621

" XBD=310 XHG=152 YBD=267 YHG=232>BIRAUD " XBD=376 XHG=331 YBD=264 YHG=233>to " XBD=473 XHG=398 YBD=263 YHG=228>call " XBD=526 XHG=491 YBD=263 YHG=229>it " XBD=570 XHG=546 YBD=263 YHG=240>a " XBD=616 XHG=594 YBD=242 YHG=228>&dquo; " XBD=940 XHG=632 YBD=273 YHG=229>hyperendemic " XBD=979 XHG=958 YBD=243 YHG=228>&dquo; " XBD=1137 XHG=1002 YBD=262 YHG=228>rather " XBD=1259 XHG=1157 YBD=262 YHG=228>than " XBD=1333 XHG=1279 YBD=261 YHG=239>an" XBD=346 XHG=151 YBD=327 YHG=279>epidemic. " XBD=443 XHG=401 YBD=312 YHG=278>It " XBD=549 XHG=470 YBD=312 YHG=276>will " XBD=627 XHG=578 YBD=310 YHG=277>be " XBD=827 XHG=657 YBD=311 YHG=276>recalled " XBD=947 XHG=854 YBD=310 YHG=277>that " XBD=1152 XHG=973 YBD=310 YHG=276>ZINSSER " XBD=1331 XHG=1179 YBD=320 YHG=275>always" XBD=390 XHG=151 YBD=365 YHG=326>maintained " XBD=504 XHG=410 YBD=360 YHG=326>that " XBD=593 XHG=523 YBD=359 YHG=325>the " XBD=766 XHG=614 YBD=370 YHG=325>typhus " XBD=831 XHG=787 YBD=358 YHG=323>of " XBD=977 XHG=848 YBD=358 YHG=325>urban " XBD=1095 XHG=997 YBD=358 YHG=325>New " XBD=1227 XHG=1114 YBD=358 YHG=324>York " XBD=1332 XHG=1248 YBD=359 YHG=324>and" XBD=308 XHG=151 YBD=417 YHG=379>Boston, " XBD=416 XHG=346 YBD=409 YHG=375>the " XBD=642 XHG=454 YBD=408 YHG=373>so-called " XBD=812 XHG=680 YBD=407 YHG=372>Brill’s " XBD=1012 XHG=848 YBD=413 YHG=373>disease, " XBD=1132 XHG=1052 YBD=406 YHG=383>was " XBD=1249 XHG=1171 YBD=407 YHG=373>due " XBD=1331 XHG=1286 YBD=406 YHG=375>to" XBD=334 XHG=151 YBD=472 YHG=425>epidemic " XBD=419 XHG=376 YBD=456 YHG=433>or " XBD=674 XHG=459 YBD=466 YHG=423>European " XBD=822 XHG=714 YBD=455 YHG=422>virus " XBD=995 XHG=860 YBD=454 YHG=421>rather " XBD=1136 XHG=1034 YBD=454 YHG=421>than " XBD=1220 XHG=1175 YBD=455 YHG=424>to " XBD=1331 XHG=1260 YBD=454 YHG=421>the" XBD=295 XHG=149 YBD=511 YHG=473>murine " XBD=420 XHG=311 YBD=505 YHG=472>virus " XBD=566 XHG=437 YBD=504 YHG=470>which " XBD=617 XHG=583 YBD=503 YHG=470>is " XBD=811 XHG=634 YBD=503 YHG=469>endemic " XBD=871 XHG=828 YBD=503 YHG=469>in " XBD=956 XHG=887 YBD=503 YHG=469>the " XBD=1163 XHG=974 YBD=503 YHG=469>southern " XBD=1333 XHG=1180 YBD=503 YHG=468>United" XBD=288 XHG=151 YBD=559 YHG=524>States. " XBD=383 XHG=342 YBD=553 YHG=520>It " XBD=432 XHG=399 YBD=552 YHG=519>is " XBD=576 XHG=448 YBD=552 YHG=518>found " XBD=737 XHG=592 YBD=551 YHG=517>almost " XBD=900 XHG=753 YBD=562 YHG=517>wholly " XBD=1061 XHG=916 YBD=561 YHG=528>among " XBD=1329 XHG=1078 YBD=563 YHG=517>immigrants" XBD=245 XHG=150 YBD=606 YHG=571>from " XBD=452 XHG=281 YBD=602 YHG=569>Eastern " XBD=664 XHG=493 YBD=611 YHG=567>Europe, " XBD=784 XHG=704 YBD=600 YHG=566>and " XBD=1002 XHG=822 YBD=599 YHG=566>ZINSSFR " XBD=1133 XHG=1040 YBD=600 YHG=528>herd " XBD=1260 XHG=1167 YBD=599 YHG=566>that " XBD=1331 XHG=1297 YBD=599 YHG=565>it" XBD=395 XHG=150 YBD=663 YHG=615>represented " XBD=436 XHG=412 YBD=649 YHG=627>a " XBD=754 XHG=452 YBD=649 YHG=614>recrudescence " XBD=816 XHG=772 YBD=648 YHG=613>of " XBD=1021 XHG=829 YBD=648 YHG=613>infection " XBD=1271 XHG=1039 YBD=648 YHG=613>contracted " XBD=1331 XHG=1288 YBD=646 YHG=614>in" XBD=281 XHG=152 YBD=701 YHG=666>earlier " XBD=424 XHG=309 YBD=708 YHG=674>years " XBD=534 XHG=452 YBD=697 YHG=663>and " XBD=672 XHG=562 YBD=707 YHG=662>lying " XBD=887 XHG=702 YBD=697 YHG=663>dormant " XBD=957 XHG=915 YBD=695 YHG=663>in " XBD=1054 XHG=985 YBD=696 YHG=663>the " XBD=1329 XHG=1082 YBD=696 YHG=661>meanwhile." XBD=198 XHG=152 YBD=750 YHG=715>In " XBD=347 XHG=229 YBD=747 YHG=713>much " XBD=454 XHG=385 YBD=746 YHG=712>the " XBD=603 XHG=495 YBD=745 YHG=723>same " XBD=735 XHG=634 YBD=755 YHG=722>way, " XBD=965 XHG=770 YBD=745 YHG=710>SERGENT " XBD=1147 XHG=998 YBD=752 YHG=711>thinks, " XBD=1331 XHG=1179 YBD=756 YHG=710>typnus" XBD=240 XHG=151 YBD=806 YHG=773>may " XBD=305 XHG=257 YBD=795 YHG=761>be " XBD=346 XHG=322 YBD=794 YHG=772>a " XBD=494 XHG=363 YBD=794 YHG=759>latent " XBD=702 XHG=510 YBD=793 YHG=759>infection " XBD=760 XHG=718 YBD=793 YHG=760>in " XBD=871 XHG=777 YBD=793 YHG=771>man " XBD=930 XHG=887 YBD=793 YHG=760>in " XBD=1078 XHG=947 YBD=794 YHG=759>North " XBD=1241 XHG=1094 YBD=800 YHG=758>Africa, " XBD=1331 XHG=1260 YBD=793 YHG=760>the" XBD=426 XHG=150 YBD=853 YHG=808>host-parasite " XBD=615 XHG=448 YBD=842 YHG=808>balance " XBD=843 XHG=636 YBD=853 YHG=808>becoming " XBD=980 XHG=863 YBD=853 YHG=812>upset " XBD=1058 XHG=1002 YBD=852 YHG=808>by " XBD=1230 XHG=1078 YBD=853 YHG=808>hunger " XBD=1332 XHG=1250 YBD=842 YHG=809>and" XBD=346 XHG=151 YBD=901 YHG=857>hardship. " XBD=452 XHG=401 YBD=889 YHG=856>In " XBD=640 XHG=471 YBD=901 YHG=859>support " XBD=704 XHG=659 YBD=890 YHG=855>of " XBD=799 XHG=718 YBD=890 YHG=857>this " XBD=918 XHG=817 YBD=890 YHG=857>view " XBD=1032 XHG=936 YBD=901 YHG=867>may " XBD=1099 XHG=1050 YBD=891 YHG=856>be " XBD=1242 XHG=1118 YBD=901 YHG=857>urged " XBD=1330 XHG=1258 YBD=891 YHG=857>the" XBD=392 XHG=152 YBD=951 YHG=915>appearance " XBD=448 XHG=403 YBD=939 YHG=903>of " XBD=643 XHG=460 YBD=949 YHG=904>sporadic " XBD=809 XHG=657 YBD=949 YHG=905>typhus " XBD=866 XHG=824 YBD=938 YHG=905>in " XBD=1032 XHG=883 YBD=939 YHG=904>central " XBD=1129 XHG=1048 YBD=939 YHG=905>and " XBD=1333 XHG=1141 YBD=939 YHG=905>southern" XBD=321 XHG=151 YBD=993 YHG=954>France; " XBD=433 XHG=351 YBD=986 YHG=952>this " XBD=524 XHG=450 YBD=986 YHG=952>has " XBD=643 XHG=542 YBD=987 YHG=954>been " XBD=806 XHG=660 YBD=987 YHG=952>almost " XBD=969 XHG=823 YBD=998 YHG=953>wholly " XBD=1028 XHG=986 YBD=986 YHG=954>in " XBD=1211 XHG=1045 YBD=987 YHG=953>arrivals " XBD=1333 XHG=1229 YBD=988 YHG=953>from" XBD=275 XHG=150 YBD=1036 YHG=1002>North " XBD=441 XHG=294 YBD=1041 YHG=1000>Africa, " XBD=537 XHG=464 YBD=1035 YHG=1004>not " XBD=654 XHG=559 YBD=1046 YHG=1000>only " XBD=716 XHG=673 YBD=1035 YHG=1002>in " XBD=870 XHG=735 YBD=1036 YHG=1005>recent " XBD=1068 XHG=890 YBD=1043 YHG=1002>arrivals, " XBD=1165 XHG=1091 YBD=1036 YHG=1002>but " XBD=1270 XHG=1186 YBD=1036 YHG=1002>also " XBD=1333 XHG=1290 YBD=1036 YHG=1003>in" XBD=301 XHG=151 YBD=1085 YHG=1050>natives " XBD=442 XHG=338 YBD=1084 YHG=1049>from " XBD=596 XHG=480 YBD=1084 YHG=1045>those " XBD=832 XHG=636 YBD=1084 YHG=1050>countries " XBD=1047 XHG=870 YBD=1096 YHG=1050>working " XBD=1127 XHG=1085 YBD=1085 YHG=1051>in " XBD=1330 XHG=1165 YBD=1086 YHG=1050>France." XBD=355 XHG=151 YBD=1133 YHG=1098>There’has " XBD=469 XHG=368 YBD=1133 YHG=1099>been " XBD=581 XHG=482 YBD=1144 YHG=1110>very " XBD=697 XHG=592 YBD=1133 YHG=1098>little " XBD=852 XHG=710 YBD=1145 YHG=1100>spread " XBD=908 XHG=864 YBD=1134 YHG=1102>to " XBD=1059 XHG=921 YBD=1134 YHG=1100>native " XBD=1332 XHG=1072 YBD=1135 YHG=1100>Frenchmen." XBD=232 XHG=152 YBD=1182 YHG=1147>One " XBD=326 XHG=253 YBD=1181 