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Cytopathology Challenge! Weekly Cases

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Cytopathology Challenge! Weekly Cases. Oct 31, 2008. Mixture of lymphocytes and follicular cells. 44 y/o female. FNA of thyroid. Unsatisfactory due to insufficient cellularity. Lymphocytic thyroiditis. Goiter Indeterminate. Papillary carcinoma. 1. Bronchoalveolar lavage. - PowerPoint PPT Presentation
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Oct 31, 2008
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Page 1: Cytopathology Challenge!  Weekly Cases

Oct 31, 2008

Page 2: Cytopathology Challenge!  Weekly Cases

44 y/o female. FNA of thyroid. A. Unsatisfactory due to insufficient

cellularity.B. Lymphocytic thyroiditis.C. GoiterD. Indeterminate.E. Papillary carcinoma. 1

Mixture of lymphocytes and Mixture of lymphocytes and follicular cells.follicular cells.

Page 3: Cytopathology Challenge!  Weekly Cases

2

Bronchoalveolar lavage.A. Unsatisfactory.B. Malignant cells present.C. PCP D. StrongyloidesE. Artifact

Page 4: Cytopathology Challenge!  Weekly Cases

3

Thyroid FNAA. Colloid with cholesterol crystals.B. Indeterminate.C. Papillary carcinoma.D. Anaplastic carcinoma.E. Metastatic carcinoma.

Large rectangular cholesterol crystals commonly seen in goiter

Page 5: Cytopathology Challenge!  Weekly Cases

4

FNA of thigh mass.A. Negative for malignancy.B. Sq. cell carcinoma.C. AdenoCa.D. Sarcoma.E. Abscess.

Some of the malignant cells are splindled.

Others are large and hyperchromatic.

Page 6: Cytopathology Challenge!  Weekly Cases

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Bronchoalveolar lavage.A. Unsatisfatory.B. Negative for malignancy.C. Small cell carcinomaD. AdenoCaE. Squamous cell carcinoma

Benign ciliated bronchial cell

Pigmented macrophages are needed for an adequate sample

Page 7: Cytopathology Challenge!  Weekly Cases

FNA of thyroid.A. Reactive, neg for malignancyB. GoiterC. Indeterminate for malignancy.D. Papillary carcinoma.E. Follicular carcinoma.

6

Intranuclear inclusion

This papillary structure viewed at high power demonstrates cells with high N/C ratios, hyperchromasia, and intranuclear inclusions.

Page 8: Cytopathology Challenge!  Weekly Cases

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54 yo female with pleural effusionA. Reactive mesothelial cellsB. AdenocarcinomaC. MesotheliomaD. Melanoma E. Lymphoma

This “cannon ball” of tumor cells is characteristic for breast carcinoma in pleural fluid. Other adenocarcinomas may form large proliferation spheres as well. Adenoca’s have smooth community borders, whereas mesotheliomas tend to have a more knobby outline.

Page 9: Cytopathology Challenge!  Weekly Cases

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FNA of pancreatic mass.A. Unsatisfactory specimenB. Reactive cellsC. Pseudocyst contentsD. Pancreatic adenocarcinomaE. Amebiasis

Compare the malignant cells to the reactive ductal cells arranged in a orderly honeycomb pattern. The malignant cells are less cohesive. Did you notice the tumor diathesis in the background?

Page 10: Cytopathology Challenge!  Weekly Cases

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GMS of corneal scrapeA. PCPB. AcanthamoebaC. FungusD. Fuch’s corneal dystrophyE. Toxic epidermal necrolysis

Acanthamoeba has a spiky outline.

Page 11: Cytopathology Challenge!  Weekly Cases

61 yo bladder wash s/p TURP.A. Benign changes. B. FungusC. Smooth muscle neoplasmD. SchistosomiasisE. High grade TCC 10

Instrumentation effect.


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