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CCUURRRRIICCUULLUUMM VVIITTAAEE NAME: John A. Dani David J. Mahoney Prof. of Neurological Sciences Chair, Dept. of Neuroscience

Director, Mahoney Institute for Neurosciences Perelman School of Medicine University of Pennsylvania Philadelphia, PA 19104

EDUCATION: 1971 – 1975 B.S., University of Michigan (Atm. & Ocean Sci., emphasis Physics) 1975 – 1980 Ph.D., University of Minnesota (Physiology, minor Physical Chemistry) July 1981 Cold Spring Harbor Laboratory (Single-channel Recording Workshop) POSTGRADUATE TRAINING: 1980 – 1982 Postdoctoral Fellow with Dr. Bertil Hille Dept. of Physiology & Biophysics, University of Washington 1982 – 1984 Postdoctoral Fellow with Dr. George Eisenman Dept. of Physiology, UCLA ACADEMIC APPOINTMENTS: 1984 – 1987 Research Associate Scientist Yale University Section of Molecular Neurobiology 1987 – 1991 Assistant Professor Baylor College of Medicine Dept. of Physiology & Biophysics (1987 - 1992) 1991 – 1999 Associate Professor Baylor College of Medicine Division of Neuroscience Professor Baylor College of Medicine 1999 – 6/2013 Department of Neuroscience (primary appointment) 1999 – 2010 Executive Committee of Graduate Program in Structural and

Computational Biology and Molecular Biophysics 2004 – 6/2013 Menninger Department of Psychiatry and Behavioral Sciences

(secondary appointment) 2005 – 6/2013 Graduate Program in Translational Biology and Molecular Medicine

(secondary appointment) 2007 – 6/2012 Merit Appointment, Michael E. DeBakey VA Medical Center 2010 – 6/2013 Director, Center on Addiction, Learning, Memory (CALM) 7/2013 – present Chair, Dept. of Neuroscience, Director, Mahoney Institute for

Neurosciences, Perelman School of Medicine, University of Pennsylvania

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HONORS AND AWARDS: 1971 – 1974 State of Michigan Scholarship 1972 Regents Alumni Scholar 1972 William J. Branstorm Prize 1973 Carol Gross Memorial Scholarship 1975 Distinguished Achievement Award College of Engineering, University of Michigan 1975 Graduated summa cum laude, Univ. of Michigan, College of Engineering 1975 – 1978 Bush Foundation Fellowship 1978 – 1980 NIH Traineeship 1980 NIH Individual NRS award (declined to accept other funding) 1982 Bacaner Basic Science Award for excellence in research Minnesota Medical Foundation 1984 NIH Postdoctoral Traineeship 1984 – 1987 NIH New Investigator Research Award 1998 DeBakey Award for outstanding research, Baylor College of Medicine 1998 – 1999 Visiting Scholar Massachusetts Institute of Technology Dept. of Brain and Cognitive Sciences 2000 Jacob Javits Neuroscience Award from the NIH National Institute of Neurological Disorders and Stroke 2003 Wiersma Visiting Professorship Dept of Biology, California Institute of Technology 2004 Distinguished Lecturer

Biological Sciences Training Program Yale University Medical School

2005 Killam Lecturer Montreal Neurological Institute, McGill University 2011 Frank G. Standaert Lectureship in Pharmacology, Georgetown University PATENTS: 1997 Oocyte Recording Chamber, OTA #95-03, BCM #1311 RESEARCH SUPPORT (chronologically to the present): 1) NIH New Investigator Research Award R01 NS21229

Technical Title: Electrically Sizing and Modifying Ion Channels Name of Funding Agency: NIH, NINDS Investigator Relationship: PI Dates of Funding: 9/1/84 – 8/31/87

2) NIH NINDS R01 NS21229 Grant

Technical Title: Physiology & Structure of the AChR Channel and Endplate Name of Funding Agency: NIH NINDS Investigator Relationship: PI Dates of Funding: 9/1/87 – 8/31/90

3) Muscular Dystrophy Association Grant

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Technical Title: Modulation of Neuromuscular Endplate Function Name of Funding Agency: Muscular Dystrophy Association Investigator Relationship: PI Dates of Funding: 7/1/89 – 6/30/92

4) Baylor Research Support Grant

Technical Title: Structure and Function of NMDA Glutamate Receptors Name of Funding Agency: NIH funds to Baylor College of Medicine Investigator Relationship: PI Dates of Funding: 1990 – 1992

5) Whitaker Foundation Bioengineering Grant

Technical Title: Combining Video Microscopy and Electrophysiology to Study Synaptic Transmission Name of Funding Agency: The Whitaker Foundation Investigator Relationship: PI Dates of Funding: 6/1/90 – 5/31/93

6) Muscular Dystrophy Association

Technical Title: Modulation of Neuromuscular Endplate Function Name of Funding Agency: Muscular Dystrophy Association Investigator Relationship: PI Dates of Funding: 7/1/92 – 6/30/95

7) NIH NINDS R01 NS21229 Grant Technical Title: Structure and Function of Excitatory Synaptic Channels Name of Funding Agency: NIH NINDS Investigator Relationship: PI Dates of Funding: 4/1/91 – 3/31/95

8) Smokeless Tobacco Research Council

Technical Title: Modulation of Nicotinic Cholinergic Properties Name of Funding Agency: Smokeless Tobacco Research Council Investigator Relationship: PI Dates of Funding: 7/1/95 – 6/30/98

9) NIH NINDS R01 NS21229 Grant

Technical Title: Function of Ligand Gated Excitatory Synaptic Channels Name of Funding Agency: NIH NINDS Investigator Relationship: PI Dates of Funding: 7/23/96 – 6/30/00

10) NIH NIDA R01 DA09411 Grant

Technical Title: Cellular and Molecular Aspects of Nicotine Addiction Name of Funding Agency: NIH NIDA Investigator Relationship: PI, 30% effort Dates of Funding: 1/15/97 – 11/30/01

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11) NIH NIDA P01 Program Project Grant

Technical Title of PPG: Analysis of Nicotinic Cholinergic Systems in Mutant Mice Name of Funding Agency: NIH NIDA Investigator Relationship on PPG: Program Project Director and PI, 35% effort Dates of Funding: 9/1/99 – 8/30/04

Title of Dani Subproject of PPG: Properties of Nicotinic Receptors in Mutant Mice Name of Funding Agency: NIH NIDA Investigator Relationship on Subproject of PPG: PI Dates of Funding: 9/1/99 – 8/30/04

12) NIH NINDS R01 NS21229-16 Grant

Technical Title: Cholinergic Influences on Neuronal Circuit Excitability Name of Funding Agency: NIH NINDS, Jacob K. Javits Award Investigator Relationship: PI, 30% effort Dates of Funding: 07/01/00 – 06/30/07

13) NIH NIDA R01 DA09411-6 Grant

Technical Title: Cellular Mechanisms of Nicotine Addiction Name of Funding Agency: NIH NIDA Investigator Relationship: PI, 30% effort Dates of Funding: 7/1/02 – 6/30/07

14) NIH NINDS R01 NS048505-1 Grant

Technical Title: Simulation-guided Nicotinic Synapse & AD Drug Mechanisms Name of Funding Agency: NIH NINDS Investigator Relationship: PI, 35% effort Dates of Funding: 07/01/04 – 04/30/08

15) NIH NINDS R01 NS21229-22 Grant

Technical Title: Nicotinic Cholinergic Influences over Hippocampal Circuits Name of Funding Agency: NIH NINDS Investigator Relationship: PI, 25% effort Dates of Funding: 06/01/2007 – 05/31/2012

16) Diana Helis Henry Medical Research Foundation Parkinson's Disease Program

Technical Title: Dopamine Signaling Dysfunction Precedes and Predicts Neuron Loss in an Animal Model of Parkinson’s Disease Investigator Relationship: PI, 10% effort Dates of Funding: 10/01/2008 – 09/31/2011

