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Code No. 4140FACULTY OF PHARMACY

M. Pharmacy I-Semester (Common to All) (Main) Examination, March 2017

Subject: Pharmaceutical Analytical TechniquesTime: 3 Hours Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1 (a) Explain wood ward fisher rules for calculating absorption maximum forunsaturated hydrocarbons with an example. (7)

(b) Write about difference and derivative spectroscopy techniques. (8)

2 (a) Explain in brief about interpretation of IR spectra of organic compounds. (10)(b) Give the absorption frequencies of the following functional groups (5)

(i) Ester(ii) Aldehydes(iii) Carboxylic acids(iv)Alcohols(v) Amide

3 (a) Write about different derivation techniques used in gas chromatography. (8)(b) Give the different applications of HPLC techniques. (7)

4 Write short notes on the following: (15)(a) Principle of NMR(b) Chemical shifts in 1H-NMR(c) Spin-spin coupling in 1H-NMR

5 (a) Describe the principle and procedure involved in ELISA technique with anexample. (8)

(b) Give theory and principle involved in electrophoresis technique. (7)

6 (a) What is Nitrogen rule in mass spectrometry? Explain with suitable examples. (5)(b) Make a note on X-Ray crystallography (5)(c) Explain powder diffraction method with its applications (5)

7 (a) Discuss the principles of DTA and DSC techniques. (5)(b) Describe the two techniques used in getting DSC thermograms. (10)

8 Explain about the following : (3x5)(a) Column efficiency parameters(b) Mobile phase selection(c) Column packing materials

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Code No. 4142FACULTY OF PHARMACY

M. Pharmacy (Pharmaceutical Chemistry) I-Semester (Main) Examination, March 2017

Subject: Advanced Pharmaceutical Organic Chemistry – ITime: 3 Hours Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1 (a) Explain the difference between DL and RS systems of nomenclature withsuitable examples and give sequence rules. (7)

(b) What is atropisomerism? Explain stereochemistry of biphenyl compoundsand allenes (8)

2 (a) Explain Cis-Trans isomerism in monocyclic and in fused ring systemstaking suitable examples. (7)

(b) Discuss any three methods for resolution of racemic compounds. (8)

3 What are rearrangement reactions? Explain the mechanism and applications of(a) Pinacol-pinacolone rearrangement(b) Fries rearrangement(c) Beckmann rearrangement (15)

4 What are the different ways of generation of carbanions, carbocations andfree radicals? Explain each in terms of structure and stability. (15)

5 (a) How do you prepare lead tetra acetate reagent? Explain its mechanism andsynthetic applications. (5)

(b) Explain the difference between lithium aluminium hydride and sodiumborohydride as reducing agents. Mention their storage, handling andapplications. (10)

6 Write mechanism and synthetic applications of (3x5)(a) DCC (Dicyclohexyl Carbodiimide)(b) DDQ (2, 3 – Dichloro – 5, 6, - Dicyano – 1, 4 – Benzoquinone)(c) NBS (N-Bromo succinamide)

7 (a) Explain mechanism and stereochemistry of nucleophilic substitutionreactions in aliphatic and aromatic compounds. (10)

(b) Explain Markovnikov and Anti Markovnikov’s addition. (5)

8 (a) Discuss in detail the mechanism and orientation of the double bond inelimination reactions. (10)

(b) Explain how the following would effect the elimination reactions : (5)(i) The structure of the substrate(ii) Base(iii) Leaving group(iv) Solvent

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Code No. 4143FACULTY OF PHARMACY

M. Pharmacy (Pharmaceutical Chemistry) I-Semester (Main) Examination, March 2017Subject: Advanced Medicinal Chemistry - I

Time: 3 Hours Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1 (a) Explain about the chiral pool and the asymmetric drug synthesis techniques. (8)(b) Explain the role of chirality in therapeutic functions with examples. (7)

2 (a) Describe the mechanism of action of proton pump inhibitor class ofanti-ulcer drugs. (6)

(b) Describe the mechanism involved in the glucorinic acid and sulphateconjugation reactions. (9)

