1 Curriculum Vitae Notarization: I have prepared and read the following and certify that this is a current and accurate statement of my professional record. Signature___ ___ Date______07/26/2014____________________ Personal Information: Office: Home: University of Maryland 9429 Penfield Rd N School of Public Health Columbia, MD 21045 Department of Kinesiology 4107720040 (home) College Park, MD 20742 5305744825 (cell) [email protected]3014052483 (office) 3014055578 (fax) Education: 2003 Postdoctoral Fellow (NIH FellowMuscle Biology) University of MissouriColumbia Department of Biomedical Sciences Columbia, MO Advisor: Frank W. Booth, Ph. D. 2000 Doctorate of Philosophy in Exercise Physiology Concentration: Muscle Physiology and Biochemistry Virginia Tech, Blacksburg, VA Advisor: Jay H. Williams, Ph. D. 1997 Master of Science in Exercise Physiology Concentration: Muscle Physiology and Biochemistry Virginia Tech, Blacksburg, VA 1995 Bachelor of Science in Exercise Physiology Double Major: Community Health Virginia Tech, Blacksburg, VA
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Curriculum Vitae Notarization: I have prepared and read the following and certify that this is a current and accurate statement of my professional record.
Signature___ ___ Date______07/26/2014____________________ Personal Information: Office: Home: University of Maryland 9429 Penfield Rd N School of Public Health Columbia, MD 21045 Department of Kinesiology 410-‐772-‐0040 (home) College Park, MD 20742 530-‐574-‐4825 (cell) [email protected] 301-‐405-‐2483 (office) 301-‐405-‐5578 (fax) Education:
2003 Post-‐doctoral Fellow (NIH Fellow-‐Muscle Biology) University of Missouri-‐Columbia Department of Biomedical Sciences Columbia, MO Advisor: Frank W. Booth, Ph. D.
2000 Doctorate of Philosophy in Exercise Physiology Concentration: Muscle Physiology and Biochemistry
Virginia Tech, Blacksburg, VA Advisor: Jay H. Williams, Ph. D.
1997 Master of Science in Exercise Physiology Concentration: Muscle Physiology and Biochemistry
Virginia Tech, Blacksburg, VA
1995 Bachelor of Science in Exercise Physiology Double Major: Community Health
Virginia Tech, Blacksburg, VA
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Work Experience: 2012 Associate Professor (with tenure)
University of Maryland School of Public Health
Department of Kinesiology College Park, MD
2010 Affiliate Faculty Baltimore Diabetes Research Training Center Johns Hopkins University and University of Maryland Baltimore, MD 2010 Affiliate Faculty Mid-‐Atlantic Nutrition Obesity Research Center University of Maryland Baltimore, MD
2008 Affiliate Faculty
University of Maryland Graduate Program in Molecular and Cell Biology College Park, MD
2007 Affiliate Faculty
University of Maryland-‐School of Medicine Interdisciplinary Training Program in Muscle Biology Baltimore, MD Previous Work Experience:
2006 Assistant Professor University of Maryland
School of Public Health Department of Kinesiology College Park, MD
2003 Assistant Professor University of California-‐Davis Dual Appointments:
• Section of Neurobiology, Physiology, and Behavior (Division of Biological Science)
• Department of Physiology and Membrane Biology (School of Medicine) 2003 NIH Post-‐doctoral Fellow (7/00-‐6/03)
University of Missouri-‐Columbia Department of Biomedical Sciences Columbia, MO
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Advisor: Frank Booth, Ph. D 2000 Research Assistant (6/99-‐6/00)
Muscle Function Laboratory Virginia Tech, Blacksburg, VA 1999 Teaching Assistant (8/98 -‐ 6/99) Neuromuscular Function during Exercise; Kinesiology; and Exercise Physiology Department of Human Nutrition, Foods, and Exercise Virginia Tech, Blacksburg, VA
1998 Research Assistant (8/96 – 10/98) Muscle Function Laboratory Virginia Tech, Blacksburg, VA
PUBLICATIONS (*denotes advisee/trainee of Dr. Spangenburg; †denotes senior or lead author) Publication Statistics: From ISI Web of Knowledge as of August 2, 2011. Authorship “h-‐index”: 24 (i.e., 24 papers cited 24 or more times; see Nature 436: 900, 2005). Total citations: 1,387. Average citations per item: 19.82. Average citations per year (over last ten years): 97. Currently, three different publications have been cited over 100 times and four more cited over 70 times. Refereed Research Articles (in chronological order):
1. Spangenburg, E. E. †, H. Metz, and J.H. Williams. Effects of membrane-‐permeant Ca2+-‐chelators on skeletal muscle force and fatigue. Res. Comm. Pharm. And Toxicology. (1998), 3(3-‐4): 123-‐129.
2. Williams, J. H., C. W. Ward, E. E. Spangenburg, and R. Nelson. Functional aspects of skeletal muscle contractile apparatus and sarcoplasmic reticulum following fatiguing activity. J. Appl. Physiol. (1998), 85(2): 619-‐626.
3. Williams, J. H., C. W. Ward, E. E. Spangenburg, R. Nelson, S. Stavrianeas, and G. A. Klug. Glucose 6-‐phosphate alters skeletal muscle contractile apparatus and sarcoplasmic reticulum function. Exp. Physiol. (1998), 83: 98-‐109.
4. Ward, C. W., E. E. Spangenburg, L. M. Diss and J. H. Williams. Effects of varied fatigue protocols on sarcoplasmic reticulum calcium uptake and release. Am. J. Physiol. (1998), 275(44): R99-‐R104.
5. Spangenburg, E. E. †, C.W. Ward, and J.H. Williams. Effects of lactate on force production by mouse EDL muscle: implications for the development of fatigue. Can. J. Physiol. Pharmacol. (1998), 76(6): 642-‐648.
6. Aschenbach, W. G., J. H. Williams, J. Ocel, L. Craft, C. W. Ward, and E. Spangenburg. Effects of oral sodium loading on high intensity arm ergometry in college wrestlers. Med. Sci. Sports. Exer. (2000), 32(3): 669-‐675.
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7. Spangenburg, E. E. †, J. H. Williams, R. R. Roy and R. J. Talmadge. Skeletal muscle calcineurin: Influence of atrophy and phenotype adaptation. Am J Physiol (Reg. Comp. Physiol) (2001), 280: R1256-‐R1260.
8. Chakravarthy, M. C., E. E. Spangenburg, and F. W. Booth. Culture in low levels of oxygen enhances in vitro proliferation potential of satellite cells from old skeletal muscle. Cell Mol Life Sciences. (2001), 58: 1150-‐1158.
9. S. J. Lees, P. D. Franks, E. E. Spangenburg, and J. H. Williams. Glycogen and glycogen phosphorylase associated with skeletal muscle sarcoplasmic reticulum: effects of fatiguing activity. J. Appl. Physiol. (2001), 91: 1638-‐1644.
10. Spangenburg, E. E. †, S. Lees, J. Otis, R. J. Talmadge, T. I. Musch, and J. H. Williams. Effects of moderate congestive heart failure and skeletal muscle functional overload on the rat plantaris. J. Appl. Physiol. (2002) 92: 18-‐24.
11. Spangenburg, E. E. †, J. H. Williams, R. J. Talmadge, T. I. Musch, P. C. Pfeifer and R. M. McAllister. Changes in skeletal muscle MHC expression from rats with varying degrees of heart failure. Eur. J. Appl. Physiol. (2002) 87: 182-‐186.
12. Spangenburg, E. E. † and F. W. Booth. Multiple signaling pathways regulate Leukemia Inhibitory Factor induced skeletal muscle satellite cell proliferation. Am J Physiol. (Cell Physiol) (2002) 283: C204-‐C211.
13. Vyas, D., E. E. Spangenburg, T. W. Abraha, T. E. Childs, and F. W. Booth. Active GSK-‐3β attenuates skeletal muscle myotube hypertrophy. Am. J. Physiol. (Cell Physiol) (2002) 283(2): C545-‐C551.
14. Spangenburg, E. E. †, T. Abraha, T. E. Childs, J. Pattison, and F. W. Booth. Skeletal muscle IGF-‐binding mRNA and protein 3, 4 and 5 expression are age, muscle, and load dependent. Am. J. Physiol (Endocrinology and Metabolism) (2003) 284: E340-‐E350.
15. Stavrianeas, S., E. Spangenburg, T. W. Batts, J. H. Williams, and G. A. Klug. Prolonged exercise potentates sarcoplasmic reticulum Ca2+ uptake in rat diaphragm. Eur. J. Appl. Physiol. (2003) 89: 63-‐68.
