February 2012
CURRICULUM VITAE
Dale Hattis, Ph.D. Research Professor
George Perkins Marsh Institute
Clark University, 950 Main Street, Worcester, Mass. 01610
(508) 751-4603; (781)-641-0305; FAX (508) 751-4600
Email: [email protected]; [email protected];
Education
1974 Ph.D. -- Genetics
Stanford University
Stanford, California
1967 B.A. -- Biochemistry
University of California
Berkeley, California
Professional Experience
9/98-Present Research Professor
George Perkins Marsh Institute, Clark University
Worcester, Massachusetts
1/90-5/98 Research Associate Professor
Center for Technology, Environment, and Development
George Perkins Marsh Institute, Clark University
Worcester, Massachusetts
7/81-9/93 Principal Research Associate
Center for Technology, Policy and Industrial Development*
Massachusetts Institute of Technology
Cambridge, Massachusetts
9/86-12/86 Visiting Senior Lecturer
Program in Social Ecology
University of California at Irvine
Irvine, California
4/75-7/81 Research Associate
Center for Policy Alternatives
Massachusetts Institute of Technology
Cambridge, Massachusetts
1/75-4/75 Consultant
Center for Policy Alternatives
Massachusetts Institute of Technology
Cambridge, Massachusetts
12/73-11/74 Senior Research Associate
Complex Systems Institute
Case Western Reserve University
Cleveland, Ohio
6/70-9/70 Summer Intern, Food and Drug Administration Project
Center for Study of Responsive Law
Washington, D.C.
Summary of Experience and Training
Research: Methodology for quantitative health risk assessment for cancer and non-
cancer health effects; Human interindividual variability in susceptibility to
toxic effects; Pharmacokinetic and Monte Carlo simulation modeling;
Implications of interindividual variability for population risk for both
carcinogens and other toxic substances; Environmental/health, economic, and
legal implications of alternative regulatory actions to control occupational
exposure to noise, perchloroethylene, ethylene oxide, butadiene, glycol ethers,
acrylamide, formaldehyde; setting priorities for control of toxic substances.
Consulting: (Pending) Member, National Toxicology Program Board of Scientific
Counselors; Past member, Clean Air Scientific Advisory Committee
(CASAC) Review Panel on Primary Standards for NOx and SOx, Member,
Food Quality Protection Act Science Review Board. Past member,
Environmental Health Committee, EPA Science Advisory Board (Ethylene
Oxide Health Risk Assessment Review Panel). Review of proposed IRIS
analysis for trichloropropane. Review of the benefits analysis for the EPA
standard for arsenic in drinking water. Review of the EPA RfD for boron.
Past memberships: Trichloroethylene Health Risk Assessment Synthesis and
Characterization Review Panel, EPA peer review committee for PCB’s, EPA
peer review committee for Hazardous Air Pollutant emissions for electric
generating plants; National Academy of Sciences/Institute of Medicine
Committee on Evaluation of the Safety of Fishery Products; National
Research Council Committee on Neurotoxicology and Models for Assessing
Risk; U. S. Food and Drug Administration (Office of Device Evaluation)--
mercury dental amalgams and polyurethane breast implants. OSHA—cancer
risk assessment policy and risks from occupational noise exposures in the
construction industry; Natural Resources Defense Council and Occupational
Safety and Health Administration, carcinogenesis by diesel exhaust; State of
California (use of PBPK modeling and uncertainty analysis in risk
assessment); International Life Sciences Institute--quantitative risk assessment
for non-cancer effects; Risks of municipal water supply and wastewater
treatment; Use of biomarkers in assessing causation of radiation-induced
cancers; Monte Carlo simulation analysis of uncertainties in carcinogenic
risks from diesel particulates in air and from different substances in drinking
water; Risks of occupational noise exposures, Dose response relationships for
acute toxicity from chlorine or ammonia.
Other: Distinguished Educator Award, Society for Risk Analysis; Lifetime
Achievement Award, American Environmental Health and Science
Foundation; Past Chair, Society for Risk Analysis Dose Response Specialty
Group; Member, Past member, National Research Council Committee on
Estimating the Health-Risk-Reduction Benefits of Proposed Air Pollution
Regulations; Fellow, Society for Risk Analysis (awarded 12/00); Councilor,
Society for Risk Analysis 12/97-12/00; Past member, Expert Panel on
Acrylamide for the National Toxicology Program’s Center for the Evaluation
of Risks to Human Reproduction, Member, Editorial Board for Risk Analysis;
Past member, National Research Council Subcommittee on Methyl Bromide,
Member, Massachusetts Department of Environmental Protection/Department
of Public Health Advisory Committee on Health Effects. Past President, New
England Chapter of the Society for Risk Analysis.