17) Nanotechnology

Title: 3-dimensional Multisensing Probes for Neural Recording Investigator Relationship: Collaboration with University of Houston; PI, Jack Wolfe Dates of Funding: 09/01/2009 – 8/31/2011

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18) Alzheimer’s Disease Pilot Funding Title: Pilot studies on a Rat Model of Alzheimer’s Disease Investigator Relationship: PI Dates of Funding: 07/01/2011 – 6/30/2013

19) 1RP101120 Cancer Prevention Research Institute of Texas (CPRIT) Research Support Title: Creation of Animal Models and Characterization of Nicotinic Receptor Cancer Risk Factors Investigator Relationship: PI, 15% effort Dates of Funding: 03/01/2010 – 3/30/2014

20) Diana Helis Henry Medical Foundation, Collaborative Research

Title: Genomic, Neural, Preclinical Analysis for Smoking Cessation Investigator Relationship: PI, 3% effort Dates of Funding: 05/01/2011 – 3/31/2014

21) NIH NIDA R01 DA09411-15 Grant Technical Title: Cellular and Synaptic Physiology the Progression to Nicotine Abuse Name of Funding Agency: NIH NIDA Investigator Relationship: PI, 25% effort Dates of Funding: 04/01/2008 – 03/31/2014

22) NIH NINDS R01 NS021229-29 Grant

Technical Title: Nicotinic & Dopaminergic Mechanisms Regulating In Vivo Plasticity Name of Funding Agency: NIH NINDS Investigator Relationship: PI, 25% effort Dates of Funding: 09/01/2012 – 06/30/2017

23) NIH NIDA R01 DA036572-01 Grant

Technical Title: Alpha 5 nAChR is a Risk Factor within the Dopamine System for Nicotine Addiction Investigator Relationship: PI, 25% effort Dates of Funding: 05/01/2014 – 04/30/2019

24) NIH NIDA R01 DA009411-16 Grant

Technical Title: Acute Nicotine Decreases Alcohol-induced Dopamine Response & Increases Drinking Investigator Relationship: PI, 25% effort Dates of Funding: 08/01/2014 – 04/30/2019

NATIONAL SCIENTIFIC PARTICIPATION: 1990 – 1996 Editorial board for The Journal of Theoretical Biology 1991, 1992 NIH study section special session review for Physiology Section 1993 NIH study section ad hoc review, Neurological Sciences 2 1994 University of Texas, outside committee member, Ph.D. thesis

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1994 – 1998 NIH study section regular member, Neurological Sciences 2 02/1998 NIH study section acting chair, Neurological Sciences 2 1996 Co-chair Membrane Biophysics Subgroup Social, Society for Neuroscience 1998 – 1999 Invited guest, Membrane Biophysics Subgroup Social, Society Neurosci. 1996, 2000 Columbia University, New York, outside committee member, Ph.D. thesis 1997 – 1998 Reviewing Editor of Editorial Board for The Journal of Neuroscience 1998 – 2011 Editorial Board for the Journal of General Physiology 1999 NIH study section review, NIDA, Collaborative Site Grants for Addiction 1999 MIT, outside committee member, Ph.D. thesis 2000 Study section review, Tobacco-related Disease Res. Program of California 2000 NIH study section review, NIDA, Microarray-Based Res. on Drug Abuse 2000 NIH NIDA, Cell Biology of Addiction, development of future funding 2000 Member, Scientific Review of Biostatistics Branch and Tenure at the NIH NIEHS, Research Triangle Park, North Carolina 2000 NIH study section ad hoc outside opinion, NINDS council ZRG1 MDCN-5 2001 NIH study section ad hoc for MDCN-4 2001 NIH study section ad hoc for MDCN-5 2002 Guest Editor with D Berg for a special issue of Journal of Neurobiology 2003 NIH, NIAAA Workshop on Multiscale Systems Neuroscience 2003 NIH, NIDA Binational Workshop on Drug Abuse and Addiction Research 2003 – present Contributing member for Faculty of 1000 2004 NIH NIDA ad hoc reviewer for Cutting-edge Basic Research Awards 2005 NIH study section ad hoc for Neurobiology of Motivated Behavior 2006 NIH study section ad hoc for MDCN-F 02, Biophysics & Protein Interactions in the Nervous System, March Meeting of a Special Emphasis Panel 2006 NIH study section ad hoc for section NTRC 2006 Member planning for Drug Abuse Exhibit, McGovern Museum of Health & Medical Sciences, Houston, Tx 2007 NIH study section for NGDDG Drug Discovery, ZMH1-ERB-Y02 2008 NIH, NIAAA, Mechanism of Behavior Change Initiative 2008 VA Merit Review Subcommittee for Mental Health 2008, 2012 Section Editor with TR Kosten and DA Gorelick for ASAM, Principles of Addiction Medicine, 4th ed, 5th ed 2009 - present Editorial Board for Frontiers in Neuroscience 2009 NIH grant review, Scientific Areas of Integrated Review Groups, Molecular, Cellular, & Developmental Neurosci IRG [MDCN] 2009 NIH grant review, Challenge Grants 2009 - present Honorary Editorial Board of Journal of Experimental Pharmacology 2010 NIH grant review, NIDA CEBRA, ZDA1 GXM-A 2010 NIH grant review, Special Emphasis Panel, ZRG1, IFCN-H 2010 - present Editorial Board for Journal of Addiction Research & Therapy 2011 - present Editorial Board for World Journal of Pharmacology 2011 NIH grant review, IFCN-C, Neurotoxicology and Alcohol 2011 NIH grant review (Chairman), PPG, Neural Plast icit y program project s 2011 NIH grant review, Special Emphasis Panel/ Scient if ic Review Group 2012/ 01 ZDA1 JXR-D 2011 Organizing Commit t ee, Nicot inic Acet ylcholine Recept ors as

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Therapeut ic Target s, 11/ 9 -11, 2011, 3rd Satellite

Meeting to the Society for Neuroscience 2011 - present Editorial Member, Frontiers in Bioscience 2012 NIH review member, Director’s Pioneer Awards 2012 NIH grant review (Chairman), ZRG1 MDCN-F (50) P 2012 - present Editorial Board for Journal of Clinical & Experimental Pharmacology 2012 NIH grant review, ZRG1 IFCN-C (02) M Special Emphasis Panel: Drugs, Alcohol and Stress 2013 Organizing Committee and Advisory Board, Nicotinic Receptor

Therapeutics: Emerging Frontiers in Research & Clinical Science, Special Issue and International Symposium, San Diego, CA

2013 NIH grant review, FDA-NIH Tobacco related applications 2013 Section Editor, Kosten, Dani, Gorelick, ASAM, Principles of Addiction

Medicine, 5th ed 2014 NIH grant review, NINDS NST-2 F31 and K99 applications 2014 - present Editorial Board for Journal of Neurology and Brain Disorders, 2014 - present Editorial Board for Journal of Neuroscience and Neuroeconomics 2015 - present Editorial Board for International Archives of Addiction Res. and Medicine SCIENTIFIC SOCIETIES: American Psychological Society Biophysical Society Society of General Physiologists Society for Neuroscience

Society for Research on Nicotine and Tobacco SELECTED MAJOR INVITED PRESENTATIONS ONLY Up until 1996 records of speaking engagements at universities were not kept. 1985 International Society of Neurochemistry Meeting "Ion Channels of the Nervous System" Vancouver, Canada 1987 FASEB Meeting, 100th Anniversary of the American Physiological Society "Symposium on Nerve Impulses" Washington, DC 1988 XXI Jerusalem Symposium on Quantum Chemistry and Biochemistry "Transport Across Membranes" Jerusalem, Israel 1990 Biophysical Society Meeting "Ion Channels: Cooperativity and Function" Baltimore, Maryland 1990 International Symposium on the Cholinergic Synapse Sir Bernard Katz, Chairperson Berlin, Germany 1990 Presentation on "Ionic Channels", Biozentrum, Basel, Switzerland 1991 Tenth Anniversary Dept. of Pharmacology By Invitation of the Graduate Students