16. Machida, S., E. E. Spangenburg, F.W. Booth. Forkhead transcription factor FoxO1 transduces insulin-‐like growth factor’s signal to p27Kip1 in primary skeletal satellite cells. J Cell Physiol. (2003) 196: 532-‐531.
17. Childs, T. E., E. E. Spangenburg, D. Vyas, and F. W. Booth. Temporal alterations in protein signaling cascades during recovery from muscle atrophy. Am. J. Physiol. (Cell Physiol) (2003) 285: C391-‐C398.
18. Pattison, J. S., L. C. Folk, R. W. Madsen, T. E. Childs, E. E. Spangenburg, and F. W. Booth. Expression profiling identifies dysregulation of myosin heavy chains IIb & IIx during mechanical unloading in soleus muscles of old rats. Journal of Physiology. (2003) 553 (2): 357-‐369.
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19. Morris, T. R., E. E. Spangenburg, and F. W. Booth. Activation of multiple intracellular signaling pathways during muscle atrophy and muscle re-‐growth in aged animals. J Appl Physiol. (2004) 96(1): 398-‐404.
20. Spangenburg, E. E. †, D. K. Bowles, and F. W. Booth. IGF-‐I-‐induced transcriptional activity of the skeletal α-‐actin gene is regulated by signaling mechanisms linked to voltage-‐gated calcium channels during myoblast differentiation. Endocrinology. (2004) 145(4): 2054-‐2063.
21. Machida, S., E. E. Spangenburg, and F.W. Booth. Passaging of primary rat muscle progenitor cells in culture alters their cellular phenotype and differentiation potential. Cell Proliferation. (2004) 37(4): 267-‐77.
22. Spangenburg, E. E†. Suppressor of cytokine signaling-‐3 induces myoblast differentiation. J Biol Chem. (2005) 280 (11): 10749–10758.
23. Spangenburg, E. E. † and T. A. McBride. Inhibition of stretch-‐activated channels during eccentric muscle contraction attenuates p70s6k activation. J Appl Physiol. (2006) 100(1):129-‐35.
24. Sitnick, M.*, A. Foley, M. B. Brown, and E. E. Spangenburg†. Ovariectomy prevents the recovery of atrophied gastrocnemius skeletal muscle mass. J Appl Physiol. (2006) 100(1):286-‐93._received editorial commentary
25. Spangenburg, E. E. †, D. A. Brown, M. S. Johnson, and R. L. Moore. Exercise-‐induced increases in SOCS-‐3 expression is associated with increases in IL-‐6 expression in muscle. J Physiol. (2006) 572: 839-‐848.
26. Spangenburg, E. E. † and F. W. Booth. Leukemia inhibitory factor restores the hypertrophic response to increased loading in the LIF(-‐/-‐) mouse. Cytokine (2006) 34(3-‐4): 125-‐130.
27. Batts, T. W., E. E. Spangenburg, C. W. Ward, S. J. Lees, and J. W. Williams. Effects of acute epinephrine treatment on skeletal muscle sarcoplasmic reticulum Ca2+ ATPase. Basic Applied Myology. (2007) 17 (6): 229-‐235.
28. Burry, M., D. A. Hawkins, E. E. Spangenburg. Lengthening Contractions Differentially Affect p70s6k Phosphorylation Compared to Isometric Contractions in Rat Skeletal Muscle. Eur. J. Appl. Physiol. (2007) 100(4):409-‐15.
29. Spangenburg, E. E. †, D. LeRoith, C. W. Ward, S. C. Bodine. A functional IGF-‐I receptor is not necessary for skeletal muscle hypertrophy. J. Physiol. (2008) 586(1): 283-‐291._received editorial commentary.
30. Wohlers, L. M*., S. M. Sweeney*, C. W. Ward, R. M. Lovering, E. E. Spangenburg†. Changes in contraction-‐induced phosphorylation of AMP-‐activated protein kinase and mitogen activated protein kinases in skeletal muscle after ovariectomy. Journal of Cell Biochem. (2009) 107: 171-‐178.
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31. Spangenburg, E. E. †, D. A. Brown, M. S. Johnson, and R. L. Moore. Alterations in peroxisome proliferator-‐activated receptor mRNA expression in skeletal muscle after acute and repeated bouts of exercise. Mol Cell Biochem. (2009) 332 (1-‐2): 225-‐231.
32. Jenkins, N. T., S. Witkowski, E. E. Spangenburg, J. M. Hagberg. Effects of acute and chronic exercise on intracellular nitric oxide in putative endothelial progenitor cells: role of NADPH oxidase. Am. J. Physiol. (2009) 297: H1798-‐H1805.
33. Witkowski, S., M. M. Lockard, N.T. Jenkins, T. O. Obisesan, E. E. Spangenburg, J. M. Hagberg. CD34+/KDR+. Endothelial Progenitor Cells and Vascular Health: Exercise and Detraining. Clin Sciences. (2010) 118 (4): 303-‐311.
34. Wohlers, L. M.* and E. E. Spangenburg†. 17β-‐estradiol supplementation attenuates ovariectomy-‐induced increases in ATGL signaling and reduced perilipin expression in visceral adipose tissue. J Cell Biochem. (2010) 110 (2): 420-‐427.
35. Lockard, M. M., S. Witkowski, N. T. Jenkins, E. E. Spangenburg, J. M. Hagberg. The effects of thrombin on putative endothelial progenitor cells with exercise and exercise training. J. Appl. Physiol. (2010) 108 (6): 1682-‐1690.
36. Witkowski, S.*, R. M. Lovering, E. E. Spangenburg†. Incomplete Activation of the IGF-‐1 Signaling Pathway after High-‐frequency Electrically Stimulated Skeletal Muscle Contractions. FEBS Letters. (2010) 584 (13) 2891-‐2895.
37. Stebbins, C. L., L. E. Hammel, B. J. Marshal, E. Spangenberg, T. I Musch. Effects of Dietary Omega-‐3 Polyunsaturated Fatty Acids (PUFA) on the skeletal muscle blood flow response to exercise in rats. Int J Sports Nutr and Exer. Met. (2010) 20: 475-‐486.
38. N. T. Jenkins, R. Q. Landers, S. J. Prior, N. Soni, E. E. Spangenburg, J. M. Hagberg. Intracellular nitric oxide and superoxide in circulating CD34+ and CD34-‐ cells of endurance-‐trained and sedentary men. J Appl Physiol. (2011) 111(3)-‐929-‐937.
39. Wohlers, L. M. *, K. M. Jackson*, E. E. Spangenburg. Lipolytic signaling in response to acute exercise is altered in female mice following ovariectomy. J Cell Biochem. (2011). 112(12) 3675-‐3684.
40. K. C. Jackson*, L. M. Wohlers*, A. Valencia*, M. Cilenti*, S. J. Borengasser, J. Thyfault, E. E. Spangenburg†. Exercise prevents alterations in fatty acid composition of triacylgycerol in the liver of ovariectomized mice. Applied Physiology, Nutrition, and Metabolism. (2011) 36(6): 798-‐810.
41. Sheppard, R. L., E. E. Spangenburg, E. R. Chin, S. M. Roth. Androgen receptor polyglutamine repeat length affects receptor activity and C2C12 cell myogenic potential. Physiol Genomics. (2011) 43(20) 1135-‐1143.
42. N. T. Jenkins, R. Q. Landers, S. J. Prior, E. E. Spangenburg, J. M. Hagberg. Endurance exercise prevents postprandial lipemia-‐induced increases in reactive oxygen species in circulating CD31+ cells. (2011) J Physiology. 589: 5539-‐5553. _received editorial commentary.
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43. E. E. Spangenburg, S. J. Pratt, L. M. Wohlers*, R. M. Lovering. Use of BODIPY (493/503) to visually localize intramuscular lipid droplets in skeletal muscle. Journal of Biomedicine and Biotechnology. (2011) 2011: 5983598.
44. R. A. Schuh, K. C. Jackson*, R. J. Khairallah, C. W. Ward, E. E. Spangenburg. Measuring mitochondrial respiration in intact single muscle fibers. Am J Physiol (Reg. Comp. Physiol) (2012) 302 (6): R712-‐R719.
45. A. T. Ludlow, S. Witkowski, M. R. Marshall, J. Wang, L. C. J. Lima, L. M. Guth, E. E. Spangenburg, Stephen M. Roth. Chronic exercise modifies age-‐related telomere dynamics in a tissue-‐specific fashion (2012). Journal of Gerontology: Biological Sciences. (2012) 67: 911-‐926.
46. S. Xu, J. P. Pratt, E. E. Spangenburg, R. M. Lovering. Early metabolic changes measured by 1H MRS in healthy and dystrophic muscle after injury. (2012). J Appl Physiol. 113: 808-‐816.
