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S. Buku ajar ilmu kesehatan anak. Jilid I Bagian Ilmu Kesehatan Anak

Fakultas Kedokteran Universitas Indonesia Jakarta. 1991.

4. Sheth RD. Neonatal Seizure. Medscape. 2013.

5. L Hellstrom-Westas IA-W, J Agren, K Kallen. Incidence and risk factors

for neonatal seizure in Sweden. Archives of Disease in Childhood. 2008;

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6. Alberto Verrotti GL, Paola Cicioni, Claudio De Felice. New Trends in

Neonatal Seizures. Journal of Pediatric Neurology. 2004.

7. Swaiman. Pediatric Neurology Principles and Practice. 5 ed.

Philadelphia: Saunders Elsevier 2012, p.33-46.

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10. Saliba RM, Annegers FJ, Waller DK, Tyson JE and Mizrahi EM. Risk

factors for neonatal seizures: a population-based study, Harris County,

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Neonatologi. Edisi pertama. Jakarta: Ikatan Dokter Anak Indonesia, 2008.

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intra-amniotic infection. Obstetrics & Gynecology. 2007; 109: 739-49.

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seizures. Lippincott-Raven Philadelphia, 1998.

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51

52

53

Lampiran 3. Biodata Penulis

Nama : Atika Nurmalitasari

NIM : 22010110130162

Tempat/Tanggal lahir : Yogyakarta/30 Maret 1992

Jenis Kelamin : Perempuan

Alamat : Jalan Bukit Unggul I nomor 15 Sampangan, Semarang

Nomor Telepon/HP : (024) 8317987/081215575792

Email : atikanurmalitasari@gmail.com

RIWAYAT PENDIDIKAN FORMAL

1. TK : TK Hj ISRIATI SEMARANG 1996-1998

2. SD : SD Hj ISRIATI SEMARANG 1998-2004

3. SMP : SMPN 5 SEMARANG Lulus Tahun: 2007

4. SMA : SMAN 3 SEMAANG Lulus Tahun: 2010

5. FK UNDIP : Masuk Tahun : 2010

KEANGGOTAAN ORGANISASI

1. PASKIBRA SD Hj ISRIATI 2002-2004

2. PASKIBRA SMPN 5 2005-2007

3. OSIS SMPN 5 2006-2007

4. OSIS SMAN 3 2008-2009

5. CEMETI SMAN 3 2008-2009

6. BEM FK UNDIP Departemen Seni dan Olahraga 2010

54

Lampiran 4. Hasil Pengolahan SPSS

KARAKTERISTIK IBU a. Umur ibu (tahun)

Kelompok kasus

N Valid 60

Missing 60

Mean 28,40

Median 27,00

Std. Deviation 6,132

Variance 37,600

Skewness ,991

Std. Error of Skewness ,309

Kurtosis 1,145

Std. Error of Kurtosis ,608

Minimum 19

Maximum 48

Kelompok kontrol

N Valid 60

Missing 60

Mean 25,22

Median 23,00

Std. Deviation 5,205

Variance 27,088

Skewness 1,288

Std. Error of Skewness ,309

Kurtosis 1,233

Std. Error of Kurtosis ,608

Minimum 17

Maximum 42

Tests of Normality

Kolmogorov-Smirnov(a) Shapiro-Wilk

Statistic df Sig. Statistic df Sig.

umur ibu ,150 120 ,000 ,907 120 ,000

a Lilliefors Significance Correction

55

Mann-Whitney Test

Test Statistics(a)

Umur ibu

Mann-Whitney U 239.500

Wilcoxon W 539.500

Z -1.003

Asymp. Sig. (2-tailed) .003

Grouping Variable: kejang neonatus

B. Penyakit Kehamilan

penyakit kehamilan (kelompok kasus)

Frequency Percent Valid Percent

Cumulative

Percent

Valid 60 50,0 50,0 50,0

tidak 54 45,0 45,0 95,0

ya 6 5,0 5,0 100,0

Total 120 100,0 100,0

penyakit kehamilan (kelompok kontrol)

Frequency Percent Valid Percent

Cumulative

Percent

Valid 60 50,0 50,0 50,0

Tidak

60 50,0 50,0 100,0

Total 120 100,0 100,0

Chi-Square Tests

Value Df

Asymp. Sig. (2-

sided)