YHG=1158>can " XBD=500 XHG=345 YBD=1191 YHG=1146>readily " XBD=691 XHG=519 YBD=1193 YHG=1148>imagine " XBD=801 XHG=711 YBD=1182 YHG=1149>how " XBD=844 XHG=820 YBD=1182 YHG=1160>a " XBD=889 XHG=867 YBD=1162 YHG=1148>&dquo; " XBD=1254 XHG=908 YBD=1193 YHG=1148>hyperendemic,&dquo; |>" XBD=1336 XHG=1271 YBD=1194 YHG=1146>by" XBD=288 XHG=151 YBD=1239 YHG=1194>widely " XBD=472 XHG=312 YBD=1240 YHG=1195>seeding " XBD=567 XHG=498 YBD=1230 YHG=1196>the " XBD=781 XHG=592 YBD=1231 YHG=1196>infective " XBD=926 XHG=806 YBD=1242 YHG=1200>agent " XBD=993 XHG=950 YBD=1231 YHG=1197>in " XBD=1042 XHG=1018 YBD=1231 YHG=1209>a " XBD=1332 XHG=1069 YBD=1242 YHG=1198>community," XBD=263 XHG=152 YBD=1278 YHG=1243>could " XBD=443 XHG=278 YBD=1289 YHG=1255>prepare " XBD=530 XHG=459 YBD=1279 YHG=1244>the " XBD=637 XHG=547 YBD=1290 YHG=1257>way " XBD=714 XHG=651 YBD=1279 YHG=1244>for " XBD=754 XHG=730 YBD=1280 YHG=1257>a " XBD=860 XHG=770 YBD=1280 YHG=1248>true " XBD=1071 XHG=876 YBD=1291 YHG=1246>epidemic " XBD=1129 XHG=1086 YBD=1280 YHG=1246>in " XBD=1169 XHG=1145 YBD=1280 YHG=1258>a " XBD=1335 XHG=1186 YBD=1291 YHG=1245>wholly" XBD=383 XHG=150 YBD=1337 YHG=1292>susceptible " XBD=639 XHG=400 YBD=1339 YHG=1293>population " XBD=781 XHG=656 YBD=1339 YHG=1293>living " XBD=841 XHG=799 YBD=1328 YHG=1295>in " XBD=929 XHG=858 YBD=1329 YHG=1295>the " XBD=1056 XHG=948 YBD=1329 YHG=1306>same " XBD=1178 XHG=1075 YBD=1330 YHG=1306>area. " XBD=1247 XHG=1242 YBD=1296 YHG=1289>’" XBD=368 XHG=198 YBD=1384 YHG=1347>Defence " XBD=585 XHG=426 YBD=1394 YHG=1350>against " XBD=790 XHG=637 YBD=1396 YHG=1350>typhus " XBD=922 XHG=843 YBD=1385 YHG=1350>will " XBD=1122 XHG=975 YBD=1396 YHG=1350>clearly " XBD=1335 XHG=1172 YBD=1385 YHG=1350>involve" XBD=343 XHG=151 YBD=1433 YHG=1409>measures " XBD=405 XHG=360 YBD=1432 YHG=1397>of " XBD=669 XHG=418 YBD=1443 YHG=1398>quarantine, " XBD=969 XHG=687 YBD=1434 YHG=1399>louse-control " XBD=1067 XHG=985 YBD=1433 YHG=1400>and " XBD=1151 XHG=1081 YBD=1433 YHG=1400>the " XBD=1281 XHG=1166 YBD=1433 YHG=1399>relief " XBD=1339 XHG=1294 YBD=1433 YHG=1399>of" XBD=397 XHG=152 YBD=1481 YHG=1446>destitution. " XBD=576 XHG=451 YBD=1482 YHG=1446>What " XBD=654 XHG=620 YBD=1482 YHG=1448>is " XBD=769 XHG=700 YBD=1481 YHG=1448>the " XBD=930 XHG=816 YBD=1493 YHG=1448>place " XBD=1023 XHG=978 YBD=1482 YHG=1447>of " XBD=1249 XHG=1065 YBD=1482 YHG=1448>vaccines " XBD=1338 XHG=1294 YBD=1481 YHG=1443>in" XBD=466 XHG=151 YBD=1542 YHG=1495>supplementing " XBD=604 XHG=491 YBD=1531 YHG=1496>these " XBD=860 XHG=627 YBD=1532 YHG=1497>measures ? " XBD=1086 XHG=916 YBD=1531 YHG=1496>BIRAUD " XBD=1210 XHG=1110 YBD=1542 YHG=1509>very " XBD=1336 XHG=1233 YBD=1541 YHG=1496>fully" XBD=306 XHG=150 YBD=1579 YHG=1545>reviews " XBD=403 XHG=332 YBD=1579 YHG=1545>the " XBD=620 XHG=430 YBD=1580 YHG=1545>evidence " XBD=708 XHG=644 YBD=1581 YHG=1545>for " XBD=814 XHG=733 YBD=1580 YHG=1546>and " XBD=998 XHG=840 YBD=1591 YHG=1546>against " XBD=1093 XHG=1023 YBD=1580 YHG=1546>the " XBD=1335 XHG=1119 YBD=1581 YHG=1557>numerous" XBD=327 XHG=150 YBD=1629 YHG=1594>vaccines " XBD=471 XHG=342 YBD=1628 YHG=1594>which " XBD=591 XHG=486 YBD=1629 YHG=1594>have " XBD=707 XHG=606 YBD=1629 YHG=1595>been " XBD=835 XHG=720 YBD=1628 YHG=1594>tried. " XBD=953 XHG=889 YBD=1630 YHG=1594>He " XBD=1051 XHG=968 YBD=1629 YHG=1594>also " XBD=1175 XHG=1067 YBD=1639 YHG=1595>gives " XBD=1335 XHG=1191 YBD=1629 YHG=1593>details" XBD=193 XHG=152 YBD=1676 YHG=1642>of " XBD=286 XHG=218 YBD=1677 YHG=1643>the " XBD=552 XHG=316 YBD=1688 YHG=1643>techniques " XBD=643 XHG=581 YBD=1677 YHG=1642>for " XBD=778 XHG=673 YBD=1677 YHG=1643>their " XBD=1077 XHG=807 YBD=1688 YHG=1644>preparation. " XBD=1187 XHG=1129 YBD=1678 YHG=1642>Of " XBD=1336 XHG=1213 YBD=1683 YHG=1642>killed" XBD=338 XHG=150 YBD=1733 YHG=1692>vaccines, " XBD=553 XHG=375 YBD=1726 YHG=1692>whether " XBD=705 XHG=586 YBD=1726 YHG=1690>made " XBD=840 XHG=737 YBD=1726 YHG=1691>from " XBD=1088 XHG=873 YBD=1726 YHG=1692>rickettsiae " XBD=1256 XHG=1121 YBD=1737 YHG=1703>grown " XBD=1332 XHG=1288 YBD=1725 YHG=1692>in" XBD=344 XHG=150 YBD=1785 YHG=1740>louse-gut " XBD=555 XHG=364 YBD=1786 YHG=1740>(Weigl’s) " XBD=621 XHG=576 YBD=1776 YHG=1752>or " XBD=692 XHG=639 YBD=1775 YHG=1752>on " XBD=910 XHG=710 YBD=1785 YHG=1740>yolk-sacs " XBD=973 XHG=930 YBD=1775 YHG=1752>or " XBD=1032 XHG=990 YBD=1774 YHG=1741>in " XBD=1189 XHG=1045 YBD=1775 YHG=1740>rodent " XBD=1333 XHG=1203 YBD=1786 YHG=1740>lungs," XBD=256 XHG=149 YBD=1824 YHG=1789>there " XBD=311 XHG=278 YBD=1824 YHG=1790>is " XBD=407 XHG=333 YBD=1824 YHG=1793>not " XBD=546 XHG=424 YBD=1824 YHG=1790>much " XBD=656 XHG=569 YBD=1824 YHG=1801>new " XBD=770 XHG=677 YBD=1824 YHG=1790>that " XBD=868 XHG=795 YBD=1823 YHG=1801>can " XBD=941 XHG=891 YBD=1823 YHG=1789>be " XBD=1063 XHG=964 YBD=1823 YHG=1789>said. " XBD=1277 XHG=1116 YBD=1834 YHG=1788>Weigl’s " XBD=1334 XHG=1300 YBD=1823 YHG=1790>is" XBD=339 XHG=137 YBD=1883 YHG=1838>certainly " XBD=400 XHG=355 YBD=1873 YHG=1838>of " XBD=543 XHG=411 YBD=1880 YHG=1837>value, " XBD=636 XHG=560 YBD=1873 YHG=1839>but " XBD=894 XHG=651 YBD=1883 YHG=1838>admittedly " XBD=1058 XHG=911 YBD=1872 YHG=1841>cannot " XBD=1123 XHG=1074 YBD=1872 YHG=1838>be " XBD=1335 XHG=1138 YBD=1883 YHG=1839>prepared" XBD=200 XHG=151 YBD=1921 YHG=1899>on " XBD=243 XHG=220 YBD=1921 YHG=1899>a " XBD=364 XHG=264 YBD=1932 YHG=1899>very " XBD=492 XHG=383 YBD=1932 YHG=1886>large " XBD=630 XHG=514 YBD=1921 YHG=1886>scale. " XBD=769 XHG=685 YBD=1920 YHG=1887>The " XBD=926 XHG=791 YBD=1921 YHG=1887>others " XBD=1014 XHG=948 YBD=1920 YHG=1898>are " XBD=1153 XHG=1036 YBD=1931 YHG=1887>being " XBD=1336 XHG=1175 YBD=1921 YHG=1886>studied" XBD=200 XHG=150 YBD=1970 YHG=1934>all " XBD=327 XHG=233 YBD=1970 YHG=1948>over " XBD=431 XHG=360 YBD=1970 YHG=1935>the " XBD=603 XHG=465 YBD=1977 YHG=1935>world, " XBD=715 XHG=639 YBD=1970 YHG=1935>but " XBD=818 XHG=747 YBD=1969 YHG=1935>the " XBD=1040 XHG=852 YBD=1969 YHG=1935>evidence " XBD=1118 XHG=1075 YBD=1969 YHG=1947>as " XBD=1196 XHG=1152 YBD=1969 YHG=1938>to " XBD=1336 XHG=1230 YBD=1969 YHG=1935>their" XBD=336 XHG=150 YBD=2030 YHG=1984>practical " XBD=584 XHG=363 YBD=2019 YHG=1984>usefulness " XBD=643 XHG=610 YBD=2018 YHG=1985>is " XBD=743 XHG=669 YBD=2019 YHG=1987>not " XBD=1074 XHG=768 YBD=2029 YHG=1983>yet. available. " XBD=1177 XHG=1127 YBD=2017 YHG=1983>In " XBD=1335 XHG=1202 YBD=2018 YHG=1983>North" XBD=292 XHG=150 YBD=2075 YHG=2033>Africa, " XBD=466 XHG=321 YBD=2068 YHG=2034>BLANC " XBD=577 XHG=496 YBD=2068 YHG=2034>and " XBD=793 XHG=604 YBD=2068 YHG=2033>LAIGRET " XBD=925 XHG=820 YBD=2067 YHG=2029>have " XBD=1121 XHG=952 YBD=2067 YHG=2032>evolved " XBD=1334 XHG=1148 YBD=2067 YHG=2033>vaccines" XBD=273 XHG=150 