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© 2010 CambridgeIP. All rights reserved
CambridgeIP
Fact-based strategy development: Accelerating your out-licensing
BIO 2010, Chicago5th May, 2010
Quentin Tannock (Chairman & Co-Founder)
Outline
• CambridgeIP snapshot
• Examples of our analysis
• Emerging Technologies in Inhaler Space
• Case study
• Working with CambridgeIP
2 © 2009 Cambridge Intellectual Property Ltd. All rights reserved
3 © 2009 CambridgeIP. All rights reserved
• CambridgeIP‟s Technology Platforms
– www.boliven.com Industry leading patent search platform
– IP Landscape® report standard
– Proprietary software analytics and workflow platform
• IP Landscape® informing IP and R&D strategy:
– Our global IP databases, proprietary methodologies and consulting provide unique patent landscape coverage, highlighting technology “white space” and informing your own FTO due diligence efforts
• Competitive Intelligence:
– Database-driven analysis and custom reporting on who the competitors are, where they are located, when they became active and who they are partnered with
• Identify Prospective Partners or Acquisitions:
– Information on top corporate, university and governmental partner/acquisition candidates operating in your area of interest
• Technology Marketing:
– Advice on active companies and consortiums who could leverage your patents and technologies around the world
Provider of Actionable Patent-based Technology Intelligence
4© 2010 CambridgeIP. All rights reserved
CambridgeIP Team
Quentin TannockChairman & co-founder
Ilian IlievCEO & co-founder
Miranda Weston-Smith Senior Associate
Angus FoxTechnical Director
Arthur LallementSenior Associate
Ralph PooleBoston
Representative
Mark MeyerBusiness Development
Manager North America
Elizabeth HudsonExecutive PA
Helena van der MerweSenior Associate
Vladimir YossifovGeneva Representative
Dr Phil Coldrick
Senior Consultant
Healthcare and Life Sciences
5
© 2010 CambridgeIP. All rights reserved
Medical Devices
DiagnosisMRI/X-rayEndoscopesMicroscopy
Molecular Based tests
TherapyAuto-injectorsInhalers…
SurgeryEndoscopyWound healing...
Tissue engineering
Stem cells...
Molecular engineeringMarkersNano-reagents...
Pharmaceutical formulationsExcipients
Propellants
...
Active Pharmaceutical ingredients
ImmunologyAsthma/COPDTransplant...
Addiction therapiesNicotine…
We have delivered more than 80 projects with leading technology organisations
6 © 2009 CambridgeIP. All rights reserved
Selected Clients:
Outline
• CambridgeIP snapshot
• Examples of our analysis
• Emerging Technologies in Inhaler Space
• Case study
• Working with CambridgeIP
7 © 2009 Cambridge Intellectual Property Ltd. All rights reserved
Our unique, data intensive approach provides evidenceto underpin your strategic and tactical decisions
8 © 2009 CambridgeIP. All rights reserved
Examples of our analysis : Informing your licensing & collaboration strategies
Network analysis
Visualising collaborations revealed in a 10,000+ patent dataset in the clients area of strategic focus
Statistical analysis
Identifying most relevant & prolific actors, year of entry to the space and strategic importance of the space to them
Reliable & efficient analysis of vast amounts of data enables fresh insights based on actual activity in your sector
9 © 2009 CambridgeIP. All rights reserved
Examples of our analysis : Informing R&D strategies
Sector composition analysis
Identifying hot-spots and new areas of R&D activity across broad technology spaces (this example: Biosensors)
Technology Evolution Maps
Identifying technology migration and diffusion patterns over time, together with interdependencies
IPC Relationship Map: 2000
The applications and location of client‟s technology are
dispersed
Over time, 2 key clusters of application have developed
IPC Relationship Map: 2007
Outline
• CambridgeIP snapshot
• Examples of our analysis
• Emerging Technologies in Inhaler Space
• Case study
• Working with CambridgeIP
10 © 2009 Cambridge Intellectual Property Ltd. All rights reserved
Inhaler Devices are composed of multiple components
11
You can regard a device as a „whole‟ invention, or multiple inventions
The perspective you adopt will impact the research results
Canister
Actuation System
