Calcium Channel Inhibitors (inhibitors, agonists and ... · EFONIDIPINE - CAS 111011-63-3 Catalog...

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Calcium Channel Inhibitors

(inhibitors, agonists and modulators)

Calcium channel blockers prevent calcium from entering cells of the heart and blood vessel walls, resulting in lower

blood pressure. Calcium channel blockers, also called calcium antagonists, relax and widen blood vessels by affecting

the muscle cells in the arterial walls.

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GAL-021 - CAS 1380341-99-0

Catalog Number:

Molecular Weight: 254.33 Molecular Formula: C11H22N6O

Description: GAL-021 a novel intravenous BKCa-channel blocker potentially for the treatment ofrespiratory depression.

NS-638 - CAS 150493-34-8

Catalog Number:

Molecular Weight: 325.72 Molecular Formula: C15H11ClF3N3

Description: NS-638 is a small nonpeptide Ca (2+)-channel blocker.

CP-060 - CAS 180090-15-7

Catalog Number:

Molecular Weight: 542.73 Molecular Formula: C30H42N2O5S

Description: CP-060 is a novel type of Ca (2+) antagonist possessing both Ca (2+) overloadinhibition, with antioxidant and cardioprotective activities.

Watanipidine monohydrochloride - CAS 116308-56-6

Catalog Number:

Molecular Weight: 723.26 Molecular Formula: C41H43ClN4O6

Description: Watanipidine, also called as AE 0047 or Calbren, is a calcium channel antagonist.

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PD0176078 - CAS 248922-46-5

Catalog Number:

Molecular Weight: 388.49 Molecular Formula: C23H30F2N2O

Description: PD0176078 is a novel N-type calcium channel blocker.

YS-201 - CAS 108852-42-2

Catalog Number:

Molecular Weight: 457.52 Molecular Formula: C24H31N3O6

Description: YS-201, also known as Diperdipine, is a dihydropyridine-type calcium channelantagonist potentially for the treatment of angina pectoris and hypertension.

Calcium channel-modulator-1 - CAS 136941-70-3

Catalog Number:

Molecular Weight: 579.45 Molecular Formula: C26H24Cl2N2O7S

Description: A calcium channel modulator that blocks aortic contraction (IC50= 0.8 μM).

McN5691 - CAS 99254-95-2

Catalog Number:

Molecular Weight: 457.6 Molecular Formula: C30H35NO3

Description: McN5691, an antihypertensive agent, is a voltage-sensitive calcium channel blocker.

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RQ-00311651 - CAS 1257116-00-9

Catalog Number:

Molecular Weight: 405.38 Molecular Formula: C19H18F3N5O2

Description: RQ-00311651 is a novel T-type Ca channel inhibitor which plays a role in neuropathicand visceral pain. RQ-00311651 notably inhibited T currents when tested at holding potentials of -

65 ∼ -60 mV' but not -80 mV' in the Cav3.1- or Cav3.2-expressing cells. RQ-00311651 also

suppressed high K-induced Ca signaling in those cells.

CALP1 - CAS 145224-99-3

Catalog Number:


Description: CALP1 is a cell-permeable calmodulin (CaM) agonist binding to the EF-hand/Ca2+-binding site and activating phosphodiesterase. CALP1 also binds to

cytoplasmic sites on other Ca2+ channels such as NMDA and HIV-1 gp120-activated

channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 μM).

Lercanidipine - CAS 100427-26-7

Catalog Number: 100427-26-7


Description: Lercanidipine hydrochloride, a dihydropyridine compound, is a third generationcalcium channel antagonist which shows longer duration of action of the past two generations' in

the treatment of mild-to-moderate hypertension.

Lacidipine - CAS 103890-78-4



Description: Lacidipine (Lacipil, Motens) is a L-type calcium channel blocker. Lacidipine (Lacipil,Motens) works by relaxing and opening up the blood vessels.

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EFONIDIPINE HCL - CAS 111011-53-1


Molecular Weight: 668.12 Molecular Formula: C34H38N3O7P.HCl

Description: The hydrochloride salt form of Efonidipine which could be effective in the treatmentof cardiovascular disease as a blocker of T-type and L-type calcium channels.