YBD=2117 YHG=2083>which " XBD=361 XHG=295 YBD=2116 YHG=2094>are " XBD=482 XHG=383 YBD=2127 YHG=2094>very " XBD=702 XHG=504 YBD=2123 YHG=2082>different, " XBD=800 XHG=724 YBD=2116 YHG=2083>but " XBD=1012 XHG=819 YBD=2116 YHG=2081>resemble " XBD=1132 XHG=1034 YBD=2116 YHG=2082>each " XBD=1269 XHG=1154 YBD=2116 YHG=2082>other " XBD=1334 XHG=1290 YBD=2115 YHG=2082>in" XBD=376 XHG=151 YBD=2176 YHG=2131>containing " XBD=525 XHG=399 YBD=2176 YHG=2131>living " XBD=704 XHG=549 YBD=2165 YHG=2132>murine " XBD=953 XHG=727 YBD=2165 YHG=2130>rickettsise." XBD=281 XHG=198 YBD=2222 YHG=2188>One " XBD=441 XHG=304 YBD=2231 YHG=2190>strong " XBD=673 XHG=463 YBD=2231 YHG=2189>argument " XBD=823 XHG=695 YBD=2220 YHG=2186>which " XBD=915 XHG=843 YBD=2219 YHG=2186>the " XBD=1090 XHG=935 YBD=2220 YHG=2186>French " XBD=1216 XHG=1110 YBD=2219 YHG=2186>have " XBD=1337 XHG=1237 YBD=2220 YHG=2185>used" XBD=188 XHG=149 YBD=2269 YHG=2236>in " XBD=349 XHG=207 YBD=2270 YHG=2236>favour " XBD=416 XHG=372 YBD=2269 YHG=2235>of " XBD=457 XHG=433 YBD=2269 YHG=2247>a " XBD=603 XHG=477 YBD=2279 YHG=2235>living " XBD=785 XHG=623 YBD=2268 YHG=2235>vaccine " XBD=848 XHG=805 YBD=2268 YHG=2234>in " XBD=999 XHG=867 YBD=2268 YHG=2234>North " XBD=1154 XHG=1020 YBD=2268 YHG=2233>Africa " XBD=1209 XHG=1175 YBD=2268 YHG=2235>is " XBD=1336 XHG=1229 YBD=2276 YHG=2235>that," XBD=189 XHG=149 YBD=2318 YHG=2284>in " XBD=395 XHG=209 YBD=2331 YHG=2284>practice, " XBD=451 XHG=418 YBD=2317 YHG=2284>it " XBD=507 XHG=472 YBD=2317 YHG=2284>is " XBD=601 XHG=528 YBD=2317 YHG=2286>not " XBD=786 XHG=623 YBD=2318 YHG=2282>feasible " XBD=851 XHG=807 YBD=2317 YHG=2285>to " XBD=1086 XHG=873 YBD=2317 YHG=2282>immunise " XBD=1176 XHG=1106 YBD=2317 YHG=2283>the " XBD=1338 XHG=1198 YBD=2317 YHG=2283>native" XBD=382 XHG=150 YBD=2379 YHG=2333>population " XBD=461 XHG=404 YBD=2377 YHG=2333>by " XBD=565 XHG=483 YBD=2377 YHG=2344>any " XBD=755 XHG=587 YBD=2366 YHG=2332>method " XBD=982 XHG=774 YBD=2377 YHG=2331>involving " XBD=1113 XHG=1004 YBD=2366 YHG=2343>more " XBD=1239 XHG=1135 YBD=2366 YHG=2331>than " XBD=1338 XHG=1261 YBD=2366 YHG=2343>one" XBD=348 XHG=149 YBD=2426 YHG=2382>injection. " XBD=487 XHG=402 YBD=2415 YHG=2382>But " XBD=630 XHG=521 YBD=2415 YHG=2381>what " XBD=697 XHG=663 YBD=2414 YHG=2381>is " XBD=948 XHG=730 YBD=2424 YHG=2380>justifiable " XBD=1065 XHG=984 YBD=2415 YHG=2381>and " XBD=1183 XHG=1099 YBD=2414 YHG=2380>safe " XBD=1278 XHG=1216 YBD=2415 YHG=2379>for " XBD=1338 XHG=1313 YBD=2415 YHG=2393>a" XBD=274 XHG=149 YBD=2465 YHG=2430>salted " XBD=539 XHG=299 YBD=2474 YHG=2429>population " XBD=659 XHG=563 YBD=2473 YHG=2440>may " XBD=734 XHG=684 YBD=2463 YHG=2429>be " XBD=907 XHG=758 YBD=2463 YHG=2429>unwise " XBD=994 XHG=931 YBD=2463 YHG=2428>for " XBD=1266 XHG=1020 YBD=2475 YHG=2429>Europeans, " XBD=1338 XHG=1294 YBD=2464 YHG=2429>in" XBD=324 XHG=150 YBD=2513 YHG=2478>whom ‘‘ " XBD=524 XHG=341 YBD=2512 YHG=2477>vaccinal " XBD=740 XHG=546 YBD=2523 YHG=2477>typhus &dquo; " XBD=798 XHG=765 YBD=2511 YHG=2478>is " XBD=930 XHG=820 YBD=2511 YHG=2489>more " XBD=1025 XHG=952 YBD=2523 YHG=2481>apt " XBD=1092 XHG=1047 YBD=2512 YHG=2481>to " XBD=1233 XHG=1115 YBD=2512 YHG=2489>occur " XBD=1338 XHG=1256 YBD=2513 YHG=2478>and" XBD=240 XHG=149 YBD=2571 YHG=2537>may " XBD=304 XHG=254 YBD=2561 YHG=2528>be " XBD=343 XHG=318 YBD=2560 YHG=2539>a " XBD=468 XHG=357 YBD=2560 YHG=2538>more " XBD=631 XHG=482 YBD=2560 YHG=2527>serious " XBD=808 XHG=646 YBD=2560 YHG=2526>disease. " XBD=939 XHG=855 YBD=2560 YHG=2527>The " XBD=1083 XHG=952 YBD=2571 YHG=2526>recipe " XBD=1158 XHG=1096 YBD=2561 YHG=2526>for " XBD=1337 XHG=1172 YBD=2572 YHG=2527>making" XBD=305 XHG=114 YBD=2609 YHG=2574>Blane’s " XBD=493 XHG=328 YBD=2609 YHG=2575>vaccine " XBD=639 XHG=519 YBD=2608 YHG=2586>runs : " XBD=837 XHG=688 YBD=2608 YHG=2574>&dquo; Take " XBD=1003 XHG=864 YBD=2617 YHG=2576>50,000 " XBD=1094 XHG=1029 YBD=2609 YHG=2578>rat " XBD=1230 XHG=1120 YBD=2617 YHG=2575>fleas, " XBD=1337 XHG=1254 YBD=2610 YHG=2576>add" XBD=225 XHG=148 YBD=2657 YHG=2626>two " XBD=589 XHG=242 YBD=2668 YHG=2622>typhus-infected " XBD=810 XHG=605 YBD=2657 YHG=2622>rats ...&dquo; " XBD=912 XHG=830 YBD=2657 YHG=2624>and " XBD=973 XHG=930 YBD=2658 YHG=2635>so " XBD=1071 XHG=992 YBD=2664 YHG=2635>on ; " XBD=1339 XHG=1107 YBD=2669 YHG=2624>ultimately" XBD=225 XHG=149 YBD=2714 YHG=2682>you " XBD=350 XHG=245 YBD=2705 YHG=2672>have " XBD=419 XHG=373 YBD=2705 YHG=2673>10 " XBD=475 XHG=439 YBD=2716 YHG=2683>g. " XBD=544 XHG=500 YBD=2705 YHG=2670>of " XBD=636 XHG=560 YBD=2706 YHG=2671>flea " XBD=782 XHG=654 YBD=2706 YHG=2670>faeces. " XBD=920 XHG=837 YBD=2706 YHG=2672>The " XBD=1049 XHG=939 YBD=2706 YHG=2664>virus " XBD=1102 XHG=1069 YBD=2706 YHG=2673>is " XBD=1235 XHG=1123 YBD=2707 YHG=2673>dried " XBD=1337 XHG=1255 YBD=2707 YHG=2673>and" XBD=302 XHG=148 YBD=2754 YHG=2720>treated " XBD=421 XHG=322 YBD=2754 YHG=2720>with " XBD=522 XHG=443 YBD=2754 YHG=2719>bile " XBD=627 XHG=543 YBD=2763 YHG=2719>just " XBD=886 XHG=649 YBD=2755 YHG=2719>before use. " XBD=1068 XHG=941 YBD=2755 YHG=2720>There " XBD=1122 XHG=1088 YBD=2755 YHG=2722>is " XBD=1195 XHG=1143 YBD=2755 YHG=2733>no " XBD=1337 XHG=1219 YBD=2755 YHG=2721>claim" XBD=236 XHG=148 YBD=2801 YHG=2767>that " XBD=318 XHG=249 YBD=2801 YHG=2768>the " XBD=500 XHG=331 YBD=2802 YHG=2768>biliated " XBD=622 XHG=512 YBD=2802 YHG=2768>virus " XBD=668 XHG=634 YBD=2802 YHG=2768>is " XBD=961 XHG=681 YBD=2814 YHG=2769>permanently " XBD=1225 XHG=973 YBD=2810 YHG=2770>attenuated, " XBD=1338 XHG=1241 YBD=2813 YHG=2768>only" XBD=236 XHG=147 YBD=2849 YHG=2815>that " XBD=311 XHG=269 YBD=2849 YHG=2817>in " XBD=520 XHG=345 YBD=2860 YHG=2816>practice " XBD=587 XHG=553 YBD=2851 YHG=2817>it " XBD=751 XHG=621 YBD=2861 YHG=2817>rarely " XBD=922 XHG=786 YBD=2852 YHG=2829>causes " XBD=1137 XHG=956 YBD=2851 YHG=2817>vaccinal " XBD=1335 XHG=1169 YBD=2862 YHG=2818>typhus." XBD=336 XHG=147 YBD=2907 YHG=2861>Laigret’s vaccine " XBD=560 XHG=526 YBD=2899 YHG=2865>is " XBD=691 XHG=573 YBD=2899 YHG=2866>made " XBD=807 XHG=704 YBD=2899 YHG=2865>from " XBD=955 XHG=820 YBD=2900 YHG=2866>brains " XBD=1014 XHG=969 YBD=2899 YHG=2865>of " XBD=1118 XHG=1022 YBD=2906 YHG=2869>rats, " XBD=1215 XHG=1133 YBD=2899 YHG=2866>and " XBD=1338 XHG=1227 YBD=2898 YHG=2876>more" XBD=321 XHG=147 YBD=2955 YHG=2911>recently " XBD=449 XHG=335 YBD=2953 YHG=2913>mice, " XBD=642 XHG=465 YBD=2947 YHG=2912>infected " XBD=754 XHG=657 YBD=2948 YHG=2914>with " XBD=924 XHG=769 YBD=2948 YHG=2915>murine " XBD=1116 XHG=938 YBD=2959 YHG=2914>typhus ; " XBD=1339 XHG=1147 YBD=2957 YHG=2912>formerly" XBD=198 XHG=148 YBD=2991 YHG=2969>an " XBD=305 XHG=225 YBD=3004 YHG=2959>oily " XBD=535 XHG=333 YBD=3005 YHG=2961>excipient " XBD=643 XHG=562 