3 (a) Classify calcium channel blockers with structural examples. (4)(b) Describe the mechanism of action and structural requirements of 1,4-

dihydropyridine class of anti hypertensives. (7)(c) Give a note on the anti-tumor antibiotics. (4)

4 (a) Explain the biochemistry involved in the antiviral agents used againstRNA virus. (5)

(b) Explain the term angiogenesis and write a note on angiogenesis inhibitors. (6)(c) Give a note on microsomal and non-microsomal drug metabolizing enzymes. (4)

5 (a) List molecular targets for the development of anticancer drugs. (3)(b) Classify alkylating agents with structural examples. (4)(c) Describe the mechanism of action and SAR of anti-metabolites. (8)

6 (a) Highlight the role of reverse transcriptase inhibitors in HIV treatment. (4)(b) Classify lipid lowering agents with structural examples. (3)(c) Explain the mechanism of action and structural activity relationship of

fibrate class of lipid lowering agents. (8)

7 (a) Describe the role enantioselectivity in the absorption and metabolismof drugs. (9)

(b) Describe the mechanism of action and SAR of H2 blockers. (6)

8 (a) Highlight the biological significance of hydrolytic and reductive bio-transformation reactions. (8)

(b) Enlist and describe about the factors influencing drug biotransformation. (7)

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Code No. 4141FACULTY OF PHARMACY

M. Pharmacy (Pharmaceutical Chemistry) I-Semester (Main) Examination, March 2017

Subject: Advanced Chemistry of Natural ProductsTime: 3 Hours Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1 (a) Explain the natural products as leads for the development of potential antibioticswith suitable examples. (10)

(b) What are alkaloids? Give the identification tests for alkaloids. (5)

2 (a) Describe the development of morphine analogues. (9)(b) Explain the structure elucidation of Rescipine. (6)

3 (a) Explain the primary, secondary and tertiary structures of proteins. Mentionthe importance of Biurette’s test. (8)

(b) Explain the following with reference to structure elucidation of alkaloids. (7)(i) Zerewitnoff’s test (ii) Herzig-Meyer test

4 (a) Discuss the end groups analysis of peptides. (7)(b) Explain in detail the discovery and development of cephalosporin antibiotics. (8)

5 (a) Explain the mechanism of action and SAR of camptothecin alkaloids. (8)(b) Write a note on chemistry of diosgenin. (7)

6 (a) Establish the following in the structure elucidation of cholesterol. (10)(i) Nature and position of side chain(ii) Position of hydroxyl group

(b) Explain the SAR of Rauwolfia alkaloids. (5)

7 (a) Write a note on chemistry of cardiac steroids. (6)(b) Discuss the steps involved in peptide synthesis and write the synthesis

of tri and tetra peptides (one method each). (9)

8 (a) Explain the mode of action and SAR of Vinca alkaloids. (8)(b) Write about morphine antagonists. (7)

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Code No. 4144FACULTY OF PHARMACY

M. Pharmacy (Pharmaceutical Chemistry) I-Semester (Main) Examination, March 2017

Subject: Drug Design and DevelopmentTime: 3 Hours Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1 (a) Discuss the concept of lead discovery. (8)(b) Explain various forces involved in drug receptor interactions. (7)

2 (a) Write in detail about the QSAR discriptors. (8)(b) Describe the rational drug design approaches used in the development

of Cimetidine. (7)

3 (a) Write the importance of quantum mechanics in drug design. (8)(b) Write a note on force field methods useful for energy minimization of

3D structures. (7)

4 (a) Explain different de-convolution Techniques. (8)(b) Discuss parallel and mixed combinatorial synthesis. (7)

5 (a) Discuss various biological databases used in homology modeling. (8)(b) Write a short note on steps in homology modeling. (7)

6 Write a short note on :(a) The application of Topliss scheme in drug design (8)(b) The steps involved in 3D QSAR (7)

7 (a) Discuss the discovery of various drugs from natural origin. (9)(b) Explain the concept of bio-isosterism. (6)