EFONIDIPINE - CAS 111011-63-3


Molecular Weight: 631.66 Molecular Formula: C34H38N3O7P

Description: Efonidipine could be effective in the treatment of cardiovascular disease as a blockerof T-type and L-type calcium channels. It could also present as the hydrochloride salt form.

(R)-(-)-Flindokalner - CAS 187523-36-0

Catalog Number:

Molecular Weight: 359.7 Molecular Formula: C16H10ClF4NO2

Description: (R)-(-)-BMS 204352 is the less active R-(-)-enantiomer of BMS-204352, which is apositive modulator at neuronal Kv7 channels and calcium-activated K+ channels (BKCa) in

HEK293 cells used as an anxiolytic agant.

Amlodipine Besylate - CAS 111470-99-6


Molecular Weight: 567.05 Molecular Formula: C20H25ClN2O5.C6H6O3S

Description: Amlodipine Besylate is a long-acting calcium channel blocker, used to lower bloodpressure and prevent chest pain.

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Ibutilide Fumarate - CAS 122647-32-9


Molecular Weight: 885.23 Molecular Formula: (C20H36N2O3S)2.C4H4O4

Description: Ibutilide is a Class III antiarrhythmic agent that is indicated for acutecardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm.

Azelnidipine - CAS 123524-52-7



Description: Azelnidipine is a dihydropyridine calcium channel blocker.

Cilnidipine - CAS 132203-70-4



Description: Cilnidipine is a unique L-type and N-type calcium channel blocker, used for highblood pressure treatment.

Tetracaine Hydrochloride - CAS 136-47-0


Molecular Weight: 300.82 Molecular Formula: C15H24N2O2.HCl

Description: Tetracaine hydrochlorideis a hydrochloride salt form of tetracaine which is a potentlocal anaesthetic and a channel function allosteric inhibitor.

Diltiazem Malate - CAS 144604-00-2



Description: Diltiazem is a calcium channel antagonist. It can relax the smooth muscles in thewalls of arteries, allow blood to flow more easily, and lower blood pressure. Meanwhile, it can lower

blood pressure through acting on the heart itself to reduce the rate, strength, and conduction

speed of each beat.

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Clevidipine Butyrate - CAS 167221-71-8


Molecular Weight: 456.32 Molecular Formula: C21H23Cl2NO6

Description: Clevidipine Butyrate is a dihydropyridine calcium channel blocker, uses as an agentfor the reduction of blood pressure.

Fluspirilene - CAS 1841-19-6


Molecular Weight: 475.57 Molecular Formula: C29H31F2N3O

Description: Fluspirilene, with antipsychotic activity, is a non-competitive antagonist of agonist-activated L-type calcium channels (IC50 = 0.03 µM). Fluspirilene is also a dopamine inhibitor.

Nifedipine - CAS 21829-25-4



Description: Nifedipine is a medication used to manage angina, high blood pressure, Raynaud'sphenomenon, and premature labor. It is one of the treatments of choice for Prinzmetal angina. It

may be used to treat severe high blood pressure in pregnancy.

Penfluridol - CAS 26864-56-2


Molecular Weight: 523.97 Molecular Formula: C28H27ClF5NO

Description: Penfluridol (Semap, Micefal, Longoperidol) is a highly potent, first generationdiphenylbutylpiperidine antipsychotic. It was discovered at Janssen Pharmaceutica in 1968.

Cinnarizine - CAS 298-57-7


Molecular Weight: 368.51 Molecular Formula: C26H28N2

Description: Cinnarizine, with antiallergic and anti-vasoconstricting activity, is a calcium channelblocker to treat cerebral apoplexy, post-trauma cerebral symptoms, and cerebral arteriosclerosis.

It also shows antihistaminic activity.

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Flunarizine Dihydrochloride - CAS 30484-77-6


Molecular Weight: 477.42 Molecular Formula: C26H26F2N2.2HCl

Description: Flunarizine 2HCl is a dihydrochloride salt form which is a calcium channel blockerwith a Ki of 68 nM.

