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Chapter 11 Cell Communication
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Chapter 11Cell Communication
Local signaling:•Paracrine•SynapticLong distance signaling:•Hormonal.
Chapter 11Cell Communication
Stage I: Reception
Chapter 11Cell Communication
Stage I: Reception
Chapter 11Cell Communication
Stage II: Transduction
Chapter 11Cell Communication
Stage II: Transduction
Chapter 11Cell Communication
Stage II: Transduction
Chapter 11Cell Communication
Stage II: Transduction
Chapter 11Cell Communication
Stage II: Transduction
Chapter 11Cell Communication
Stage II: Transduction
Chapter 11Cell Communication
Stage II: Transduction
Chapter 11Cell Communication
Stage II: Transduction
Chapter 11Cell Communication
Stage III: Response
Chapter 11Cell Communication
Stage III: Response
Chapter 11Cell Communication
Ligand:A molecule that binds
specifically to another molecule.
Chapter 11Cell Communication
Three kinds of surface receptors:•G-protein linked receptors•Receptor tyrosine kinases•Ion channel receptors
(Kinase = enzyme that transfers phosphate groups.)
Chapter 11Cell Communication
G-protein linked receptors
Chapter 11Cell Communication
G-protein linked receptors
Chapter 11Cell Communication
G-protein
GDP
GTPenzyme
G-protein linked receptors
Chapter 11Cell Communication
G-protein enzymeGTP
GDP
G-protein linked receptors
Chapter 11Cell Communication
G-protein linked receptors
Chapter 11Cell Communication
G-protein linked receptors
Chapter 11Cell Communication
G-protein linked receptors
Chapter 11Cell Communication
G-protein linked receptors
Chapter 11Cell Communication
G-protein linked receptors
Chapter 11Cell Communication
Receptor Tyrosine Kinase
Chapter 11Cell Communication
Receptor Tyrosine Kinase
Chapter 11Cell Communication
ATP ATP ATP ATP ATP ATP
Tyr Tyr Tyr
Tyr Tyr Tyr Relay proteins
Receptor Tyrosine Kinase
Chapter 11Cell Communication
Receptor Tyrosine Kinase
Chapter 11Cell Communication
Receptor Tyrosine Kinase
Chapter 11Cell Communication
Receptor Tyrosine Kinase
Chapter 11Cell Communication
Receptor Tyrosine Kinase
Chapter 11Cell Communication
Receptor Tyrosine Kinase
Chapter 11Cell Communication
Receptor Tyrosine Kinase
Chapter 11Cell Communication
Ion channel receptor
Chapter 11Cell Communication
Ion channel receptor
Chapter 11Cell Communication
Ion channel receptor
Chapter 11Cell Communication
Ion channel receptor
Chapter 11Cell Communication
Ion channel receptor
Chapter 11Cell Communication
Ion channel receptor
Chapter 11Cell Communication
Ion channel receptor
Chapter 11Cell Communication
Ion channel receptor
Chapter 11Cell Communication
Ion channel receptor
Chapter 11Cell Communication
Ion channel receptor
Chapter 11Cell Communication
Ion channel receptor
Chapter 11Cell Communication
Ion channel receptor
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
ATP
Protein kinases
Inactive protein
Relay molecule
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
Why bother with such a complicated system?
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
A Phophosphorylation Cascade
Chapter 11Cell Communication
Scaffolding proteins and specificity
Chapter 11Cell Communication
Scaffolding proteins and specificity
Chapter 11Cell Communication
Scaffolding proteins and specificity
Chapter 11Cell Communication
Scaffolding proteins and specificity
Chapter 11Cell Communication
Scaffolding proteins and specificity
Chapter 11Cell Communication