47. A. T. Ludlow, L. C. J. Lima, L. M. Guth, E. E. Spangenburg, Stephen M. Roth Exercise alters mRNA expression of telomere-‐repeat binding factor 1 in skeletal muscle via p38 MAPK. J Appl Physiol. (2012) 113: 1737-‐1746.
48. Jackson, K. C.*, L. M. Wohlers,* R. M. Lovering, R. A. Schuh, A. C. Maher, A. Bonen, T. R. Koves, O. Ilkayeva, D. M. Thomson, D. M. Muoio, E. E. Spangenburg. Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice. Am J Physiol (Reg. Comp. Physiol) (2013) 304: R206-‐R217.
49. Wohlers, L. M.*, B. Powell*, E.R. Chin, E. E. Spangenburg. Using a novel co-‐culture model to dissect the role of intramuscular lipid load on skeletal muscle insulin responsiveness under reduced estrogen conditions. Am J Physiol (Endo and Metabolism). (2013) 304: E1199-‐2212.
50. Guth, L. M., A. T. Ludlow, S. Witkowski, M. R. Marshall, L. C. Lima, A. C. Venezia, T. Xiao, M. L. Lee, E. E. Spangenburg, S. M. Roth. Sex-‐specific Effects of Exercise Ancestry on Metabolic, Morphological, and Gene Expression Phenotypes in Multiple Generations of Mouse Offspring. Exp Physiol. (2013) 98 (10): 1469-‐1484.
51. Spangenburg, E. E., K. C. Jackson*, R. A. Schuh. AICAR inhibits oxygen consumption of intact skeletal muscle cells in culture. J Physiol and Biochem. (2013). 69(4): 909-‐917.
52. Brandauer, J., R. Q. Landers-‐Ramos, N. T. Jenkins, E. E. Spangenburg, J. M. Hagberg, S. J. Prior. Effects of prior acute exercise on circulating cytokine concentrations in responses to a high fat meal. Physiol Rep. 2013 1: (3): eooo40
53. Ludlow, A. T., E. E. Spangenburg, E. R. Chin, W. H. Cheng, S. M. Roth. Telomeres shorten in response to oxidative stress in mouse skeletal muscle fibers. Journal of Gerontology: Biological Sciences. (2014) 69: 821-‐830.
54. Schuh, R. A., K. C. Jackson*, A. E. Schappal, E. E. Spangenburg, C. W. Ward, J. H. Park, N. Dugger, G. L. Shi, P. S. Fishman. Mitochondrial oxygen consumption deficits in skeletal
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muscle isolated from an Alzheimer’s disease relevant murine model. BMC Neuroscience. (2014) 15 (1): 24.
55. Jackson, K. C.*, E.K. Gidlund, J. Norrbom, A. P. Valencia*, D. M. Thomson, R. A. Schuh, D. P. Neufer, E. E. Spangenburg. BRCA1 is a Novel Regulator of Metabolic Function in Skeletal Muscle. Journal of Lipid Research. (2014) 55 (4) 668-‐680.
56. Landers-‐Ramos, R. Q., N. T. Jenkins, E. E. Spangenburg, J. M. Hagberg, S. J. Prior. Circulating angiogenic and inflammatory cytokine responses to acute exercise in trained and sedentary young men. Eur J Appl Physiol. (2014) 114: 1377-‐1384.
Invited Review Articles/Editorials/Commentary: (*denotes advisee/trainee of Dr. Spangenburg; †denotes senior or lead author)
1. Spangenburg, E. E. † and F. W. Booth. Invited Editorial. Myogenic satellite cells: physiology to molecular biology. J Appl Physiol. (2001), 91: 533.
2. Chakravarthy, M. V., F. W. Booth, and E. E. Spangenburg. The molecular responses of skeletal muscle satellite cells to continuous expression of IGF-‐I: implications for the rescue of induced muscular atrophy in aged rats. Int. J. Sports Nut. and Exer. Metab. (2001), 11: S42-‐S46.
3. Booth, F. W., M. V. Chakravarthy, S. E. Gordon, and E. E. Spangenburg. Waging war on physical inactivity: Using modern ammunition against an ancient enemy. Invited review. J Appl. Physiol. (2002) 93: 3-‐30.
4. Booth, F. W., M. V. Chakravarthy, and E. E. Spangenburg. Exercise and gene expression: Physiological regulation of the human genome through physical activity. Invited review. J Physiol.(London). (2002) 543(2): 399-‐411.
5. Spangenburg, E. E. †, M. V. Chakravarthy, and F. W. Booth. p27kip1-‐ a Potential Regulator of Skeletal Muscle Satellite Cell Proliferation. Clinical Orthopedics. (2002) 403S: S221-‐S227.
6. Spangenburg, E. E. † Perspective. IGF-‐I and aging skeletal muscle: a ‘missing’ hypertrophy agent. J Physiol. (2003) 547:2.
7. Spangenburg, E. E. † and F. W. Booth. Molecular regulation of skeletal muscle fiber type expression. Invited Review. Acta. Physiol. Scand. (2003) 178: 413-‐424.
8. Rennie, M. J., H. Wackerhage, E. E. Spangenburg, and F. W. Booth. Control of human skeletal muscle mass. Invited Review. Ann. Rev. Physiol. (2004) 66: 799-‐828.
9. Spangenburg, E. E. † (point/counterpoint_comment). Interleukin-‐6 does/does not have a beneficial role in insulin sensitivity and glucose homeostasis J Appl Physiol. (2007) 102(2): 820.
10. Spangenburg, E. E. † SOCS, skeletal muscle, and chronic health conditions: the potential interactions. Invited Review. Exer Sci Sport Rev. (2007) 35(3):156-‐62.
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11. Witkowski, S.* and E. E. Spangenburg. † Reduced Physical Activity and the Retired Athlete: a dangerous combination? British Journal of Sports Medicine. (2008) 42(12): 952-‐953.
12. Spangenburg, E. E. † Changes in muscle mass with mechanical load: possible cellular mechanisms. Invited Review. Applied Physiology Nutrition and Metabolism. (2009) 34(3): 328-‐335.
13. Booth, F. W., M. J. Laye, and E. E. Spangenburg. † Gold standards for scientists who are conducting animal-‐based exercise studies. Viewpoint. J. Appl Physiol. (2010) 108: 219-‐221.
14. Spangenburg, E. E. †IGF-‐I lucidity…the murky waters begin to clear? J. Appl Physiol. (2010) 108 (5) 1032-‐1033.
15. Spangenburg, E. E. † (point/counterpoint_comment). IGF is/is not the major physiological regulator of muscle mass. J Appl Physiol. (2010) 108(6): 1825.
16. Spangenburg, E. E. †, P. C. Geiger, L. A. Leinwand, D. A. Lowe. Regulation of Physiological and Metabolic Function of Muscle by Female Sex Steroids. Invited Review. Med Sci Sport Exercise. (2012). 44: 1653-‐1662.
17. Spangenburg, E. E. †, L. M. Wohlers*, A. P. Valencia*. Metabolic dysfunction under reduced estrogen levels: looking to exercise for prevention. Exer Sci Sport Rev (2012) 40: 195-‐203. (Appeared on Cover)
18. Hagberg, J. H., E. E. Spangenburg, N. T. Jenkins. Exercise Training, Genetics, and Type 2 Diabetes-‐related Phenotypes. Acta Physiol. (2012). 205: 456-‐471.
19. Valencia, A. P.* and E. E. Spangenburg. Remembering those “lazy” days-‐imprinting memory in our satellite cells. J Physiol. (2013). 15 (591): 4371.
Edited Books:
1. Spangenburg, E. E. (Ed.). Integrative Biology of Women’s Health. Springer Publishing. New York, NY. In press
Book Chapters:
1. Spangenburg, E. E. Suppressor of Cytokine Signaling. Encyclopedia of Exercise Medicine in Health and Disease. Frank Mooren and James Skinner (Eds). Springer Publishing. New York, NY. (2010).
2. Spangenburg, E. E. and K. C. Jackson. The contribution of ovarian hormones to the cellular regulation of lipid metabolism. Integrative Biology of Women’s Health. E. E. Spangenburg (Eds). Springer Publishing. New York, NY.
Invited National Presentations
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1. National Institute of Aging (NIA). May 2002. IGF-‐I and Aging Tissues Workshop. IGF-‐I improves aged skeletal muscle recovery from hindlimb immobilization: possible cellular mechanisms.
2. American College of Sports Medicine Meeting. San Francisco. June 2003. Symposium. The role of LIF in skeletal muscle hypertrophy.
3. Virginia Polytechnic Institute and State University. Department of Human Nutrition, Foods, and Exercise. November 2003. Leukemia Inhibitory Factor expression is necessary for mechanical load induced muscle hypertrophy.