Pearson Chi-Square 120,000(a) 2 ,365

Likelihood Ratio 166,355 2 ,000

N of Valid Cases 120

56

KARAKTERISTIK NEONATUS

a. Berat lahir (gram)

Kelompok kasus

N Valid 60

Missing 60

Mean 2897,00

Median 2980,00

Std. Deviation 417,459

Variance 174272,20

3

Skewness -,147

Std. Error of Skewness ,309

Kurtosis ,467

Std. Error of Kurtosis ,608

Minimum 1800

Maximum 3900

Kelompok kontrol

N Valid 60

Missing 60

Mean 3083,17

Median 3000,00

Std. Deviation 479,178

Variance 229611,83

6

Skewness 1,087

Std. Error of Skewness ,309

Kurtosis 2,980

Std. Error of Kurtosis ,608

Minimum 2200

Maximum 5000

Tests of Normality

Kolmogorov-Smirnov(a) Shapiro-Wilk

Statistic df Sig. Statistic df Sig.

berat lahir ,147 120 ,000 ,957 120 ,001

a Lilliefors Significance Correction

57

Mann-Whitney Test

Test Statistics(a)

berat lahir

Mann-Whitney U 261.000

Wilcoxon W 561.000

Z -.560

Asymp. Sig. (2-tailed) .025

a Grouping Variable: kejang neonatus

b. Jenis kelamin Case Processing Summary

Cases

Valid Missing Total

N Percent N Percent N Percent

JK kontrol * JK kasus 60 100,0% 0 ,0% 60 100,0%

JK kontrol * JK kasus Crosstabulation

JK kasus Total

1 2 1

JK kontrol LAKI-LAKI Count 33 16 49

Expected Count 35,1 13,9 49,0

PEREMPUAN Count 10 1 11

Expected Count 7,9 3,1 11,0

Total Count 43 17 60

Expected Count 43,0 17,0 60,0

Chi-Square Tests

Value df Asymp. Sig.

(2-sided) Exact Sig. (2-sided)

Exact Sig. (1-sided)

Pearson Chi-Square 2,456(b) 1 ,195

Continuity Correction(a)

1,433 1 ,231

Likelihood Ratio 2,921 1 ,087

Fisher's Exact Test ,155 ,112

N of Valid Cases 60 a Computed only for a 2x2 table b 1 cells (25,0%) have expected count less than 5. The minimum expected count is 3,12