YBD=2996 YHG=2974>was " XBD=782 XHG=670 YBD=3003 YHG=2963>used, " XBD=885 XHG=809 YBD=2997 YHG=2963>but " XBD=993 XHG=911 YBD=2996 YHG=2962>this " XBD=1092 XHG=1019 YBD=2995 YHG=2962>has " XBD=1210 XHG=1117 YBD=2995 YHG=2973>now " XBD=1339 XHG=1236 YBD=2995 YHG=2961>been" XBD=325 XHG=144 YBD=3050 YHG=3007>replaced " XBD=399 XHG=342 YBD=3053 YHG=3008>by " XBD=552 XHG=416 YBD=3044 YHG=3012>water. " XBD=648 XHG=610 YBD=3044 YHG=3011>It " XBD=699 XHG=665 YBD=3043 YHG=3010>is " XBD=885 XHG=718 YBD=3050 YHG=3010>claimed " XBD=996 XHG=903 YBD=3043 YHG=3011>that " XBD=1177 XHG=1014 YBD=3049 YHG=3009>220,000 " XBD=1338 XHG=1196 YBD=3054 YHG=3009>people" XBD=247 XHG=147 YBD=3088 YHG=3052>have " XBD=381 XHG=280 YBD=3090 YHG=3056>been " XBD=539 XHG=413 YBD=3102 YHG=3056>lately " XBD=819 XHG=572 YBD=3098 YHG=3047>inoculated " XBD=1007 XHG=836 YBD=3092 YHG=3058>without " XBD=1122 XHG=1040 YBD=3101 YHG=3069>any " XBD=1338 XHG=1154 YBD=3091 YHG=3057>vaccinal" XBD=293 XHG=146 YBD=3146 YHG=3103>typhus " XBD=560 XHG=309 YBD=3150 YHG=3104>developing. " XBD=783 XHG=615 YBD=3150 YHG=3094>Though " XBD=919 XHG=798 YBD=3139 YHG=3106>much " XBD=1043 XHG=934 YBD=3139 YHG=3116>more " XBD=1248 XHG=1060 YBD=3138 YHG=3105>evidence " XBD=1338 XHG=1264 YBD=3139 YHG=3105>has" XBD=244 XHG=147 YBD=3184 YHG=3149>been " XBD=333 XHG=258 YBD=3196 YHG=3155>put " XBD=521 XHG=347 YBD=3187 YHG=3152>forward " XBD=598 XHG=536 YBD=3186 YHG=3153>for " XBD=682 XHG=613 YBD=3186 YHG=3154>the " XBD=861 XHG=698 YBD=3196 YHG=3153>efficacy " XBD=922 XHG=876 YBD=3186 YHG=3152>of " XBD=1043 XHG=931 YBD=3186 YHG=3153>these " XBD=1138 XHG=1058 YBD=3185 YHG=3152>live " XBD=1338 XHG=1153 YBD=3186 YHG=3152>vaccines" XBD=243 XHG=146 YBD=3232 YHG=3198>than " XBD=339 XHG=278 YBD=3233 YHG=3199>for " XBD=499 XHG=376 YBD=3234 YHG=3200>killed " XBD=643 XHG=536 YBD=3241 YHG=3212>ones, " XBD=795 XHG=682 YBD=3234 YHG=3201>there " XBD=898 XHG=832 YBD=3233 YHG=3212>are " XBD=1039 XHG=935 YBD=3243 YHG=3200>good " XBD=1238 XHG=1075 YBD=3233 YHG=3211>reasons " XBD=1338 XHG=1275 YBD=3234 YHG=3200>for" XBD=358 XHG=146 YBD=3292 YHG=3244>hesitating " XBD=443 XHG=398 YBD=3282 YHG=3251>to " XBD=625 XHG=484 YBD=3292 YHG=3252>accept " XBD=777 XHG=664 YBD=3281 YHG=3248>them " XBD=878 XHG=816 YBD=3281 YHG=3247>for " XBD=1077 XHG=919 YBD=3291 YHG=3247>general " XBD=1199 XHG=1116 YBD=3281 YHG=3259>use. " XBD=1338 XHG=1253 YBD=3281 YHG=3248>The" XBD=286 XHG=146 YBD=3329 YHG=3295>results " XBD=372 XHG=304 YBD=3330 YHG=3307>are " XBD=633 XHG=391 YBD=3340 YHG=3295>apparently " XBD=894 XHG=650 YBD=3335 YHG=3296>inconstant, " XBD=1087 XHG=915 YBD=3340 YHG=3296>perhaps " XBD=1275 XHG=1106 YBD=3329 YHG=3296>because " XBD=1342 XHG=1297 YBD=3330 YHG=3295>of" XBD=367 XHG=145 YBD=3377 YHG=3340>difficulties " XBD=426 XHG=384 YBD=3377 YHG=3345>in " XBD=811 XHG=444 YBD=3383 YHG=3343>standardisation ; " XBD=1164 XHG=848 YBD=3388 YHG=3343>comparatively " XBD=1285 XHG=1179 YBD=3377 YHG=3343>little " XBD=1337 XHG=1304 YBD=3377 YHG=3344>is" XBD=289 XHG=146 YBD=3425 YHG=3390>known " XBD=362 XHG=316 YBD=3425 YHG=3391>of " XBD=456 XHG=386 YBD=3425 YHG=3392>the " XBD=554 XHG=483 YBD=3425 YHG=3403>use " XBD=628 XHG=583 YBD=3424 YHG=3391>of " XBD=764 XHG=651 YBD=3424 YHG=3391>these " XBD=975 XHG=791 YBD=3424 YHG=3391>vaccines " XBD=1044 XHG=1002 YBD=3424 YHG=3392>in " XBD=1335 XHG=1073 YBD=3435 YHG=3392>Europeans ;" XBD=253 XHG=145 YBD=3474 YHG=3439>there " XBD=306 XHG=273 YBD=3473 YHG=3440>is " XBD=399 XHG=327 YBD=3473 YHG=3443>not " XBD=518 XHG=420 YBD=3473 YHG=3436>such " XBD=777 XHG=541 YBD=3483 YHG=3438>convincing " XBD=986 XHG=797 YBD=3472 YHG=3439>evidence " XBD=1050 XHG=1007 YBD=3472 YHG=3450>as " XBD=1128 XHG=1071 YBD=3472 YHG=3451>we " XBD=1254 XHG=1149 YBD=3472 YHG=3439>have " XBD=1338 XHG=1274 YBD=3472 YHG=3438>for

" XBD=1463 XHG=1392 YBD=262 YHG=228>the " XBD=1604 XHG=1493 YBD=262 YHG=228>virus " XBD=1732 XHG=1633 YBD=262 YHG=228>used " XBD=1823 XHG=1760 YBD=261 YHG=227>for " XBD=2121 XHG=1852 YBD=272 YHG=227>yellow-fever " XBD=2413 XHG=2150 YBD=269 YHG=227>inoculation, " XBD=2539 XHG=2444 YBD=262 YHG=228>that " XBD=2592 XHG=2568 YBD=262 YHG=240>a" XBD=1523 XHG=1393 YBD=310 YHG=277>stable " XBD=1791 XHG=1551 YBD=310 YHG=276>attenuated " XBD=1946 XHG=1819 YBD=310 YHG=276>strain " XBD=2005 XHG=1971 YBD=309 YHG=276>is " XBD=2077 XHG=2032 YBD=309 YHG=278>to " XBD=2226 XHG=2102 YBD=316 YHG=275>hand, " XBD=2338 XHG=2256 YBD=310 YHG=276>and " XBD=2437 XHG=2365 YBD=310 YHG=276>the " XBD=2591 XHG=2464 YBD=310 YHG=274>Blanc" XBD=1569 XHG=1392 YBD=365 YHG=326>vaccine, " XBD=1679 XHG=1604 YBD=359 YHG=335>one " XBD=1821 XHG=1712 YBD=359 YHG=327>must " XBD=1995 XHG=1854 YBD=365 YHG=325>admit, " XBD=2126 XHG=2030 YBD=358 YHG=324>does " XBD=2232 XHG=2159 YBD=358 YHG=327>not " XBD=2398 XHG=2266 YBD=358 YHG=321>sound " XBD=2456 XHG=2431 YBD=358 YHG=336>a " XBD=2588 XHG=2488 YBD=369 YHG=335>very" XBD=1594 XHG=1394 YBD=417 YHG=372>&dquo;elegant " XBD=1922 XHG=1624 YBD=418 YHG=373>preparation.&dquo; " XBD=2257 XHG=1976 YBD=407 YHG=371>Nevertheless " XBD=2321 XHG=2286 YBD=406 YHG=372>it " XBD=2383 XHG=2349 YBD=406 YHG=373>is " XBD=2519 XHG=2413 YBD=417 YHG=373>good " XBD=2597 XHG=2547 YBD=407 YHG=376>to" XBD=1512 XHG=1391 YBD=455 YHG=420>know " XBD=1629 XHG=1536 YBD=455 YHG=422>that " XBD=1730 XHG=1648 YBD=455 YHG=422>this " XBD=1859 XHG=1749 YBD=456 YHG=422>work " XBD=1911 XHG=1876 YBD=455 YHG=422>is " XBD=2048 XHG=1929 YBD=466 YHG=422>going " XBD=2147 XHG=2068 YBD=462 YHG=432>on ; " XBD=2259 XHG=2184 YBD=455 YHG=431>one " XBD=2355 XHG=2278 YBD=455 YHG=432>can " XBD=2548 XHG=2372 YBD=465 YHG=421>imagine " XBD=2592 XHG=2568 YBD=454 YHG=432>a" XBD=1588 XHG=1392 YBD=503 YHG=469>situation " XBD=1672 XHG=1620 YBD=503 YHG=481>on " XBD=1772 XHG=1703 YBD=504 YHG=470>the " XBD=2019 XHG=1805 YBD=517 YHG=471>European " XBD=2269 XHG=2051 YBD=504 YHG=470>Continent " XBD=2344 XHG=2301 YBD=502 YHG=469>in " XBD=2507 XHG=2375 YBD=503 YHG=469>which " XBD=2592 XHG=2538 YBD=503 YHG=480>an" XBD=1633 XHG=1392 YBD=552 YHG=518>attenuated " XBD=1778 XHG=1653 YBD=563 YHG=518>living " XBD=1964 XHG=1800 YBD=553 YHG=506>vaccine " XBD=2118 XHG=1984 YBD=553 YHG=518>would " XBD=2231 XHG=2139 YBD=564 YHG=517>help " XBD=2298 XHG=2253 YBD=552 YHG=520>to " XBD=2415 XHG=2320 YBD=562 YHG=518>gain " XBD=2592 XHG=2437 YBD=551 YHG=516>control" XBD=1507 XHG=1391 YBD=600 YHG=567>when " XBD=1653 XHG=1530 YBD=600 YHG=565>killed " XBD=1859 XHG=1676 YBD=601 YHG=567>vaccines " XBD=2016 XHG=1883 YBD=602 YHG=567>would " XBD=2089 XHG=2039 YBD=602 YHG=568>be " XBD=2269 XHG=2112 YBD=601 YHG=567>neither " XBD=2496 XHG=2293 YBD=601 YHG=565>available " XBD=2593 XHG=2518 YBD=600 YHG=577>nor" XBD=1627 XHG=1391 YBD=659 YHG=614>applicable.