4. Virginia Tech. Department of Human Nutrition, Foods, and Exercise. October 2006. The role of SOCS in skeletal muscle.
5. Penn State University. Noll Physiological Research Center. November 2006. The role of SOCS in skeletal muscle.
6. Texas A&M University. Department of Kinesiology. February 2008. The many faces of insulin-‐like growth factor-‐I in skeletal muscle.
7. American College of Sports Medicine Meeting. Seattle. May 2009. Symposium speaker. Exercise training or estradiol prevents menopause-‐induced activation of lipolysis in visceral fat.
8. 14th International Conference on the Biochemistry of Exercise. Guelph, Canada. Muscles as molecular and metabolic machines. June 2009. Invited Symposium participant. Mechanisms of loading-‐induced muscle hypertrophy.
9. Physiological Society. Main Meeting. Dublin, Ireland. July 2009. Invited symposium participant. Muscle plasticity and determinants of muscle performance. The role of IGF-‐I in skeletal muscle function.
10. University of South Carolina. Department of Exercise Science. Identifying cellular alterations in metabolic function during female sex steroid deficiency. October 2010.
11. Experimental Biology 2011. Washington, DC. Contribution of female sex hormones to the cellular regulation of muscle metabolic function.
12. American College of Sports Medicine Meeting. Denver. 2011. Reductions in circulating estrogens contribute to a unique metabolic profile in skeletal muscle.
13. University of Alabama-‐Birmingham. Dept of Physiology and Biophysics. 2012. Reductions in circulating estrogens contribute to metabolic disease in women.
14. Canadian Society of Exercise Physiology. Regina, Saskatchewan. 2012. The Impact of estrogen deficiency on metabolic function in muscle.
15. MONET-‐SOMET Research Day. IRCM, Montreal, Canada. 2013. Keynote Speaker. Reductions in circulating estrogens contribute to metabolic dysfunction: defining the cellular mechanisms.
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16. Advances in Skeletal Muscle Biology and Disease. Gainesville, FL. 2014. Invited Speaker. Breast Cancer 1, early onset (BRCA1) gene expression is critical for physiological and mitochondrial function of skeletal muscle.
17. East Carolina University. Obesity and Diabetes Center. 2014. Invited Speaker. Estrogens and BRCA1 in skeletal muscle: considering metabolic mechanisms in both sexes.
18. Physiological Society. Main Meeting. Cardiff, Wales. July 2015. Invited symposium participant. Novel regulators of mitochondrial biogenesis in skeletal muscle: Implications for health and disease. The role of BRCA1 in skeletal muscle function.
Invited Local Presentations
1. University of Missouri-‐Columbia-‐Department of Biomedical Science. March 2002. Do components of inflammation after increased loading contribute to skeletal muscle hypertrophy?
2. University of Missouri-‐Columbia-‐Department of Biomedical Science. March 2003. Leukemia Inhibitory Factor is necessary for skeletal muscle hypertrophy.
3. University of California-‐Davis. Dept of Physiology and Membrane Biology. School of Medicine. September 2004. Suppressor of cytokine signaling-‐3 induces myoblast differentiation.
4. University of California-‐Davis. Medical Center. Dietetic Internship Program. March 2005. Physical Inactivity: The battle we should be fighting.
5. University of California-‐Davis. Exercise Science Graduate Group. April 2005. Physical Inactivity: The battle we should be fighting.
6. University of California-‐Davis. Medical Center. Dietetic Internship Program. February 2006. Physical Inactivity: The battle we should be fighting.
7. University of Maryland. School of Medicine. Division of Gerontology. February 2007. The role of SOCS in skeletal muscle.
8. University of Maryland. UMBI: Center for Biosystems Research. December 2007. The many faces of insulin-‐like growth factor-‐I in skeletal muscle.
9. University of Maryland. School of Public Health Board of Visitors. February 2008. What is inactivity physiology?
10. University of Maryland. Molecular and Cell Biology Seminar Series. May 2008. The critical role of IGF-‐I signaling in myoblast function.
11. University of Maryland-‐Baltimore. Department of Endocrinology. Estrogens play a critical role in visceral adipose tissue function. July 2010.
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12. University of Maryland-‐Baltimore. School of Medicine. Division of Gerontology and Geriatric Medicine. August 2011. Chronic reductions in female sex steroids results in visceral adiposity and the development of metabolic dysfunction in muscle.
13. Johns Hopkins University. School of Medicine. Dept of Physiology. BRCA1 regulates skeletal muscle function: a role in non-‐proliferating cells. November 2013.
Scientific Meeting Abstracts/Poster Presentations (*denotes advisee/trainee of Dr. Spangenburg; †denotes senior or lead author)
1. Spangenburg, E. E. †, C.W. Ward, and J. H. Williams. Effects of lactate on skeletal muscle force production and sarcoplasmic reticulum function. (Experimental Biology ‘97, New Orleans, LA April 1997).
2. Williams, J. H., E. E. Spangenburg, C. W. Ward, and R. M. Nelson. Changes in skeletal muscle actomyosin and Ca2+ ATPase activities following fatiguing activity. (Experimental Biology ‘98, San Francisco, CA April 1998).
3. Spangenburg, E. E. †, H. Metz, and J. H .Williams. Effects of membrane permeant Ca2+-‐chelators on skeletal muscle force output and fatigue. (Experimental Biology ‘98, San Francisco, CA April 1998).
4. Spangenburg, E. E. †, C.W. Ward, R. M. Nelson, H. Metz, and J. H. Williams. The effects of glycolytic metabolites on sarcoplasmic reticulum Ca2+ handling. (SEACSM ‘99, Free Communication, Norfolk, VA Feburary 1999).
5. Williams, J. H., T. N. Perkins, C. W. Ward, and E. E. Spangenburg. Skeletal muscle sarcoplasmic reticulum (SR) function in aging: effects of reactive oxygen species. (Experimental Biology ‘99, Washington, DC April 1999).
6. Spangenburg, E. E. †, J. H. Williams, R. J. Talmadge, and T. I. Musch. Peripheral and respiratory muscle heavy chain (MHC) expression in rats with moderate heart failure. (Experimental Biology ‘99, Washington, DC April 1999).
7. Stavrianeas, S., E. E. Spangenburg, T. W. Batts, J. H. Williams, and G. A. Klug. Sarcoplasmic reticulum function in rat diaphragm following prolonged exercise. (ACSM ‘99, Seattle, WA June 1999).
8. Lees, S., Spangenburg, E. E., and J. H. Williams. Measurement of glycogen associated with the skeletal muscle sarcoplasmic reticulum. (Experimental Biology '00, San Diego, CA April 2000).
9. Spangenburg, E. E. †, J. H. Williams, and R. J. Talmadge. Muscle fiber type specific distribution of calcineurin. (Experimental Biology '00, San Diego, CA April 2000).
10. Spangenburg, E. E. †, J. H. Williams, R. J. Talmadge, T. I. Musch, P. C. Pfeifer and R. M. McAllister. Skeletal muscle myosin heavy chain (MHC) expression with various degrees of heart failure. (Experimental Biology '00, San Diego, CA April 2000).
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11. Spangenburg, E. E. †, S. L. Lees, J. Otis, R. J. Talmadge, T. I. Musch, and J. H. Williams. The effects of congestive heart failure and skeletal muscle functional overload on rat plantaris SERCA expression and sarcoplasmic reticulum Ca2+ uptake rates. (Integrative Biology of Exercise ’00, Portland, ME September 2000)
12. Williams, J. H., P. D. Franks, S. J. Lees, M. Stockunas, T. W. Batts, E. E. Spangenburg, and R. J. Talmadge. Ca2+ handling proteins in sarcoplasmic reticulum (SR) vesicles isolated from rested and fatigued muscles. (Experimental Biology, Orlando, FL April 2001)
13. Spangenburg, E. E. †, J. N. Holstein, and F. W. Booth. LIF induced satellite cell proliferation is mediated by the JAK2-‐STAT3 and PI3K signaling pathways. (Experimental Biology, New Orleans, LA April 2002)
14. J.H. Williams, M. Spangenburg, E. E. Spangenburg, S.E Vidt, S.J. Lees, R.B. Hunter and S.C. Kandarian. Differential Effects of Heart Failure on Skeletal Muscle Sarcoplasmic Reticulum Calcium Handling and ATPase Activity (Experimental Biology '03, San Diego, CA April 2003).
15. Morris, T. R., E. E. Spangenburg, and F. W. Booth. Activation of multiple intracellular signaling pathways during muscle atrophy and muscle re-‐growth in aged animals. (Experimental Biology '03, San Diego, CA April 2003).