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Cornell University, Ithaca, New York 1992 Keystone Symposium "Synapse Formation and Function" Bozeman, Montana 1992 Satellite Symposium, 15th European Neuroscience Association Congress "International Symposium on Nonselective Cation Channels" University of Regensburg Regensburg, Germany 1992 First Puerto Rico Neuroscience Conference Universidad Central del Caribe Bayamon, Puerto Rico 1994 Twenty-seventh Winter Conference on Brain Research "New views on Neuronal Acetylcholine Receptors" Snowbird, Utah 1994 American Society of Addiction Medicine 7th National Conference on Nicotine Dependence "The Fourth Nicotine Research Workshop" Boston, Mass. 1994 International Symposium on the Cholinergic Synapse Baltimore, Maryland 1995 University of Padova Department of Pharmacology Padova, Italy Presentations in: 1996 Columbia University, College of Physicians and Surgeons Center for Neurobiology and Behavior New York, New York Texas A&M University, College of Medicine Department of Pharmacology and Toxicology College Station, Texas University of Pennsylvania, School of Medicine David Mahoney Institute of Neurological Sciences Department of Neuroscience Philadelphia, Pennsylvania University of Pittsburgh, School of Medicine Department of Neurobiology Pittsburgh, Pennsylvania 1997 American Society of Addiction Medicine Conference Sponsored by NIDA and NIAAA Washington, DC University of Chicago Program in Cellular and Molecular Physiology Chicago, Illinois 15th Annual Houston Conference on Biomedical Engineering Research University of Houston

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Houston, Texas Mount Sinai School of Medicine Department of Physiology & Biophysics New York, New York Michigan State University Neuroscience Program Lansing, Michigan Massachusetts Institute of Technology Neurobiology Program Cambridge, Massachusetts Pharmacology Forum "The Genetic & Molecular Basis of Drug Addiction" Vanderbilt University, Nashville, Tennessee 1998 Annual FASEB Meeting Symposium "The Mechanism & Regulation of Neurotransmitter Release" San Francisco, California New York Academy of Sciences, Conference "Molecular & Functional Diversity of Ion Channels & Receptors" New York, New York Drug Policy Forum of Texas Houston, Texas NIEHS, National Institutes of Health Laboratory of Signal Transduction Research Triangle Park, NC Tenth International Symposium on Cholinergic Mechanisms Arcachon, France University of Texas Medical School Department of Neurobiology Houston, Texas Cornell University School of Medicine Department of Physiology New York, New York Forum of European Neuroscience Symposium on "Molecular Links between

Neurodevelopment and Neurodeterioration" Berlin, Germany 1999 International Symposium on Neuronal Nicotinic Receptors "Functional Role in CNS Disorders, therapeutic implications" Karolinska Institutet Stockholm, Sweden University of California San Francisco Neuroscience Program San Francisco, California Symposium on Smoking and Cigarette Abuse

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University of Padua Padua, Italy IBC's 2nd International Symposium on Nicotinic Acetylcholine Receptors "Advances in Molecular Pharmacology and Drug Development" Annapolis, Maryland Symposium on Epilepsy Houston, Texas International Symposium on "Neuronal Nicotinic Receptors: from structure to therapeutics" CNR Cellular and Molecular Pharmacology Center University of Milan and with the Emilio Trabucchi Foundation Venice, Italy 2000 Symposium on "Nicotinic Mechanisms in Alzheimer's Disease" Society of Biological Psychiatry Puerto Rico Columbia University School of Medicine Department of Physiology New York, New York Hippocampal Research Conference Grand Cayman Janssen Pharmaceutical Nicotinic Advisory Board Meeting Boston, Massachusetts International School for Advanced Studies (SISSA-ISAS)

Section of Biophysics Trieste, Italy Benzon Symposium "Molecular Pharmacology of Ion Channels" Copenhagen, Denmark Kings College London

Section of Behavioral Pharmacology Institute of Psychiatry

London, England University of Texas Neurobiology Program Austin, Texas The First Sino-US Symposium Medicine in the 21st Century Presentation, "Frontiers in Neuroscience" Houston, Texas University of Florida Interdepartmental Graduate Program Gainesville, Florida 1st Lilly Neuronal Nicotinic Receptors Symposium Surrey, England University of Texas Medical Branch Department of Pharmacology & Toxicology

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Galveston, Texas 10th Neuropharmacology Conference "Neuronal Nicotinic Receptors" Society for Neuroscience Satellite Meeting New Orleans, Louisiana 2001 University of Alabama at Birmingham Department of Neurobiology Birmingham, Alabama

University of Colorado School of Medicine Department of Physiology and Biophysics Denver, Colorado

Universidad Central del Caribe Department of Biochemistry Bayamon, Puerto Rico

Emory University School of Medicine Department of Pharmacology Atlanta, Georgia 2002 Federation of European Neuroscience Meeting Symposium on “Nicotinic Acetylcholine Receptors:

modulators or mediators of brain activity?” Paris, France

Society for Research on Nicotine and Tobacco Eighth Annual Meeting Symposium on “Nicotine Receptor Pharmacology and Physiology”

Savannah, Georgia University of Texas

Cajal Neuroscience Research Center San Antonio, Texas

XXIII Collegium Internationale Neuro-Psychopharmacologium (CINP) Symposium on “Nicotinic Acetylcholine Receptors:

from molecular biology to clinical psychiatry” Montreal, Canada

8th Annual Duke Nicotine Research Conference “Nicotinic Interactions with GABA and Glutamate Systems” Duke University

Durham, North Carolina 2003 California Institute of Technology Wiersma Professorship Lecture Division of Biology Pasadena, California

Winter Conference on Brain Research "Nicotinic acetylcholine receptors in the 21st century:

genetic manipulations of nAChRs in mice." Snowbird, Utah

University of Texas

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Neurobiology Program Austin, Texas

Massachusetts Medical Society McLean Hospital, Harvard Medical School “Role of the Cholinergic System”

Waltham, Massachusetts Stanford Brain Research Institute Stanford University School of Medicine Stanford, California University of California at San Francisco Gladstone Institute San Francisco, California Symposium on Nicotinic Ligands and Receptors as Targets for Medication NIH, NIDA Bal Harbour, Florida

Workshop on Multiscale Systems Neuroscience NIH, NIAAA

Washington, DC Binational Workshop on Drug Abuse and Addiction Research NIH, NIDA Washington, DC Satellite Symposium of 2003 Society for Neuroscience Meeting NIH, NIEHS Sponsored

Nicotine and Nicotinic Receptors: Potential for Parkinson’s disease therapy New Orleans, Louisiana

2004 21st Annual Houston Conference on Biomedical Engineering Research Symposium on Synapses - Electrical Recordings and Novel

Spectroscopies Houston, Texas

Yale University Medical School Distinguished Lecturer, Biological Sciences Training Program

New Haven, Connecticut Frontiers in Addiction Biology: Genomics and Beyond Vanderbilt University School of Medicine Nashville, Tennessee

Stanford University School of Medicine Stanford Brain Research Institute

Stanford, California 2005 Vanderbilt University School of Medicine Oates Institute for Experimental Therapeutics Nashville, Tennessee

University of Texas Medical Branch Center for Addiction Research Department of Pharmacology and Toxicology

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Galveston, Texas University of Pittsburgh School of Medicine Department of Neurobiology & Center for Neuroscience