DICOUMARIN FOR THROMBOSIS" XBD=1499 XHG=1446 YBD=794 YHG=761>IN " XBD=1619 XHG=1524 YBD=794 YHG=761>1933 " XBD=1710 XHG=1640 YBD=794 YHG=760>the " XBD=1989 XHG=1730 YBD=804 YHG=758>preparation " XBD=2053 XHG=2008 YBD=793 YHG=759>of " XBD=2281 XHG=2068 YBD=805 YHG=760>relatively " XBD=2400 XHG=2300 YBD=805 YHG=771>pure " XBD=2595 XHG=2421 YBD=806 YHG=759>samples" XBD=1441 XHG=1397 YBD=843 YHG=808>of " XBD=1630 XHG=1461 YBD=853 YHG=809>heparin " XBD=1746 XHG=1652 YBD=842 YHG=808>that " XBD=1887 XHG=1770 YBD=842 YHG=807>could " XBD=2038 XHG=1912 YBD=853 YHG=808>safely " XBD=2110 XHG=2061 YBD=843 YHG=808>be " XBD=2253 XHG=2133 YBD=854 YHG=809>given " XBD=2321 XHG=2276 YBD=843 YHG=812>to " XBD=2525 XHG=2344 YBD=854 YHG=809>patients " XBD=2595 XHG=2548 YBD=843 YHG=812>to" XBD=1516 XHG=1396 YBD=892 YHG=857>make " XBD=1637 XHG=1533 YBD=891 YHG=857>their " XBD=1770 XHG=1650 YBD=891 YHG=857>blood " XBD=1858 XHG=1781 YBD=891 YHG=856>less " XBD=2108 XHG=1876 YBD=902 YHG=856>coagulable " XBD=2185 XHG=2119 YBD=891 YHG=857>led " XBD=2246 XHG=2201 YBD=891 YHG=860>to " XBD=2530 XHG=2258 YBD=902 YHG=858>experiments " XBD=2595 XHG=2547 YBD=892 YHG=861>to" XBD=1618 XHG=1396 YBD=940 YHG=905>determine " XBD=1722 XHG=1632 YBD=940 YHG=906>how " XBD=1863 XHG=1734 YBD=940 YHG=905>useful " XBD=2043 XHG=1875 YBD=951 YHG=906>heparin " XBD=2189 XHG=2056 YBD=940 YHG=905>would " XBD=2253 XHG=2202 YBD=940 YHG=906>be " XBD=2309 XHG=2265 YBD=939 YHG=906>in " XBD=2597 XHG=2321 YBD=951 YHG=906>pathological" XBD=1654 XHG=1396 YBD=995 YHG=955>thrombosis, " XBD=1784 XHG=1684 YBD=989 YHG=955>both " XBD=1997 XHG=1818 YBD=1000 YHG=955>primary " XBD=2105 XHG=2023 YBD=989 YHG=954>and " XBD=2340 XHG=2136 YBD=1000 YHG=954>following " XBD=2589 XHG=2367 YBD=991 YHG=955>embolism." XBD=1481 XHG=1397 YBD=1038 YHG=1004>The |>" XBD=1690 XHG=1516 YBD=1037 YHG=1003>results showed " XBD=2027 XHG=1934 YBD=1038 YHG=1002>that " XBD=2161 XHG=2063 YBD=1038 YHG=1004>such " XBD=2250 XHG=2196 YBD=1037 YHG=1015>an " XBD=2594 XHG=2285 YBD=1049 YHG=1004>anticoagulant" XBD=1534 XHG=1397 YBD=1087 YHG=1053>action " XBD=1639 XHG=1557 YBD=1087 YHG=1064>was " XBD=1808 XHG=1663 YBD=1088 YHG=1053>indeed " XBD=2041 XHG=1834 YBD=1094 YHG=1051>desirable, " XBD=2144 XHG=2068 YBD=1088 YHG=1052>but " XBD=2239 XHG=2168 YBD=1087 YHG=1052>the " XBD=2334 XHG=2263 YBD=1087 YHG=1064>use " XBD=2405 XHG=2359 YBD=1087 YHG=1051>of " XBD=2596 XHG=2425 YBD=1098 YHG=1052>heparin" XBD=1470 XHG=1396 YBD=1137 YHG=1100>has " XBD=1567 XHG=1494 YBD=1137 YHG=1105>not " XBD=1693 XHG=1592 YBD=1136 YHG=1102>been " XBD=1886 XHG=1717 YBD=1147 YHG=1101>popular " XBD=1972 XHG=1910 YBD=1137 YHG=1100>for " XBD=2148 XHG=1996 YBD=1137 YHG=1101>several " XBD=2347 XHG=2171 YBD=1136 YHG=1113>reasons. " XBD=2454 XHG=2403 YBD=1136 YHG=1101>In |>" XBD=2595 XHG=2477 YBD=1141 YHG=1102>order" XBD=1441 XHG=1396 YBD=1185 YHG=1154>to " XBD=1571 XHG=1468 YBD=1196 YHG=1151>keep " XBD=1654 XHG=1598 YBD=1196 YHG=1162>up " XBD=1751 XHG=1681 YBD=1185 YHG=1151>the " XBD=1910 XHG=1779 YBD=1191 YHG=1151>effect, " XBD=2106 XHG=1938 YBD=1196 YHG=1151>heparin " XBD=2206 XHG=2132 YBD=1185 YHG=1151>has " XBD=2278 XHG=2232 YBD=1185 YHG=1154>to " XBD=2357 XHG=2306 YBD=1185 YHG=1151>be " XBD=2506 XHG=2385 YBD=1196 YHG=1151>given " XBD=2591 XHG=2534 YBD=1196 YHG=1151>by" XBD=1638 XHG=1397 YBD=1234 YHG=1200>continuous " XBD=1910 XHG=1648 YBD=1234 YHG=1200>intravenous " XBD=2024 XHG=1922 YBD=1245 YHG=1199>drip, " XBD=2082 XHG=2037 YBD=1234 YHG=1211>or " XBD=2138 XHG=2094 YBD=1234 YHG=1203>at " XBD=2251 XHG=2149 YBD=1234 YHG=1198>least " XBD=2320 XHG=2263 YBD=1244 YHG=1199>by " XBD=2594 XHG=2330 YBD=1234 YHG=1199>intravenous" XBD=1610 XHG=1395 YBD=1292 YHG=1248>injections " XBD=1746 XHG=1625 YBD=1293 YHG=1259>every " XBD=1783 XHG=1760 YBD=1283 YHG=1249>6 " XBD=1932 XHG=1799 YBD=1288 YHG=1248>hours, " XBD=2031 XHG=1950 YBD=1282 YHG=1248>and " XBD=2115 XHG=2045 YBD=1282 YHG=1248>the " XBD=2304 XHG=2131 YBD=1293 YHG=1259>expense " XBD=2365 XHG=2319 YBD=1282 YHG=1246>of " XBD=2591 XHG=2374 YBD=1282 YHG=1247>maintain-" XBD=1464 XHG=1396 YBD=1342 YHG=1297>ing " XBD=1518 XHG=1492 YBD=1331 YHG=1309>a " XBD=1703 XHG=1543 YBD=1342 YHG=1296>patient " XBD=1783 XHG=1730 YBD=1331 YHG=1309>on " XBD=1977 XHG=1810 YBD=1342 YHG=1296>heparin " XBD=2065 XHG=2002 YBD=1330 YHG=1295>for " XBD=2116 XHG=2091 YBD=1331 YHG=1308>a " XBD=2237 XHG=2142 YBD=1342 YHG=1296>long " XBD=2424 XHG=2264 YBD=1341 YHG=1296>enough " XBD=2590 XHG=2451 YBD=1342 YHG=1297>period" XBD=1430 XHG=1396 YBD=1380 YHG=1346>is " XBD=1582 XHG=1447 YBD=1391 YHG=1346>large ; " XBD=1787 XHG=1616 YBD=1392 YHG=1345>samples " XBD=1850 XHG=1805 YBD=1380 YHG=1344>of " XBD=1933 XHG=1862 YBD=1380 YHG=1346>the " XBD=2051 XHG=1950 YBD=1391 YHG=1346>drug " XBD=2171 XHG=2068 YBD=1391 YHG=1356>vary " XBD=2343 XHG=2186 YBD=1391 YHG=1344>greatly " XBD=2403 XHG=2359 YBD=1379 YHG=1345>in " XBD=2594 XHG=2420 YBD=1391 YHG=1346>activity" XBD=1480 XHG=1397 YBD=1429 YHG=1395>and " XBD=1585 XHG=1515 YBD=1429 YHG=1395>the " XBD=1716 XHG=1621 YBD=1429 YHG=1395>dose " XBD=1785 XHG=1751 YBD=1429 YHG=1395>is " XBD=2017 XHG=1820 YBD=1429 YHG=1394>therefore " XBD=2224 XHG=2053 YBD=1429 YHG=1394>difficult " XBD=2303 XHG=2258 YBD=1429 YHG=1398>to " XBD=2589 XHG=2340 YBD=1436 YHG=1394>determine ;" XBD=1550 XHG=1396 YBD=1488 YHG=1442>finally, " XBD=1687 XHG=1574 YBD=1477 YHG=1443>there " XBD=1814 XHG=1709 YBD=1478 YHG=1443>have " XBD=1938 XHG=1837 YBD=1477 YHG=1443>been " XBD=2112 XHG=1961 YBD=1477 YHG=1443>several " XBD=2325 XHG=2135 YBD=1478 YHG=1443>disasters " XBD=2392 XHG=2347 YBD=1477 YHG=1444>in " XBD=2594 XHG=2414 YBD=1488 YHG=1444>patients" XBD=1496 XHG=1397 YBD=1527 YHG=1492>with " XBD=1724 XHG=1529 YBD=1527 YHG=1492>subacute " XBD=1948 XHG=1755 YBD=1527 YHG=1491>bacterial " XBD=2248 XHG=1979 YBD=1526 YHG=1492>endocarditis " XBD=2402 XHG=2281 YBD=1537 YHG=1491>being " XBD=2596 XHG=2434 YBD=1526 YHG=1492>treated" XBD=1496 XHG=1397 YBD=1576 YHG=1541>with " XBD=1836 XHG=1510 YBD=1586 YHG=1540>sulphonamides " XBD=1929 XHG=1848 YBD=1576 YHG=1541>and " XBD=2121 XHG=1940 YBD=1587 YHG=1541>heparin. " XBD=2226 XHG=2176 YBD=1575 YHG=1541>In " XBD=2337 XHG=2241 YBD=1575 YHG=1542>1941 " XBD=2407 XHG=2351 YBD=1576 YHG=1541>K. " XBD=2466 XHG=2421 YBD=1575 YHG=1541>P. " XBD=2596 XHG=2480 YBD=1575 YHG=1541>LINK" XBD=1443 XHG=1397 YBD=1624 YHG=1589>of " XBD=1676 XHG=1451 YBD=1624 YHG=1589>Wisconsin " XBD=1857 XHG=1687 YBD=1624 YHG=1588>isolated " XBD=1939 XHG=1868 YBD=1624 YHG=1590>the " XBD=2237 XHG=1951 YBD=1634 YHG=1586>hsemorrhagic " XBD=2372 XHG=2250 YBD=1634 YHG=1593>agent " XBD=2432 XHG=2385 YBD=1624 YHG=1589>of " XBD=2593 XHG=2441 YBD=1635 YHG=1589>spoiled" XBD=1518 XHG=1397 YBD=1672 YHG=1641>sweet " XBD=1663 XHG=1532 YBD=1672 YHG=1638>clover " XBD=1756 XHG=1675 YBD=1673 YHG=1632>and " XBD=2027 XHG=1768 YBD=1673 YHG=1638>showed that " XBD=2072 XHG=2038 YBD=1672 YHG=1639>it " XBD=2165 XHG=2084 YBD=1673 YHG=1650>was 3:3-methylene-bi&" XBD=1893 XHG=1398 YBD=1732 YHG=1687>(4-hydroxycoumarin) ; " XBD=1959 XHG=1916 YBD=1722 YHG=1699>or " XBD=2165 XHG=1979 YBD=1732 YHG=1686>briefly &dquo; " XBD=2474 XHG=2182 YBD=1721 YHG=1686>dicoumarin.