16. Machida, S., E. E. Spangenburg, F.W. Booth. Forkhead transcription factor FoxO1 transduces insulin-‐like growth factor’s signal to p27Kip1 in primary skeletal satellite cells (European College of Sports Science ’03, Salzburg, Austria July 2003)
17. Spangenburg, E. E. †, D. K. Bowles, S. J. Lees and F. W. Booth. Insulin-‐like growth factor induces skeletal alpha actin promoter activity in differentiating myoblasts through membrane localized Ca2+ channels and calcineurin. (FASEB Summer Conference 2003-‐Skeletal Muscle Satellite Cells)
18. Shuichi Machida, E. E. Spangenburg, and Frank W. Booth. Passaging alters the phenotype of primary rat satellite cells in culture (FASEB Summer Conference 2003-‐Skeletal Muscle Satellite Cells).
19. Spangenburg, E. E. † and Emily Pettycrew. Suppressor of Cytokine Signaling-‐3 (SOCS-‐3) induces C2C12 myoblast differentiation. (2004 American Physiological Society Integrative Biology of Exercise).
20. Todd A. McBride, Emily Pettycrew, and E. E. Spangenburg†. The phosphorylation of Akt, GSK-‐3, and p70s6k in response to eccentric contractions is dependent upon functional stretch activated channels. (2004 American Physiological Society Integrative Biology of Exercise).
21. Spangenburg, E. E. †, David A. Brown, Micah S. Johnson, Brittany Kearney, Emily Pettycrew, Russell L. Moore. Suppressor of cytokine signaling-‐3 (SOCS-‐3) expression contributes to increases in interleukin-‐6 (IL-‐6) expression after exercise training. (Experimental Biology '06, San Francisco, CA April 2006)
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22. David A. Hawkins, Martin E. Burry, E. E. Spangenburg. Exercise Modality, Phosphorylation of p70s6k, and Skeletal Muscle Hypertrophy. (2006 American College of Sports Medicine Annual Meeting, Denver, CO).
23. Spangenburg, E. E. †, D. LeRoith, S. Bodine. A functional IGF-‐I receptor is not necessary for skeletal muscle hypertrophy. (Experimental Biology '07, Washington, DC April 2007)
24. Wohlers, L. M.*, S. M. Sweeney*, C. W. Ward, R. M. Lovering, E. E. Spangenburg†. Changes in contraction-‐induced phosphorylation of AMP-‐activated protein kinase and mitogen activated protein kinases in skeletal muscle after ovariectomy. (2008 American Physiological Society Integrative Biology of Exercise).
25. Spangenburg, E. E. † Overexpression of SOCS-‐3 attenuates TNF-‐α-‐induced inhibition of insulin signaling in cultured myocytes. (2008 American Physiological Society Integrative Biology of Exercise).
26. Ludlow, A. T., M. Auriemma*, P. Nadendla, K. Y. Ngai, E. E. Spangenburg, S. M. Roth. Does DNA methylation of the myosin heavy chain gene IIb promoter regulate gene expression during skeletal muscle differentiation? (2008 American Physiological Society Integrative Biology of Exercise).
27. Witkowski, S., M. M. Lockard, R. Harley, N.T. Jenkins, E. E. Spangenburg, James M. Hagberg. CD34+/KDR+ Endothelial Progenitor Cells and Vascular Health: Exercise and Detraining. (2008 American Physiological Society Integrative Biology of Exercise).
28. McBride, T. and E. E. Spangenburg. Depolarization of muscle cells following eccentric contractions can be reversed. (2008 American Physiological Society Integrative Biology of Exercise).
29. Jenkins, N.T., S. Witkowski*, E. E. Spangenburg, J. M. Hagberg. Endurance exercise improves endothelial progenitor cell function and reduces expression of oxidative stress-‐related genes. (2009 American College of Sports Medicine Annual Meeting, Seattle, WA).
30. Ludlow, A. T., P. Nadendla, S. Witkowski*, L. M. Wohlers*, E. E. Spangenburg, S. M. Roth. Physical activity ancestry affects body composition phenotypes and gene expression in mice offspring. (2009 American College of Sports Medicine Annual Meeting, Seattle, WA).
31. Wohlers, L. M.*, S. M. Sweeney*, E. E. Spangenburg†. Estrogen and not exercise attenuates increases in lipolysis and ATGL signaling in the visceral fat of OVX mice. (2009 International Biochemistry of Exercise Meeting, Guelph, Canada).
32. Campbell, K. M.*, L. M. Wohlers*, S. M. Sweeney*, S. Witkowski*, T. K. Koves, D. M. Muoio, E. E. Spangenburg†. Increases in visceral fat mass in OVX mice is associated with decreases in skeletal muscle cytochrome C protein expression (2009 International Biochemistry of Exercise Meeting, Guelph, Canada).
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33. Ludlow, A., M Marshall, S Witkowski*, E. Spangenburg, S Roth. High levels of physical activity accelerate telomere shortening in Cast/ei J mice (2009 Keystone Meeting. Telomere Biology and DNA Repair, Queensland, AU)
34. Spangenburg, E. E. †, K. M. Campbell*, L. M. Wohlers*, A. C. Maher, T. K. Koves, A. Bonen, D. M. Muoio. Loss of ovarian function alters multiple aspects of lipid metabolism in adipose tissue and skeletal muscle from female mice. (Experimental Biology '10, Anaheim, CA April 2010)
35. Witkowski, S.*, R. M. Lovering, D. LeRoith, E. E. Spangenburg†. Incomplete Activation of the IGF-‐1 Signaling Pathway after High-‐frequency Electrically Stimulated Skeletal Muscle Contractions. (2010 American College of Sports Medicine Annual Meeting, Baltimore, MD).
36. Ludlow, A., S Witkowski*, M. R. Marshall, J Wang, L Guth, E. E. Spangenburg, S Roth. Year long wheel running alters telomere dynamics and markers of DNA damage in mice. (2010 American College of Sports Medicine Annual Meeting, Baltimore, MD).
37. Marshall, M. R., S Witkowski*, A. T. Ludlow, J Wang, L Guth, S. Frank, E. E. Spangenburg, S Roth. Chronic wheel running alters telomere biology in CAST/Ei mouse liver tissue. (2010 American College of Sports Medicine Annual Meeting, Baltimore, MD).
38. R. Sheppard, E. R. Chin, E. E. Spangenburg, S Roth. Androgen Receptor CAG Repeat Length Affects Receptor Activity and C2C12 Myogenic Potential. (2010 American College of Sports Medicine Annual Meeting, Baltimore, MD).
39. Wohlers, L. M.*, K. M. Campbell*, E. E. Spangenburg†. Reduced ovarian function alters basal and stimulated lipolytic cell signaling in omental/mesenteric fat. FASEB Summer conference. Lipid Droplet Biology. 2010.
40. Jackson, K. C.*, L. M. Wohlers*, E. E. Spangenburg†. BRCA1 is expressed in skeletal muscle and binds to phosphorylated Acetyl CoA Carboxylase. 2010 IPE/ACSM meeting, Miami FL.
41. Spangenburg, E. E. †, K. M. Campbell*, L. M. Wohlers*, M. Cilenti*, S. J. Borengasser, J. Thyfault. Exercise prevents alterations in fatty acid composition of triacylgycerol in the liver of ovariectomized mice. 2010 IPE/ACSM meeting, Miami FL.
42. Guth, L. M., A. T. Ludlow, S. Witkowski, M. R. Marshall, L. Lima, K. Perret, N. Caffes, A. C. Venezia, E. E. Spangenburg, S. M. Roth. Transgenerational Effects of Physical Activity Ancestry on Mouse Body Composition, Glucose Metabolism, and Gene Expression. 2010 IPE/ACSM meeting, Miami FL.
43. Ludlow, A. T., L. Lima, E. E. Spangenburg, S. M. Roth. Telomere binding protein mRNA expression in response to an acute exercise bout. 2010 IPE/ACSM meeting, Miami FL.
44. Jenkins, N. T., E. E. Spangenburg, S. J. Prior, J. M. Hagberg. Role of NADPH oxidase in training-‐related differences in NO levels of circulating CD34+ and CD34-‐ cells. 2010 IPE/ACSM meeting, Miami FL.
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45. Venezia, A. C., A. T. Ludlow, S. Witkowski, M. R. Marshall, E. E. Spangenburg, S. M. Roth. Effect of one-‐year of voluntary wheel running on transcript specific hippocampus Bdnf gene expression. 2010 IPE/ACSM meeting, Miami FL.
