Warm-Up1. What are the leading causes of death worldwide?2. How is the economic development of a country
related to disease?3. Rank the following in order of highest probability of
death to lowest probability (in the U.S.):A. Motor vehicle accidentB. DrowningC. Airplane accidentD. Heart disease and cancerE. Firearm assault
Warm-Up1. What are the leading causes of death in the U.S.?
Worldwide?2. How is the economic development of a country
related to disease?3. Rank the following in order of highest probability of
death to lowest probability (in the U.S.):A. Heart disease and cancerB. Motor vehicle accidentC. Firearm assaultD. DrowningE. Airplane accident (1 in 8,015)
(1 in 1,113)
(1 in 358)(1 in 112)
(1 in 7)
Source: National Safety Council estimates based on data from National Center for Health Statistics–Mortality Data for 2011
Top Ten Causes of Death in the U.S.1. Heart disease2. Cancer3. Chronic lower respiratory diseases (bronchitis,
emphysema, asthma)4. Accidents (unintentional injuries)5. Stroke6. Alzheimer’s disease7. Diabetes8. Influenza and pneumonia9. Nephritis/nephrosis (kidney disease)10.Suicide
Source: CDC’s Deaths: Final Data for 2013, tables 1, 7, 10, 20
Human Health Risks
• Physical – harm caused by environmental factors – Natural disasters– Sunburn
• Biological – harm caused by pathogens– Malaria– Influenza
• Chemical – harm caused by chemicals– Arsenic– Pesticides
Biological Risks
• Infectious diseases: those caused by infectious agents, known as pathogens– Ex: pneumonia and
venereal diseases
Pathogens• Bacteria:
– Cholera– Tuberculosis– Syphilis
• Virus:– HIV/AIDS– Hepatitis– Ebola
• Protozoa:– Malaria
What causes disease?
• Infectious agents (pathogens) that are spread by:– Air– Water– Food– Body fluids– Vectors (nonhuman carriers, like mosquitoes)
Biological Risks
• Chronic disease: slowly impairs the functioning of a person’s body– Ex: heart disease, cancer, diabetes– 70% of all deaths in the U.S.
• Acute disease: rapidly impairs the functioning of a person’s body– Ex: Ebola hemorrhagic fever
Emergent Diseases
• HIV/AIDS• Ebola• Mad Cow Disease• Bird Flu• West Nile Virus• Swine Flu (www.youtube.com/watch?v=lFl3FRNpU4E )
Chemical Risks
• Neurotoxins: chemicals that disrupt the nervous system
• Carcinogens: chemicals that cause cancer
• Teratogens: chemicals that interfere with the normal development of embryos and fetuses
• Allergens: chemicals that cause allergic reactions
• Endocrine disruptors: chemicals that interfere with the normal functioning of hormones
Toxicology Studies
• Retrospective studies– “Looking back” – Monitoring people who have already been
exposed to a chemical to determine the effects• Prospective studies
– “Looking forward”– Monitoring people who might become exposed to
a chemical to determine the effects
Toxicology Studies
• Epidemiology: field of science that seeks to understand the causes of illness and disease
• Retrospective and prospective studies allow researchers to determine the effects of chemicals on individuals
Toxicology
• Dose: the amount of a substance that a person has in their body– Can be:
• Ingested• Inhaled• Injected • Absorbed
• “The dose makes the poison”
Dose-Response Studies
• Exposing organisms to different doses of a chemical and then observing their response allows scientists to determine how chemicals affect living things
• Response: the effect that a substance has on an organism (ex: mortality, change in behavior, etc.)
• LD50: the lethal dose that kills 50% of the individuals within a test population
Dose-Response StudiesDose (hypothetical units) Percent Mortality
1 0%2 0%3 4%4 10%5 40%6 60%7 90%8 96%9 100%
10 100%
Do The Math
• If the LD50 of a pesticide is 20 mg/kg for a mouse, what amount would be considered safe to ingest for a human?
• (Calculate the “safe” amount by taking the LD50 and dividing it by 1,000)
20 mg/kg ÷ 1000 = 0.02 mg/kg• Calculate the maximum amount that a 80 kg
man could ingest and still be considered “safe”80 kg × 0.02 mg/kg = 1.6 mg
Poisons
• Poisons: materials that kill at a very small dose (50 milligrams or less per kilogram of weight)
Toxicity Rating LD50
Average Lethal Dose Examples
super toxic < 0.01 less than 1 drop nerve gases, botulism, mushroom toxins, dioxin
extremely toxic
< 5 less than 7 drops potassium cyanide, heroin, atropine, parathion, nicotine
very toxic 5–50 7 drop to 1 teaspoon
mercury salts, morphine, codeine
toxic 50–500 1 teaspoon to 1 ounce
lead salts, DDT, sodium hydroxide, fluoride, sulfuric acid, caffeine, carbon tetrachloride
moderately toxic
500–5,000 1 ounce to 1 pint methyl alcohol, ether, pehobarbital, amphetamines, kerosine, aspirin
slightly toxic 5,000–15,000 1 pint to 1 quart ethyl alcohol, lysol, soapsessentially nontoxic
> 15,000 more than 1 quart water, glycerin, table sugar
Dose-Response Studies
• ED50: effective dose that causes 50% of the individuals to display the harmful, but nonlethal, effect
• These effects that change the behavior of the individuals or cause harm are called sublethal effects
• The LD50 and ED50 values for mice are often divided by 1,000 to determine the safe value for humans
Interactions• Synergistic interactions: when two (or more)
risk factors have a greater effect together than each by themselves– Ex: being exposed to asbestos and smoking gives
you a 400 times greater chance of developing lung cancer than if you experienced only one of those risks
+ =
Do The Math
If the element Strogenium has an LD50 of 40 mg/kg, how big of a dose is necessary to kill a 30 kg goat?
Toxicology
• Solubility: what can the chemical dissolve in?– Water-soluble toxins– Oil/Fat-soluble toxins
• Which do you think is generally “better” for the health of an organism?– Water is “better” since it can be diluted– Fats aren’t good since chemicals can gather
in body fat of animals
Toxicology
• Bioaccumulation: an increased concentration of a chemical within an individual organism over time– The chemical is usually stored in
body fat • Biomagnification: the increase
in a chemical concentration in animal tissues as the chemical moves up the food chain
Qualitative vs. Quantitative
• Qualitative risk assessment: judging the relative risk of various decisions (ex: low, medium, or high)
• Judgments based on perception, not on actual data
• Quantitative risk assessment: determining the probability of an event occurring using data (ex: 83% chance)
Risk Analysis
Risk =Probability of being exposed to a hazard
Probability of being harmed if exposedx
Risk Analysis
• What is riskier: flying on a plane for 1,000 miles per year or eating 40 tablespoons of peanut butter per year?– The probability of a plane crash is low, but the
probability of dying if the plane crashes is high– The probability of eating peanut butter is high, but
the probability of developing cancer from the peanut butter is low
– Both behaviors produce a risk of about 1 in 1 million
Chemical Regulation
• Trade-off:– Greater potential risk with a greater rate of
discovery of beneficial chemicalsvs.
– Greater safety with slower introduction of beneficial chemicals