&dquo; " XBD=2593 XHG=2530 YBD=1721 YHG=1687>He" XBD=1616 XHG=1397 YBD=1771 YHG=1736>succeeded " XBD=1677 XHG=1633 YBD=1770 YHG=1736>in " XBD=1965 XHG=1697 YBD=1782 YHG=1736>synthesising " XBD=2248 XHG=1985 YBD=1777 YHG=1735>dicoumarin, " XBD=2314 XHG=2270 YBD=1770 YHG=1747>so " XBD=2429 XHG=2334 YBD=1770 YHG=1736>that " XBD=2473 XHG=2449 YBD=1770 YHG=1747>a " XBD=2596 XHG=2493 YBD=1781 YHG=1747>pure" XBD=1657 XHG=1396 YBD=1831 YHG=1785>preparation " XBD=1769 XHG=1687 YBD=1819 YHG=1796>was " XBD=1999 XHG=1801 YBD=1820 YHG=1784>available " XBD=2092 XHG=2029 YBD=1819 YHG=1784>for " XBD=2387 XHG=2123 YBD=1831 YHG=1784>experiment, " XBD=2503 XHG=2420 YBD=1819 YHG=1785>and " XBD=2597 XHG=2534 YBD=1819 YHG=1796>we-" XBD=1487 XHG=1396 YBD=1869 YHG=1845>now " XBD=1607 XHG=1502 YBD=1868 YHG=1834>have " XBD=1752 XHG=1622 YBD=1868 YHG=1833>useful " XBD=2028 XHG=1766 YBD=1868 YHG=1833>information " XBD=2171 XHG=2043 YBD=1872 YHG=1834>about " XBD=2240 XHG=2185 YBD=1868 YHG=1833>its " XBD=2489 XHG=2255 YBD=1879 YHG=1834>properties." XBD=1579 XHG=1449 YBD=1918 YHG=1882>Given " XBD=1662 XHG=1604 YBD=1927 YHG=1882>by " XBD=1831 XHG=1686 YBD=1917 YHG=1883>mouth " XBD=1899 XHG=1855 YBD=1916 YHG=1883>in " XBD=2080 XHG=1928 YBD=1927 YHG=1882>gelatin " XBD=2309 XHG=2112 YBD=1928 YHG=1881>capsules, " XBD=2595 XHG=2339 YBD=1917 YHG=1882>dicoumarin" XBD=1562 XHG=1396 YBD=1965 YHG=1931>reduces " XBD=1656 XHG=1585 YBD=1965 YHG=1931>the " XBD=1969 XHG=1682 YBD=1977 YHG=1930>coagulability " XBD=2037 XHG=1992 YBD=1965 YHG=1930>of " XBD=2128 XHG=2056 YBD=1965 YHG=1931>the " XBD=2274 XHG=2151 YBD=1966 YHG=1930>blood " XBD=2443 XHG=2298 YBD=1966 YHG=1930>within " XBD=2598 XHG=2466 YBD=1965 YHG=1932>24-48." XBD=1521 XHG=1397 YBD=2014 YHG=1980>hours " XBD=1588 XHG=1542 YBD=2014 YHG=1979>of " XBD=1675 XHG=1604 YBD=2016 YHG=1979>the " XBD=1783 XHG=1695 YBD=2014 YHG=1979>first " XBD=1913 XHG=1804 YBD=2014 YHG=1980>dose. " XBD=2050 XHG=1966 YBD=2014 YHG=1980>The " XBD=2189 XHG=2071 YBD=2015 YHG=1980>effect " XBD=2381 XHG=2210 YBD=2026 YHG=1991>appears " XBD=2447 XHG=2402 YBD=2015 YHG=1983>to " XBD=2519 XHG=2469 YBD=2015 YHG=1980>be " XBD=2601 XHG=2541 YBD=2015 YHG=1992>an" XBD=1615 XHG=1396 YBD=2063 YHG=2029>inhibition " XBD=1688 XHG=1642 YBD=2063 YHG=2027>of " XBD=1991 XHG=1710 YBD=2075 YHG=2029>prothrombin " XBD=2098 XHG=2017 YBD=2064 YHG=2029>and " XBD=2179 XHG=2125 YBD=2064 YHG=2041>an " XBD=2468 XHG=2204 YBD=2063 YHG=2028>interference " XBD=2594 XHG=2495 YBD=2064 YHG=2030>with" XBD=1480 XHG=1399 YBD=2112 YHG=2078>clot " XBD=1731 XHG=1499 YBD=2112 YHG=2078>retraction. " XBD=1882 XHG=1784 YBD=2112 YHG=2078>Like " XBD=2080 XHG=1900 YBD=2124 YHG=2078>heparin, " XBD=2133 XHG=2098 YBD=2113 YHG=2079>it " XBD=2231 XHG=2151 YBD=2113 YHG=2077>will " XBD=2422 XHG=2249 YBD=2123 YHG=2081>prevent " XBD=2599 XHG=2440 YBD=2123 YHG=2079>experi-" XBD=1553 XHG=1397 YBD=2161 YHG=2126>mental " XBD=1845 XHG=1564 YBD=2161 YHG=2126>thromboses.2 " XBD=2056 XHG=1897 YBD=2172 YHG=2126>If large " XBD=2183 XHG=2068 YBD=2161 YHG=2128>doses " XBD=2263 XHG=2196 YBD=2161 YHG=2137>are " XBD=2397 XHG=2276 YBD=2171 YHG=2126>given " XBD=2601 XHG=2409 YBD=2172 YHG=2126>bleeding-" XBD=1496 XHG=1398 YBD=2220 YHG=2186>may " XBD=1646 XHG=1515 YBD=2217 YHG=2187>occur, " XBD=1742 XHG=1666 YBD=2210 YHG=2176>but " XBD=1814 XHG=1760 YBD=2210 YHG=2188>no " XBD=1942 XHG=1832 YBD=2210 YHG=2176>toxic " XBD=2044 XHG=1960 YBD=2210 YHG=2176>side " XBD=2202 XHG=2063 YBD=2209 YHG=2175>effects " XBD=2326 XHG=2219 YBD=2209 YHG=2175>have " XBD=2389 XHG=2345 YBD=2209 YHG=2187>so " XBD=2473 XHG=2408 YBD=2209 YHG=2174>far " XBD=2602 XHG=2492 YBD=2210 YHG=2176>been-" XBD=1537 XHG=1399 YBD=2258 YHG=2224>noted. " XBD=1676 XHG=1591 YBD=2258 YHG=2224>The " XBD=1798 XHG=1702 YBD=2259 YHG=2224>dose " XBD=1934 XHG=1823 YBD=2259 YHG=2228>must " XBD=2009 XHG=1959 YBD=2258 YHG=2224>be " XBD=2258 XHG=2036 YBD=2258 YHG=2222>controlled " XBD=2342 XHG=2283 YBD=2268 YHG=2223>by " XBD=2479 XHG=2366 YBD=2267 YHG=2222>daily " XBD=2600 XHG=2504 YBD=2269 YHG=2235>pro--" XBD=1725 XHG=1399 YBD=2308 YHG=2272>thrombin-time " XBD=2474 XHG=1776 YBD=2317 YHG=2271>estimations-coagulation-times |>" XBD=2603 XHG=2528 YBD=2307 YHG=2284>are" XBD=1754 XHG=1399 YBD=2357 YHG=2321>unreliable-and " XBD=1890 XHG=1782 YBD=2357 YHG=2325>most " XBD=2090 XHG=1920 YBD=2356 YHG=2321>workers " XBD=2225 XHG=2120 YBD=2356 YHG=2321>have " XBD=2384 XHG=2254 YBD=2356 YHG=2320>found " XBD=2592 XHG=2415 YBD=2362 YHG=2320>QUICK’S" XBD=1629 XHG=1399 YBD=2416 YHG=2370>technique, " XBD=1760 XHG=1644 YBD=2416 YHG=2371>using " XBD=2114 XHG=1773 YBD=2415 YHG=2369>thromboplastin " XBD=2325 XHG=2128 YBD=2415 YHG=2370>prepared " XBD=2443 XHG=2337 YBD=2404 YHG=2369>from " XBD=2594 XHG=2457 YBD=2405 YHG=2370>rabbit" XBD=1517 XHG=1399 YBD=2455 YHG=2420>brain " XBD=1682 XHG=1528 YBD=2461 YHG=2421>tissue,3 " XBD=1803 XHG=1695 YBD=2454 YHG=2422>most " XBD=2001 XHG=1815 YBD=2459 YHG=2418>reliable ; " XBD=2141 XHG=2032 YBD=2453 YHG=2430>some " XBD=2284 XHG=2153 YBD=2453 YHG=2419>minor " XBD=2603 XHG=2297 YBD=2453 YHG=2418>modifications." XBD=1505 XHG=1399 YBD=2502 YHG=2469>have " XBD=1642 XHG=1541 YBD=2503 YHG=2469>been " XBD=1888 XHG=1678 YBD=2513 YHG=2467>proposed. " XBD=2026 XHG=1942 YBD=2501 YHG=2467>The " XBD=2198 XHG=2063 YBD=2511 YHG=2467>object " XBD=2267 XHG=2232 YBD=2501 YHG=2467>is " XBD=2348 XHG=2303 YBD=2501 YHG=2471>to " XBD=2487 XHG=2383 YBD=2512 YHG=2468>keep " XBD=2602 XHG=2523 YBD=2501 YHG=2468>the-" XBD=1683 XHG=1399 YBD=2562 YHG=2517>prothrombin " XBD=2073 XHG=1722 YBD=2559 YHG=2514>time-normally " XBD=2237 XHG=2114 YBD=2549 YHG=2516>11-12 " XBD=2597 XHG=2281 YBD=2560 YHG=2517>see.-between" XBD=1448 XHG=1400 YBD=2600 YHG=2567>35 " XBD=1563 XHG=1481 YBD=2599 YHG=2565>and " XBD=1643 XHG=1594 YBD=2599 YHG=2566>60 " XBD=1780 XHG=1677 YBD=2605 YHG=2576>sec. ; " XBD=1899 XHG=1829 YBD=2597 YHG=2564>the " XBD=2072 XHG=1926 YBD=2608 YHG=2564>dosage " XBD=2318 XHG=2105 YBD=2609 YHG=2564>suggested " XBD=2407 XHG=2349 YBD=2609 YHG=2564>by " XBD=2592 XHG=2432 YBD=2606 YHG=2564>ALLEN," XBD=1580 XHG=1398 YBD=2648 YHG=2614>BARKER " XBD=1688 XHG=1607 YBD=2647 YHG=2614>and WAUGH " XBD=1970 XHG=1896 YBD=2645 YHG=2612>4 is " XBD=2072 XHG=1997 YBD=2654 YHG=2613>300 " XBD=2178 XHG=2098 YBD=2657 YHG=2624>mg. " XBD=2260 XHG=2207 YBD=2647 YHG=2624>on " XBD=2357 XHG=2287 YBD=2647 YHG=2613>the " XBD=2472 XHG=2383 YBD=2647 YHG=2613>first " XBD=2597 XHG=2500 YBD=2657 YHG=2613>day," XBD=1473 XHG=1398 YBD=2697 YHG=2662>200 " XBD=1569 XHG=1489 YBD=2706 YHG=2673>mg. " XBD=1641 XHG=1588 YBD=2696 YHG=2673>on " XBD=1728 XHG=1656 YBD=2695 YHG=2661>the " XBD=1905 XHG=1745 YBD=2702 YHG=2660>second, " XBD=2012 XHG=1924 YBD=2695 YHG=2650>and " XBD=2121 XHG=2022 YBD=2695 YHG=2660>then " XBD=2212 XHG=2138 YBD=2696 YHG=2662>200 " XBD=2309 XHG=2228 YBD=2706 YHG=2673>mg. " XBD=2381 XHG=2328 YBD=2696 YHG=2672>on " XBD=2497 XHG=2398 YBD=2695 YHG=2661>each " XBD=2596 XHG=2514 YBD=2706 YHG=2662>day" XBD=1469 XHG=1397 YBD=2744 YHG=2711>the " XBD=1781 XHG=1500 YBD=2754 YHG=2708>prothrombin " XBD=1911 XHG=1811 YBD=2743 YHG=2708>time " XBD=1975 XHG=1941 YBD=2742 YHG=2708>is " XBD=2082 XHG=2006 YBD=2743 