8 Write a short note on :(a) Types of molecular docking (8)

(b) Types of scoring techniques in docking (8)

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Code No. 4097 / NFACULTY OF PHARMACY

M. Pharmacy (Common to All) I-Semester(New) (Suppl.) Examination, October 2016(Except Pharmacognosy / Ind. Pharm.)

Subject: Pharmaceutical Analytical TechniquesTime: 3 Hours Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1 (a) Explain the following terms with respect to UV-visible spectroscopy. (8)(i) Chromophore (ii) Auxo chrome(iii) Bathochromic shift (iv) Hypsochromic shift

(b) Describe the effect of conjugation and pH on UV absorption of organicmolecules. (7)

2 (a) Write the principle and instrumentation of Fourier Transform Infra Red (FTIR)spectrophotometer with a neat labeled diagram. List out its advantages overconventional IR instrument. (10)

(b) What are ‘IR active and IR inactive groups’? Give the absorption frequencies forthe following functional groups. (3+2)(i) Carboxylic acid (ii) Aldehyde (iii) Primary amine (iv) Alcohol

3 (a) What is spin-spin coupling? Explain with suitable examples. (8)(b) Explain the term ‘chemical shift’? Discuss the factors affecting chemical shift. (7)

4 (a) List out various ionization techniques in mass spectrometry. Explain electronimpact and chemical ionization techniques. (8)

(b) Explain the following:(i) Nitrogen Rule (7)(ii) Molecular ions(iii) Meta stable ion

5 (a) Give the principle of Gas chromatography. Explain any three derivatisationmethods. (9)

(b) Write the applications of Gas chromatography in pharmaceutical analysis. (5)

6 (a) Explain the principle and working of HPLC with a schematic diagram. (8)(b) Discuss the principle and applications of flash chromatography. (7)

7 (a) Write the principle and instrumentation of capillary electrophoresis. (7)(b) Explain the principle, applications and limitations of ELISA. (8)

8 (a) Explain Bragg’s equation and Miller indices. Write the applications ofcrystallographic studies. (8)

(b) Briefly explain the principle and working procedure of TGA. (7)

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Code No. 4105 / NFACULTY OF PHARMACY

M. Pharmacy (Pharmaceutical Chemistry) I-Semester (New) (Suppl.) Examination,November 2016

Subject : Drug Design and Development

Time : 3 hours Max. Marks : 75

Note : Answer any FIVE questions. All questions carry equal marks.

1 a) Discuss the forces involved in drug receptor interactions.b) What are Isosters? Explain the concept of Bio-isoterism with suitable examples.

8+7

2 a) Write in detail about the QSAR descriptors.b) What is rational drug design? Discuss the development of cimetidine. 8+7

3 a) Write the importance of quantum mechanics in drug designing.b) Explain various scoring techniques in Molecular docking. 8+7

4 a) Discuss parallel combinatorial synthesis.b) Write a note on High throughput screening. 8+7

5 Write in detail about the steps involved in homology modeling of a protein. 15

6 Write a note on 7+4+4a) Deconvolution b) Tagging c) Photolithography

7 a) Write a note on sustituent hydrophobicity constant and Hammet constant.b) Discuss Hansch analysis and its advantages. 7+8

8 a) Discuss the theories of drug-receptor interactions.b) Write a note on various approaches used in rational drug design. 8+7

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Code No. 4102 / NFACULTY OF PHARMACY

M. Pharmacy (Pharmaceutical Chemistry) I-Semester (New) (Suppl.) Examination,October 2016

Subject: Advanced Chemistry of Natural ProductsTime: 3 Hours Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1 (a) Discuss the structural elucidation of morphine through chemical anddegradation reactions. (12)

(b) Write a note on the development of morphine analogues. (3)

2 (a) Explain in detail the lead optimization in case of cardiovascular drugs. (7)(b) Discuss the development of CNS drugs. (8)

3 Write note on :(a) End group analysis (8)(b) Primary, secondary, tertiary and quaternary structure of proteins (7)

4 (a) Explain how the structure of cholesterol is elucidated. (11)(b) Write the chemistry of cardiac steroids. (4)