Teaching: Tools for Quantitative Policy Analysis (Clark University graduate course;
MIT Summer Session); Quantitative Risk Assessment for Ecological Risks for
Near-Shore Systems (in cooperation with the U.S. EPA’s Narragansett RI
Laboratory); Cancer, Science and Society (Clark University, undergraduate
course).
Grants and Contracts Through Clark University
U. S. Environmental Protection Agency— Use of Biomarkers and Physiologically Based Pharmacokinetic (PBPK)
Modeling in Risk Analysis for Developmental Effects of Chlorpyrifos--$677.5K—9/07-9/11
U. S. Environmental Protection Agency—Interspecies Differences and Human Inter-Individual Variability in
Tissue-Level Pharmacokinetic Parameters—68K—9/05-10/06.
U. S. Environmental Protection Agency—Age-Related Differences in Susceptibility to Carcinogenesis by Non-
Mutagenic Mechanisms—98K 6/1/05-5/31/07.
U.S. Environmental Protection Agency— PBPK Model Development and Use in Support of the IRIS Assessment
for Acrylamide—20k, 2/1/05-7/31/05.
U. S. Department of Energy—Low Dose Modeling of the Risks of Ionizing Radiation (Rob Goble, PI)—200K/year
9/1/03-8/31/05.
U.S. Environmental Protection Agency, Role of Dosimetric Scaling and Species Extrapolation in Evaluating risks
Across Life Stages—90K 11/25/02-3/31/04.
U.S. Environmental Protection Agency, Age-Related Differences in Susceptibility to Carcinogenesis—100K 6/1/02-
10/30/03.
Connecticut Department of Public Health (subcontract from an original contract from EPA), Pharmacokinetic
Parameters—Adult Child Comparisons and Interindividual Variability—15 months, 70K, beginning 4/99; extended
11/00-8/1/02 for an additional 175K; new 2 year project—case studies in adult/child pharmacokinetic differences
and implications of genetic differences in metabolism begun 8/1/02--154K.
U.S. Environmental Protection Agency, Interindividual Variability in Response to Particulates--3 year 190K project
initiated by EPA personnel started 10/98 (Principal Investigator, with Rob Goble).
U.S. Environmental Protection Agency grant, “Human Variability in Parameters Potentially Related to
Susceptibility for Noncancer Risks” 332K over 3 years, beginning 12/96.
State of California, Project on Electromagnetic Fields (Rob Goble, PI) 1 year effort beginning 12/97, 1.25 months of
support.
State of Connecticut subcontract on work for the U.S. Environmental Protection Agency “Pharmacokinetic
Modeling for Site-Acting Carcinogens” $52K, 11/15/96 - 11/14/97.
U.S. Environmental Protection Agency, via subcontract to Research Triangle Institute, “Considerations for
Hazardous Waste Identification Rules--Development of Toxicity Values for Chemicals that Do Not Have Official
RfD’s ” $10.8K, 12/96-9/97.
State of Connecticut subcontract on work for the U.S. Environmental Protection Agency “Pharmacokinetic
Modeling for Site-Acting Carcinogens” $30K, 11/15/95 - 11/14/96
Ministry of Health, Canada, (Dale Hattis, Principal Investigator) “New Estimates Of Variability In Parameters
Putatively Related To Individual Cancer Risk” $14K, 1/31 - 3/31/95
U.S. Environmental Protection Agency, Measures of Pollution Prevention (Sam Ratick, PI) 1994-95, 3 months of
support.
Office of Technology Assessment (Rob Goble, PI) “Implementation of the Occupational Lead Standard the
Secondary Lead Smelting Industry“ 20K 7/1/94 - 9/30/94.
U. S. Environmental Protection Agency, “Principles of Ecological Risk Analysis and Management as Applied to
Near-Coastal Waters” (two year project, with involvement by Halina Brown, Sam Ratick, Rob Goble, Andrea
Lemerise, and Arshad Bahl) 2nd Year FY 1992 and 1993--$230K.