58

FREKUENSI SUBJEK PENELITIAN

Kelompok

60 50,0 50,0 50,0

60 50,0 50,0 100,0

120 100,0 100,0

Kasus

Kontrol

Total

Valid

Frequency Percent Valid Percent

Cumulat iv e

Percent

Infeksi IU

10 8,3 8,3 8,3

110 91,7 91,7 100,0

120 100,0 100,0

Ya

Tidak

Total

Valid

Frequency Percent Valid Percent

Cumulat iv e

Percent

Status paritas

65 54,2 54,2 54,2

55 45,8 45,8 100,0

120 100,0 100,0

primipara

multipara

Total

Valid

Frequency Percent Valid Percent

Cumulat iv e

Percent

cara.persal inan

31 25,8 25,8 25,8

89 74,2 74,2 100,0

120 100,0 100,0

SC

Perv aginam

Total

Valid

Frequency Percent Valid Percent

Cumulativ e

Percent

Gawat janin

24 20,0 20,0 20,0

96 80,0 80,0 100,0

120 100,0 100,0

Ya

Tidak

Total

Valid

Frequency Percent Valid Percent

Cumulat iv e

Percent

59

HASIL ANALISIS FAKTOR-FAKTOR YANG BERPENGARUH

A. Infeksi intrauterin

Resusitasi

37 30,8 30,8 30,8

83 69,2 69,2 100,0

120 100,0 100,0

Ya

Tidak

Total

Valid

Frequency Percent Valid Percent

Cumulat iv e

Percent

Masa gestasi

14 11,7 11,7 11,7

106 88,3 88,3 100,0

120 100,0 100,0

preterm

aterm

Total

Valid

Frequency Percent Valid Percent

Cumulat iv e

Percent

Crosstab

9 1 10

5,0 5,0 10,0

15,0% 1,7% 8,3%

7,5% ,8% 8,3%

51 59 110

55,0 55,0 110,0

85,0% 98,3% 91,7%

42,5% 49,2% 91,7%

60 60 120

60,0 60,0 120,0

100,0% 100,0% 100,0%

50,0% 50,0% 100,0%

Count

Expected Count

% within Kelompok

% of Total

Count

Expected Count

% within Kelompok

% of Total

Count

Expected Count

% within Kelompok

% of Total

Ya

Tidak

Inf eksi

IU

Total

Kasus Kontrol

Kelompok

Total

60

Chi-Square Tests

6,982b 1 ,008

5,345 1 ,021

7,944 1 ,005

,017 ,008

6,924 1 ,009

120

Pearson Chi-Square

Continuity Correctiona

Likelihood Ratio

Fisher's Exact Test

Linear-by-Linear

Association

N of Valid Cases

Value df

Asy mp. Sig.

(2-sided)

Exact Sig.

(2-sided)

Exact Sig.

(1-sided)

Computed only f or a 2x2 tablea.

0 cells (,0%) hav e expected count less than 5. The minimum expected count is

5,00.

b.

Risk Estimate

10,412 1,275 84,998

1,941 1,455 2,590

,186 ,029 1,207

120

Odds Rat io f or

Inf eksi IU (Ya / Tidak)

For cohort Kelompok

= Kasus

For cohort Kelompok

= Kontrol

N of Valid Cases

Value Lower Upper

95% Conf idence

Interv al

61

B. Status paritas

Chi-Square Tests

,034b 1 ,855

,000 1 1,000

,034 1 ,855

1,000 ,500

,033 1 ,855

120

Pearson Chi-Square

Continuity Correctiona

Likelihood Ratio

Fisher's Exact Test

Linear-by-Linear

Association

N of Valid Cases

Value df

Asy mp. Sig.

(2-sided)

Exact Sig.

(2-sided)

Exact Sig.

(1-sided)

Computed only f or a 2x2 tablea.

0 cells (,0%) hav e expected count less than 5. The minimum expected count is

27,50.

b.

Crosstab

32 33 65

32,5 32,5 65,0

53,3% 55,0% 54,2%

26,7% 27,5% 54,2%

28 27 55

27,5 27,5 55,0

46,7% 45,0% 45,8%

23,3% 22,5% 45,8%

60 60 120

60,0 60,0 120,0

100,0% 100,0% 100,0%

50,0% 50,0% 100,0%

Count

Expected Count

% within Kelompok

% of Total

Count

Expected Count

% within Kelompok

% of Total

Count

Expected Count

% within Kelompok

% of Total

primipara

multipara

Status paritas

Total

Kasus Kontrol

Kelompok

Total

Risk Estimate

,935 ,456 1,918

,967 ,676 1,384

1,034 ,721 1,483

120

Odds Rat io for Status

paritas (primipara /

multipara)

For cohort Kelompok

= Kasus

For cohort Kelompok

= Kontrol

N of Valid Cases

Value Lower Upper

95% Conf idence

Interv al

62

C. Cara Persalinan

Crosstab

18 13 31

15,5 15,5 31,0

30,0% 21,7% 25,8%

15,0% 10,8% 25,8%

42 47 89

44,5 44,5 89,0

70,0% 78,3% 74,2%

35,0% 39,2% 74,2%

60 60 120

60,0 60,0 120,0

100,0% 100,0% 100,0%

50,0% 50,0% 100,0%

Count

Expected Count

% within Kelompok

% of Total

Count

Expected Count

% within Kelompok

% of Total

Count

Expected Count

% within Kelompok

% of Total

SC

Perv aginam

cara.persalinan

Total

Kasus Kontrol

Kelompok

Total

Chi-Square Tests

1,087b 1 ,297

,696 1 ,404

1,091 1 ,296

,404 ,202

1,078 1 ,299

120

Pearson Chi-Square

Continuity Correctiona

Likelihood Ratio

Fisher's Exact Test

Linear-by-Linear

Association

N of Valid Cases

Value df

Asy mp. Sig.

(2-sided)

Exact Sig.

(2-sided)

Exact Sig.

(1-sided)

Computed only f or a 2x2 tablea.

0 cells (,0%) hav e expected count less than 5. The minimum expected count is

15,50.

b.

