CTBE: R&D Programs and Facilities

8/3/2019 CTBE: R&D Programs and Facilities

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Communication Department - CNPEM - Campinas, Sao Paulo - 2011

Editor: Luiz Paulo Juttel / Design: William Barbosa / Printed by: Grca E-Color

Photos:Gustavo Tlio, Luiz Paulo Juttel, Pablo Levinsky and William Barbosa

Brazilian Bioethanol Science

and Technology Laboratory

Basic science and technological innovation

in the sugarcane/ ethanol cycle


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Agricultural Program 12

Industrial Program 13

Basic Research Program 15

Technology Assessment Program 16

Sustainability Program 17

Laboratories of Physics and Chemistry for the

Pretreatment of Lignocellulosic Material 20

Laboratories of Functional and Structural

Biology 21Laboratories of Biotechnology for Hydrolysis and

Alcoholic Fermentation 23

PPDP 1 and PPDP 2 26

PPDP 3 and PPDP 4 27

PPDP 5 29

PPDP 6 and Biosafety Level 2 Lab 30

CNPEM: Science, Technology and Innovation

in the Frontier of Knowledge 34

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9

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25

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Research Programs: performance in the

entire production cycle of bioethanol

R,D&I to Increase the

Competitiveness of Ethanol

Research Infrastructure:

Laboratories and Pilot Plant

Pilot Plant for Process

Development (PPDP)

Relationship with

the Industry

Contents


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CTBEs professionals see thesugarcane as a carbon source that

can be efciently transformed

into fuels and others products.

CTBEs facilities: 9.000 m2

of built area located in Campinas, Brazilfor research in the sugarcane/ ethanol cycle


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In the current global context, discussions on

energy security and climate change have placed

biofuels in evidence, especially ethanol. This scenario

congures a good opportunity for Brazil.

Due to the virtuous history of sugarcane and

its products in the country, we envision a prosperous

future in the area of bioenergy for the country. From

1975 (beginning of Prolcool Program) to 2008, the

Brazilian ethanol production for each hectare of

sugarcane has grown 125% and production costs

dropped 70%. This was only possible due to research

and development (R&D) across the supply chain.

Against this backdrop, the Brazilian Bioethanol

Science and Technology Laboratory (CTBE) comes

back to Brazils energy future. Our professionals

see the sugarcane as a carbon source that can

be efciently transformed into fuels and others

products for the food, chemical and pharmaceutical

industries and consolidating plants in bioreneries.

This publication covers the objectives ofCTBE, its infrastructure of science and technological

development and research programs. Through

scientic improvement throughout the production

cycle of sugarcane ethanol, we hope to collaborate

in the construction of a global scientic agenda

connected to national technological interests.

Presentation


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Laboratory of Fungi Hydrolases Biosynthesis: prospection and production

of enzymes for second generation ethanol technology


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The Brazilian Bioethanol Science and

Technology Laboratory (CTBE) is a multidisciplinary

R, D & I institution in the ethanol from sugarcane

area committed to the Brazilian future in biofuels

and opened to external users.

Inaugurated in January 2010, the CTBEs mission

is to contribute to consolidate the leadership of

Brazil in bioethanol production, seeking answers to

scientic and technological challenges in the entire

production cycle.

The creation of CTBE was inspired by an

exploratory study commissioned in 2005 for the

Center for Strategic Studies and Management

Science, Technology and Innovation (CGEE), at the

request of the Brazilian Ministry of Science and

Technology (MCT). This research analyzed the

feasibility of Brazil to replace 10% of the gasolineused in the world for ethanol of sugarcane by 2025.

Named as Ethanol Project, this study was conducted

in an agreement between the Interdisciplinary

Center of Energy Planning (NIPE/Unicamp) and

the CGEE/MCT.

In its nal report, the Ethanol Project discovers

that the country may become a major global

supplier of biofuel without signicantly increasing

the sugarcane planted area, as soon as overcomes

important agricultural, industrial and logistic

bottlenecks. It was concluded that the answer to

this challenge pass by investing heavily in R,D&I,

now materialized in the constitution of a National

Laboratory of basic and applied research directed

exclusively to that purpose.

CTBEs MissionTo contribute for the Brazilian leadership in the

renewable energy sources and chemical industry raw

material production sectors, mainly by improving

the sugarcane bioethanol production chain, through

state-of-the-art of research, development and

innovation.