Pittsburgh, Pennsylvania University of Maryland Baltimore Program in Neuroscience & Maryland Psychiatric Research Center Baltimore, Maryland University of Kentucky Pharmaceutical Sciences Lexington, Kentucky Virginia Commonwealth University Department of Pharmacology and Toxicology Richmond, Virginia Universite de Montreal Department of Physiology Montreal, Qc, Canada McGill University Killam Lecture, Montreal Neurological Institute Montreal, Qc, Canada Vollum Institute Oregon Health Sciences University Portland, Oregon Society for Research on Nicotine and Tobacco 11th Annual Meeting & the 7th Annual Meeting of the European SRNT Conference “Role of Nicotine in Smoking Reinforcement” Prague, Czech Republic 2006 Association of Health Care Journalists Health Journalism 2006 Conference Houston, Texas Drexel University College of Medicine Department of Pharmacology & Physiology Philadelphia, Pennsylvania University of Houston College of Pharmacy Houston, Texas NIDA National Institutes of Health -IRP Baltimore, Maryland Vrije Universiteit (Free University) Amsterdam Centre Neurogenomics & Cognitive Research Amsterdam, The Netherlands 2007 International Movement Disorder Society Parkinson’s Disease Symposium and the Department of Neurology Ruijin Hospital Shanghai, China

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University of Texas, San Antonio Featured Speaker Texas Dopamine Club San Antonio, Texas University of Texas, Southwestern Medical Center Department of Neuroscience Dallas, Texas 55th Annual Nebraska Symposium on Motivation Department of Psychology University of Nebraska Lincoln, Nebraska 60th Annual Symposium on Cancer Research M.D. Anderson Cancer Center University of Texas Houston, Texas Satellite to the 2007 Meeting of the Society for Neuroscience “Nicotinic Acetylcholine Receptors as Therapeutic Targets: Emerging Frontiers in Basic Research & Clinical Science” San Diego, California University of Texas Health Science Center at Houston Cell and Regulatory Biology Graduate Program Houston, Texas Washington University School of Medicine Department of Anesthesiology 660 South Euclid Saint Louis, Missouri Pasteur Institute Neurobiologie intégrative des systèmes cholinergiques CNRS URA 2182 Department of Neuroscience 25, rue du Dr Roux 75724 Paris Cedex 15 Paris, France 2008 Abbott Laboratories Abbott Park, Illinois University of Minnesota School of Medicine Department of Neuroscience Minneapolis, Minnesota AREADNE 2008 “Research in Encoding & Decoding Neural Ensembles” Nomikos Conference Center Santorini, Greece XIII International Symposium on Cholinergic Mechanisms “Neuronal and Non-Neuronal Cholinergic Systems: Molecular and Translational Significance” Foz do Iguacu, Brazil

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2009 YPO/WPO Lifelong Leadership Group Mini-University on the Brain Houston, Texas National Institutes of Health Web Based “Seminars on Genetics of Nicotine Dependence & Lung Cancer” M.D. Andersen Cancer Center Dept. of Behavioral Science Houston, Texas The Scripps Research Institute Scripps at Jupiter, Florida Eli Lilly and Company Neuroscience Research Program Indianapolis, Indiana University of Colorado School of Medicine Department of Pharmacology Denver, Colorado 2010 M.D. Andersen Cancer Center Cancer Prevention Research Training Program Houston, Texas University of Washington Department of Pharmacology Seattle, Washington University of Massachusetts Program in Neuroscience Worcester, Massachusetts Virginia Tech Department. of Biology Blacksburg, Virginia Symposium Celebrating Bertil Hille Seattle, Washington 2011 Washington University School of Medicine Department of Anesthesiology 660 South Euclid Saint Louis, Missouri M.D. Andersen Cancer Center Cancer Prevention Research Training Program Houston, Texas 21st Annual Helen and Rush Record Neuroscience Forum Galveston, Texas

University of Utah Neuroscience Seminar Series Salt Lake City, Utah Rice University Brain Awareness Week Lecture Series

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Houston, Texas University of Pennsylvania Center for Interdisciplinary Research on Nicotine Addiction Philadelphia, Pennsylvania California Institutue of Technology Division of Biology Pasadena, California Wellcome Trust Nicotinic Acetylcholine Receptors 2011 conference Hinxton, Cambridge, UK Symposium: Nicotinic Acetylcholine Receptors as Therapeutic Targets 3rd Satellite Meeting to the Society for Neuroscience Washington, DC Symposium: Re-Engineering the Human Nervous System Center for NeuroEngineering Rice University Houston, Texas Frank G. Standaert Lectureship in Pharmacology, Georgetown University Washington, DC 2012 Society for Research on Nicotine and Tobacco “Cholinergic Regulation of Addiction and Disease” Houston, Texas Gill Center of Biomolecular Science University of Indiana ` Bloomington, Indiana M.D. Andersen Cancer Center Cancer Prevention Research Training Program Houston, Texas 2nd Annual NeuroEngineering Symposium, Session Chair Center for NeuroEngineering Gulf Coast Consortia for Quantitative Biomedical Science Houston, Texas University of Pennsylvania Department of Psychiatry Center for Interdisciplinary Research on Nicotine Addiction Philadelphia, Pennsylvania International Workshop (Plenary Speaker) Motivated behavior, stress and addiction: from molecules to behavior Federation of Neuroscience Societies Universidad Técnica Federico Santa María Valparaíso, Chile 2013 Texas A & M University Institute for Neuroscience Interdisciplinary Life Sciences

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College Station, Texas NIH, Intramural Research Program National Institute on Drug Addiction Baltimore, Maryland University of Texas

Waggoner Center for Alcohol & Addiction First Research Symposium Austin, Texas

2nd Annual Conference & Exhibition on Addiction Research & Therapy Co-Chair and Speaker, Drug Addiction and Neurotoxicology and Addiction Biology session Las Vegas, Nevada

Dopamine International Congress, May 2013 Alghero, Italy University of Texas Department of Neuroscience

Austin, Texas Nicotinic Receptor Therapeutics: Emerging Frontiers in Research & Clinical Science, Special Issue and International Symposium

Opening Introduction San Diego, California

2014 The State University of New York Stony Brook University Department of Neurobiology and Behavior Stony Brook, New York

The University of Pennsylvania Neurosurgery Seminar Series Philadelphia, Pennsylvania

NIH, National Institute on Alcohol Abuse and Alcoholism Division of Neuroscience and Behavior Bethesda, Maryland

Drexel University College of Medicine (Student Campus) Department of Neurobiology and Anatomy Philadelphia, Pennsylvania

Scheie Eye Institute Grand Rounds University of Pennsylvania Philadelphia, Pennsylvania

Nicotinic Acetylcholine Receptors 2014 International Symposium Churchill College; Wellcome Trust Cambridge, UK

The Bar Harbor Club MDI Hospital-Penn Medicine Collaboration Bar Harbor, Maine

Nebraska Research and Innovation Neuroscience Conference Neuroscience Conference Planning Committee and the Nebraska EPSCoR/IDeA Committee

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Omaha, Nebraska 2015 Vanderbilt University

Department of Pharmacology Nashville, Tn Society for Research on Nicotine and Tobacco Annual Meeting

Symposium - Nicotine & Alcohol Co-abuse: from mechanism to treatment

Philadelphia, PA The University of Pennsylvania

Neurology Grand Rounds Philadelphia, Pennsylvania

Drexel University (City Center Campus) Department of Pharmacology Philadelphia, Pennsylvania

BIBLIOGRAPHY: (no abstracts listed) McLaughlin I, Dani JA, De Biasi M. (2015) Nicotine withdrawal. Current Topics Behavioral

Neuroscience 24:99-123. doi: 10.1007/978-3-319-13482-6_4. PMID: 25638335 Cui Y, Robinson JD, Engelmann JM, Lam CY, Minnix JA, Karam-Hage M, Wetter DW, Dani JA,