YHG=2709>less " XBD=2217 XHG=2114 YBD=2744 YHG=2709>than " XBD=2297 XHG=2248 YBD=2744 YHG=2711>35 " XBD=2411 XHG=2334 YBD=2744 YHG=2721>sec. " XBD=2596 XHG=2465 YBD=2744 YHG=2710>When" XBD=1648 XHG=1398 YBD=2793 YHG=2758>dicoumarin " XBD=1701 XHG=1667 YBD=2790 YHG=2758>is " XBD=1907 XHG=1723 YBD=2802 YHG=2758>stopped, " XBD=1998 XHG=1928 YBD=2791 YHG=2757>the " XBD=2137 XHG=2020 YBD=2792 YHG=2758>effect " XBD=2256 XHG=2156 YBD=2793 YHG=2758>lasts " XBD=2352 XHG=2278 YBD=2793 YHG=2760>3-7 " XBD=2502 XHG=2373 YBD=2803 YHG=2759>days ; " XBD=2604 XHG=2526 YBD=2793 YHG=2759>the" XBD=1628 XHG=1398 YBD=2851 YHG=2805>possibility " XBD=1693 XHG=1649 YBD=2839 YHG=2804>of " XBD=1982 XHG=1710 YBD=2851 YHG=2805>haemorrhage " XBD=2171 XHG=2002 YBD=2852 YHG=2807>needing " XBD=2349 XHG=2193 YBD=2841 YHG=2806>control " XBD=2444 XHG=2369 YBD=2840 YHG=2807>has " XBD=2593 XHG=2465 YBD=2840 YHG=2807>there-" XBD=1482 XHG=1397 YBD=2888 YHG=2855>fore " XBD=1560 XHG=1515 YBD=2888 YHG=2857>to " XBD=1643 XHG=1593 YBD=2887 YHG=2854>be " XBD=1802 XHG=1674 YBD=2894 YHG=2852>faced, " XBD=1918 XHG=1837 YBD=2888 YHG=2854>and " XBD=2181 XHG=1950 YBD=2899 YHG=2855>experience " XBD=2287 XHG=2213 YBD=2889 YHG=2855>has " XBD=2470 XHG=2331 YBD=2888 YHG=2855>shown " XBD=2596 XHG=2502 YBD=2887 YHG=2854>that" XBD=1646 XHG=1398 YBD=2936 YHG=2901>transfusion " XBD=1817 XHG=1661 YBD=2945 YHG=2901>of fresh " XBD=1952 XHG=1831 YBD=2937 YHG=2902>blood " XBD=2009 XHG=1966 YBD=2937 YHG=2915>or " XBD=2155 XHG=2023 YBD=2937 YHG=2915>serum " XBD=2202 XHG=2168 YBD=2937 YHG=2903>is " XBD=2286 XHG=2215 YBD=2937 YHG=2903>the " XBD=2398 XHG=2301 YBD=2947 YHG=2902>only " XBD=2595 XHG=2411 YBD=2936 YHG=2901>effective" XBD=1606 XHG=1398 YBD=2991 YHG=2961>measure ; " XBD=1772 XHG=1638 YBD=2984 YHG=2950>stored " XBD=1919 XHG=1797 YBD=2986 YHG=2950>blood " XBD=1972 XHG=1937 YBD=2986 YHG=2951>is " XBD=2071 XHG=1994 YBD=2986 YHG=2951>less " XBD=2269 XHG=2085 YBD=2986 YHG=2951>effective " XBD=2424 XHG=2294 YBD=2995 YHG=2951>owing " XBD=2493 XHG=2448 YBD=2984 YHG=2953>to " XBD=2605 XHG=2517 YBD=2984 YHG=2949>loss" XBD=1445 XHG=1399 YBD=3033 YHG=2998>of " XBD=1760 XHG=1468 YBD=3043 YHG=2999>prothrombin, " XBD=1868 XHG=1788 YBD=3033 YHG=2999>and " XBD=2065 XHG=1891 YBD=3034 YHG=3000>vitamin " XBD=2130 XHG=2088 YBD=3034 YHG=3000>K " XBD=2190 XHG=2156 YBD=3033 YHG=3000>is " XBD=2374 XHG=2214 YBD=3033 YHG=2997>useless. " XBD=2596 XHG=2430 YBD=3032 YHG=2998>Contra-" XBD=1641 XHG=1398 YBD=3081 YHG=3047>indications " XBD=1706 XHG=1661 YBD=3081 YHG=3050>to " XBD=1970 XHG=1721 YBD=3082 YHG=3048>dicoumarin " XBD=2050 XHG=1984 YBD=3082 YHG=3060>are " XBD=2175 XHG=2064 YBD=3081 YHG=3046>renal " XBD=2481 XHG=2193 YBD=3090 YHG=3047>insufficiency, |>" XBD=2605 XHG=2496 YBD=3081 YHG=3047>liver" XBD=1565 XHG=1400 YBD=3136 YHG=3095>disease, " XBD=1796 XHG=1602 YBD=3129 YHG=3095>subacute " XBD=2023 XHG=1832 YBD=3130 YHG=3096>bacterial " XBD=2340 XHG=2056 YBD=3135 YHG=3095>endocarditis, " XBD=2595 XHG=2376 YBD=3140 YHG=3095>deficiency" XBD=1446 XHG=1401 YBD=3177 YHG=3142>of " XBD=1636 XHG=1462 YBD=3177 YHG=3143>vitamin " XBD=1709 XHG=1655 YBD=3184 YHG=3144>K, " XBD=1812 XHG=1731 YBD=3177 YHG=3144>and " XBD=2062 XHG=1832 YBD=3188 YHG=3155>pregnancy " XBD=2162 XHG=2081 YBD=3177 YHG=3143>and " XBD=2253 XHG=2182 YBD=3176 YHG=3142>the " XBD=2361 XHG=2273 YBD=3176 YHG=3142>first " XBD=2406 XHG=2382 YBD=3176 YHG=3143>5 " XBD=2529 XHG=2428 YBD=3187 YHG=3143>days " XBD=2604 XHG=2550 YBD=3177 YHG=3143>of" XBD=1471 XHG=1400 YBD=3224 YHG=3191>the " XBD=1759 XHG=1492 YBD=3236 YHG=3192>puerperium." XBD=1577 XHG=1451 YBD=3273 YHG=3239>These " XBD=1816 XHG=1597 YBD=3284 YHG=3240>properties " XBD=2031 XHG=1838 YBD=3282 YHG=3238>certainly " XBD=2211 XHG=2050 YBD=3281 YHG=3241>suggest " XBD=2325 XHG=2231 YBD=3271 YHG=3238>that |>" XBD=2602 XHG=2346 YBD=3272 YHG=3237>dicoumarin!

1. Lancet, 1941, ii, 314.2. Dale, D. O. and Jaques, L. B. Canad. med. Ass. J. 1942, 46, 547.3. Quick, A. J. The Hæmorrhagic Diseases, Springfield, Ill., 1942,

p. 312.4. Allen, E. W., Barker, N. W. and Waugh, J. M. J. Amer. med.

Ass. 1942, 120, 1009.

622

" XBD=227 XHG=109 YBD=263 YHG=228>could " XBD=415 XHG=258 YBD=275 YHG=228>replace " XBD=614 XHG=446 YBD=275 YHG=229>heparin " XBD=741 XHG=645 YBD=264 YHG=230>with " XBD=1003 XHG=774 YBD=274 YHG=230>advantage " XBD=1116 XHG=1035 YBD=264 YHG=230>and " XBD=1302 XHG=1148 YBD=263 YHG=229>several" XBD=281 XHG=108 YBD=322 YHG=278>workers " XBD=425 XHG=319 YBD=313 YHG=276>have " XBD=629 XHG=464 YBD=325 YHG=279>already " XBD=967 XHG=666 YBD=314 YHG=279>demonstrated " XBD=1099 XHG=1006 YBD=313 YHG=278>that " XBD=1171 XHG=1137 YBD=312 YHG=278>it " XBD=1299 XHG=1211 YBD=313 YHG=290>can." XBD=173 XHG=109 YBD=363 YHG=327>On " XBD=364 XHG=193 YBD=363 YHG=328>another " XBD=486 XHG=384 YBD=375 YHG=340>page " XBD=730 XHG=515 YBD=364 YHG=328>LEHMANN " XBD=796 XHG=752 YBD=363 YHG=327>of " XBD=1079 XHG=817 YBD=373 YHG=328>Gothenburg " XBD=1302 XHG=1100 YBD=362 YHG=328>describes" XBD=172 XHG=109 YBD=412 YHG=377>his " XBD=445 XHG=193 YBD=423 YHG=378>experiences " XBD=564 XHG=466 YBD=413 YHG=378>with " XBD=661 XHG=589 YBD=413 YHG=379>100 " XBD=924 XHG=681 YBD=412 YHG=376>established " XBD=1055 XHG=947 YBD=411 YHG=388>cases " XBD=1122 XHG=1077 YBD=411 YHG=376>of " XBD=1302 XHG=1140 YBD=411 YHG=377>various" XBD=228 XHG=108 YBD=473 YHG=430>types " XBD=295 XHG=249 YBD=461 YHG=426>of " XBD=555 XHG=310 YBD=463 YHG=427>thrombosis " XBD=618 XHG=575 YBD=461 YHG=427>in " XBD=706 XHG=637 YBD=461 YHG=427>the " XBD=787 XHG=725 YBD=471 YHG=426>leg " XBD=889 XHG=807 YBD=461 YHG=426>and " XBD=1007 XHG=909 YBD=460 YHG=425>with " XBD=1102 XHG=1031 YBD=461 YHG=427>170 " XBD=1302 XHG=1122 YBD=471 YHG=426>patients" XBD=198 XHG=108 YBD=510 YHG=476>who " XBD=302 XHG=216 YBD=510 YHG=476>had " XBD=566 XHG=317 YBD=511 YHG=476>dicoumarin " XBD=947 XHG=584 YBD=520 YHG=474>prophylactically " XBD=1099 XHG=965 YBD=510 YHG=474>before " XBD=1299 XHG=1118 YBD=520 YHG=486>gynaeco-" XBD=251 XHG=108 YBD=570 YHG=524>logical " XBD=523 XHG=281 YBD=571 YHG=525>operations. " XBD=641 XHG=577 YBD=559 YHG=524>He " XBD=768 XHG=671 YBD=559 YHG=523>used " XBD=924 XHG=796 YBD=569 YHG=522>larger " XBD=1068 XHG=953 YBD=559 YHG=523>doses " XBD=1201 XHG=1098 YBD=558 YHG=524>than " XBD=1301 XHG=1230 YBD=558 YHG=524>the" XBD=321 XHG=108 YBD=612 YHG=574>American " XBD=521 XHG=348 YBD=609 YHG=574>workers " XBD=629 XHG=547 YBD=607 YHG=569>and " XBD=688 XHG=655 YBD=606 YHG=572>is " XBD=970 XHG=723 YBD=618 YHG=571>thoroughly " XBD=1175 XHG=997 YBD=608 YHG=573>satisfied " XBD=1302 XHG=1202 YBD=608 YHG=565>with" XBD=180 XHG=108 YBD=657 YHG=623>the " XBD=380 XHG=208 YBD=664 YHG=622>results ; " XBD=496 XHG=426 YBD=656 YHG=622>the " XBD=769 XHG=526 YBD=656 YHG=622>thrombosis " XBD=909 XHG=799 YBD=656 YHG=633>cases " XBD=1150 XHG=936 YBD=657 YHG=622>recovered " XBD=1302 XHG=1180 YBD=657 YHG=623>much" XBD=220 XHG=109 YBD=705 YHG=682>more " XBD=402 XHG=240 YBD=717 YHG=670>rapidly " XBD=526 XHG=423 YBD=705 YHG=671>than " XBD=629 XHG=547 YBD=704 YHG=682>was " XBD=767 XHG=651 YBD=705 YHG=670>usual " XBD=830 XHG=787 YBD=705 YHG=671>in " XBD=1017 XHG=852 YBD=706 YHG=670>Sweden " XBD=1175 