5 Discuss the structure, mechanism of action, synthetic analogues andtherapeutic uses of(a) Taxol (8)(b) Vinca alkaloids (7)

6 (a) Discuss the structural modifications and therapeutic uses of anti inflammatorysteroids. (8)

(b) Explain the chemistry of insulin. (7)

7 (a) Describe the structural elucidation of reserpine. (12)(b) Explain the importance of Hoffmann exhaustive methylation in structural

elucidation of alkaloids. (3)

8 (a) Discuss the general methods of synthesis of peptides. (8)(b) Explain the chemistry, synthetic analogues and therapeutic uses of

camptothecin. (7)

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Code No. 4103 / NFACULTY OF PHARMACY

M. Pharmacy (Pharmaceutical Chemistry) I-Semester (New) (Suppl.) Examination,November 2016

Subject: Advanced Pharmaceutical Organic Chemistry – ITime: 3 Hours Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1 (a) Explain stereochemistry of Allenes and biphenyls with suitable examples. (8)(b) Discuss cis-trans isomerism in alkenes and monocyclic compounds. (7)

2 Write structure, stability and important reactions of (3x5)(a) Carbocations(b) Carbanions(c) Free radicals

3 (a) Discuss mechanism of stereochemistry involved in SN1 and SN2 reactions. (9)(b) Define the following with suitable examples. (5)

(i) Plane of symmetry(ii) Centre of symmetry

4 Write the synthetic applications of following synthetic reagents: (3x5)(a) N-Bromosuccinamide(b) Lithium aluminium hydride(c) Osmonium tetroxide

5 Write the mechanism and applications of (3x5)(a) Pinacol-pinacolone rearrangement(b) Hoffmann rearrangement(c) Baeyer – Villiger rearrangement

6 What is racemic modification? Discuss the different methods of resolution of racemicmixtures. (15)

7 (a) Discuss the orientation and reactivity of monosubstituted benzene towardsnitration, sulphonation and halogenations with suitable examples. (8)

(b) Explain mechanism involved in E2 and E1Cb reactions. (7)

8 Explain the mechanism involved in the following: (3x5)(a) Beckmann rearrangement(b) Benzil-Benzilic acid rearrangement(c) Lead tetra acetates as oxidizing agent and methylating agent.

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Code No. 4104 / NFACULTY OF PHARMACY

M. Pharmacy (Pharmaceutical Chemistry) I-Semester (New) (Main) Examination,November 2016

Subject: Advanced Medicinal Chemistry – ITime: 3 Hours Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1 (a) Explain the asymmetric synthesis and enzymatic transformation techniques ofchiral drug preparation. (10)

(b) Chirality influences the drug action. Explain with examples. (5)

2 (a) Describe the functions of microsomal and non-microsomal enzymes in drugmetabolism. (6)

(b) Describe cytochrome P450 catalysed oxidative metabolism. (9)

3 (a) Classify calcium channel blockers, describe their mechanism of action and SAR. (10)(b) Explain the structural features of folic acid and purine antagonists used in

anti-cancer therapy. (5)

4 (a) Outline the virus life cycle and list targets for the development of anti-viralagents. (10)

(b) Explain the biochemistry involved in the antiviral agents used againstDNA virus. (5)

5 (a) Enumerate newer molecular targets for the development of anticancer agents. (3)(b) Classify and outline the mechanism of action of anti cancer alkylating agents. (8)(c) Explain about the molecular basis of cancer. (4)

6 (a) Enlist the molecular targets for the development of antiulcer agents. (01)(b) Describe the mechanism of action and SAR of proton pump inhibitors. (6)(c) Classify lipid lowering agents with structural examples and explain the structural

activity relationship of statins. (8)

7 Give a note on the following:(a) Anti-angiogenesis agents (7)(b) Anti-metabolites (8)

8 (a) Describe the influence of chirality in the pharmacokinetics of the drugs. (10)(b) Highlight the importance of hydrolytic and reductive bio-transformation reactions.(5)

