genentech

Cancer Genomics for Drug Discovery

Stefano Gustincich, Head Laboratory of Neurogenomics, Scuola Internazionale Superiore di Studi Avanzati (SISSA)

New Directions For Fragment Based Discovery Fragments to activate enzymes

Identifying potential targets in a molecular machine

Expanding diversity in fragment shape

Rod Hubbard, Professor & Senior Fellow, Vernalis

15.00 – 15.15 Afternoon Refreshments

15.15 – 15.45 Small Molecule Targeting Of The Wnt-pathway Guido Zaman, Managing Director & Head of Biology, Netherlands Translational Research Center

High-Throughput Imaging And Genomics Kinetic Parameters and Modification Matthias Frech, Director Molecular Interactions & Biophysics, Merck Serono

Page 10: Benefits to Attending Discover collaborative solutions to ... · Fragment-Based Drug Discovery Hits to Leads and Integrating Leads from HTS Screens Day 2 Stream 3: Discovery Chemistry,

For more information please contact [email protected]

17th Annual Drug Discovery Summit and 4th Annual Discovery Chemistry and Drug Design Congress Day 2 – 13th June 2017

Drug Discovery Summit Discovery Chemistry & Drug Design Congress

Drug Target Discovery For Immuno-Therapy, Autoimmune Diseases And Oncology

Open Innovation and Outsourcing Medicinal Chemistry and Drug Design: Novel Approaches

15.45 – 16.15 oNKord® – Innovative Allogeneic Natural Killer Cell Therapy For Hematopoietic And Solid Tumors

Successful phase I clinical trial in AML

Use of oNKord in solid tumors

Strategies to increase efficacy of oNKord through combination with immunotherapeutic drugs

Jan Spanholtz, CSO, Glycostem Therapeutics

siRNA Screening For Drug Target Identification

Oral Bioavailability Of Peptides Maintain balance of solubility and permeability for cyclic

peptides by choice of appropriate building blocks

Enhance uptake by shielding polar backbone atoms using unnatural side chain modifications

And modify selected residues to avoid first pass liver effects

Corroborate in-vitro-profiling of cyclic peptides for permeability by the corresponding rat PK studies

Thomas Vorherr, Director Peptide Discovery Novartis Institutes for BioMedical Research, GDC/IDDT

16.15 – 16.45 Novel Small Molecule Approaches To Cancer Therapy Constance Höfer, Chief Operating Officer, Priaxon

3D Cell Culture-Based Screen Discovery and Development of Theranostic Radiopharmaceuticals For Oncology

Concept of Theranostic Radiopharmaceuticals

Target-Identification

Hit-Identification (Peptides + Small molecules)

Case Study: Development of 3BP-227 as treatment of pancreatic adenocarcinoma

Frank Osterkamp, Director Chemistry & Analytics, 3B Pharmaceuticals GmbH

16.45 – 17.15 Using In Vivo Optogenetics to Identify Novel Druggable Targets In Specific Neuronal Circuits

The use of optogenetics to dissect brain circuitry

Optogenetic rodent models of brain diseases

Identification of novel drugable targets in neuronal circuits

Daniel Zwilling, Director of CNS Discovery, Circuit Therapeutics

Gene Editing For Drug Discovery

Design & Development of Novel, Oral, Selective PI3K-p110β/δ Inhibitors: Combined Tumor Immunotherapeutic, Growth Inhibition and Anti-Metastatic Activity

Stephen J. Shuttleworth, CSO, Karus Therapeutics, Ltd.

17.15- 17.45 Cancer Immunotherapy Targets Beyond PD-1 Andrea van Elsas, CSO, Aduro Biotech Europe

Targeted Covalent Inhibitors Design RESERVED: Brion W. Murray, Research Fellow, Senior Director, Pfizer Oncology Research Unit

17.45 End of Conference

Page 11: Benefits to Attending Discover collaborative solutions to ... · Fragment-Based Drug Discovery Hits to Leads and Integrating Leads from HTS Screens Day 2 Stream 3: Discovery Chemistry,

18th Annual Drug Discovery Leaders Summit & 5th Annual Discovery Chemistry and Drug Design Congress

Conference: 12-13 June 2017, Hotel Place Berlin, Berlin, Germany www.drugdiscovery-summit1.com www.discoverychemistry-congress1.com