Nitrendipine - CAS 39562-70-4



Description: Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM. It isused in the treatment of primary (essential) hypertension to decrease blood pressure.

Diltiazem - CAS 42399-41-7



Description: Diltiazem is a nondihydropyridines (non-DHP) calcium channel blocker used in thetreatment of hypertension, angina pectoris, and some types of arrhythmia as a potent vasodilator,

increasing blood flow and variably decreasing the heart rate via strong depression of A-V node

conduction.

Gabapentin enacarbil - CAS 478296-72-9



Description: Gabapentin enacarbil (XP-13512) is a prodrug for the anticonvulsant and analgesicdrug gabapentin.

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Flunarizine - CAS 52468-60-7


Molecular Weight: 404.50 Molecular Formula: C26H26F2N2

Description: Flunarizine is a selective calcium entry blocker, which has calmodulin bindingproperties and histamine H1 blocking activity. It may help to reduce the severity and duration of

attacks of paralysis and is effective in rapid onset dystonia-parkinsonism.

Nicardipine Hydrochloride - CAS 54527-84-3



Description: Nicardipine is a dihydropyridine calcium-channel blocking agent used for thetreatment of vascular disorders.

Nicardipine - CAS 55985-32-5



Description: Nicardipine is a calcium channel blocker used to treat high blood pressure andangina.

Nisoldipine - CAS 63675-72-9



Description: Nisoldipine is a calcium channel blocker, specific for L-type Cav1.2 with IC50 of 10 nM.

Nimodipine - CAS 66085-59-4



Description: Nimodipine is a dihydropyridine derivative and an analogue of the calcium channelblocker nifedipine, with antihypertensive activity. Nimodipine decreases intracellular free Ca2+,

Beclin-1 and autophagy.

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Zonisamide - CAS 68291-97-4

Catalog Number: B0084-075118 Price: $269/1 g


Description: Zonisamide is the first agent of this chemical class to be developed as anantiepileptic drug blocks repetitive firing of voltagesensitive sodium channels and reduces

voltage-sensitive T-type calcium currents.

Felodipine - CAS 72509-76-3


Molecular Weight: 384.25 Molecular Formula: C18H19Cl2NO4

Description: Felodipine is a selective L-type Ca2+ channel blocker with IC50 of 0.15 nM. It can lowerblood pressure by reducing peripheral vascular resistance via a highly selective effect on smooth

muscle in arteriolar resistance vessels.

Nilvadipine - CAS 75530-68-6



Description: Nilvadipine is a potent calcium channel blocker with an IC50 of 0.03 nM.

Isradipine - CAS 75695-93-1



Description: Isradipine is a potent and selective L-type voltage-gated calcium channel blocker,used to treat high blood pressure.

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Amlodipine - CAS 88150-42-9



Description: Amlodipine is a long-acting calcium channel blocker, used to lower blood pressureand prevent chest pain.

Amlodipine maleate - CAS 88150-47-4



Description: Amlodipine maleate is a long-acting dihydropyridine calcium antagonist (calciumion antagonist or slow-channel blocker). It inhibits the movement of calcium ions into vascular

smooth muscle cells and cardiac muscle cells. It is a peripheral arterial vasodilator that acts

directly on vascular smooth muscle to cause a reduction in peripheral vascular resistance and

reduction in blood pressure.

Benidipine HCl - CAS 91599-74-5


Molecular Weight: 542.02 Molecular Formula: C28H31N3O6·HCl

Description: Benidipine HCl is a hydrochloride salt form of benidipine which is a dihydropyridinecalcium channel blocker.

Ranolazine 2HCl - CAS 95635-56-6


Molecular Weight: 500.46 Molecular Formula: C24H35Cl2N3O4

Description: Ranolazine 2HCl is a calcium uptake inhibitor via the sodium/calcium channal, usedto treat chronic angina.

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Verapamil HCl - CAS 152-11-4



Description: Verapamil HCl is an L-type calcium channel blocker that is a class IV anti-arrhythmiaagent.