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Code No. 6097 / NFACULTY OF PHARMACY

M. Pharmacy (Common to All) I-Semester (New) (Main) Examination, April 2016(Except Pharmacognosy / Ind. Pharm.)

Subject: Pharmaceutical Analytical TechniquesTime: 3 Hours Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1 (a) Explain Woodward – Fieser rules for calculating max for unsaturatedhydrocarbons. (5)

(b) Describe various electronic transitions in UV-visible spectroscopy. (5)(c) List out different IR instruments and discuss their advantages and

Disadvantages. (5)

2 (a) Describe various sample-handling techniques for IR spectroscopy. (8)(b) Write a short note on 13C NMR. (7)

3 (a) How do you determine the molecular formula of a compound with the followingisotopic abundance? (6)

M+ M+1 M+2m/z 94 95 96% R.A. 100 1.1 98

(b) Explain the following with examples. (9)(i) Nitrogen Rule(ii) Shielding and deshielding(iii) Spin-spin coupling

4 (a) Explain the principle of gas chromatography and discuss instrumentation of GCwith a labeled diagram. Give its applications. (9)

(b) Describe the principle and working of any two detectors used in GCinstruments. (6)

5 (a) Explain the principle of HPLC. Describe the stationary phases used in HPLCinstruments. (8)

(b) Discuss the principle and applications of supercritical fluid chromatography. (7)

6 Write a note on :(a) Miller indices and Bragg’s equation (8)(b) SDS-gel electrophoresis (7)

7 (a) Write the principle and instrumentation of zone electrophoresis. (7)(b) Explain the principle, applications and limitations of RIA. (8)

8 (a) List out different thermal analytical techniques. Briefly explain the theory,instrumentation and applications of DSC. (10)

(b) Explain the rotating crystal technique for X-ray diffraction studies. (5)

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Code No. 6102 / N

FACULTY OF PHARMACYM. Pharmacy (Ph. Chem.) I – Semester (New) (Main) Examination, April 2016

Subject : Advanced Chemistry of Natural Products

Time : 3 hours Max. Marks : 75

Note : Answer any FIVE questions. All questions carry equal marks.

1 a) Describe the Development of antibiotics. 7b) Explain the mechanism of action and SAR of comptothecin alkaloids. Give their

uses. 8

2 a) Discuss the structure elucidation of Reserpine. 8b) Explain the SAR and therapeutic uses of Rawlofia alkaloids. 7

3 a) Explain in detail the lead optimization of cephalosporin antibiotics. 10b) List the drawbacks of natural penicillin with example. 5

4 a) Describe the structural elucidation of Morphine. 13b) What is a peptide linkage? How do you identify it by a chemical reaction? 2

5 a) Describe the chemistry of Cardiac steroids. 8b) Describe Sanger’s and Edmans method of end group analysis of proteins. 7

6 a) Describe the significance of Barbier wieland degradation reactions in thestructural elucidation of cholesterol. 5

b) Explain the methods of degradative reactions helping in the structural elucidationof alkaloids with suitable example. 10

7 a) Explain the chemistry of diosgenin. 7b) Describe the structures and therapeutic uses of steroidal anti-inflammatory

agents. 8

8 a) Explain the primary, secondary and tertiary structures of proteins. 8b) How are the positions of a double bond and hydroxyl group in a sterol is

determined? Illustrate your answer giving suitable example. 7

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Code No. 6103 / NFACULTY OF PHARMACY

M. Pharmacy (Pharmaceutical Chemistry) I-Semester(New) (Main) Examination,April 2016

Subject: Advanced Pharmaceutical Organic Chemistry – ITime: 3 Hours Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1 (a) Explain different elements of symmetry with suitable examples. (5)(b) Discuss stereochemistry of biphenyls, allenes and spiranes. (10)

2 Write definition, structure, stability and reactions of (3x5)(a) Carbanions (b) Free radicals (c) Carbenes

3 Explain mechanism and stereochemistry involved in E1, E2 and EIcbeliminations. (3x5)

4 What are rearrangement reactions? Explain the mechanism and applicationsof (3x5)(a) Wagner-Meerwein rearrangement(b) Curtius and Lossen rearrangement(c) Baeyer – Villiger rearrangement

5 Write a note on : (3x5)(a) Electrophilic addition(b) Discuss SN1 and SN2 mechanisms(c) Explain the mechanism of aromatic electrophilic substitution with suitable

example.

