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Papilloma. The lesion consists of thickened fingers of

epithelium. Slender vascular cores of connective tissue support each

frond

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Papilloma arising at the commissure

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Keratoacanthoma

Keratoacanthoma of the upper lip

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Keratoacanthoma. Note the cup-shaped symmetry and verruciform surface.

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Squamous cell carcinoma, floor of mouth

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Squamous cell carcinoma, gingiva

Squamous cell carcinoma of the lip.

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Exophytic squamous cell carcinoma of the lip.

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Advanced squamous cell carcinoma of the posterior-lateral tongue

Squamous cell carcinoma of the lateral tongue in a 34-year-old man

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Squamous cell carcinoma of the lateral tongue.

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Squamous cell carcinoma of the ventral surface of the tongue.

Early squamous cell carcinoma of the floor of the mouth

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Early squamous cell carcinoma of the floor of the mouth.

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Squamous cell carcinoma of the floor of the mouth

Squamous cell carcinoma of the floor of the mouth.

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Squamous cell carcinoma of the gingiva.

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Metastasis of squamous cell carcinoma of the tongue to a submandibular lymph node.

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Metastatic squamous cell carcinoma (right) in a lymph node.

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A and B, Squamous cell carcinoma of the tongue.

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Squamous cell carcinoma showing tumor nest invading skeletal muscle.

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A, Spindle cell squamous cell carcinoma. B, Immunohistochemical stain for keratins

showing positive

staining of tumor cells.

Postradiation scar in the floor of the mouth, the site of the patient's primary squamous

cell carcinoma.

TNM Clinical Staging System for Oral Squamous Cell Carcinoma

TTumor

T1: tumor 4cm

T4: tumor invades deep subjacent structures

NNodes

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N0: no palpable nodes

N1: single ipsilateral node 3cm

N2A: single ipsilateral node 36cm

N2B: multiple ipsilateral nodes 6cm

N2C: contralateral or bilateral nodes 6cm

N3: node >6cm

MMetastasis

M0: no distant metastasis

M1: distant metastasis

Lymph nodes in TNM staging

Stage TNM Designation

I T1, N0, M0

II T2, N0, M0

III

T3, N0, M0

T13, N1, M0

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IV

T4, N0, M0

T4, N1, M0

Tany, N2-3, M0

Tany, Nany, M1

TNM Clinical Staging of Oral Squamous Cell Carcinoma

Idiopathic leukoplakia of the lateral tongue. The microscopic diagnosis was squamous

cell carcinoma.

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Exophytic well differentiated papillary squamous cell carcinoma in the buccal sulcus in

a 54-year-old

woman.

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A and B, Basal cell carcinoma.

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Basal cell carcinoma.

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Basal cell carcinoma. Note solid tumor (left) and nested tumor (right

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Nevoid basal cell carcinoma syndrome patient. Note bifid (arrow).

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Verrucous carcinoma of the maxillary alveolar ridge.

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Verrucous carcinoma of the mandibular vestibule.

Verrucous carcinoma of the tongue.

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Verrucous carcinoma of the lingual gingival,

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Verrucous carcinoma showing broad, pushing, well-differentiated rete ridges.

Verrucous carcinoma showing well-differentiated epithelium in a verruciform profile.

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Proliferative verrucous leukoplakia.

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Verrucous carcinoma developed from persistent proliferative verrucous leukoplakia.