U. S. Environmental Protection Agency, "Interspecies Projection of Carcinogenic Risks per Unit of Active Dose
Delivered to Target Sites" (with involvement by Rob Goble, Halina Brown, and Joanne Shatkin) 3 Years in FY
1991, 1992, 1993--$200K.
Health and Welfare Ministry, Government of Canada, "Pharmacokinetic Modeling of Lead in Primates--Parameters
of Interest for Adapting Human Models and Representing the Effects of Pregnancy," (7 Month effort with
involvement by Mary Ballew) $25K, FY 1991.
Hattis D. 2010 Intermediate effect biomarkers--alternatives to direct concentration-response data for regulatory
benefits analyses. The Open Epidemiology Journal 2011 4:70-77. Available at
http://benthamscience.com/open/toepij/openaccess2.htm [DOI: 10.2174/1874297101104011070]
5.
7.
8. Thompson CM, Johns DO, Sonawane B, Barton HA, Hattis D, Tardif R, Krishnan K. Database for
physiologically based pharmacokinetic (PBPK) modeling: physiological data for healthy and health-
impaired elderly. J Toxicol Environ Health B Crit Rev. 12(1):1-24, 2009.
9. Hattis D. “The Role of Uncertainty and Susceptible Populations in Environmental Health Decision-Making.” In
Cable Y, Coussens C, and Quinn K, Rapporteurs, Environmental Health Sciences Decision Making—Risk
Management, Evidence, and Ethics, Institute of Medicine, National Academy Press, Washington, D.C. pp.
24-27, 2009.
10. Hattis D. “High Throughput Testing—the NRC Vision, The Challenge of Modeling Dynamic Changes in
Biological Systems, and the Reality of Low Throughput Environmental Health Decision-Making.” Risk
Analysis, 29:483-484, 2009.
11. Ginsberg G, Smolenski S, Neafsey P, Hattis D, Walker K Guyton KZ, Johns DO, Sonawane B. Analysis of the
influence of genetic polymorphisms on inter-individual variability in xenobiotic metabolism for six enzyme
systems. J Toxicol Environ Health, Part B, 12(5-6): 307-333, 2009.
. J Toxicol Environ Health, Part B, 12(5-6): 334-361, 2009.
J Toxicol Environ Health, Part B, 12(5-6): 362-388, 2009.
J Toxicol
Environ Health, Part B, 12(5-6): 389-439, 2009.
J Toxicol Environ Health,
Part B, 12(5-6): 440-472, 2009.
J Toxicol Environ Health, Part B, 12(5-6): 473-507,
2009.
17. Hattis D, Chu M., Rahmioglu N., Goble R., Verma P, Hartman K, and Kozlak, M, A Preliminary Operational
Classification System for Non-Mutagenic Modes of Action for Carcinogenesis. Critical Reviews in
Toxicology, 13:1-42, 2008.
18.
19. White RH, Cote I, Zeise L, Fox M, Dominici F, Burke TA, White PD, Hattis DB, Samet JM. State-of-the-
science workshop report: Issues and approaches in low dose dose-response extrapolation for environmental
health risk assessment. Environmental Health Perspectives 117:283-287, 2009.
20. Woodruff TJ, Zeise L, Axelrad DA, Guyton KZ, Janssen S, Miller GG, Schwartz JM, Alexeef G, Anderson H,
Birnbaum L, Bois F, Cogliano VJ, Crofton K, Euling SY, Foster PMD, Germolec DR, Gray E, Hattis DB,
Kyle AD, Luebke RW, Luster MI, Portier C, Rice DC, Solomon G, Vandenberg J, Zoeller RT. Moving
upstream: Evaluating adverse upstream endpoints for improved risk assessment and decision-making.
Environmental Health Perspectives 116:1657-1675 2008.
21. Hattis, D. “Distributional Analyses for Children’s Inhalation Risk Assessments.” Journal of Toxicology and
Environmental Health, 71(3):218-226, 2008.
www.cityofinglewood.org
Distributions of Individual Susceptibility Among Humans for Toxic
Effects--For What Fraction of Which Kinds of Chemicals and Effects Does the Traditional 10-Fold Factor
Provide How Much Protection?”