Risk Estimate

1,549 ,678 3,539

1,230 ,849 1,783

,794 ,502 1,256

120

Odds Ratio f or cara.

persalinan (SC /

Perv aginam)

For cohort

Kelompok = Kasus

For cohort

Kelompok = Kontrol

N of Valid Cases

Value Lower Upper

95% Conf idence

Interv al

63

D. Gawat Janin

Crosstab

21 3 24

12,0 12,0 24,0

35,0% 5,0% 20,0%

17,5% 2,5% 20,0%

39 57 96

48,0 48,0 96,0

65,0% 95,0% 80,0%

32,5% 47,5% 80,0%

60 60 120

60,0 60,0 120,0

100,0% 100,0% 100,0%

50,0% 50,0% 100,0%

Count

Expected Count

% within Kelompok

% of Total

Count

Expected Count

% within Kelompok

% of Total

Count

Expected Count

% within Kelompok

% of Total

Ya

Tidak

Gawat

janin

Total

Kasus Kontrol

Kelompok

Total

Chi-Square Tests

16,875b 1 ,000

15,052 1 ,000

18,581 1 ,000

,000 ,000

16,734 1 ,000

120

Pearson Chi-Square

Continuity Correctiona

Likelihood Ratio

Fisher's Exact Test

Linear-by-Linear

Association

N of Valid Cases

Value df

Asy mp. Sig.

(2-sided)

Exact Sig.

(2-sided)

Exact Sig.

(1-sided)

Computed only f or a 2x2 tablea.

0 cells (,0%) hav e expected count less than 5. The minimum expected count is

12,00.

b.

Risk Estimate

10,231 2,855 36,666

2,154 1,619 2,865

,211 ,072 ,615

120

Odds Rat io for Gawat

janin (Ya / Tidak)

For cohort Kelompok

= Kasus

For cohort Kelompok

= Kontrol

N of Valid Cases

Value Lower Upper

95% Conf idence

Interv al

64

E. Riwayat resusitasi

Crosstab

30 7 37

18,5 18,5 37,0

50,0% 11,7% 30,8%

25,0% 5,8% 30,8%

30 53 83

41,5 41,5 83,0

50,0% 88,3% 69,2%

25,0% 44,2% 69,2%

60 60 120

60,0 60,0 120,0

100,0% 100,0% 100,0%

50,0% 50,0% 100,0%

Count

Expected Count

% within Kelompok

% of Total

Count

Expected Count

% within Kelompok

% of Total

Count

Expected Count

% within Kelompok

% of Total

Ya

Tidak

Resusitasi

Total

Kasus Kontrol

Kelompok

Total

Chi-Square Tests

20,671b 1 ,000

18,912 1 ,000

21,857 1 ,000

,000 ,000

20,499 1 ,000

120

Pearson Chi-Square

Continuity Correctiona

Likelihood Ratio

Fisher's Exact Test

Linear-by-Linear

Association

N of Valid Cases

Value df

Asy mp. Sig.

(2-sided)

Exact Sig.

(2-sided)

Exact Sig.

(1-sided)

Computed only f or a 2x2 tablea.

0 cells (,0%) hav e expected count less than 5. The minimum expected count is

18,50.

b.

Risk Estimate

7,571 2,967 19,318

2,243 1,620 3,106

,296 ,149 ,589

120

Odds Rat io f or

Resusitasi (Ya / Tidak)

For cohort Kelompok =

Kasus

For cohort Kelompok =

Kontrol

N of Valid Cases

Value Lower Upper

95% Conf idence

Interv al

65

F. Masa Gestasi

Crosstab

6 8 14

7,0 7,0 14,0

10,0% 13,3% 11,7%

5,0% 6,7% 11,7%

54 52 106

53,0 53,0 106,0

90,0% 86,7% 88,3%

45,0% 43,3% 88,3%

60 60 120

60,0 60,0 120,0

100,0% 100,0% 100,0%

50,0% 50,0% 100,0%

Count

Expected Count

% within Kelompok

% of Total

Count

Expected Count

% within Kelompok

% of Total

Count

Expected Count

% within Kelompok

% of Total

preterm

aterm

Masa gestasi

Total

Kasus Kontrol

Kelompok

Total

Chi-Square Tests

,323b 1 ,570

,081 1 ,776

,324 1 ,569

,777 ,389

,321 1 ,571

120

Pearson Chi-Square

Continuity Correctiona

Likelihood Ratio

Fisher's Exact Test

Linear-by-Linear

Association

N of Valid Cases

Value df

Asy mp. Sig.