Kosten TR, Cinciripini PM. (2015) Reinforcement Sensitivity Underlying Treatment-Seeking Smokers' Affect, Smoking Reinforcement Motives, and Affective Responses. Psychology of Addictive Behaviors [Epub ahead of print] PMID: 25621416

Thompson-Lake DG, Cooper KN, Mahoney JJ 3rd, Bordnick PS, Salas R, Kosten TR, Dani JA, De La Garza R 2nd. (2014) Withdrawal Symptoms and Nicotine Dependence Severity Predict Virtual Reality Craving in Cigarette-Deprived Smokers. Nicotine Tobacco Research pii: ntu245. [Epub ahead of print] PMID: 25475087

Yang K, Dani JA (2014) Dopamine D1 and D5 receptors modulate spike timing-dependent plasticity at medial perforant path to dentate granule cell synapses. J Neuroscience 34:15888-97. doi: 10.1523/JNEUROSCI.2400-14.2014. PMID: 25429131

Jenson D, Yang K, Acevedo-Rodriguez A, Levine A, Broussard JI, Tang J, Dani JA. (2014) Dopamine and norepinephrine receptors participate in methylphenidate enhancement of in vivo hippocampal synaptic plasticity. Neuropharmacology 90C:23-32. doi: 10.1016/j.neuropharm.2014.10.029. [Epub ahead of print] PMID: 25445492

Acevedo-Rodriguez A, Zhang L, Zhou F, Gong S, Gu H, De Biasi M, Zhou FM, Dani JA (2014) Cocaine inhibition of nicotinic acetylcholine receptors influences dopamine release. Frontiers in Synaptic Neuroscience 6(19). PMID: 25237305

Dao DQ, Perez EE, Teng Y, Dani JA, De Biasi M (2014) Nicotine enhances excitability of medial habenular neurons via facilitation of neurokinins signaling. J Neuroscience 34:4273-84. PMID: 24647947

Doyon WM, Dong Y, Ostroumov A, Thomas AM, Zhang TA, Dani JA (2013) Nicotine Decreases Ethanol-Induced Dopamine Signaling and Increases Self-Administration via Stress Hormones. Neuron 79:530-40. PMID:23871233

Dani JA, De Biasi M (2013) Mesolimbic dopamine and habenulo-interpeduncular pathways in nicotine withdrawal. Cold Spring Harbor Perspectives Medicine 3(6). pii: a012138. doi: 10.1101/cshperspect.a012138. PMID: 23732854

Dong Y, Dani JA, Blakely RD (2013) Choline Transporter Hemizygosity Results in Diminished Basal Extracellular Dopamine Levels in Nucleus Accumbens and Blunts Dopamine

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Elevations Following Cocaine or Nicotine. Biochemical Pharmacology 86(8):1084-8. PMID: 23939187

Doyon WM, Thomas AM, Ostroumov A, Dong Y, Dani JA (2013) Potential substrates for nicotine and alcohol interactions: A focus on the mesocorticolimbic dopamine system. Biochemical Pharmacology 86(8):1181-93. PMID:23876345

Dani JA, Donnelly-Roberts D, Bertrand D (2013) Nicotinic acetylcholine receptors as therapeutic targets: Emerging frontiers in basic research and clinical science-Editorial comments. Biochemical Pharmacology 86(8):1041. PMID:23684691

Cui Y, Versace F, Engelmann JM, Minnix JA, Robinson JD, Lam CY, Karam-Hage M, Brown VL, Wetter DW, Dani JA, Kosten TR, Cinciripini PM (2013) Alpha Oscillations in Response to Affective and Cigarette-Related Stimuli in Smokers. Nicotine and Tobacco Research 15:917–924. PMID: 23060019

Lin S-T, Wolfe JC, Dani JA, Shih W-C (2012) Flexible optitrode for localized light delivery and electrical recording. Optics Letters 37(11):1781-1783. PMID: 22660027

Cui Y, Robinson JD, Versace F, Lam CY, Minnix JA, Karam-Hage M, Dani JA, Kosten TR, Wetter DW, Brown VL, Cinciripini PM (2012) Differential cigarette-related startle cue reactivity among light, moderate, and heavy smokers. Addictive Behaviors 37:885-889. PMID: 22571920

Li W, Doyon WM, Dani JA (2012) Quantitative unit classification of ventral tegmental area neurons in vivo. Journal of Neurophysiology 107(10):2808-20. PMID: 22378178

Zhang L, Dong Y, Doyon WM, Dani JA (2012) Withdrawal from chronic nicotine exposure alters dopamine signaling dynamics in the nucleus accumbens. Biological Psychiatry 71:184-91. PMID: 21872847 (Selected as Priority Communication by Biological Psych.)

Zhang L, Le W, Xie W, Dani JA (2012). Age-related changes in dopamine signaling in Nurr1 deficient mice as a model of Parkinson's disease. Neurobiology Aging 33:1001.e7-1001.e16. PMID: 21531044

Dani JA, Jenson D, Broussard JI, De Biasi M (2011) Neurophysiology of nicotine addiction. Journal of Addiction Research and Therapeutics S1(1). PMID: 22454789

Dani JA, Balfour DJ (2011) Historical and current perspective on tobacco use and nicotine addiction. Trends Neuroscience. 34:383-92. PMID: 21696833

Li W, Doyon WM, Dani JA (2011) Acute in vivo nicotine administration enhances synchrony among dopamine neurons. Biochemical Pharmacology 82:977-83. PMID:21684263

De Biasi M, Dani JA. (2011). Reward, Addiction, Withdrawal to Nicotine. Annual Review Neuroscience 34:105-30. PMID: 21438686

Zhang T, Tang J, Pidoplichko VI, Dani JA (2010) Addictive nicotine alters local circuit inhibition during the induction of in vivo hippocampal synaptic potentiation. J Neuroscience 30:6443-53. PMID: 20445070

Zhang T, Placzek AN, Dani JA (2010) In Vitro identification and electrophysiological characterization of dopamine neurons in the lateral ventral tegmental area. Neuropharmacology 59(6):431-6. PMID: 20600174.

Dong Y, Zhang T, Li W, Doyon W, Dani JA (2010) Route of nicotine administration influences in vivo dopamine neuron activity: habituation, needle injections, and cannula administration. J Molecular Neuroscience 40:164-171. PMID: 19714495

Zhou F-M, Dani JA (2009) Dopamine and serotonin crosstalk within the dopaminergic and serotonergic systems. In, Co-existence and co-release of classical neurotransmitters. Gutierrez R (ed.) pp. 145-180, Springer Science, New York, NY.

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Zhang T, Zhang L, Liang Y, Siapas AG, Zhou FM, Dani JA (2009) Dopamine signaling differences in the nucleus accumbens and dorsal striatum exploited by nicotine. J Neuroscience 29:4035-4043. PMID: 19339599

Zhang L, Doyon WM, Clark JJ, Phillips PE and Dani JA (2009) Controls of tonic and phasic dopamine transmission in the dorsal and ventral striatum. Molecular Pharmacology 76(2):396-404. PMID: 19460877

Tang J, Dani JA (2009) Dopamine enables in vivo synaptic plasticity associated with addictive nicotine. Neuron 63:673-682. PMID: 19755109 (Highlighted for Preview by Neuron)

Rezvani K, Teng Y, Pang Y, Dani J, Lindstrom J, Garcia Gras EA, McIntosh JM, De Biasi M (2009) UBXD4, a UBX-containing protein, regulates the cell surface number and the subunit stability of α3-containing nicotinic acetylcholine receptors. J Neuroscience 29:6883-6896. PMID: 19474315

Placzek AN, Zhang TA, Dani JA (2009) Nicotinic mechanisms influencing synaptic plasticity in the hippocampus. Acta Pharmacologica Sinica 30:752-760. PMID: 19434057

Placzek AN, Zhang TA, Dani JA (2009) Age dependent nicotinic influences over dopamine neuron synaptic plasticity. Biochemical Pharmacology 78:686-92. PMID: 19464268

Placzek AN, Dani JA (2009) Synaptic plasticity within midbrain dopamine centers contributes to nicotine addiction. In, The Motivational Impact of Nicotine and its Role in Tobacco Use. Bevins RA, Caggiula AR (Eds.) Series: Nebraska Symposium on Motivation, 55:5-15, Springer. PMID: 19013936

Li J, Dani JA, Le W (2009) Role of transcription factor Pitx3 in dopamine neuron development and Parkinson’s disease. Current Topics Medicinal Chemistry 9:855-859. PMID: 19754401

Dani JA, Kosten TR, Benowitz NL (2009) The pharmacology of nicotine and tobacco. in ASAM, Principles of Addiction Medicine, eds: RK Ries, DA Fiellin, SC Miller, R Saitz, 4th ed, Wolters Kluwer, Lippincott Williams & Wilkins, pg., 179-191.