R,D&I to Increasethe Competitiveness

of Ethanol


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The Research Programs of the Brazilian Bioethanol

Science and Technology Laboratory (CTBE) includes

the agricultural, industrial, technology assessment,

sustainability and basic research areas. The scientic

communities, business and foreign experts evaluated

each of these Programs.

Culm of sugarcane


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Research Programs:performance in the entire production

cycle of bioethanol

Information Evaluation

Methodology and Assessment


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Processes related to agriculture account for

around 70% of the ethanol production cost. This fact

motivated CTBE to focus the Agricultural Program

on productivity increase and cost reduction ofsugarcane production through the implementation

of the no-till farming system. This system was well

succeeded for the production of grains, as a way to

reduce costs, preserve soil nutrients and use water

resources more rationally.

A less aggressive mechanization approach is

required to make no-till farming feasible in sugarcane

elds. This need led CTBE to develop a Controlled

Trafc Structure (ETC) capable to execute all the

mechanized operations of the agronomic cycle

of sugarcane. Among other benets, this machine

should reduce trafc on the planted area and fuel

consumption as well as soil compaction and erosion.This program has the support of FUNTEC/

BNDES (R$ 16 million for 4 years). The partner

company is Mquinas Agrcolas Jacto S.A. and the

agronomic studies are coordinated by the Brazilian

Agricultural Research Corporation (Embrapa),

The Agricultural Program is also

exploring the potential of Precision Agriculture to

increase productivity, reduce fertilizing costs and

environmental impacts.

AgriculturalProgram

CTBEs Controlled Trafc Structure (ETC): 3D image


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The Industrial Program focuses on developing

the technology of cellulosic bioethanol production.

The Pilot Plant for Process Development (PPDP)

will provide this; the pilot plant will enable the

development of parametric studies, to assess

the technical-economic and environmental

performance of the processes. Advanced industrialplant models will be considered in these cases

within the technological concept of biorenery.

The pilot plant building area is 2,500m2 which

will be used by researchers from anywhere around

the world in developing and scheduling techniques

for the production of cellulosic ethanol and other

strategic products from sugarcane bagasse and

trash. Flexible, multipurpose, the PPDP will be

useful to development researches related to the

cycle sugarcane/ethanol in semi-industrial scale.

Other institutions may use the pilot plant

facilities to scaling up your researching processes.

On the other hand, scaling down could be

development to improve technologies. The CTBE

Pilot Plant will be used even optimization of rst

ethanol generation processes - produced from

sugarcane juice and the development of new

products related to ethanol industry.

IndustrialProgram

Reactor used to enzymatic hydrolysis bioethanol processes

researching from sugar cane bagasse and straw

Efcient

Pretreatment

Best Enzymes for

Hydrolysis

Optimized

Fermentation

Economically Viable Technology

for Cellulosic Ethanol


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Comparison of cell walls of sugarcane from

different cells under (A) Atomic Force and (B)

Electron with electon-diffaction microscopies.

Both walls present amorphous materials that

possibly correspond to hemicelluloses and

pectins present in the wall.

Tridimensional structure of a cellulase

A B


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The Program focus on the scientic development

needed to solve the bottlenecks pointed out by

other programs of CTBE, in addition to its own

agenda. This agenda is centered on studies that favors

the advancement of scientic knowledge on basic

phenomena related to the production of cellulosic

ethanol such as photosynthesis, carbohydrates and

proteins molecular structure, polysaccharides synthesis

and degradation, plant metabolism, nanotechnology

related to plant material, green chemistry, conversion

of chemical energy in mechanical energy, combustion

of ethanol among others. In addition, CTBEs laboratory

facilities will be available to researchers from academic

and industrial areas.

The research developed at CTBE should be

fully integrated with other national and international

groups in their respective areas. It is expected that the

Laboratory is recognized as an institution that generates

new ideas in the various sectors of science. This should

occur through scientic publications, reports, articles

and especially through the link between the produced

knowledge and technological applications.

Basic Research

Program

Sugarcane cell wall: a challenge for second generation ethanol


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TechnologyAssessment Program

The Technological Assessment Program

develops a Virtual Sugarcane Biorenery (BVC),

computational simulation platform that will analyze

the impact of new technologies on the economical,

social and environmental sustainability impacts of

ethanol production.

The BVC, for example, will evaluate the

economic and technological feasibility of joining

the production of cellulosic ethanol to the rst

generation, coupled with the production of

bioelectricity and high-value adjoined compounds

for the chemical, food and pharmaceutical industries

among others.