Elpetrigine - CAS 212778-82-0


Molecular Weight: 289.54 Molecular Formula: C10H7Cl3N4

Description: Elpetrigine, also known as GW 273293 and JZP-4, has a blocking effect on calciumchannels and potassium channels which has been in clinical bipolar disorders and epilepsy.

Gabapentin - CAS 60142-96-3



Description: Gabapentin is structurally similar to GABA and is reported in various research studiesto increase GABA concentrations within the brain. Gabapentin is also noted to bind to a novel site

on voltage-sensitive Ca2+ channels.

Imagabalin - CAS 610300-07-7



Description: Imagabalin acts as a ligand for the α2δ subunit of the voltage-dependent calciumchannel, which has some selectivity for the α2δ1 subunit over α2δ2. It has anxiolytic, analgesic,

hypnotic, and anticonvulsant-like activity. It was developed by Pfizer and is currently in phase III

clinical trials for the treatment of generalized anxiety disorder.

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Zonisamide sodium salt - CAS 68291-98-5


Molecular Weight: 234.21 Molecular Formula: C8H7N2NaO3S

Description: Zonisamide is the first agent of this chemical class to be developed as anantiepileptic drug blocks repetitive firing of voltagesensitive sodium channels and reduces

voltage-sensitive T-type calcium currents.

Bepridil hydrochloride hydrate - CAS 74764-40-2

Catalog Number:

Molecular Weight: 421.022 Molecular Formula: C24H34N2O.HCl.H2O

Description: Bepridil is an amine Calcium channel antagonist that used to treat angina. But it isno longer sold in the United States. It may be a possible option in the treatment of atrial fibrillation.

Manidipine - CAS 89226-50-6



Description: Manidipine is a dihydropyridine calcium antagonist with an IC50 of 2.6 nM.

CALP2 - CAS 261969-04-4

Catalog Number:


Description: CALP2 is a cell-permeable calmodulin (CaM) antagonist binding to the EF-hand/Ca2+-binding site. CALP2 exhibits an inhibitory effect on CaM-dependant

phosphodiesterase activity, and leads to an increase on intracellular Ca2+ level by

modulating Ca2+-channel activity. CALP2 was also shown to be a potent activator of

alveolar macrophages.

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CALP3 - CAS 261969-05-5

Catalog Number:


Description: CALP3 is a cell-permeable calmodulin (CaM) agonist binding to the EF-hand/Ca2+-binding site. It activates phosphodiesterase in the absence of Ca2+ and suppresses Ca2+-

mediated cytotoxicity and apoptosis (IC50 = 33 μM).

Huwentoxin XVI - CAS 1600543-88-1

Catalog Number:

Molecular Weight: 4437.13 Molecular Formula: C196H292N50O56S6

Description: Huwentoxin XVI is a potent and selective N-type Ca2+ channel blocker (IC50 ~ 60 nM)with no inhibitory effect on T-type Ca2+ channels, K+ channels or Na+ channels. Huwentoxin XVI

exhibits analgesic effects in vivo.

Dopropidil - CAS 79700-61-1

Catalog Number:


Description: Dopropidil, also called as ORG 30701, is a cardioactive drug to be classified as acalcium antagonist with combined class I and class VI antiarrhythmic properties.

Gabapentin hydrochloride - CAS 60142-95-2


Molecular Weight: 207.7 Molecular Formula: C9H17NO2.HCl

Description: Gabapentin HCl is a GABA analogue. Originally it was developed to treat epilepsy,and is currently used to relieve neuropathic pain and restless leg syndrome.

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Efonidipine hydrochloride monoethanolate - CAS 111011-76-8


Molecular Weight: 631.66 Molecular Formula: C36H45ClN3O8P

Description: The hydrochloride monoethanolate salt form of Efonidipine which has been launchedfor hypertension and discontinued for cerebrovascular disorders.

(R)-(+)-Nor Verapamil Hydrochloride - CAS 123932-43-4



Description: This active molecular is a chiral metabolite of Verapamil which is a calcium channelblocker applicated in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and

cluster headaches recently.