46. Hargrove, J. R.*, R. Lockett*, K. C. Jackson*, E. E. Spangenburg†. Effects of estrogen treatments on PGC-‐1 and GLUT gene expression in C2C12 skeletal muscle. (ABRCMS ’10, Charlotte, NC)—Won student award
47. Guth, L. M., A. T. Ludlow, S. Witkowski, M. R. Marshall, L. Lima, A. C. Venezia, T. Xiao, M. T. Lee, E. E. Spangenburg, S. M. Roth. Exercise ancestry decreases lipogenesis-‐related gene expression in skeletal muscle of male offspring. (Experimental Biology ’11, Washington, DC)
48. Jenkins, N. T., R. Q. Landers, S. J. Prior, N. Soni, E. E. Spangenburg, J. M. Hagberg. Acute and chronic endurance exercise effects on nitric oxide, superoxide, and redox-‐related gene expression in circulating CD34+ cells. (Experimental Biology ’11, Washington, DC)
49. L. Lima, A. T. Ludlow, E. E. Spangenburg, S. M. Roth. MAPK signaling is associated with acute exercise-‐induced changes in mRNA levels of telomere-‐related genes. (Experimental Biology ’11, Washington, DC)
50. Landers-‐Ramos, R. Q., N. T. Jenkins, E. E. Spangenburg, J. M. Hagberg, S. J. Prior. Effects of prior endurance exercise on post-‐prandial lipemia-‐induced changes in circulating angiogenic cytokines in young men. (Experimental Biology ‘12, San Deigo, CA).
51. Landers-‐Ramos, R. Q., N. T. Jenkins, E. E. Spangenburg, J. M. Hagberg, S. J. Prior. Training status does not influences acute exercise-‐induced increases in plasma angiogenic cytokines in young men. (2012 American College of Sports Medicine Annual Meeting, San Francisco, CA).
52. Guth, L. M., A. C. Venezia, M. P. Marini, E. P. Beltran, E. E. Spangenburg, S. M. Roth. Effects of Physical Activity Ancestry on Aspects of Body Composition and Glucose Tolerances in Mice. (2012 American College of Sports Medicine Annual Meeting, San Francisco, CA).
53. Venezia, A. C., L. M. Guth, M. P. Marini, E. P. Beltran, E. E. Spangenburg, S. M. Roth. Effects of Parental Physical Activity on Hippocampal Gene Expression in C57BL/6 Mice. (2012 American College of Sports Medicine Annual Meeting, San Francisco, CA).
54. Marini, M. P., L. M. Guth, A. C. Venezia, E. P. Beltran, E. E. Spangenburg, S. M. Roth. Effects of chronic exercise on DNA methyltransferase expression in mouse testes. (2012 American College of Sports Medicine Annual Meeting, San Francisco, CA).
55. Jackson, K. C.*, R. M. Lovering, R. A. Schuh, E. E. Spangenburg†. Increased intramuscular lipid coupled with reduced mitochondrial function in OVX mice. International Biochemistry of Exercise Meeting. (2012 Stockholm, Sweden).
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56. Landers-‐Ramos, R. Q., J. Brandauer, N. T. Jenkins, E. E. Spangenburg, J. M. Hagberg, S. J. Prior. Effects of prior exercise on the inflammatory response to a high-‐fat meal in young men. (2012 Integrative Biology of Exercise, Westminster, CO).
57. Jackson, K. C.*, L. M Wohlers*, C. W. Ward, E. E. Spangenburg†. The Advantages/Disadvantages to Using Cultured Single Muscle Fibers as an In Vitro Model to Mechanistically Research Skeletal Muscle. (2012 Integrative Biology of Exercise, Westminster, CO).
58. Valencia*, A. P., M. E. Morris, J. P. Thyfault, E. E. Spangenburg†. Ovariectomy increases hepatic mitochondrial ROS production in mice. (2012 Integrative Biology of Exercise, Westminster, CO).
59. Landers-‐Ramos, R. Q., N. T. Jenkins, A. E. Roth, L. Cancre, E. E. Spangenburg, J. M. Hagberg. Effects of training status on circulating angiogenic cell paracrine activity in young men and women. (Experimental Biology 2013, Boston, MA)
60. Guth, L. M., A. C. Venezia, M. P. Marini, E. P. Beltran, E. E. Spangenburg, S. M. Roth. Effects of exercise ancestry on multiple generations of mature mouse offspring. (Experimental Biology 2013, Boston, MA)
61. Jackson, K. C.*, E. K. Sallstedt, J. Norrbom, D. M. Thomson, R. A. Schuh, P. D. Neufer, E. E. Spangenburg†. BRCA1 is a critical regulator of lipid metabolism in skeletal muscle. NHBLI Mitochondrial Biology Symposium. 2013. (Bethesda, MD).
Extramural/Intramural Grant Funding Current/Funded:
1. National Institutes of Health (NIA). Predoctoral Training in Exercise Physiology and Aging. Co-‐Investigator. $1,500,000. 2009-‐2013.
2. National Institutes of Health. (NIAMS) R21 The role of BRCA1 in regulation of lipid metabolism in skeletal muscle. (Principal Investigator). $275,000 direct costs_2011-‐2013.
3. Maryland Diabetes Research Training Center (DRTC). Estrogens regulate endocrine influences of visceral adipose tissue on skeletal muscle. (Principal Investigator). $88,000_2011-‐2013.
4. National Institutes of Health (NIHLB). R21. Translational Studies of EPCs as a Novel Cardiovascular Disease Risk Factor. Co-‐Investigator. (PI: James Hagberg). $275,000 direct cost_2011-‐2013.
Pending: 1. National Institutes of Health. RO1. BRCA1 expression is critical for optimal skeletal
muscle function. (Principal Investigator). $ 1,887,500 indirect and direct costs_2014-‐2019.
2. American Diabetes Association. Estrogens protect skeletal muscle from metabolic insults. (Principal Investigator). $345,000 indirect and direct costs_2014-‐2017.
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Completed/Funded. Extramural
1. National Institutes of Health (NIAMS). Small Grant Program for New Investigators. RO3. Regulation of the alpha actin gene expression during muscle atrophy and re-‐growth. Principal Investigator. $150,000-‐direct costs (2006-‐2009).
2. Individual National Research Service Award. NIH. The role of leukemia inhibitory factor in satellite cell proliferation and skeletal muscle re-‐growth. (2002-‐2005). Principal Investigator. $127,224-‐completed.
3. American College of Sports Medicine Doctoral Student Foundation Grant. Skeletal muscle calcium handling in congestive heart failure. (1999-‐2000). Principal Investigator. $ 4,992.00-‐completed
4. National Institutes of Health (NIA). R21 Role of maternal exercise environment on transgenerational offspring health. Co-‐Investigator. (PI: Steve M. Roth). $275,000 direct costs 2010-‐2011_no cost extension.
Intramural 1. University of Missouri-‐College of Veterinary Medicine COR Grant. The effects of
leukemia inhibitory factor (LIF) on satellite cell proliferation and skeletal muscle hypertrophy. (2001). Principal Investigator. $ 6,000.00-‐completed.
2. UC-‐Davis-‐New Faculty Research Grant. 2003. IGF-‐I induces transcriptional activation of the skeletal alpha actin gene through calcium-‐mediated mechanisms. (2003-‐2005). Principal Investigator. $2, 500-‐funded_completed.
3. Grant Research Board_University of Maryland. Exercise-‐induced SOCS-‐3 gene expression prevents insulin resistance in skeletal muscle. Principal Investigator. (2007). $11,000_completed.
4. UMD School of Public Health Seed Grant Program. Influence of physical activity ancestry on brain gene expression and cognitive function. (PI: Stephen M. Roth) Co-‐Investigator. $10,000 (2007-‐2008)._completed.
5. University of Maryland RASA award. BRCA1 expression is critical for optimal lipid oxidation by skeletal muscle in women. 2010. $9,000_completed.