6 Write mechanism and applications of following synthetic reagents: (3x5)(a) Sodium borohydride(b) Lead tetracetate(c) Dicyclohexyl carbodi imide

7 (a) Discuss cis-trans isomerism in monocyclic and fused ring systems. (5)(b) Discuss different methods of resolution of racemic mixtures . (10)

8 Write the mechanism and applications of : (3x5)(a) Pinacol – pinacolone rearrangement(b) Benzil – benzilic acid rearrangement(c) 2, 3 Dichloro – 5, 6 Dicyano – 1, 4 – benzoquinone

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Code No. 6104 / NFACULTY OF PHARMACY

M. Pharmacy (Pharmaceutical Chemistry) I-Semester(New) (Main) Examination,April 2016

Subject: Advanced Medicinal Chemistry – ITime: 3 Hours Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1 (a) Enumerate different chiral drug synthesis techniques and explain any one indetail. (7)

(b) Highlight the influence of chirality in the pharmacokinetic aspect of thedrugs. (8)

2 (a) Explain the mechanism involved in the glucuronic acid conjugationreactions. (5)

(b) Mention the biological significance of reductive metabolism. (3)(c) Explain about the various factors influencing biotransformation. (7)

3 (a) Explain the role of chirality in the drug action with examples. (5)(b) Classify angiotensin converting enzyme inhibitors, describe their mechanism

of action and SAR. (10)

4 (a) Indicate the biochemical functions of HIV protease in virus replicationprocess. (3)

(b) Describe the role of reverse transcriptase inhibitors in HIV treatment. (3)(c) Explain the biochemistry involved in the anti-viral agents used in the

treatment of influenza. (9)

5 (a) Explain about the drug resistance of anticancer agents. (5)(b) Illustrate the oxidative metabolism catalyzed by cytochrome P450. (10)

6 (a) Enlist proton pump inhibitors giving their structures, explain their mechanismof action and SAR. (9)

(b) Explain the term angiogenesis and suggest targets to modulate theangiogenesis function. (6)

7 (a) Enumerate newer molecular targets for the development of anti-canceragents. (5)

(b) Explain the mechanism of action and significant structural features ofanti-metabolites. (10)

8 Write a note on the following:(a) HMG CoA reductase inhibitors (8)(b) Anti-tumor anti-biotics (7)

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Code No. 6105 / NFACULTY OF PHARMACY

M. Pharmacy (Pharmaceutical Chemistry) I-Semester (New) (Main) Examination,April 2016

Subject : Drug Design and Development

Time : 3 hours Max. Marks : 75

Note : Answer any FIVE questions. All questions carry equal marks.

1 a) How does stereochemistry of drugs influence their biological activity? Explain.b) Discuss serendipity, Random and Non-Random screening with examples. 8+7

2 a) Discuss Free-Wilson analysis and write its importance.b) Explain Topliss scheme for aromatic and aliphatic compounds. 8+7

3 a) Write a note on force-field calculation.b) Discuss modeling ligands for known receptors. 8+7

4 a) Explain about the solid phase synthesis.b) Discuss about tagging and photolithiography. 8+7

5 a) What is homology modeling and write its significance in drug designing?b) Write a short notes on sequence alignments. 9+6

6 Write a short note ona) Knolwedge based and Consensus scoring in dockingb) Abintio and semi-empirical Quantum mechanic calculations. 8+7

7 a) Discuss various molecular modifications approaches in the genesis of new drugs.b) Explain molecular perturbation and activation aggregation theories of drug-

receptor interactions. 9+6

8 Write a short note on :a) 3D QSAR and its applications.b) Explain the strategies in designing ligands for unknown receptors. 8+7

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