The data generated by BVC can help companies,

governments and research and funding institutions

to set study priorities or technological development,to evaluate the success of projects and to plan the

investment in new technologies.

Biorefneries technological routes

evaluated by BVC:

First generation ethanol, sugar and electricity

Second generation bioethanol (hydrolysis)

Liquid fuels from biomass (gasication)

Alcohol chemistry Sucrochemistry

Lignin route

Other routes

Sugarcane

Ethanol Production/ others

Ethanol Usage / others

Economic

Environmental

Social

Process

Data

Sustainability

Impacts

Mathematical

Models

Institutions

Net

Sugarcane Virtual

Biorefnery


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CTBEs Sustainability Program has an

international reach and aims at the production

of data to address the sustainability theme in a

scientic way. Its main focus is on studies of impacts

of new technologies on the sustainability of the

sugarcane/ bioethanol production cycle. Due to

the wide concept of sustainability, priority aspects

were dened by CTBE taking into account both the

national and the international agenda.

CTBEs activities on sustainability of bioethanol

from sugarcane are organized in research projects

that will be conducted simultaneously:

energy and GHG emission balances;

soil carbon stock changes and emissions

of N2O and CH4; direct and indirect impacts of land use change

(LUC and ILUC);

socio-economic impacts;

impacts on availability and quality of

water resources;

impacts on biodiversity.

Institutional Agreements

The Sustainability Program activities occur in

partnership with renowned research institutions

such as Imperial College London, England, and the

National Renewable Energy Laboratory (NREL),

United States. In Brazil, the Center for Strategic

Studies and Management Science, Technology and

Innovation (CGEE), the Institute for International

Trade Negotiations (ICONE) and the Delta CO2

collaborates with CTBE in this theme. Other

partnerships are in progress.

SustainabilityProgram


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High-performance Liquid Chromatography (HPLC): quantifying of sugars,

organic alcohols and alcohols in the CTBEs Instrumental Lab


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The CTBEs main building has 6.000m2

divided into two floors that have placed the

following facilities:

Laboratories of Physics and Chemistry for the

Pretreatment of Lignocellulosic Material

Laboratories of Functional and Structural

Biology

Laboratories of Biotechnology for Hydrolysis

and Alcohol Fermentation

The Pilot Plant for Process Development

(PPDP) has a built area of 2.500m2 and operates,

initially, with six multipurpose units:

ResearchInfrastructure:

Laboratories and Pilot Plant

In the Laboratory of Agricultural Prototypes,

with 250m2, will be developed the Controlled

Traffic Structure (ETC), farm machinery that will

contribute to the implementation of the direct

planting system in the sugarcanes culture.

PPDP 1: Physical Treatment of Sugarcane

Bagasse and Straw.

PPDP 2: Physical Chemical Pretreatment of

Lignocellulosic Material

PPDP 3: Fungi, Yeast and Bacteria Production

PPDP 4: Enzymatic Hydrolysis ofBiomass

PPDP 5: Separation and Purication

PPDP 6: Alcoholic Fermentation


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The pretreatment of sugarcane bagasse and straw

aims to decrease the resistance of the lignocellulosic

material to further action of enzymes that will break

the cellulose chains in order to release the sugars

that are converted to ethanol through fermentation.

The raw material is washed and can be

fractionated and milled before going through thepre-physical and chemical treatments as steam

explosion, organosolv, acid or alkaline hydrolysis and

plasma, among others. The goal of these studies is to

identify a combination of variables (reaction time,

pH, temperature etc.) able to optimize the process

of celluloses enzymatic conversion.

Physical and chemical characterizations of

the lignocellulosic material are also realized to

determine the composition and the structure of the

biomass raw and pre-treated. These processes allowdetermining the levels of sugars, lignin and elemental

constituents, the size distribution of particles and

their porosity.

Laboratories of Physics andChemistry for the Pretreatment

of Lignocellulosic Material

EquipmentsCutting millImpact and shear millPARR reactors 2.0L and 7.5LTubular reactorMicrowave digesterNutsche lterIon ChromatographElemental Analyzer CHNOSUV-Visible SpectrophotometerFTIR/NIR SpectrophotometerSurface Area and Porosity AnalyzerParticle Size AnalyzerDifferential Scanning CalorimeterSimultaneous Thermal AnalyzerThermogravimetric Sorption AnalyzerOscilloscopes (2.5 GHz and 3.5 GHz)Mass Spectrometer (up to 500 a.m.u.)