Honors and Awards
1. Virginia Tech, Graduate Student Organization travel award. 1997-‐2000. 2. National Institute of Health Individual Postdoctoral Fellowship. 2002-‐2003. 3. UCD Academic Research Travel Award. 2004, 2006. 4. 2007 American Physiological Society New Investigator Award (EEP section) 5. 2008-‐2014 NIH Extramural Loan Repayment Grant Recipient 6. 2009-‐2010 Virginia Tech Department of Human Nutrition, Foods, and Exercise
Outstanding Alumnus Award 7. 2011 Best Paper Award UMD School of Public Health Research Interaction Day 8. 2013-‐2014 Leda Amick Wilson UMD SPH Mentoring Award
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Professional Service NIH Round Table Invited Participant
1. Title: Connecting Muscle Physiology to Common Diseases and Disorders (2011)-‐sponsored by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Conference Organizing Committee
1. American Physiological Society Integrative Biology of Exercise Meeting. Colorado 2012 Grant Reviewing Activity (number of grants reviewed are listed in parentheses after the year)
1. National Institutes of Health Study Sections RO3 Special Emphasis Study Section: 2006 (11), 2007 (7), 2008 (14), 2009 (4), 2010 (4) Skeletal Muscle and Exercise Physiology (SMEP) Study Section: 2011 (8), 2013-‐2x (10; 9), 2014 (9)
SCORE Study Section: 2010 (4) Womens Health Initiative: 2012 (3)
MOSS: Special Emphasis Study Section: 2013 (2); 2014 (1) 2. NASA
3. Murdock Charitable Trust Foundation 2013 (1) 4. Biotechnology and Biological Sciences Research Council UK 2013 (1) 5. Medical Research Council UK 2012 (1) 6. Toledo University Internal Grant Mechanism (1) 7. Texas A&M Huffines Institute for Sports Medicine: 2011 (3) 8. Special Congressional Interest Proposal Review: Fighting combat-‐related fatigue, Ad Hoc
Member, 2011 (1) 9. Maryland Agricultural Experimental Station at UMD: 2012 (1)
Editorial Board Service 2008-‐present Editorial Board Member Journal of Applied Physiology 2011-‐present Editorial Board Member Frontiers in Skeletal Muscle Physiology 2011-‐present Associate Editor Exercise Science and Sport Review (ESSR) 2011-‐Named to the Faculty of 1000 2012-‐present Editorial Board Member American Journal of Physiology: Cell Physiology Manuscript Reviewing-‐listed since 2006 (number reviewed in parentheses) 2006-‐Journal of Applied Physiology (6), Differentiation (1), Experimental Physiology (1) 2007-‐Journal of Applied Physiology (7) (Named one of the top 25 reviewers for the journal in 2006), American Journal of Physiology: Cell (2), Medicine Science Sport and Exercise (2), Journal
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of Physiology (1), Acta Physiologica (1), Rejuvenation Research (1), Exercise Science Sport Review (1) 2008-‐ Journal of Applied Physiology (4), Journal of Physiology (4), American Journal of Physiology: Cell (2), Acta Physiologica (3), Experimental Physiology (1), American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology (1), Journal of Cell Physiology (1), Endocrinology (1), British Journal of Sports Medicine (1) 2009-‐ Journal of Applied Physiology (6), Journal of Cellular Biochemistry (2), Journal of Physiology (1), Experimental Physiology (1), Journal of Endocrinology (1), Physiological Genomics (1), American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology (1), Journal of Sport Science and Medicine (1), Journal of Endocrinology (1) 2010-‐Journal of Applied Physiology (4), Journal of Cellular Biochemistry (2), American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology (2), Medicine Science Sport and Exercise (2), American Journal of Physiology: Endocrinology and Metabolism (1), PLOS One (1), Applied Physiology, Nutrition, and Metabolism (2) 2011-‐Cytokine (1), Metabolism (1), American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology (2), Journal of Applied Physiology (1), American Journal of Physiology: Cell (1), American Journal of Physiology: Endocrinology and Metabolism (1), Journal of Applied Physiology (1), Diabetes (1), European Journal of Applied Physiology (1), American Journal of Physiology: Gastrointestinal and Liver Physiology (1), Obesity (1) 2012-‐ Medicine Science Sport and Exercise (1), Diabetes (1), American Journal of Physiology: Endocrinology and Metabolism (2), J Cellular Biochemistry (1), J Applied Physiology (1), Lipids (1), Obesity (2), American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology (3), PLOS One (1), American Journal of Physiology: Cell (1) 2013-‐Diabetes (2), FASEB (1), PLOS One (3), Cell Proliferation (1), J Applied Physiology (2); American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology (1); Journal of Physiology (1); Applied Physiology, Nutrition and Metabolism (1); JOVE (1); MSSE (1) 2014-‐ FASEB (1), American Journal of Physiology: Cell (1), J Applied Physiology (2); Horm and Meta Res (1), American Journal of Physiology: Endocrinology and Metabolism (1) Membership (year joined to current) 1998 American College of Sports Medicine (ACSM) 1997 American Physiological Society (APS) 2000 Research Against Inactivity-‐related Disorders (RID) 2006 American Diabetes Association ACSM Committees:
1. ACSM Molecular and Cellular Special Interest Group Co-‐Chair 2009-‐2013 2. ACSM Assistant to Special Topics Representative (Skeletal Muscle, Bone, Connective
Tissue 2010-‐present)
Chaired Symposium:
1. Chaired Symposium for National 2004 ACSM meeting in Indianapolis “The Regulation of Satellite Cell Proliferation in Skeletal Muscle Growth.”
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2. Chaired Symposium for National 2006 ACSM meeting in Denver “The role of estrogens in skeletal muscle function and adaptation.”
3. Chaired Free Communication Session (Molecular Biology of Muscle II) for National 2009 ACSM meeting in Seattle.
4. Chaired Symposium for National 2009 ACSM meeting in Seattle “Novel mechanisms affecting adipose tissue function and fat storage.”
5. Chaired Thematic Poster Session (Myogenic Stem Cells) for National 2010 ACSM meeting in Baltimore, MD
6. Chaired Featured Topic for Experimental Biology in Washington, DC 2011 7. Chaired Symposium for National 2011 ACSM meeting in Denver, CO
Community Service
1. SAC Youth Soccer Coach (2011-‐present) 2. Thunder Hill Elementary School Wellness Committee (2012) 3. Thunder Hill Elementary School Monthly Guest Reader (2013) 4. Invited Speaker for 2014 STEM day
Teaching (since 2006) Fall 2006: Given course relief as part of recruitment package to UMD for this semester Spring 2007:
KNES 464 Exercise Metabolism: Role in Health and Disease (known as KNES 498L) (3 Cr.) Fall 2007: KNES691 Muscular Aspects of Exercise Physiology (3 Cr.) KNES689 Special Problems in Kinesiology (2 Cr.) Spring 2008:
KNES 464 Exercise Metabolism: Role in Health and Disease (known as KNES 498L) (3 Cr.) KNES689 Special Problems in Kinesiology (4 Cr.)
Fall 2008: KNES 464 Exercise Metabolism: Role in Health and Disease (3 Cr.) KNES 689 Special Problems in Kinesiology (6 Cr.) KNES 799 Master Thesis (6 Cr.)
Spring 2009: KNES 389 Topical Investigations (3 Cr.)
KNES 464 Exercise Metabolism: Role in Health and Disease (3 Cr.) KNES 689F Neuromechanics of Muscle (3 Cr.)
KNES 689 Special Problems in Kinesiology (6 Cr.) Fall 2009:
KNES 464 Exercise Metabolism: Role in Health and Disease (3 Cr.) KNES455 Scientific Basis of Athletic Training (3 Cr.) KNES 689 Special Problems in Kinesiology (6 Cr.)
Spring 2010: KNES 498 Special Topics in Kinesiology (3 Cr.) KNES 464 Exercise Metabolism: Role in Health and Disease (3 Cr.)
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KNES 455 Scientific Basis of Athletic Training (3 Cr.) KNES 689 Special Problems in Kinesiology (6 Cr.)
Fall 2010: KNES455 Scientific Basis of Athletic Training (3 Cr.) KNES 694 Metabolic Aspects of Exercise Physiology (3 Cr.) KNES 689 Special Problems in Kinesiology (9 Cr.)
Spring 2011: KNES455 Scientific Basis of Athletic Training (3 Cr.) KNES 689 Special Problems in Kinesiology (6 Cr.) KNES898 Pre-‐Candidacy Research (6 Cr.)
Fall 2011 KNES289 Topical Investigation (3 Cr) KNES455 Scientific Basis of Athletic Training (3 Cr.) KNES 689 Special Problems in Kinesiology (3 Cr.) KNES899 Doctoral Dissertation Research (6 Cr.)
Spring 2012 KNES455 Scientific Basis of Athletic Training (3 Cr.) KNES 799 Masters Thesis Research (6 Cr.) KNES899 Doctoral Dissertation Research (6 Cr.)
KNES694 Metabolic Aspects of Exercise Physiology (3 Cr.) Spring 2013 KNES476 Honors Thesis Proposal (3Cr.) KNES478 Honors Seminar (1Cr.) KNES618 Kinesiogenomic Readings (1Cr.) Fall 2013
KNES455 Scientific Basis of Athletic Training (3 Cr.) KNES476 Honors Thesis Proposal (3Cr.)