McKay BE, Placzek AN, Dani JA (2007) Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors. Biochemical Pharmacology 74:1120-1133. PMID: 17689497

Dani JA, Bertrand D (2007) Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system. Annual Reviews Pharmacology Toxicology 47:699-729. PMID: 17009926

Dani JA and Montague PR (2007) Disrupting addiction through the loss of drug-associated internal states. Nature Neuroscience 10:403-404. PMID: 17387327

Dani JA (2007) Overview: Nicotinic receptors and their roles in the central nervous system. in Alzheimer’s disease and nicotinic acetylcholine receptors: neurocognitive enhancement and neuroprotection. S. Shimohama, ed., Excerpta Medica, Netherlands, pp. 7-18.

Zhou FM, Dani JA (2006) Antidepressants alter mesostriatal dopamine interactions with serotonin signaling. Current Psychiatry Reviews 2:453-461.

Pidoplichko VI, Dani JA (2006) Acid-sensitive ionic channels in midbrain dopamine neurons are sensitive to ammonium, which may contribute to hyperammonemia damage. Proc Natl Acad Sci USA 103:11376-11380. PMID: 16847263

Zhou FM, Liang Y, Salas R, Zhang L, De Biasi M, Dani JA. (2005) Corelease of dopamine and serotonin from striatal dopamine terminals. Neuron 46:65-74. PMID: 15820694 (Highlighted for Preview by Neuron)

Tsuneki H, You Y, Toyooka N, Sasaoka T, Nemoto H, Dani JA, Kimura I (2005) Marine

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alkaloids (-)-pictamine and (-)-lepadin B block neuronal nicotinic acetylcholine receptors. Biological & Pharmaceutical Bulletin 28:611-614. PMID: 15802796

Pidoplichko VI, Dani JA (2005) Applying small quantities of multiple compounds to defined locations of in vitro brain slices. J Neuroscience Methods 142:55-66. PMID: 15652617

Liang Y, Salas R, Marubio L, Bercovich D, De Biasi M, Beaudet AL, Dani JA (2005) Functional polymorphisms in the human 4 subunit of nicotinic acetylcholine receptors. Neurogenetics 6:37-44. PMID: 15742216

Ge S, Dani JA (2005) Nicotinic acetylcholine receptors at glutamate synapses facilitate long-term depression or potentiation. J Neuroscience 25:6084-6091. PMID: 15987938

Dani JA, Lester RAJ (2005 edition) Nicotinic acetylcholine receptors in neurons. in Embryonic Encyclopedia of Life Sciences, John Wiley & Sons, Inc, www.els.net.

Dani JA, Harris RA (2005) Nicotine addiction and comorbidity with alcohol abuse and mental illness. Nature Neuroscience 8:1465-1470. PMID: 16251989

Zhang L, Zhou FM, Dani JA (2004) Cholinergic drugs for Alzheimer’s disease enhance in vitro

dopamine release. Molecular Pharmacology 66:538-544. PMID: 15322245 Tsuneki H, You Y, Toyooka N, Kagawa S, Kobayashi S, Sasaoka T, Nemoto H, Kimura I, Dani

JA (2004) Alkaloids indolizidine 235B', quinolizidine 1-epi-207I and the tricyclic 205B are potent and selective non-competitive inhibitors of nicotinic acetylcholine receptors. Molecular Pharmacology 66:1061-1069. PMID: 15258256

Pidoplichko VP, Noguchi J, Areola OO, Liang Y, Peterson J, Zhang T, Dani JA (2004) Nicotinic cholinergic synaptic mechanisms in the ventral tegmental area contribute to nicotine addiction. Learning & Memory 11:60-69. This article also provided the cover art for this Special Issue of Learning & Memory entitled, “The Cholinergic Systems in Learning and Memory”. PMID: 14747518

Lape R, Dani JA (2004) Complex response of striatal medium spiny neurons to afferent excitatory bursts. J Neurophysiology 92:1276-84. PMID: 15331641

Dani JA, Zhou FM (2004) Selective dopamine filter of glutamate striatal afferents. Neuron 42:522-524. PMID: 15157413

Dani JA, De Biasi M, Liang Y, Peterson J, Zhang L, Zhang T, Zhou F-M (2004) Potential applications of nicotinic ligands in the laboratory and clinic. Bioorganic & Medicinal Chemistry Letters 14:1837-1839. PMID: 15050611

Zhou F-M, Wilson CJ, Dani JA (2003) Muscarinic and nicotinic cholinergic mechanisms in the mesostriatal dopamine systems. The Neuroscientist 9:23-36 PMID: 12580337

Wooltorton JRA, Pidoplichko VI, Broide RS, Dani, JA (2003) Differential desensitization and distribution of nicotinic acetylcholine receptor subtypes in midbrain dopamine areas. J Neuroscience 23(8):3176-3185. PMID: 12716925

Tsuneki H, Salas R, Dani JA (2003) Mouse muscle denervation increases expression of an α7 nicotinic receptor with unusual pharmacology. J Physiology, London 547.1:169-179. PMID: 12562921

Salas R, Pieri F, Fung B, Dani JA, De Biasi M (2003) Altered anxiety-related responses in mutant mice lacking the α4 subunit of the nicotinic receptor. J Neuroscience 23: 6255-6263. PMID: 12867510

Karan LD, Dani JA, Benowitz NL (2003) Pharmacology of nicotine. in ASAM, Principles of Addiction Medicine, 3rd ed. 225-248.

De Biasi M, Dani, JA (2003) Stress hormone enhances synaptic NMDA response on dopamine neurons. Neuron 39:387-388. PMID: 12895412

Dani JA (2003) Roles of dopamine signaling in nicotine addiction. Molecular Psychiatry 8:255-

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256. PMID: 12660795 Zhou F-M, Wilson CJ, Dani JA (2002) Cholinergic interneuron characteristics and nicotinic

properties in the striatum. J Neurobiology 53:590-605. PMID: 12436423 Broide RS, Salas R, Ji D, Paylor R, Patrick JW, Dani, JA, De Biasi, M. (2002) Increased

sensitivity to nicotine-induced seizures in mice expressing the L250T 7 nicotinic acetylcholine receptor mutation. Molecular Pharmacology 61:695-705. PMID: 11854451

Berg DK, Dani JA (2002) Introduction: Issue on nicotinic signaling. J Neurobiology 53:429-430. Zhou FM, Liang Y, Dani JA (2001) Endogenous nicotinic cholinergic activity regulates dopamine

release in the striatum. Nature Neuroscience 4:1224-1229. PMID: 11713470 Ji D, Lape R, Dani JA (2001) Timing and location of nicotinic activity enhances or depresses

hippocampal synaptic plasticity. Neuron 31:131-141. PMID: 11498056 Dani JA, Ji D, Zhou F-M (2001) Synaptic plasticity and nicotine addiction. Neuron 31:349-352.