Valves and Mouthpiece
© 2010 CambridgeIP. All rights reserved
Nebulizer
SMI
DPI
pMDI
Design
Drug ejection mechanisms
Formulations
Example - Space definition: We define the technology space with your inventors
• The technology space is the result of combination of several search techniques as applied to Inhalers technological boundaries
• We use our filters and patent ranking engine as a way of identifying a shortlist of the patents of interest to the user
• We capture relevant patents from different „perspectives‟
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Inhalers industrial field-
Analysed dataset boundaries
© 2010 CambridgeIP. All rights reserved
A methodology applicable to many fieldOther example: Autoinjectors field
13
Design
Needle
Drug reconstitution
© 2010 CambridgeIP. All rights reserved
Monitoring
Electronic
Needle Free
injector
Pen Shape Electronic
AutoInjectorDisposable x x
Cartridge x x x
Drug Mixing x x xSingle dose x x xMulti Dose x x
Needle x x x
Retractable x x xShield x x x
Piston x x x
Spring x x xHigh Pressure x x xPump x x xAir Jet x
Display x x x
LCD Screen x x xMechanical x x x
Auto-Activation x x x
Mechanic x x xSensor x x x
Data Storage x x x
Mechanic x x xElectronic x x x
Dose control x x x
Mechanic x x xElectronic x x x
We can map the whole technology value chain: Example – assignees identified in inhaler sub fields
14
Top 5 Assignees - DPI
Glaxo Smithkline
Boehringer Ingelheim Int
Astra Zeneca Inc
Nektar Therapeutics
Microdrug AG
Top 5 Assignees - pMDI
Glaxo Smithkline
Boehringer Ingelheim Int
Chiesi Farmaceutici SPA
3M Company
AstraZeneca Inc
Top 5 Assignees - Nebuliser
Pari
Aerogen Inc
Trudell Medical International
Boehringer Ingelheim Int
Novartis
Top 5 Assignees - SMI
Boehringer Ingelheim Int
Glaxo Smithkline
Aradigm Co
Siemens
Aerogen Inc
© 2010 CambridgeIP. All rights reserved
0
50
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50
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1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010
Pate
nts
-C
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ula
tive
Pate
nts
-Y
earl
y
Number of Patents: Annual and Cumulative
Number of New Applications Cumulative
© 2010
Patent Portfolio Analysis: Technology Evolution (example printed electronics)
Where device development is also focused around competitor trends, patent portfolio analysis can help you identify new trends
Patent applications may be unpublished for 18+ months. Therefore the number of reported patents for the last 2 years may be under-represented.
Applications for a flexible touch screen display and an electronic document reader system filed.
From this point strong emphasis on deploying an encapsulated flexible display device is clear.
University patents provide seed for future developments.
Note: very few granted patents from the early applications indicate possible prior art concerns
Identify Key R&D relationships: Network Analysis
16© 2010 CambridgeIP Ltd. All rights reserved
Case Study: Plastic Logic
(printed electronics)
Blue: Inventor
Red: Owner
Size: Quantity
Regulatory Pressures: Channels of Impact on Design
• Regulatory pressures and changes both within and outside of the inhaler industry can have a significant impact on what design features are:
– Required within a timeframe
– Made possible or desirable
• Such pressures may come directly to you through law, client pressures or competitor innovation
17 © 2009 Cambridge Intellectual Property Ltd. All rights reserved
• The 1987 Montreal Protocol introduced a range of control measures for the production and use of CFCs
• This had a major impact on the inhaler industry overall, and pMDI manufacturers in particular
• Two strategies emerged to deal with this market development, resulting in accelerated patenting
18 © 2009 Cambridge Intellectual Property Ltd. All rights reserved
Moving out of pMDIs: A number of companies moved out of pMDIs and into Dry Powder Inhalers
pMDI space innovations in propellants based on the 2 HFAs that were allowed to be used (HFA 134a & 227)
Montreal Protocol on CFCs: Structural Impact on Inhaler Industry
On April 13, 2010, the FDA announced that seven metered dose inhalers that contain CFCs are being phased out in the United States.