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Research physiology, biochemistry and molecular

biology of plants and microorganisms. Chemical,

physical, structural and ultrastructural characterization

of biomass (plant tissue, bagasse and straw).

Studies on conversion of biomass such as

the impact of pretreatment and hydrolysis using

hightroughput techniques. Pentose fermentationpathways in yeast. Data aquisition processing and

visualization using eScience approach.

Laboratories of Functional andStructural Biology

Equipments. Confocal microscopy. Fentoseconds laser. Optical tweezers + microdissection. Imaging and spectroscopy. Liquid chromatograph with mass spectrometer (LC-MS)

Greenhouse:. Conviron chambers (cells, seed and plantlets: plants frombuds). Scholander chambers and leaf area meters. Open top chambers. Photosynthesis measurements (IRGA and uorometer). Weather stations and sensors


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SDS-PAGE Electrophoresis: analysis of expression, quantifying and purity level of recombinant

proteins for cellulosic ethanol production

Colony picker prepares samples of cloned bacteria for DNA sequencing


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In the CTBEs Laboratories of Molecular

Biology are conducted researches in bioprospecting,

metagenomics and genetic improvement of

microorganisms for the production of enzyme

cocktails and engineering strategies to increase

the efciency of cellulases. Studies conducted in

Bioprocess Laboratories seeks the development,optimization and scale up of enzyme production

processes, of biomass hydrolysis and of alcoholic

fermentation.

These studies includes bioreactors engineering

and biomolecules separation and purication

processes.

The research goals is to contribute to supplant

the main bottlenecks of the second generation

ethanol production: the high cost of enzymes that

convert cellulose and hemicellulose into fermentablesugars, enzymatic hydrolysis of lignocellulosic

biomass and alcoholic fermentation of hydrolysates

rich in pentoses and hexoses.

Laboratories of Biotechnologyfor Hydrolysis and AlcoholicFermentation

Equipments. 10 Bioreactors - 3L. 4 Bioreactors - 20L. Chromatography systems (AKTAPurier e AKTA FPLC). Liquid and ion chromatographysystems (HPLC IR/UV and Dionex). Colony picker. Crossow ltration system. Automated pipetting system. On-line biomass sensor. Fluorescence spectrophotometer. Ultra centrifuge. Image analysis system. Scintillator. Optical microscopy with imageanalysis software


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Flexible, multipurpose, the PPDP will be useful to development researches related to the cycle sugar

cane/ ethanol in semi-industrial scale.


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Setor

de Inovao

Pilot Plant for Process

Development (PPDP)

The Pilot Plant for Process Development (PPDP)

is constituted for six independents modules where

each one represents a step of cellulosic bioethanol

production including raw material pretreatment,

byproducts fermentation, recovery, purication,

concentration and fermentation.

There are new concepts modules related to

sugar, ethanol and lignin chemistry, and thermal

conversion processes. The remaining area is for the

future demand on scaling up processes. The owchart

above presents the general process since receipt

bagasse until ethanol product.


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Objective: Promote the efciency of

processes by washing, separation, milling and

fractionation of the lignocellulosic biomass.

Raw Materials: sugarcane bagasse and straw.

Products: bagasse and straw separated, ground,

fractionated and characterized physically.

Main Process

Receipt, handling and storage: the raw material

from the mills is transported in big bags and storaged

in external area of the Pilot Plant until the time of

its processing.

Washing and physical-mechanical treatment:

the raw material is washed with water in a rotating

Objective: Develop technology to degradate

the lignocellulosic matrix to improve enzymatic

hydrolysis of cellulose into fermentable sugars.

Raw material: integral bagasse, medulla, ber,

fractionated and classied ber and sugarcane straw.

Products: bagasse pulp suspension, bagassepulp and pretreatment liquor.

Main Process

Steam Explosion: the lignocellulosic material is

deaerated with direct injection of steam, heating by oil

heat and pressurized. After short period pressurized

and heated, the product is discharged abruptly; the

sudden expansion promotes the disintegration of

sieve to removal mineral and organic impurities.

Then the material is sent to the systems depithed

and the solid-liquid separation or sent to the

classicatory sieves. The solid fraction is dried in

kilns and storaged in refrigeration chambers.

Grinding: solid fractions (dried or not) are

reduced and homogenized in grinding process.