PMID: 11516393 Dani JA (2001) Nicotinic receptor activity alters synaptic plasticity. The Scientific World

Journal (TheScientificWorld); Directions in Science 1:393-395. PMID: 12806076 Dani JA (2001) Overview of nicotinic receptors and their roles in the central nervous system.

Biological Psychiatry 49:166-174. PMID: 11230867 Dani JA, De Biasi M (2001) Cellular mechanisms of nicotine addiction. Pharm Biochem Behav

70:439-446. PMID: 11796143 Orr-Urtreger A, Broide RS, Kasten MR, Dani JA, Beaudet AL, Patrick, JW (2000) Mice

homozygous for the L250T mutation in the α7 nicotinic acetylcholine receptor show

increased neuronal apoptosis and die within one day of birth. J Neurochemistry 74:2154-2166. PMID: 10800961

Ji D, Dani JA (2000) Inhibition and disinhibition of pyramidal neurons by activation of nicotinic receptors on hippocampal interneurons. J Neurophysiology 83:2682-2690. PMID: 10805668

Hicks JH, Dani JA, Lester RAJ (2000) Regulation of the sensitivity of acetylcholine receptors to nicotine in rat habenula neurons. J Physiology, London 529:579-597. PMID: 11118491

Fisher J, Dani JA (2000) Nicotinic activity can increase synaptic glutamate responses while decreasing the NMDA component. Neuropharmacology 39:2756-2769. PMID: 11044745

Dani JA, Radcliffe KA, Pidoplichko V (2000) Variations in desensitization of nicotinic acetylcholine receptors from hippocampus and midbrain dopamine areas. European J Pharmacology 393:31-38. PMID: 10770995

Dani JA (2000) Properties underlying the influence of nicotinic receptors on neuronal excitability and epilepsy. Epilepsia 41:1063-1065. PMID: 10961642

Zarei M, Radcliffe KA, Chen D, Patrick JW, Dani, JA (1999) Distribution of nicotinic acetylcholine receptor α7 and 2 subunits on cultured hippocampal neurons. Neuroscience 88:755-764. PMID: 10363815

Saggau P, Gray R, Dani JA (1999) Optical measurement of calcium signals mediated by ion channels in mammalian presynaptic terminals. In: P.M.Conn (Ed.), Ion Channels, Methods in Enzymology 294:3-19, Academic Press. PMID: 9916220

Radcliffe KA, Fisher J, Gray R, Dani, JA (1999) Nicotine potentiates glutamate and GABA synaptic transmission. Annals New York Academy Science 868:591-610. PMID: 10414340

Lukas RJ, Changeux JP, le Novere N, Albuquerque EX, Balfour DJ, Berg DK, Bertrand D, Chiappinelli VA, Clarke PB, Collins AC, Dani JA, Grady SR, Kellar KJ, Lindstrom JM, Marks MJ, Quik M, Taylor PW, Wonnacott S (1999) International union of pharmacology.

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XX. Current status of the nomenclature for nicotinic acetylcholine receptors and their subunits. Pharmacol Rev 51:397-401. PMID: 10353988

Dani JA, Lester RAJ (November, 1999) Nicotinic acetylcholine receptors in neurons. in Embryonic Encyclopedia of Life Sciences, Nature Publishing Group, London, www.els.net.

Radcliffe K, Dani JA (1998) Nicotinic stimulation produces multiple forms of glutamatergic synaptic enhancement. J Neuroscience 18:7075-7083. PMID: 9736631

Fisher J, Pidoplichko V, Dani JA (1998) Nicotine modifies the activity of ventral tegmental area dopaminergic neurons and hippocampal GABAergic neurons. J Physiology, Paris 92:209-213. PMID: 9789810

Dani JA (1998) Actions of nicotine on midbrain dopamine neurons. Biomedicine & Pharmacotherapy 52:468.

Rogers M, Colquhoun LM, Patrick JW, Dani JA (1997) Calcium flux through predominantly independent purinergic ATP and nicotinic acetylcholine receptors. J Neurophysiology 77:1407-1417. PMID: 9084606

Pidoplichko V, DeBiasi M, Williams JT, Dani JA (1997) Nicotine activates and desensitizes midbrain dopamine neurons. Nature 390:401-404. PMID: 9389479

Orr-Urtreger A, Goldner FM, Saeki M, Lorenzo I, Goldberg L, DeBiasi M, Dani JA, Patrick JW, Beaudet AL (1997) Mice deficient in the neuronal nicotinic α7 subunit lack α-bungarotoxin binding sites and hippocampal fast nicotinic currents. J Neuroscience 17:9165-9171. PMID: 9364063

Gray R, Rajan AS, Radcliffe KA, Yakehiro M, Dani JA (1996) Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature 383:713-716. PMID: 8878480

Dani JA, Heinemann S (1996) Molecular and cellular aspects of nicotine abuse. Neuron 16:905-908. PMID: 8630247

Zarei M, Dani JA (1995) Structural basis for explaining open-channel blockade of the NMDA receptor. J Neuroscience 15:1446-1454. PMID: 7532704

Rogers M, Dani JA (1995) Comparison of quantitative calcium flux through NMDA, ATP, and ACh receptor channels. Biophysical J 68:501-506. PMID: 7696503

Lester RAJ, Dani JA (1995) Acetylcholine receptor desensitization induced by nicotine in rat medial habenula neurons. J Neurophysiology 74:195-206. PMID: 7472323

Dani JA, Mayer ML (1995) Structure and function of glutamate and nicotinic acetylcholine receptors. Current Opinion Neurobiology 5:310-317. PMID: 7580153

Amador M, Dani JA (1995) Mechanism for modulation of nicotinic acetylcholine receptors that can influence synaptic transmission. J Neuroscience 15:4525-4532. PMID: 7790921

Zarei M, Dani, J.A. (1994) Ionic permeability characteristics of the N-methyl-D-aspartate receptor channel. J General Physiology 103:231-248. PMID: 7514645

Vernino S, Rogers M, Radcliffe K, Dani, J.A. (1994) Quantitative measurement of calcium flux through muscle and neuronal nicotinic acetylcholine receptors. J Neuroscience 14:5514-5524. PMID: 8083751

Lester RAJ, Dani, JA (1994) Time-dependent changes in central nicotinic acetylcholine channel kinetics in excised patches. Neuropharmacology 33:27-34. PMID: 7514279

Costa ACS, Patrick JW, Dani JA (1994) Improved technique for studying ion channels expressed in Xenopus oocytes, including fast superfusion. Biophysical J 67:395-401. PMID: 7522597

Séguéla P, Wadiche J, Dineley-Miller K, Dani JA, Patrick JW (1993) Molecular cloning,

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functional properties and distribution of rat brain α7: a nicotinic cation channel highly permeable to calcium. J Neuroscience 13:596-604. PMID: 7678857

Patrick J, Séguéla P, Vernino S, Amador M, Luetje C, Dani JA (1993) Functional diversity of neuronal nicotinic acetylcholine receptors. Progress Brain Research 98:113-120. PMID: 8248498

Dani JA (1993) Structure, diversity, and ionic permeability of neuronal and muscle acetylcholine receptors. Nonselective cation channels: physiology and pharmacology. D. Siemen and J. Hescheler, eds., Birkhauser Verlag Basel, Switzerland 47-59. PMID: 7505663

Vernino S, Amador M, Luetje CW, Patrick J, Dani JA (1992) Calcium modulation and high calcium permeability of neuronal nicotinic acetylcholine receptors. Neuron 8:127-134. PMID: 1370370

Reuhl T, Moorman JR, Amador M, Pinkham J, Dani JA (1992) Nicotinic acetylcholine receptors are directly affected by agents used to study protein phosphorylation. J Neurophysiology 68:407-416. PMID: 1382118

Dani JA, Fox JA (1991) Mechanisms for conductance substates of a single ionic channel. J Theoretical Biology 153:401-423. PMID: 1724679