KNES478 Honors Seminar (1Cr.) KNES618 Kinesiogenomic Readings (1Cr.) Spring 2014
KNES476 Honors Thesis Proposal (3Cr.) KNES478 Honors Seminar (1Cr.) KNES618 Kinesiogenomic Readings (1Cr.) Undergraduate Research Advising Active
Jay Patel, Carrie Allen Prior undergraduate students
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Matt Laye: Completed Ph. D. in Medical Pharmacology and Physiology University of Missouri Maggie Cheng: unknown Physical Therapy School Erin Phillips: Physical Therapy School-‐ Sacramento State University Matt Lucero: Medical School-‐unknown (UCD) Acknowledged in published manuscript Brittany Kearney: Dietetic internship Acknowledged in published manuscript Andrew Battenberg: UCLA medical school Christian Alvarez: Optometry School Acknowledged in published manuscript Sean Sweeney (2007-‐2009)__industry research position
1. Co-‐author on paper 2. Presented poster at undergraduate research day 3. Co-‐author on two different abstracts
1. Dean’s Scholar Award 2. NASPEC KNES Major of Year Award 3. Author on abstract at APS Integrative Biology of Exercise 2008
Shannon Brown (2008-‐2009)-‐Virginia/Maryland Veterinary School 1. Was awarded GRIP award for undergraduate thesis project
Michelle Cilenti_honors student (2009-‐2010)-‐NYU DPT School 1. Dean’s Scholar Award 2. Co-‐Author on abstract at ACSM IPE 2010 3. Co-‐author on paper
Brittany Powers_honors student (2010-‐2011)-‐USC DPT School Ralston Lockett
1. Funded by UM-‐STAR NIH grant Eric Walker
1. Funded by UM-‐STAR NIH grant Jac’quese Hargrove
1. Funded by UM-‐STAR NIH grant 2. Awarded research travel award at ABRCMS conference
Samantha Goldklang_KNES Honors Student Camilo Vanegas_PhD Grad School Molecular Medicine University of Maryland SOM Carrie Allen_KNES Honors Student
Graduate Students Post-‐doctoral
1. Former
Sarah Witkowski, Ph. D._UMD_Kinesiology (co-‐mentor w/ Dr. Stephen Roth) 1. Assistant Professor UMASS-‐Amherst Dept Kinesiology
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Graduate Students 1. Former
Major Advisor: (2005) Kyle H. Henderson. Masters degree (UCD). The role of dysferlin in skeletal muscle regeneration.
Last known position: Research Technician-‐(unknown company)-‐CA.
(2008) Lindsay M. Wohlers. Masters degree (UMD). Physical activity and estradiol supplementation can prevent the onset of the metabolic syndrome in ovariectomized mice.
(2012) Ana P. Valencia. Masters degree (UMD). Association between increased hepatic lipid storage and impaired hepatic mitochondrial function in ovariectomized mice Current position: Ph. D. Student_University of Maryland (2012) Lindsay M. Wohlers. Ph. D. (UMD) Reductions in estrogenic function lead to metabolic dysfunction in adipose tissue and skeletal muscle. Current position: Post-‐Doc_SMU University
1. Awarded KNES Humphries Award for best paper 2. Awarded KNES GRIF Award 2008, 2010 3. UMD PCWI Graduate Student of the Year 2012
(2013) Kathryn C. Jackson Ph. D. (UMD) BRCA1 is a critical regulator of lipid metabolism in skeletal muscle. Current Postion: FDA Policy Fellow at Avalere Health
1. Awarded KNES GRIF Award 2009, 2010 2. Awarded ACSM Doctoral Student Grant 2011 3. Awarded UMD Summer Research Fellowship 2011 4. Awarded UMD Goldfaber Travel Award 2012 5. Awarded ICSSA Travel Award 2012 6. Awarded Seahorse Biosciences Travel Award 2012 7. Deans Honor Award 2013 8. KNES Humphries Award 2013 Best paper
Committee Member:
(2004) Sina Wallace. Doctor of Philosophy. (UCD) Lactate Accumulation and Bicarbonate Buffering in Trained and Untrained Humans. Nutraceutical Company in California.
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(2006) Martin Burry. Masters degree (UCD). Exercise Modality, Phosphorylation of p70s6k, and skeletal muscle hypertrophy. Research Technician-‐UCSD (2006) Joyce Riehl. Doctor of Philosophy. Pharmacology and Toxicology (UCD). Mutations in the Ryanodine Receptor and Malignant Hyperthermia. Residency UCD (2007) Stacey Vidt. Masters degree (VT). The effect of AICAR on sarcoplasmic reticulum function and possible links to muscle fatigue. Assistant Cross County Coach-‐VT (2007) Andy Ludlow. Masters Degree (UMD). Relationship between physical activity and telomere maintenance in peripheral blood mononucleocytes. Ph. D. Student UMD Dept. Kinesiology (2007) David Charbonneau. Masters Degree (UMD). Association between ACE genotype and skeletal muscle strength and volume, and their response to strength training in older adults. Unknown (2007) Darren Hwee. Masters Degree (UCD). The role of caloric restriction in age attenuated muscle hypertrophy. Ph. D. Student UCD. UCD MCIP Graduate Program. (2008) Dongmei Liu. Doctor of Philosophy (UMD). The Association of TNF-‐a Promoter Polymorphisms with Skeletal Muscle Phenotypes in humans. Current position: Post-‐Doc University of Michigan. (2008) Sarah Witkowski. Doctor of Philosophy (UMD). Effect of long-‐term exercise on endothelial progenitor cells in healthy humans. Current position: Assistant Professor, University of Massachusetts (2010). (2008) Sarah Camhi Doctor of Philosophy (UMD). The effects of low-‐fat diet and exercise on C-‐reactive protein and metabolic syndrome: findings from a randomized controlled trial. Current position: Post-‐Doc Louisiana State University.
(2008) Jennifer MacKenzie. Doctor of Philosophy (UMD). The influence of visfatin and visfatin gene polymorphisms on glucose and obesity-‐related variables and their responses to aerobic exercise training. Current position: Assistant Professor McDaniel University. (2009) Michael M. Lockhard. Doctor of Philosophy (UMD). The effect of thrombin on endothelial progenitor cells with exercise and exercise training. Current position: Assistant Professor Willamette University.
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(2010) Ryan L. Sheppard. Doctor of Philosophy (UMD). Androgen receptor polyglutamine repeat length affects receptor activity and C2C12 cell myogenic potential. Current position: Research Scientist. US Navy.
(2010) Mallory Marshall. Masters of Arts (UMD). The effects of diet and physical activity on telomere length and telomere-‐related genes in mice bred for high voluntary wheel running. Current Position: Ph. D. Student Michigan State University (2010) Lori Bjork. Masters of Arts (UMD). Circulating biomarkers of nitro-‐oxidative stress in young and older active and inactive men. Current position: professional basketball player (2011) Erik Hanson. Doctor of Philosophy (UMD). Can strength training improve musculoskeletal health and body composition in black men with prostate cancer on androgen deprivation therapy? Current Position: Post-‐doctoral fellow University of Deakin-‐Australia. (2011) Nathan T. Jenkins. Doctor of Philosophy (UMD). Regulatory effects of acute and chronic endurance exercise on nitric oxide and reactive oxygen species in human circulating angiogenic cells. Post-‐doctoral fellow: University of Missouri. (2011) Andrew T. Ludlow. Doctor of Philosophy (UMD). Telomere dynamics and regulation: effects of chronic exercise, acute exercise, and oxidative stress. Post-‐doctoral fellow: University of Texas-‐Southwest. (2012) Samuel English Masters of Arts (UMD). Alterations in myogenic capacity of satellite cells in a mouse model of ALS. (2012) Michael Marini Masters of Arts (UMD). Effects of chronic exercise on global DNA methylation and epigenetic factors in sperm and testes of mice. (2012) Kara Duffy Doctor of Philosophy (UMD). Development of Alzheimer’s-‐like pathology in non-‐human primates with reduced levels of norepinephrine. (2014) Lisa Guth Doctor of Philosophy (UMD). The effects of exercise ancestry on health-‐related traits in two generations of mouse offspring.
External Reviewer
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(2010) Marissa K. Trenerry. Investigation of JAK/STAT signaling in human skeletal muscle. Deakin University, Melbourne. Australia. (2013) Tara McDonald. Adipose, liver, and skeletal muscle function during estrogen deficiency in women: is exercise an appropriate alternative to hormone replacement therapy? Guelph University, Guelph ON.
2. Current
Major Advisor: Ana Valencia_UMD_MA Kinesiology 1. NIH-‐NIDDK Travel Award Melissa Inigo_UMD_PhD Kinesiology 1. CTE-‐International Teaching Fellow Adam Amorese_UMD_MA_Kinesiology
1. F. Daniel Wagner Graduate Student Teaching Award 2. Deans Honor Award