Main Equipments

Washing and screening system

Primary depithed system

Set of mills

Refrigeration chamber

Pneumatic sorter

the ber, release lignin and hemicellulose hydrolysis.

Pre-hydrolysis system: the process is based on the

use of solvents, acid or alkali to catalyze the reaction

of delignication and pre-hydrolysis of biomass.

After separation, the lignocellulosic material

(solid fraction) goes to PPDP 4 and pretreatmentliquor goes to PPDP 5.

Main Equipments

Stainless steel steam explosion reactor

Alloy pre-hydrolysis reactor

Stainless steel solid-liquid mixer

Alloy pressure lter Nutsche

Alloy basket centrifuge

PPDP 1: Unit for Physical Treatment ofSugarcane Bagasse and Straw

PPDP 2: Unit for Physical Chemical

Pretreatment of Lignocellulosic Material


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Objective: The purpose is to develop

microorganisms and enzymes production processes

that will be used in other stages of the process.

Raw Materials: sugar cane syrup, pretreatment

liquor, hydrolysis liquor, cellulosic material, other

carbon and nitrogen sources, mineral salts and other

micronutrients used in culture medium.

Products: microorganisms used in alcoholic

fermentation and biomolecules, especially enzymes.

Main Process

Yeast production for the alcoholic fermentation

step (PPDP 6).

Enzymes production, mainly cellulases. These

Objective: Development of the enzymatic

hydrolysis process of pretreated sugarcane bagasse

using hydrolases, achieving high yields and best

conditions of operation.

Raw material: preatreated sugarcane bagasse,

enzymes complex and yeast.Products: hydrolysis liquor rich in hexoses and

ethanol, in the case of hydrolysis and fermentation

simultaneously.

Main Process

Hydrolysis of sugarcane bagasse and other

lignocellulosic materials using complex or enzymatic

preparations obtained from fungal or enzymatic

enzymes can be produced using lamentous fungi

or bacteria in batch processes or fed batch process.

According to the type of microorganism, enzyme

can be extracellular or intracellular.

Production of different kind of substances, such

as proteins, amino acids, vitamins.

Main Equipments

Stainless steel 125L fermentor

Stainless steel 300L fermentor

Stainless steel 150L/h continuous sterilizer

Fermentor (Semisolid Fermentation)

preparations which obtained from more than one

organism, e.g. recombinant bacteria, recombinant

yeast or co-cultivation of lamentous fungi.

Hydrolysis of sugarcane bagasse and other

lignocellulosic materials with consecutive or

simultaneous fermentation. This process is catalyzedby complexes or enzymatic preparations and

monosaccharides produced is converted to ethanol

by yeasts that are also in the bioreactor.

Main Equipments

Stainless steel saccharier bioreactor

PPDP 3: Unit for Fungi, Yeast andBacteria Production

PPDP 4: Unit for Enzymatic

Hydrolysis of Biomass


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Facilities

Objective: Supply high pressure and

low pressure steam, thermal uid, compressed

air, hot water, cooling water and cold water to

CTBEs laboratories and PPDP (Pilot Plant).

Main Equipments

3 LPG boilers

Thermal uid heater

Air compressors

Water heater

2 Cooling towers

ChillerIntern view of PPDPs fermentor used to produce enzymes

for the hydrolysis of lignocellulosic material


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Objective: The purpose is to develop

processes used for separation, detoxication and

concentration of pretreatment and hydrolysis

liquors, and for separation and purication of

hydrolases produced from different kinds of

fermentative processes.

Raw Material: pretreatment liquor, hydrolysis

liquor and fermentation broth.

Products: detoxied pretreatment and hydrolysis

liquors and puried proteins.

Main Process

Liquors treatment: pretreatment liquor and

hydrolysis liquor produced in PPDP 2 and PPDP

4, respectively, contain solid materials not reacted,

mineral salts, lignin and secondary products such as

alcoholic fermentation inhibitors. Filter press andmicroltration are used to remove solid materials.

After this, inhibitors are removed using precipitation,

solvent extraction, activated carbon adsorption, ion

exchange resins or distillation. The detoxied liquor

is concentrated using an evaporator and goes to the

alcoholic fermentation step (PPDP 6).