Lavendustin C - CAS 125697-93-0

Catalog Number:


Description: Lavendustin C, also known as HDBA and NSC 666251, inhibits Ca2+/CaMKII(calmodulin kinase II) (IC50=0.2 μM), EGFR tyrosine kinase (IC50=44 nM) and SRC (IC50=0.5 μM).

At a concentration of 10-150 µM, Lavendustin C inhibits tyrosine kinase-associated neutrophil

degranulation and superoxide generation.

Fendiline hydrochloride - CAS 13636-18-5


Molecular Weight: 351.91 Molecular Formula: C23H26ClN

Description: The hydrochloride salt form of Fendiline, a benzenepropanamine derivative, has beenfound to be a calcium channel blocker and alpha2-adrenergic receptor antagonist. It could

probably restrain the proliferation of tumor cells transformed by K-Ras.

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Osthole - CAS 484-12-8


Molecular Weight: 244.29 Molecular Formula: C15H16O3

Description: Osthole is a coumarin which is isolated from Cnidium monnieri (L.) Cusson. Ostholeis a calcium channel modulator via inhibiting phosphodiesterases. It also regulates the expression

of TNF-α, NF-κB, TGF-β, cyclooxygenases, leukotrienes, nitric oxide, ERK, and JNK.

Bepridil hydrochloride - CAS 68099-86-5

Catalog Number:

Molecular Weight: 403.007 Molecular Formula: C24H34N2O.HCl

Description: Bepridil is an amine Calcium channel antagonist that used to treat angina. But it isno longer sold in the United States. It may be a possible option in the treatment of atrial fibrillation.

FPL 64176 - CAS 120934-96-5

Catalog Number:


Description: FPL 64176 is a potent L-type Ca2+ channel activator (EC50 = 16 nM) displaying 40-fold potency against Bay K 8644 as a positive inotrope in guinea pig atria.

METHSUXIMIDE - CAS 77-41-8



Description: Mesuximide is a succinimide anticonvulsant medication. The therapeutic efficacy ofmethosuximide is due to its pharmacologically active metabolite, N-desmethylmethosuximide.

This active metabolite has a longer half-life and attains much higher plasma levels than its parent.

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Mibefradil - CAS 116644-53-2


Molecular Weight: 568.55 Molecular Formula: C29H38FN3O3

Description: Mibefradil, a calcium channel blocker, has modest selectivity for T-type Ca2+channels so that could be used in the treatment of sorts of cardiovascular disease like

hypertension and chronic angina pectoris. IC50: 2.7 μM (for T-type).

S (-)-BAY K 8644 - CAS 98625-26-4



Description: S (-)-BAY K 8644 is an activator of voltage-sensitive L-type calcium channels withpositive inotropic, vasoconstrictive and behavioral effects in vivo. It is the enantiomer of (±)-Bay K

8644. It increased whole-cell Ca2+ currents in A7r5 smooth muscle cells but effectively blocked

further stimulatio. It enhanced transcoronary exchange more markedly than (+/-)-Bay W 5035 or

(+/-)-Bay T 5006, reflecting the differences in coronary constrictor activity.

NNC 55-0396 dihydrochloride - CAS 357400-13-6


Molecular Weight: 564.56 Molecular Formula: C30H38FN3O2.2HCl

Description: NNC 55-0396 is a derivative of Mibefradil as a T-type calcium channel blocker(IC50=6.8 nM).

NP-118809 - CAS 41332-24-5



Description: NP-118809 is a N-type calcium channel blocker exhibits both anti-allodynic and anti-hyperalgesic activity in the spinal nerve ligation model of neuropathic pain.

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Darodipine - CAS 72803-02-2

Catalog Number:


Description: Darodipine, also known as PY 108-068, is an antagonist of calcium channel.

Disodium Cromoglycate - CAS 15826-37-6


Molecular Weight: 512.33 Molecular Formula: C23H14O11.2Na

Description: Disodium Cromoglycate is an antiallergic drug with IC50 of 39 μg/mL.

