Biology @ IIT-Kanpur

“While the entire world is investing heavily in biology, IITK has not even started. Lack of funds is the main problem”

From the “Report of the Committee on MEGA PROJECTS” submitted in the year 2000

http://www.iitk.ac.in/drpg/megaprojects.PDF

http://www.iitk.ac.in/drpg/megaprojects.PDF

From the “Report of the Committee on MEGA PROJECTS” submitted in the year 2000

Mr. Arun Shourie pledged Rs. 11.9 crores under MPLADS scheme

National Advisory Committee

BSBE – The planning stage

BSBE Core Committee

BSBE – A multidisciplinary initiative

BSBE Department was established on 13th

September 2001

The new BSBE Complex was inaugurated by Prime Minister Vajpayee in October 2003

2001-2002

2004 2006

2010

Team BSBE

Genetics, Genomics & Developmental Biology

BSBE

Structural & Computational Biology

Bioengineering(Cell separation/ Tissue engineering, Biomechanics and Bioelectronics)

Facilities in BSBE

Cancer genetics using model organisms

Germ Cell Development

Plant-pathogen interactions using RNAi

Neurodegenerative disorders

Mouse model for osteoarthiritis

Enzyme mechanism using structural biology

Computational studies of membrane proteins

Controlled drug delivery

Biomaterials and Tissue Engineering

Current Research at BSBE

BSBE

Chemistry

Chemical Engineering

Electrical Engineering

Centre for Environment Science

& Engineering

Materials Science & Engineering

Mechanical Engineering

Computer Science & Engineering

Industrial & Management Engineering

Australia

Belgium

Japan

Russia

Sweden

United Kingdom

United States

Synergy with other departments at IIT-K

International Collaboration

At National level

Other IITs, Universities, CSIR Labs, Industries and also with Medical Community

• Chemistry – Synthesis & structure

• Physics– Biophysics & imaging

• Materials– Prosthesis & Biomaterials

• Mechanics– Biomechanics & Devices– Bio-MEMS

• Chemical Engineering– Nanostructure & Bio-mimetics

Intellectual & Technical Capital in Engineering & Natural Sciences at IITK

S. Ganesh

Human Molecular Genetics

CNS DisorderIdiopathic Epilepsies

Cardiovascular DisorderMyocardial Infraction

Developmental DisorderCleft lip/cleft palate

R. Sankararamakrishnan

• Genome-wide identification of aquaporin genes in plants

• Interactions involving Asx/Glx residues in providing stability to protein structures

• Protein-protein interactions in apoptotic pathway: MD simulations

• GPCR peptide hormones: Conformational studies in lipid bilayers

• Alternate initiation in translation: nonAUG start codons and AUG codons with weak Kozak context

Structural Bioinformatics and Computational Biology

Balaji PrakashWellcome Trust Senior

Research Fellow

•Structure-function relationships in

• GTPases involved in ribosome biogenesis

• Ser/Thr Kinases of M.Tuberculosis

• Rel family of proteins

Structural Biology

X-ray crystallography, Biochemistry, Bioinformatics

Anupam Pal

•Computational modeling of muscle and biofluid mechanics

•High performance computing methods

•Image processing and data visualization

Biomechanics and Modeling

• Biomaterials (biodegradable polymers)

• Tissue Engineering (musculoskeletal}

• Drug Delivery Systems (Cancer therapy)

• Nanotechnology (polymer nanofiber for tissue engineering and drug delivery)

Dhirendra S. Katti

Tissue Engineering

K SubramaniamWellcome Trust Senior

Research Fellow

• Germ cell development – C. elegans model • Functional genomics approaches to

Parasitic nematode biology

Wild type Transgenic

Germ cell development and parasitic nematode biology

Tobacco plant

Human disease models in animals

Mouse model for Osteoporosis:

Amitabha Bandhopadhyay

BMP2 conditional mutants

Wild type

Peer-reviewed publications from BSBE

Source: Web of Science

Search term used in the Address field:

Kanpur and Biol* and Bioen* and 208016

Total number of publications in the last nine years: 118

Number of patents filed: 14

DevelopmentDevelopmental BiologyJ. Biol. Chem. Human Mol. GeneticsNucleic Acids Res.Nature ProtocolsProteins: Struct. Func. Bioinf.Protein Sci.BMC Plant Biol.Biochem. Biophys. Res. Commn.BMC Struct. Biol.J. Phys. Chem. BJ. Comp. Chem.Mol. Biochem. Parasitol.AutophagyHuman Mutation

International/National Grants and Awards

Indo – US Joint Center for Biomaterials

IBM Shared University Resources Grant

Indo-UK Science Bridge in Biopharma

UK – India Education and Research Initiative

National Agricultural Innovation Project

Wellcome Trust International Fellowship (2)

National Bioscience Award for Career Development (3)

Scopus Young Scientist Award

DAE-SRC Outstanding Research Award

B. M. Birla Science Prize

Programmes offered in BSBE

B. Tech

M. Tech

Ph. D

BSBE PG program: Some details

No. of Ph. D. students: ~70

No. of M. Tech students: ~ 40

No. of M. Tech students graduated: ~100

No. of students who received Ph. D. degree: ~20

No. of UG students: ~120

No. of students graduated: ~50

BSBE core courses taught to UG studentsIntroduction to Biological Sciences & Bioengineering

Molecular Biology

Biochemistry

Molecular Biology LAB

Biochemical Engineering

Biochemistry and Biochemical Engineering LAB

Biomaterials

Structural Biology & Bioinformatics

Biomechanics

Structural Biology & Bioinformatics LAB

Biomechanics & Biomaterials LAB

Project

What is the future of Biology @ IIT-Kanpur ?

Innovation

Education Research

New revised UG program

Enter PG program after B. Sc.

MBBS Graduates

Interdisciplinary

IIT-postdoc progarms

Animal House facility

Interface with Engineering departments

Fundamental research

Health, Agriculture, drug, diagnosis, product

Research Vision at BSBE