Outline
• CambridgeIP snapshot
• Examples of our analysis
• Emerging Technologies in Inhaler Space
• Case study
• Working with CambridgeIP
19 © 2009 Cambridge Intellectual Property Ltd. All rights reserved
Key directions of innovation
We see broadly three directions of innovation:
1. „Constraint based' innovation: move to frugal products by taking the needs of the poor consumers as a starting point. Tough, easy to use, simpler, cheaper, but using the last technologies available.
2. “Smartening up” of devices by adding new features
3. Use for wider range of applications: nicotine replacement, OTCs, biologics (Lung targeting)...
20 © 2009 Cambridge Intellectual Property Ltd. All rights reserved
„Smartening up‟ and interconnectivity: E.g. Continua Alliance
21 © 2009 Cambridge Intellectual Property Ltd. All rights reserved.
What does this mean?
Integration of inhalation drug-delivery platforms in emerging E-Health systems?Focus on improved user design and inter-connectivity with other devices?
Continua Alliance Objectives:
To create a rich eco-system of interoperable health and fitness devices, focused on busy professionals, elderly patients and chronic sufferers
Founded 2006 by Intel, Samsung, Sharp Electronics, Medtronic, IBM, Phillips
Focus on user interface, inter-
connectivity of devices, user friendly design
Wireless Fingertip Pulse Oximeter
?
22 © 2010 CambridgeIP. All rights reserved..
Advanced in Printed Electronics: Entry into Inhaler Devices ?
Flexible Displays
E-books and
E-newspapers
Smart Packaging
Electronic
Paper
Thin Flexible batteries
Roll to roll printing
Conductive Inks
Printed Sensors
Cosmetic patches
Low cost roll-to-roll printing makes it very cheap to produce simple electronic circuits on plastic which can open up ways to manufacture disposable devices with functionality that would not
previously have been cost effective. E.g. Kimberly Clarke are looking at putting plastic electronics into disposable nappies.
We are investigating a number of opportunities for convergence between inhaler devices and printed electronics technology
Future Developments: There is a likely increase in interest in the next generation of pulmonary delivery technologies
•Nanobodies
•Antibodies
•Vaccines
•DNA
•Proteins
•siRNA
•Peptides
Biomolecules for
pulmonary
delivery
• Novel
nanoparticles and
polymers
Controlled drug
release in the
lung and
targeted delivery
23 © 2009 Cambridge Intellectual Property Ltd. All rights reserved.
- Attack by microphages
- Solubility
- Bioavailability
- Dosage delivery
New challenges
What does this mean?
Increased focus on innovations for appropriate pulmonary delivery devices and excipients
Outline
• CambridgeIP snapshot
• Examples of our analysis
• Emerging Technologies in Inhaler Space
• Case study
• Working with CambridgeIP
24 © 2009 Cambridge Intellectual Property Ltd. All rights reserved
© 2009 CambridgeIP. All rights reserved
• We defined the technology space and implemented a multi-layer search strategy that aimed at identifying
• licensing candidates
• potential collaboration partners
• key markets & applications
• critical geographical areas
• Information useful to marketing the technology
• Results and recommendations were presented to the client in a PowerPoint summary report, and cross-referenced Excel dataset
• A workshop with the client's TTO representatives and client‟s academic experts aids understanding and dissemination of results and recommendations
• Previous market research had not resulted in uptake of the technology by corporate prospects
• A go / stop decision point was imminent as international PCT roll-out of an initial patent application approached
Business Situation
Our Approach
• 20+ organisations were identified, were categorised by type and arranged in order of priority for approach by our client
• Marketing objectives and recommendations were made in relation to each organisation type
• Key geographical markets containing high profile licensing prospects were identified for addition to PCT designated states lists
• Information on similar approaches, including diagrams, were provided to client academic experts in a convenient format
Results and Benefits
A leading UK University asked us to help identify market opportunities for an early stage surgical materials development Client Profile
Case Study 3: Accelerate licensing strategy development –Early stage surgical materials technology
Outline
• CambridgeIP snapshot
• Approaching design problems using Patent-based Analytics
• Regulatory Changes: Impact on Innovation
• Emerging Technologies in Inhaler Space
• Working with CambridgeIP
26 © 2009 Cambridge Intellectual Property Ltd. All rights reserved
CambridgeIP Production Process Overview
27Fidelity Internal Information
© 2009 CambridgeIP. All rights reserved27
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…and finally…
CambridgeIP can provide you with a cost-effective solution: whether for a one-off project or repeat needs
Visit CambridgeIP‟s www.boliven.com for free patent searches
Feel free to discuss your specific IP Intelligence requirements with Ilian or Arthur
Thank You !