Diltiazem Hydrochloride - CAS 33286-22-5


Molecular Weight: 450.98 Molecular Formula: C22H26N2O4S.HCl

Description: Diltiazem HCl (Tiazac) is a benzothiazepine derivative with vasodilating action dueto its antagonism of the actions of the calcium ion in membrane functions.

Risedronate acid - CAS 105462-24-6


Molecular Weight: 283.113 Molecular Formula: C7H11NO7P2

Description: Risedronate is a bisphosphonate and a calcium channel blocker that is used tostrengthen bone, treat or prevent osteoporosis, and treat Paget's disease of bone.

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Tetrandrine - CAS 518-34-3



Description: Tetrandrine is a bisbenylisoquinoline alkaloid isolated from the dried root ofStephenia tetrandra S Moore. Tetrandrine exhibits very broad pharmacological actions, including

anti-tumor activity. Tetrandrine has the potential either as a tumoricidal agent or as an adjunct

to chemotherapy and radiotherapy.

Manidipine 2HCl - CAS 89226-75-5


Molecular Weight: 683.62 Molecular Formula: C35H38N4O6·2HCl

Description: Manidipine 2HCl, a HCl salt form of Manidipine, is a calcium channel blocker with IC50of 2.6 nM.

CGS 9343B - CAS 109826-27-9

Catalog Number:

Molecular Weight: 544.61 Molecular Formula: C26H28N4O2.C4H4O4

Description: CGS 9343B is a calmodulin (CaM) antagonist that inhibits calmodulin-stimulatedcAMP phosphodiesterase activity (an IC50 = 3.3 nM). It also prevents estrogen-induced

transcription activation by ER, reversibly blocks voltage-activated Na+, Ca2+ and K+ currents in

PC12 cells and inhibits nAChR.

Mibefradil dihydrochloride hydrate - CAS 116666-63-8


Molecular Weight: 568.55 (anhydrous basis) Molecular Formula: C29H40Cl2FN3O3

Description: Mibefradil, also known as Ro 405967 or Ro 40-5967, is a drug for the treatment ofhypertension and chronic angina pectoris. Mibefradil dihydrochloride is a calcium channel

blocker with moderate selectivity for T-type Ca2+ channels displaying IC50s of 2.7 μM and 18.6 μM

for T-type and L-type currents, respectively.

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Autocamtide 2 - CAS 129198-88-5

Catalog Number:


Description: Autocamtide 2 is a highly selective synthetic peptide substrate ofcalcium/calmodulin-dependent protein kinase II (CaMKII). It can be used in the CaMKII

activity assay.

TAMOLARIZINE - CAS 128229-52-7



Description: Tamolarizin is a calcium antagonist originated by Nippon Chemiphar. Tamolarizincan induce the increase of GABA in the cerebellum and medulla oblongata following continuous

administration in animal models. It also has a mild behavior-facilitating effect. Treatment for

Neurological disorders was discontinued.

TTA-P2 - CAS 1072018-68-8

Catalog Number:

Molecular Weight: 431.373 Molecular Formula: C21H29Cl2FN2O2

Description: TTA-P2 is a selective T-type calcium channel blocker. It blocks T-type currents withan IC50 of 100 nM and stabilized channel in the inactive state in rats DRGs. TTA-P2 potentially acts

as an antinociceptive and an antiinflammatory agent.

L-phenylalanine - CAS 63-91-2



Description: L-Phenylalanine, a α-amino acid, is an antagonist at α2δ calcium channels (Ki =980nM).

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ABT-639 - CAS 1235560-28-7

Catalog Number: B0084-474418 Price: $688/300 mg

Molecular Weight: 455.91 Molecular Formula: C20H20ClF2N3O3S

Description: ABT-639, a new blocker of selective T-type Ca2+ channel blocker, has been found tohave potential effect against neuropathic and nociceptive pain in studies. It has already been

discontinued in the treatment of diabetic neuropathies.

Lercanidipine Hydrochloride - CAS 132866-11-6



Description: The hydrochloride salt form of Lercanidipine, a dihydropyridine derivative, could beused as an antihypertensive agent through influencing the L-type Ca2+ channel at some extent.