HOW TO REGISTER: FAX your booking form to +44(0)1865 250985 | PHONE on +44(0)1865 248455 | EMAIL: [email protected]

Please complete fully and clearly. Please photocopy for additional delegates Title:_____Forename:_______________Surname:________________ Job Title:_________________________________________________ Company/Organisation:_____________________________________ Email:___________________________________________________ Address:_________________________________________________ ________________________________________________________ Postcode: ____________________ Country: ___________________ Direct Telephone ________________ Direct Fax: ________________ Mobile: ________________________ Switchboard: _____________ Signature: ______________________ Date: _____________________

Number of delegates:

Industry del(s) Academic dels(s) Vendor dels(s) Special Offer: 3 for 2

Offer is only valid on the congress and for those registering at Industry or Academic rates

CREDIT CARD: Visa MasterCard Maestro Amex Credit Card Number:

Valid from: / Expiry Date: /

Security code:

Cardholders name: _______________________________________

Signature: ______________________________ Date: ___________ PLEASE INVOICE ME:

Invoice Address (if different from above)_______________________

*Please note there is a €65/£50 handling charge for payment via invoice *All card payments will be subject to a 3% bank charge or 4% AMEX charge

Registration Fees

Agreed Terms between the Organiser (Oxford Global Marketing Ltd) and the Delegate: Delegate Booking Fee The Delegate Booking Fee includes: lunches and refreshments throughout the Congress event, conference presentations, workshop and panel sessions, scheduled one-to-one meetings and networking/social events, conference and speaker notes. Delegates may attend, free of charge, all sessions arranged by the Organiser. An admin surcharge of €65/£50 will be applied to payments settled following the receipt of an invoice. This charge will not be applied to payments settled online. Vendor Delegates will not be eligible for one to one meetings unless they purchase a sponsorship meetings package. These can only be purchased directly from Oxford Global Marketing Ltd and not via the online booking facility. Poster Presentations Those who have booked a poster presentation at the event must provide the poster title, abstract (200 words or less), principal author, organisation, mailing address, email, telephone, fax and additional authors, within a month of registration. All poster spaces will be for A0 (841mm x 1189mm) portrait size. Cancellation and Curtailment Delegates and vendor delegates are subject to the following charges and refunds upon withdrawal or cancellation. More than 6 months prior 35% cancellation fee / 65% refund Between 6 and 3 months prior 75% cancellation fee/ 25% refund Less than 3 months prior to the event Full cancellation fee / No refund Data Protection The data controller is the Organiser. The Organiser may disclose such personal information to Registered Event Sellers (Solution Providers) and other Delegates but solely for the purposes of the Event. The Delegate consents to the use of his/her personal and company information on the terms set out herein. Miscellaneous This Agreement may not be transferred or assigned by either the Delegate or the Delegate’s Company. The Organiser will determine the scope and content of Congress conference events, seminars, workshops and activities throughout the Event. The Organiser reserves the right to cancel the Event without liability to Delegate’s Company or individual Delegate. If for any reason the Organiser has to cancel or postpone this Event, the Organiser reserves the right to transfer this Booking to another Congress within the same sector to be held within twelve months. Should another Congress in the same sector not be available within this period, the Booking Fee will be refunded.

I agree to the above Terms and Conditions

How to Pay (choose one of the following payment options)

I would like to attend: (Please tick as appropriate) Industry Delegates (Biopharma, Pharma or Biotech Companies)

Congress €985 £799 1 day pass €620 £499

Day 1 Day 2

Academic Delegates

Congress €620 £499 1 day pass €370 £299 Day 1 Day 2

Vendor Delegates (CROs, Consultants, Technology and Service Providers)

Congress Only €1665 £1350 1 day pass €985 £799

Day 1 Day 2

Poster Presentation €310 £250

PROMOTIONAL LITERATURE DISTRIBUTION

Distribution of your company’s promotional literature to all conference attendees €1210 £999

Documentation

I cannot attend but would like to purchase access to the following:

Access to the online conference presentations €620 £499 Conference presentations - paper copy €620 £499

If you have any further queries please call the marketing team on +44(0)1865 248455 or email [email protected]

Terms & Conditions of Booking

Delegate Details


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