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Cancer Cachexia and FatMuscle

Physiology

Kenneth C.H. Fearon, M.D.

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Contents

1. What is cancer cachexia?

2. What is fat-muscle physiology?

3. The experiment involving two mouse models.4. Obese patients can live longer than thin

patients...

5. What is the translational relevance of thesefindings?

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What is cancer cachexia?

Cachexia : Greek word

Kakos : bad

Hexis : condition

Characteristics The loss of skeletal muscle

The loss of adipose tissue

Weight loss

Anorexia

Chronic nausea

Asthenia Anemia

Electrolyte and water abnormalities

Psychological distress

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Contents

1. What is cancer cachexia?

2. What is fat-muscle physiology?

3. The experiment involving two mouse models.4. Obese patients can live longer than thin

patients...

5. What is the translational relevance of thesefindings?

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Fat(adipocyte)-muscle physiology in

the study of integrative physiology

chronic inflammation

increased adipocyte lipolysis

increased free fatty acids

Lipotoxicity

insulin resistance

adipocyte

muscle

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Fat(adipocyte)-muscle physiology in

the study of exercise physiology

Secretion of adipo-cytokine

Secretion of myokine

adipocyte

muscle

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Contents

1. What is cancer cachexia?

2. What is fat-muscle physiology?

3. The experiment involving twomouse models.

4. Obese patients can live longer than thinpatients...

5. What is the translational relevance of thesefindings?

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The experiment involving two mouse models

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Why the mouse that doesnt haveAtgl

meinteined skeletal-muscle mass?

Proinflammatorycytokines

Zinc-2-glycoprotein

Free fatty acids

adipo-cytokines

Proteincatabolism

Protein

anabolism

Skeletal musclemass

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Contents

1. What is cancer cachexia?

2. What is fat-muscle physiology?

3. The experiment involving two mouse models.4. Obese patients can live longer than

thin patients...

5. What is the translational relevance of these

findings?

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Obese patients can live

longer than thin patients...

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Contents

1. What is cancer cachexia?

2. What is fat-muscle physiology?

3. The experiment involving two mouse models.4. Obese patients can live longer than thin

patients...

5. What is the translational relevanceof these findings?

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We should understand the precise

mechanism underlying the findings of

Das andcolleagues

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Todays Main Points In cancer cachexia, muscle and fat is

reduced. According to a study by Das, a model

mouse of cachexia that has theinhibition of lipolysis decreased themuscle loss.

The presence of molecular crosstalkbetween fat and muscle has been

suggested from the result of his study. However, its pathogenesis is not

completely understood. It may be

cleared by Further studies.

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True or False1 Cachexia is defined by an ongoing increase of

skeletal-muscle mass and leads to progressive

functional impairment.

2 The loss of skeletal muscle in cachexia is the

result of an imbalance between protein

synthesis and degradation.

3 The study made by Das and colleagues opens up

the possibility that hitherto unrecognized,

physiologically important cross-talk between

adipose tissue and skeletal muscle exists in the

context of cancer cachexia.