Ca2+ Channel Agonist 1 - CAS 1402821-24-2



Description: A Ca2+ Channel Agonist that selectively acting on N-type Ca2+ channel and also befound to restrain the cdk activity at some extent. IC50: 14.23 uM (EC50, Ca2+ channel) 3.34 μM

(EC50, cdk2).

GV-58 - CAS 1402821-41-3


Molecular Weight: 374.50 Molecular Formula: C18H26N6OS

Description: GV-58, a pupin derivative, has been found to be a P/Q-type Ca²⁺-channel agonist thatcould be used to against neuromuscular weakness. IC50: 7.21/8.81 uM (N-type/P-Q-type Ca2+

channel).

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Dantrolene Sodium - CAS 14663-23-1


Molecular Weight: 336.23 Molecular Formula: C14H9N4NaO5

Description: Dantrolene Sodium, an inhibitor of calcium channel proteins that markedlysuppresses the release of calcium previously sequestered by skeletal, but not cardiac, muscle

sarcoplasmic reticulum.

Evenamide - CAS 1092977-61-1



Description: Evenamide is a selective voltage-gated sodium and/or calcium channel modulator,including subtypes Nav1.3, Nav1.7, and Nav1.8. It may be potentia useful in preventing, alleviating

and curing a wide range of pathologies, including neurol, cognitive, psychiatric, inflammatory,

urogenital and gastrointestinal diseases.

Mirogabalin - CAS 1138245-13-2



Description: This active molecular is an α2δ-1 ligand being developed for pain associated withdiabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia which related to related

to drugs such as gabapentin and pregabalin. Mirogabalin binds to the α2δ calcium channels (1

and 2) and was estimated to be much more potent than pregabalin.

PD 122860 - CAS 122576-86-7


Molecular Weight: 491.48 Molecular Formula: C23H20F3N3O4S

Description: This active molecular is a calcium channel antagonist with sodium channelstimulating property as a dihydropyridine. PD 122860 can increase left ventricular contractility,

decrease coronary resistance and alter the shape of the electrocardiogram T-wave in the animal

model.

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CI 951 - CAS 126661-07-2



Description: CI 951 is a dihydronaphthyridine Ca2+ channel antagonist and it may be applicatedfor the treatment of focal cerebral ischemia. CI 951 has potential as a cerebral vasodilator.

Flindokalner - CAS 187523-35-9


Molecular Weight: 359.7 Molecular Formula: C16H10ClF4NO2

Description: Flindokalner, an anxiolytic agent, is a positive modulator at neuronal Kv7 channelsand calcium-activated K+ channels (BKCa) in HEK293 cells. Flindokalner can be also used to treat

stroke.

Etripamil - CAS 1593673-23-4



Description: Etripamil, a benzoates derivative, has been found to be a calcium channel antagonistthat could be used against hypertension and arrhythmic. It is currently under Phase II trial against

paroxysmal supraventricular tachycardia.

UK-1745 - CAS 170684-14-7



Description: UK-1745, an indole derivative, has been found to be a Calcium channel antagonistthat was once studied in the treatment of arrhythmias as well as heart failure.

https://www.bocsci.com/ci-951-cas-126661-07-2-item-475255.htmlhttps://www.bocsci.com/flindokalner-cas-187523-35-9-item-475486.htmlhttps://www.bocsci.com/etripamil-cas-1593673-23-4-item-475886.htmlhttps://www.bocsci.com/uk-1745-cas-170684-14-7-item-475955.html

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OPC 13463 - CAS 73372-63-1



Description: OPC 13463 is one of the metabolites of pranidipine. Pranidipine is a long actingcalcium channel antagonist of the dihydropyridine group.

Ethosuximide - CAS 77-67-8



Description: Ethosuximide is a Calcium channel antagonist originated by Pfizer. It can be used forthe treatment of Absence epilepsy and absence seizures. It may be used by itself or with other

antiseizure medications such as valproic acid.

https://www.bocsci.com/opc-13463-cas-73372-63-1-item-476586.htmlhttps://www.bocsci.com/ethosuximide-cas-77-67-8-item-476616.html

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