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Papilloma. The lesion consists of thickened fingers of
epithelium. Slender vascular cores of connective tissue support each
frond
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Papilloma arising at the commissure
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Keratoacanthoma
Keratoacanthoma of the upper lip
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Keratoacanthoma. Note the cup-shaped symmetry and verruciform surface.
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Squamous cell carcinoma, floor of mouth
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Squamous cell carcinoma, gingiva
Squamous cell carcinoma of the lip.
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Exophytic squamous cell carcinoma of the lip.
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Advanced squamous cell carcinoma of the posterior-lateral tongue
Squamous cell carcinoma of the lateral tongue in a 34-year-old man
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Squamous cell carcinoma of the lateral tongue.
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Squamous cell carcinoma of the ventral surface of the tongue.
Early squamous cell carcinoma of the floor of the mouth
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Early squamous cell carcinoma of the floor of the mouth.
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Squamous cell carcinoma of the floor of the mouth
Squamous cell carcinoma of the floor of the mouth.
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Squamous cell carcinoma of the gingiva.
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Metastasis of squamous cell carcinoma of the tongue to a submandibular lymph node.
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Metastatic squamous cell carcinoma (right) in a lymph node.
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A and B, Squamous cell carcinoma of the tongue.
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Squamous cell carcinoma showing tumor nest invading skeletal muscle.
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A, Spindle cell squamous cell carcinoma. B, Immunohistochemical stain for keratins
showing positive
staining of tumor cells.
Postradiation scar in the floor of the mouth, the site of the patient's primary squamous
cell carcinoma.
TNM Clinical Staging System for Oral Squamous Cell Carcinoma
TTumor
T1: tumor 4cm
T4: tumor invades deep subjacent structures
NNodes
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N0: no palpable nodes
N1: single ipsilateral node 3cm
N2A: single ipsilateral node 36cm
N2B: multiple ipsilateral nodes 6cm
N2C: contralateral or bilateral nodes 6cm
N3: node >6cm
MMetastasis
M0: no distant metastasis
M1: distant metastasis
Lymph nodes in TNM staging
Stage TNM Designation
I T1, N0, M0
II T2, N0, M0
III
T3, N0, M0
T13, N1, M0
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IV
T4, N0, M0
T4, N1, M0
Tany, N2-3, M0
Tany, Nany, M1
TNM Clinical Staging of Oral Squamous Cell Carcinoma
Idiopathic leukoplakia of the lateral tongue. The microscopic diagnosis was squamous
cell carcinoma.
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Exophytic well differentiated papillary squamous cell carcinoma in the buccal sulcus in
a 54-year-old
woman.
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A and B, Basal cell carcinoma.
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Basal cell carcinoma.
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Basal cell carcinoma. Note solid tumor (left) and nested tumor (right
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Nevoid basal cell carcinoma syndrome patient. Note bifid (arrow).
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Verrucous carcinoma of the maxillary alveolar ridge.
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Verrucous carcinoma of the mandibular vestibule.
Verrucous carcinoma of the tongue.
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Verrucous carcinoma of the lingual gingival,
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Verrucous carcinoma showing broad, pushing, well-differentiated rete ridges.
Verrucous carcinoma showing well-differentiated epithelium in a verruciform profile.
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Proliferative verrucous leukoplakia.
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Verrucous carcinoma developed from persistent proliferative verrucous leukoplakia.