(2-sided)

Exact Sig.

(2-sided)

Exact Sig.

(1-sided)

Computed only f or a 2x2 tablea.

0 cells (,0%) hav e expected count less than 5. The minimum expected count is

7,00.

b.

Risk Estimate

,722 ,234 2,224

,841 ,447 1,584

1,165 ,711 1,908

120

Odds Rat io for Masa

gestasi (preterm / aterm)

For cohort Kelompok =

Kasus

For cohort Kelompok =

Kontrol

N of Valid Cases

Value Lower Upper

95% Conf idence

Interv al

66

ANALISIS MULTIVARIAT REGRESI LOGISTIK

Omnibus Tests of Model Coefficients

66.463 5 .000

66.463 5 .000

66.463 5 .000

-.471 1 .492

65.991 4 .000

65.991 4 .000

Step

Block

Model

Step

Block

Model

Step 1

Step 2a

Chi-square df Sig.

A negat iv e Chi-squares v alue indicates that the

Chi-squares value has decreased f rom the

prev ious step.

a.

Model Summary

99.893a .425 .567

100.364a .423 .564

Step

1

2

-2 Log

likelihood

Cox & Snell

R Square

Nagelkerke

R Square

Estimation terminated at iteration number 6 because

parameter est imates changed by less than .001.

a.

Classification Tablea

43 17 71.7

7 53 88.3

80.0

43 17 71.7

6 54 90.0

80.8

Observed

Kasus

Kontrol

Kelompok

Overall Percentage

Kasus

Kontrol

Kelompok

Overall Percentage

Step 1

Step 2

Kasus Kontrol

Kelompok Percentage

Correct

Predicted

The cut v alue is .500a.

67

Step Variabel p OR

95% CI

Bawah Atas

2 Infeksi IU 0,008 9,668 1,104 84,669

Gawat Janin 0,000 10,231 2,855 36,666

Resusitasi 0,000 7,384 0,284 19,167

Umur ibu 0,039 0,915 0,841 0,995

BBL 0,064 1,001 1,000 1,002

Variables in the Equation

-.095 .044 4.599 1 .032 .910 .834 .992

.001 .001 3.458 1 .063 1.001 1.000 1.002

.478 .709 .455 1 .500 1.613 .402 6.471

4.173 1.082 14.866 1 .000 64.891 7.780 541.231

2.367 .743 10.148 1 .001 10.667 2.486 45.768

-13.470 3.675 13.434 1 .000 .000

-.089 .043 4.276 1 .039 .915 .841 .995

.001 .001 3.419 1 .064 1.001 1.000 1.002

4.091 1.075 14.479 1 .000 59.813 7.271 492.023

2.343 .737 10.097 1 .001 10.417 2.455 44.206

-12.819 3.541 13.109 1 .000 .000

Umur.ibu

BBL

sex

Resusitasi

gawat.janin

Constant

Step

1a

Umur.ibu

BBL

Resusitasi

gawat.janin

Constant

Step

2a

B S.E. Wald df Sig. Exp(B) Lower Upper

95.0% C.I.f or EXP(B)

Variable(s) entered on step 1: Umur.ibu, BBL, sex, Resusitasi, gawat.janin.a.

Model if Term Removed

-52.419 4.946 1 .026

-51.835 3.778 1 .052

-50.182 .471 1 .492

-67.728 35.563 1 .000

-56.240 12.588 1 .000

-52.469 4.575 1 .032

-52.059 3.754 1 .053

-67.904 35.445 1 .000

-56.415 12.466 1 .000

Variable

Umur.ibu

BBL

sex

Resusitasi

gawat. janin

Step

1

Umur.ibu

BBL

Resusitasi

gawat. janin

Step

2

Model Log

Likelihood

Change in

-2 Log

Likelihood df

Sig. of the

Change

Variables not in the Equation

.458 1 .498

.458 1 .498

sexVariables

Overall Statistics

Step 2a

Score df Sig.

Variable(s) remov ed on step 2: sex.a.

68

Lampiran 5. Dokumentasi