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CERTIFICATE OF ANALYSIS

Conforms to Standard

Baicalin should be stored at or below room temperature in a tightly sealed durable container. Baicalin should be protected from excess heat, direct sunlight, excess humidity and moisture. Baicalin has a stable shelf life of 2 years from the date of manufacture when properly stored.

Baicalin What is Baicalin?

Baicalin is a remarkably healthful molecule extracted from several Skullcap species,

including Scutellaria lateriflora (blue skullcap), Scutellaria galericulata (common skullcap),

and Scutellaria baicalensis (Baikal Skullcap) and has been used in Chinese herbal medicine

for over 1000 years. Our Baicalin is extracted specifically from the root of Scutellaria

baicalensis (Baikal Skullcap). Baicalin is the glycoside of the flavone flavonoid baicalein,

which is also found in the Skullcap species, and the two molecules have synergistic

properties. Baicalin is known to exhibit a multitude of beneficial effects including pain-relief,

anti-inflammatory, anti-viral, anti-oxidant, anti-tumour and antibiotic effects.Baicalin is

commonly used for promotion of relaxation due to its effects on GABA type A receptors.[1]

Baicalin effects / benefits

Baicalin supplementation has a wide variety of highly beneficial effects. Its use as an ethanol

extract from the Skullcap plant species extends for over 1000 years in herbal Chinese

medicine. Baicalin can help to promote a feeling of healthy well-being, due to its effects on

GABA subtype A receptors, but this is only one of many great things about using Baicalin.

Pain-relief and promotion of relaxation

Baicalin has been found to act selectively on GABA subtype A receptors, on the receptor

allosteric modulating benzodiazepine (BZ) sites. This allows the chemical to create anxiolytic

effects (pain-relief) devoid of sedation and muscle-relaxation that is characteristic of most

GABA agonists.[2] GABA agonists that act on all subtype A receptors also generally cause

alcohol-like effects including pain-relief, sedation and muscle-relaxation, but Baicalin acts

selectively on certain specific BZ subtype sites so it causes pain-relief and feelings of well-

being without the side effects of sedation, memory impairment or tolerance.[3]

Anti-inflammation

Baicalin has been found to work as an effective anti-inflammatory agent by inhibiting binding

of leukocytes to chemokines and inhibiting cell migration (a characteristic cause of

inflammation). It does not interfere directly with chemokines but rather binds to specific

ligands to prevent chemokine-leukocyte binding. [4]

Anti-oxidant

Recent scientific studies into the effects of Baicalin use have confirmed that it is also an

effective anti-oxidant. In a study on the antioxidant effects of Baicalin, bacalein, and

wogonin (all extracts from Skullcap species), it was found that Baicalin was effective in

reducing chytochrome c as well as eliminating superoxide free-radicals, testifying to its anti-

oxidant nature.[7]

Baicalin recommended usage

From examine.com:

“Although there is a lack of human evidence to support the optimal dosage of scutellaria

baicalensis for supplementation purposes, the doses that appear optimal in rat and mouse

models suggest that an oral dose of around 500mg of the root extract should be

efficacious.”

From a Baicalin patent application for antianxiety treatment:

“According to the radio of body weight of mouse to that of human, the individual dosage of

Baicalin for oral administration is 0.8-3.5mg/kg." (Hong et al., 2004)

In a 75kg person, the above recommended dose equates to 60-265mg daily.

Baicalin side effects and warnings

Even through 1000 years of use in Chinese herbal medicine, Baicalin appears to have no

negative side effects in humans even after using high doses. WebMD warns that gas, nausea

or diarrhoea may occur. Health Central warns that people should consult a physician before

using Baicalin if they have a history of stomach ulcers. Both WebMD and Health Central

have a warning about the possibility of an allergic reaction to Baicalin, which can include:

yellowing of the eyes and skin, itchiness, rash and/or severe dizziness. (Examine)