Enzymatic complex recuperation: during

this step, the proteins (enzymes) produced by

fermentation in PPDP 3 are recovered. In the case

of intracellular enzymes, the fermentation broth is

sent to the cellular rupture homogenizer to liberate

the produced enzymes. Then, the liquid portion,

rich in enzymes, is separated by centrifugation or

microltration. In the case of extracellular enzyme,

the fermentation broth is centrifuged or ltered

to remove the solid part (cells) to obtain the

supernatant rich in enzymes. This liquid fraction

is sent to the protein precipitation tank, further,

proteins are separated by microltration. In this case,

ultraltration can be used to improve the purication

and to increase the enzyme concentration. In the last

case, semisolid fermentation, the product (mixture

of microorganisms, solid substrate and enzymes)

goes to a milling process to reduce the particles

size. The intention is to facilitate the enzyme

extraction before going to the centrifugation. After

cellular separation, protein precipitation is made

and nally the product goes to microltration and

ultraltration processes. This process line (semisolid

fermentation) will be developed in the future. The

product obtained (concentrated enzyme) is used

during the enzymatic hydrolysis in PPDP 4.

Main Equipments56 L lter press 4,36 m2 ltration area

Stainless steel microltration system,

250 L precipitation tank

250 L liquid-liquid extractor

100 L/h adsorption columns

100 L/h distillation column

100 L/h scraped surface evaporator

120 L/h cells homogenizer

Disc centrifuge

In the future, other systems will be provided

for: deegmation, rectication, reactive distillation,

dehydration using azeotropic distillation, pre-evaporation,

absorption, liolization, and milling.

PPDP 5: Unit for Separationand Purifcation


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PPDP Processes Workows

PPDP 1 PPDP 2

PPDP 3 PPDP 4

PPDP 5a PPDP 5b

PPDP 6 Biosafety L2 Lab


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CTBEs main business goal isto provide its partners freedom

to operate, crucial factor to

technology transfer success.

UK Government Chief Scientic Adviser, Sir John Beddington, visits the CTBEs facilities in order toestablish partnerships with Brazil in bioenergy area


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One of CTBEs challenges is making partnerships that

impact meaningfully on sugarcanes business. This sector

involves ethanol and other co-products, applicable to several

industry segments, such as: pharmaceutical, food, chemical,

petrochemical and others. The Laboratorys Business

Management aims to ensure the quality of its scientic and

technological cooperation, providing the partners trust,

security and achievement of their interests.Among CTBEs business goals is also to provide its

partners freedom to operate, that includes: legal security,

intellectual property, condentiality, exclusivity, development

of policies, practices, procedures and trainings, in addition

to win-win negotiations that lead to long term relationships.

These are crucial factors to technology transfers and

industry innovations success.

There several possibilities of cooperation with CTBE:

joint research and development, infrastructure provisioning

(Pilot Plant, laboratories and ofces), technologys and

materials transfer, commercial and non-commercial

licenses, human resources exchange, co-investments in high-

risk projects and creation of new companies (start-ups).

Access www.bioetanol.org.br for details and to meet

our current R&D partners.

Setor

de Inovao

Relationship with

the Industry


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The Brazilian Center for Research in Energy andMaterials (CNPEM), located in Campinas, SP, Brazil,

gathers four National Laboratories: Synchrotron

(LNLS), Biosciences (LNBio), Bioethanol (CTBE) and

Nanotechnology (LNNano) managed by Brazilian

Association for Synchrotron Light Technology (ABTLuS)

for the Ministry of Science and Technology.

Since 1997 LNLS operates the only Synchrotron

Light Source in Latin America and a set of scientic

instrumentation for the application of UV and X-ray on

studies of Advanced Materials, Nanosciences, Biological

Materials, Oil Industries, Metallurgy and others.

The Brazilian Bioscience National Laboratory

CNPEM: Science, Technology and

Innovation in the Frontier of Knowledge

(LNBio) is a multiuser opened laboratory, focused onresearch, development and innovation in biotechnology.

Its facilities are dedicated to Structural Biology, Molecular

and Cellular Proteomics, Genomics, Metabolomics and

Chemical Synthesis.

The challenge of the Brazilian Bioethanol Science

and Technology Laboratory (CTBE) is to work on

solutions for technological bottlenecks in the production

chain of ethanol from sugarcane.

The Brazilian Nanotechnology National Laboratory

(LNNano) holds a complex set of microscopes and

microfabrication equipments. The Laboratory has a team of

qualified scientists that conducts research in a variety of fields.

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CTBE: R&D Programs and Facilities

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