Amador M, Dani JA (1991) Protein kinase inhibitor, H-7, directly affects NMDA receptor channels. Neuroscience Letters 124:251-255. PMID: 1829797

Amador M, Dani JA (1991) MK-801 inhibits nicotinic acetylcholine-induced currents. Synapse 7:207-215. PMID: 1715611

Reuhl TOK, Amador M, Dani JA (1990) Tissue culture tube contaminant inhibits excitatory synaptic channels. Brain Research Bulletin 25:433-435. PMID: 1705471

Decker ER, Dani JA (1990) Calcium permeability of the nicotinic acetylcholine receptor: the single-channel calcium influx is significant. J Neuroscience 10:3413-3420. PMID: 2170596

Dani JA, Levitt DG (1990) Diffusion and kinetic approaches to describe permeation in ion channels. J Theoretical Biology 146:289-301. PMID: 1701840

Dani JA (1989) Site-directed mutagenesis and single-channel currents define the ionic channel of the nicotinic acetylcholine receptor. Trends in Neuroscience 12:125-128. PMID: 2470168

Dani JA (1989) Open channel structure and ion binding sites of the nicotinic acetylcholine receptor channel. J Neuroscience 9:884-892. PMID: 2466967

Dani JA (1989) Ion channels of nerve and muscle. Current Opinions Cell Biology 1(4):753-764. PMID: 2483333

Dani JA (1988) Ionic permeability and the open channel structure of the nicotinic acetylcholine receptor. In: Transport through Membranes: carriers, channels and pumps. A. Pullman, ed., D. Reidel Publishing Co., Dordrecht, Holland pp. 297-319.

Eisenman G, Dani JA (1987) An introduction to molecular architecture and permeability of ionic channels. Annual Review Biophysics Biophysical Chemistry 16:205-226. PMID: 2439095

Dani JA, Eisenman G (1987) Monovalent and divalent cation permeation in acetylcholine receptor channels: ion transport related to structure. J General Physiology 89:959-983. PMID: 2440979

Sánchez JA, Dani JA, Siemen D, Hille B (1986) Slow permeation of organic cations in acetylcholine receptor channels. J General Physiology 87:985-1001. PMID: 2425045

Eisenman G, Dani JA (1986) Characterizing the electrical behavior of an open channel via the energy profile for ion permeation: a prototype using a fluctuating barrier model for the

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acetylcholine receptor channel. In: Ionic Channels in Cells and Model Systems. R. Latorre, ed., Plenum Publishing Corporation. New York. pp. 53-87.

Dani JA (1986) Ion-channel entrances influence permeation: net charge, size, shape, and binding considerations. Biophysical J 49:607-618. PMID: 2421791

Eisenman G, Dani JA, Sandblom J (1985) Recent studies on the energy profiles underlying permeation and ion selectivity of the gramicidin and acetylcholine receptor channels. In: Recent Advances in the Theory and Application of Ion Selective Electrodes in Physiology and Medicine. M. Kessler, D.K. Harrison, and J. Hoper, eds., Springer-Verlag. Berlin-Heidelberg-New York pp. 54-66.

Eisenman G, Dani JA (1985) A fluctuating 2 barrier 1 site model compared with electrical data from the acetylcholine receptor channel. In: Water and Ions in Biological Systems. Proceedings of the Third International Conference. A. Pullman, V. Vasilescu and L. Parker, eds., Union of Societies for Medical Sciences. Bucharest, Romania, pp. 437-450.

Dani JA, Eisenman G (1984) Acetylcholine-activated channel current-voltage relations in symmetrical Na+ solutions. Biophysical J 45:10-12. PMID: 19431525

Dani JA, Sánchez J, Hille B (1983) Lyotropic anions: Na channel gating and Ca electrode response. J General Physiology 81:255-282. PMID: 6302198

Dani JA, Levitt DG (1981) Water transport and ion-water interaction in the gramicidin channel. Biophysical J 35:501-508. PMID: 6168311

Dani JA, Levitt DG (1981) Binding constants of Li+, K+, and T1+ in the gramicidin channel determined from water permeability measurements. Biophysical J 35:485-500. PMID: 6168310

SERVICE AT BAYLOR COLLEGE OF MEDICINE: 1988 – 1990 Lecturer in “Ion Channels and Excitable Membranes” 1998 – 2004 Lecturer to the M.D./Ph.D. students and/or Summer Research students 1990 – 1997 Director of “Teaching Club on Special Topics in Neuroscience”, The class was run year around from 1990 - 1994. The class was run 1 or more blocks from 1995 - 1997 2002 – 2011 The Teaching Club meets sporadically since 2002 . 2002 – 2005 Lecturer in required General Neuroscience graduate course (ended 2005) 2006 – 2013 Lecturer in required Introduction to Neuroscience Methods graduate course 2006 – 2013 Lecturer in required Neurobiology of Disease graduate course 2007 – 2013 Lecturer in required Higher Systems Neuroscience graduate course 1990 – 1992 BCM Promotions Committee 1990 – 1997 BCM Information Technology Standing Committee 1992 – 1997 Chairman, BCM Information Technology Networking Subcommittee 1992 – 1998 Baylor Research Grant Support Internal Review Committee 1987 – 2013 Total of >40 Baylor Student Thesis Committees 1992 – 1998 Neuroscience Admissions Committee 1993 – 1998 Neuroscience Graduate Program Committee 1993 – 1995 Neuroscience Ad Hoc Tenure Committees 1997, '8,'0,'1,’3,’5 Neuroscience Ad Hoc Tenure Committees 1995 – 1996 Neuroscience MD/PhD Recruiting 1994 – 1998 Neuroscience Curriculum Committee 1994 – 1997 Neuroscience Seminar Series

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1998 Neuroscience Faculty Recruiting Committee 2003 – 2004 Institute for Brain and Behavior Recruiting Committee 2000 – 2011 Executive Committee of the Program in Structural and Computational Biology and Molecular Biophysics 2004 – 5 Neuroscience Graduate Student Oral Examine Committees 2005 Neuroscience Cellular Search Committee 2005 – 2007 Recruiting Committee for Joint Rice University and BCM 2006 – 2008 Neuroscience Admissions Committee 2008 – 2010 Co-chair Neuroscience Admissions Committee 2006 – 2012 Chair, Neuroscience Promotion and Tenure Committee 2013 Neuroscience Promotion and Tenure Committee 2006 – 2007 Neuroscience Neurosystems Search Committee 2006 – 2007 Neuroscience Computational Search Committee 2006 Member BCM Strategic Plan for Excellence 2006 – 2012 Member BCM Faculty Appointments & Promotions Committee 2006 Member BCM Task Force for Non-academic Services 2006 Member BCM Subcommittee Integrated Technology (IT) Responsibilities 2006 Member BCM Faculty Operating Committee of the M.D./Ph.D. Medical Scientist Training Program (MSTP) 2007 Member Neuroscience Committee to analyze quantitative coursework 2007 Member Integrative Neuroscience Search Committee 2009 – 2010 Member McNair Scholars BCM-wide Search Committee 1999 – 2010 Executive Committee of Graduate Program in Structural and Computational Biology and Molecular Biophysics 2011, 2012 Chair, Search Committee for Assistant Professor tenure-track position into

the Center on Addiction, Learning, Memory 2012 Judge, Neuroscience Research Center (NRC) 19th Annual Neuroscience Poster Session SERVICE AT THE UNIVERSITY OF PENNSYLVANIA: 2013 – present Penn Medicine Neuroscience Center Steering Committee 2013 – present Committee of Center and Institute Directors 2013 – present Standing Committee of Department Chairs and Directors of Centers &

Institutes 2013 – present NeuroBehavioral Institute Scientific Advisory Board 2013 – present Penn Integrates Knowledge Committee 2014 Chair, Neuroscience recruiting committee 2015 Chair, Neuroscience recruiting committee