Ilian Iliev
(CEO and Founder)
GSM: +44-077-863-73965
Tel: +44-1223-370-098
Corporate Office
Cambridge Intellectual Property LtdSheraton HouseCastle Park, CambridgeCB3 OAX United KingdomUK: +44 (0) 1223 370 098Fax: +44 (0) 1223 370 040
Internet Resources
Website: www.cambridgeip.comBlog: www.cambridgeip.com/blog
Sign-up for our Free Newsletteron our Home Page
© 2010 CambridgeIP. All rights reserved
Quentin Tannock
(Chairman and Founder)
GSM: +44-077-8621-0305
29 © 2009 CambridgeIP. All rights reserved
Thought Leadership and leading edge thinking applied to client projects (1)
Pending: From IP Assets to IP Revenues, chapter in European Patent Office approved textbook „IP Management in Europe‟
Ongoing: Developing the most complete to-date patent landscaping exercise across 6 low-carbon energy technologies
Jun 2009: “Challenges and Opportunities in the Licensing of Renewable Technologies”, Journal of Commercial Biotechnology
May 2009: Patenting trends in the CleanTech space, presentation to Cambridge Network, Cambridgeshire‟s high-tech community
Mar 2009: Patent trends in low-carbon energy systems and emerging markets technology transfer, presentation to WIPO, Geneva
Feb 2009: Marketing Patents, industry survey of 25 leading Universities and Research Institutes with assistance from PRAXIS
We are committed to continual improvement of methods and tools
30 © 2009 CambridgeIP. All rights reserved
Thought Leadership and leading edge thinking applied to client projects (2)
Feb 2009: Energy Harvesting Device patents and patent applications, industry report with the Integrated Products Manufacturing KTN
Oct 2008: Climate Strategies on patent landscape in Clean Coal/Super-critical applications, Climate Strategies Report
Oct 2008: The Patent Landscape of AIM, publication with Growth Investor in Business XL magazine
Aug 2008: Toward Phase 2 in the Evolution of IP Intelligence, article in The Innovation Handbook
Jun 2008: Member of Technology Licensing for Renewables Group at the Licensing Executives Society, presentation to LES, “Renewable Energy: Emerging Challenges to the Patent Licensing System”
Dec 2007: Corporate uses of IP Intelligence, Industry survey of 29 leading corporations sponsored by EEDA
© 2009 CambridgeIP. All rights reserved
Thought Leadership and leading edge thinking applied to client projects (3)
China-UK showcase: King‟s College London „Chinese University patenting trends and China-UK business opportunities‟ www.cambridgeip.com/blog/?p=28
AIM company executives: Business Excel Live event „Intellectual Property – how to keep it safe‟ www.cambridgeip.com/blog/?p=25
CleanTech companies: Cambridge Network: „Global Patenting Trends in Key Low-Carbon Energy Technologies: Results of Joint Research with Chatham House‟
WIPO, Geneva: Patent trends in low-carbon energy systems and emerging markets technology transfer
University TTOs: PRAXIS Technology market research master-class „Marketing patents‟, www.cambridgeip.com/blog/?p=85
Health Technology companies: KTN webinar ‘Developing a fact based IP strategy’
Displays & Lighting corporations: KTN tutorial: ‘Patent strategies’, www.cambridgeip.com/blog/?p=31
Licensing Executives: LES Workshop 'Advanced corporate uses of patent intelligence', www.cambridgeip.com/blog/?p=76
Licensing Executives: LES Annual Conference „Emerging Challenges to the patent system‟ www.cambridgeip.com/blog/?p=29
Our experts regularly conduct training and executive education: