Correction: Growth and Morphology of Colonies of Chinese Hamster Ovary Cells Growing onAgar is Affected by InsulinSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 76, No. 6 (Jun., 1979), p. 3039Published by: National Academy of SciencesStable URL: http://www.jstor.org/stable/69913 .

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Corrections Proc. Natl. Acad. Sci. USA 76(1979) 3039

Correction. In the article "Conformation of uncomplexed natural antamanide crystallized from CH3CN/H20" by Isa- bella L. Karle, T. Wieland, D. Schermer, and H. C. Ottenheym,

which appeared in the April 1979 issue of Proc. Natl. Acad. Sci. USA (76, 1532-1536), Figs. 1, 3, and 4 were not printed well. The figures and their legends are reprinted here.

FIG. 1. Stereodiagram of nat-ural anta- manide drawn by computer from experimentally determined coordinates. The peptide backbone is outlined by heavy bonds and the Ca atoms are labeled 1 to 10. Four H20 molecules are indicated by Roman numerals.

I - FIG. 3. Channel formation in the crystal of [Phe4 Val6lanta- G rfDg <) nmanide. Three water molecules closely associated with each

649 ?\3AD peptide molecule are indicated by darkened circles. The axial di- rections are c t, b , and a directed up from the page.

FIG. 4. Stereodiagram of the packing in the crystal of natural an- tamanide. Water molecules are indi- cated by darkened circles and hydro- gen bonds are denoted by light lines.

_________________________ ~~~~~~~ ~~~~~~~The axial directions are a b, b -b, and c directed up from the page.

Correction. In the article "Growth and morphology of colonies of Chinese hamster ovary cells growing on agar is affected by insulin" by Bruce D. Aidells, Michael W. Konrad, and Donald A. Glaser, which appeared in the April 1979 issue of Proc. Natl. Acad. Sci. USA (76, 1863-1867), Fig. 4 failed to show all the details of the original. The figure and its legend are reproduced below.

, c

I m m

FIG. 4. Determnination of mounding index. By dividing the radius of each colony into thirds, we can quantitate morphological differ-

Correction. In the article "Repair of 06-methylguanine in adapted Escherichia coli" by Paul F. Schendel and Peter E. Robins, which appeared in the December 1978 issue of Proc. Natl. Acad. Sci. USA (75,6017-6020), the authors request the following change. The units given for the left vertical axis of Fig. 2 should be cpm in O6MeGua/3 X 107 cells.

Correction. In the article "Modification of the blood-brain barrier: Increased concentration and fate of enzymes entering the brain" by John A. Barranger, Stanley I. Rapoport, Wendy R. Fredericks, Peter G. Pentchev, Kaye D. MacDermot, Jan K. Steusing, and Roscoe 0. Brady, which appeared in the January 1979 issue of the Proc. Natl. Acad. Sci. USA (76,481-485), the authors wish the following correction to be made. On page 485, line 1 of the left-hand column, ref. 18 should be deleted and added on page 484 to the end of line 8 from the bottom of the right-hand column so that the references in these parentheses will be "(18, 20)."

ences, using a parameter we call the mounding index, defined as logio [(B/C)/(A/13)], in which A, B, and C are the amounts of light scattered by the corresponding zones of the colony. On the bottom are com- puter-drawn topological contours of a typical colony grown in 10% FCS on day 14 (mounding index <0) (Left) and another colony with the addition of insulin at 50 ng/ml (mounding index > 0) (Right). The vertical axis is exaggerated.

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