XHG=1040 YBD=705 YHG=670>before " XBD=1301 XHG=1198 YBD=705 YHG=671>anti-" XBD=346 XHG=111 YBD=765 YHG=719>coagulants " XBD=461 XHG=359 YBD=754 YHG=730>were " XBD=724 XHG=473 YBD=762 YHG=719>introduced, " XBD=821 XHG=740 YBD=754 YHG=720>and " XBD=903 XHG=831 YBD=754 YHG=720>the " XBD=1017 XHG=916 YBD=765 YHG=720>drug " XBD=1303 XHG=1031 YBD=765 YHG=720>significantly" XBD=282 XHG=108 YBD=804 YHG=765>reduced " XBD=385 XHG=313 YBD=803 YHG=768>the " XBD=620 XHG=412 YBD=803 YHG=768>incidence " XBD=698 XHG=654 YBD=803 YHG=768>of " XBD=1026 XHG=726 YBD=815 YHG=770>postoperative " XBD=1304 XHG=1058 YBD=804 YHG=769>thrombosis" XBD=190 XHG=109 YBD=853 YHG=818>and " XBD=428 XHG=218 YBD=853 YHG=817>embolism " XBD=498 XHG=455 YBD=852 YHG=818>in " XBD=601 XHG=531 YBD=853 YHG=818>the " XBD=934 XHG=629 YBD=864 YHG=817>gynaecological " XBD=1150 XHG=961 YBD=864 YHG=818>patients. " XBD=1304 XHG=1203 YBD=853 YHG=818>Like" XBD=257 XHG=109 YBD=908 YHG=868>others, " XBD=499 XHG=282 YBD=901 YHG=866>LEHMANN " XBD=642 XHG=527 YBD=902 YHG=870>notes " XBD=960 XHG=669 YBD=913 YHG=867>haemorrhages " XBD=1025 XHG=983 YBD=902 YHG=868>in " XBD=1178 XHG=1051 YBD=903 YHG=868>about " XBD=1300 XHG=1206 YBD=914 YHG=868>10%" XBD=155 XHG=110 YBD=952 YHG=916>of " XBD=364 XHG=172 YBD=962 YHG=916>patients, " XBD=463 XHG=387 YBD=951 YHG=916>but " XBD=527 XHG=483 YBD=950 YHG=916>in " XBD=607 XHG=546 YBD=950 YHG=916>his " XBD=746 XHG=629 YBD=951 YHG=917>series " XBD=801 XHG=767 YBD=951 YHG=917>it " XBD=902 XHG=822 YBD=951 YHG=928>was " XBD=1044 XHG=923 YBD=951 YHG=928>never " XBD=1200 XHG=1066 YBD=951 YHG=928>severe " XBD=1304 XHG=1222 YBD=951 YHG=918>and" XBD=260 XHG=110 YBD=1011 YHG=965>always " XBD=584 XHG=312 YBD=1000 YHG=964>controllable. " XBD=784 XHG=639 YBD=1000 YHG=965>ALLEN " XBD=917 XHG=837 YBD=1000 YHG=965>and " XBD=1030 XHG=969 YBD=1000 YHG=966>his " XBD=1304 XHG=1083 YBD=1011 YHG=965>colleagues" XBD=246 XHG=110 YBD=1062 YHG=1018>report " XBD=322 XHG=269 YBD=1050 YHG=1026>on " XBD=418 XHG=343 YBD=1051 YHG=1015>368 " XBD=550 XHG=441 YBD=1049 YHG=1025>cases " XBD=618 XHG=571 YBD=1049 YHG=1014>of " XBD=796 XHG=636 YBD=1050 YHG=1014>arterial " XBD=862 XHG=818 YBD=1050 YHG=1026>or " XBD=1035 XHG=884 YBD=1050 YHG=1026>venous " XBD=1304 XHG=1057 YBD=1051 YHG=1015>thrombosis" XBD=156 XHG=111 YBD=1101 YHG=1077>or " XBD=418 XHG=175 YBD=1111 YHG=1064>pulmonary " XBD=648 XHG=438 YBD=1099 YHG=1064>embolism " XBD=750 XHG=668 YBD=1099 YHG=1065>and " XBD=869 XHG=770 YBD=1110 YHG=1065>they " XBD=974 XHG=891 YBD=1100 YHG=1064>also " XBD=1063 XHG=996 YBD=1099 YHG=1076>are " XBD=1304 XHG=1083 YBD=1111 YHG=1065>impressed" XBD=167 XHG=111 YBD=1163 YHG=1116>by " XBD=254 XHG=182 YBD=1149 YHG=1115>the " XBD=388 XHG=268 YBD=1150 YHG=1114>value " XBD=450 XHG=404 YBD=1149 YHG=1113>of " XBD=711 XHG=458 YBD=1149 YHG=1114>dicoumarin " XBD=768 XHG=725 YBD=1148 YHG=1115>in " XBD=1020 XHG=783 YBD=1160 YHG=1115>preventing " XBD=1246 XHG=1036 YBD=1149 YHG=1115>extension " XBD=1309 XHG=1263 YBD=1149 YHG=1114>of" XBD=368 XHG=111 YBD=1200 YHG=1164>thrombosis. " XBD=535 XHG=422 YBD=1209 YHG=1164>They " XBD=718 XHG=564 YBD=1199 YHG=1164>started " XBD=996 XHG=748 YBD=1199 YHG=1164>dicoumarin " XBD=1074 XHG=1025 YBD=1198 YHG=1165>24 " XBD=1165 XHG=1104 YBD=1199 YHG=1164>hr. " XBD=1304 XHG=1199 YBD=1199 YHG=1164>after" XBD=323 XHG=113 YBD=1260 YHG=1214>operation " XBD=383 XHG=340 YBD=1248 YHG=1213>in " XBD=577 XHG=400 YBD=1259 YHG=1213>patients " XBD=744 XHG=595 YBD=1260 YHG=1213>judged " XBD=884 XHG=761 YBD=1259 YHG=1213>likely " XBD=945 XHG=901 YBD=1248 YHG=1217>to " XBD=1132 XHG=963 YBD=1259 YHG=1212>develop " XBD=1302 XHG=1150 YBD=1249 YHG=1213>throm-" XBD=247 XHG=114 YBD=1305 YHG=1264>bosis ; " XBD=359 XHG=287 YBD=1298 YHG=1264>124 " XBD=487 XHG=379 YBD=1298 YHG=1274>cases " XBD=552 XHG=507 YBD=1299 YHG=1253>of " XBD=799 XHG=567 YBD=1298 YHG=1250>abdominal " XBD=1118 XHG=817 YBD=1309 YHG=1263>hysterectomy " XBD=1239 XHG=1137 YBD=1298 YHG=1263>were " XBD=1304 XHG=1259 YBD=1298 YHG=1275>so" XBD=272 XHG=112 YBD=1348 YHG=1313>treated " XBD=392 XHG=310 YBD=1348 YHG=1313>and " XBD=534 XHG=430 YBD=1348 YHG=1325>none " XBD=654 XHG=572 YBD=1352 YHG=1313>had " XBD=936 XHG=693 YBD=1359 YHG=1312>subsequent " XBD=1220 XHG=975 YBD=1348 YHG=1313>thrombosis " XBD=1304 XHG=1260 YBD=1348 YHG=1325>or" XBD=335 XHG=112 YBD=1404 YHG=1362>embolism, " XBD=560 XHG=365 YBD=1410 YHG=1362>although " XBD=692 XHG=588 YBD=1398 YHG=1362>from " XBD=906 XHG=720 YBD=1410 YHG=1363>previous " XBD=1166 XHG=935 YBD=1409 YHG=1364>experience " XBD=1305 XHG=1196 YBD=1398 YHG=1374>some" XBD=242 XHG=112 YBD=1458 YHG=1412>might " XBD=376 XHG=270 YBD=1447 YHG=1412>have " XBD=506 XHG=405 YBD=1448 YHG=1414>been " XBD=740 XHG=535 YBD=1459 YHG=1413>expected. " XBD=880 XHG=795 YBD=1448 YHG=1413>One " XBD=954 XHG=910 YBD=1447 YHG=1412>of " XBD=1048 XHG=979 YBD=1447 YHG=1413>the " XBD=1305 XHG=1078 YBD=1448 YHG=1412>difficulties" XBD=212 XHG=112 YBD=1508 YHG=1462>they " XBD=332 XHG=236 YBD=1497 YHG=1465>note " XBD=392 XHG=358 YBD=1496 YHG=1463>is " XBD=488 XHG=418 YBD=1497 YHG=1463>the " XBD=612 XHG=514 YBD=1497 YHG=1464>time " XBD=885 XHG=638 YBD=1498 YHG=1463>dicoumarin " XBD=1026 XHG=911 YBD=1497 YHG=1463>takes " XBD=1096 XHG=1052 YBD=1498 YHG=1466>to " XBD=1189 XHG=1123 YBD=1508 YHG=1466>get " XBD=1304 XHG=1215 YBD=1498 YHG=1463>into" XBD=248 XHG=112 YBD=1546 YHG=1512>action " XBD=350 XHG=268 YBD=1547 YHG=1512>and " XBD=453 XHG=370 YBD=1546 YHG=1512>this " XBD=560 XHG=473 YBD=1547 YHG=1512>first " XBD=630 XHG=581 YBD=1547 YHG=1514>24 " XBD=771 XHG=651 YBD=1547 YHG=1513>hours " XBD=895 XHG=792 YBD=1548 YHG=1512>after " XBD=940 XHG=916 YBD=1547 YHG=1525>a " XBD=1204 XHG=960 YBD=1547 YHG=1513>thrombosis " XBD=1259 XHG=1225 YBD=1547 YHG=1512>is " XBD=1305 XHG=1280 YBD=1547 YHG=1525>a" XBD=219 XHG=111 YBD=1597 YHG=1564>most " XBD=463 XHG=237 YBD=1608 YHG=1561>important " XBD=646 XHG=481 YBD=1608 YHG=1562>period ; " XBD=942 XHG=681 YBD=1597 YHG=1563>intravenous " XBD=1154 XHG=961 YBD=1607 YHG=1563>injection " XBD=1219 XHG=1174 YBD=1597 YHG=1561>of " XBD=1306 XHG=1235 YBD=1597 YHG=1562>the" XBD=299 XHG=111 YBD=1646 YHG=1610>unstable " XBD=524 XHG=322 YBD=1646 YHG=1611>disodium " XBD=627 XHG=549 YBD=1646 YHG=1611>salt " XBD=732 XHG=651 YBD=1647 YHG=1611>still " XBD=884 XHG=756 YBD=1647 YHG=1613>shows " XBD=989 XHG=908 YBD=1647 YHG=1613>this " XBD=1143 XHG=1012 YBD=1647 YHG=1612>latent " XBD=1305 XHG=1166 YBD=1658 YHG=1612>period" XBD=193 XHG=111 YBD=1696 YHG=1661>and LEHMANN " XBD=552 XHG=443 YBD=1703 YHG=1661>5 has " XBD=678 XHG=573 YBD=1697 YHG=1662>tried " XBD=812 XHG=698 YBD=1697 YHG=1663>other " XBD=1039 XHG=834 YBD=1696 YHG=1659>coumarin " XBD=1305 XHG=1059 YBD=1697 YHG=1661>derivatives" XBD=285 XHG=110 YBD=1746 YHG=1711>without " XBD=496 XHG=316 YBD=1746 YHG=1722>success : ’it " XBD=645 XHG=611 YBD=1745 YHG=1711>is " XBD=873 XHG=675 YBD=1746 YHG=1710>therefore " XBD=1104 XHG=906 YBD=1757 YHG=1711>proposed " XBD=1180 XHG=1135 YBD=1746 YHG=1714>to " XBD=1304 XHG=1211 YBD=1757 YHG=1711>give" XBD=278 XHG=109 YBD=1806 YHG=1760>heparin " XBD=374 XHG=317 YBD=1806 YHG=1760>by " XBD=484 XHG=414 YBD=1794 YHG=1761>the " XBD=711 XHG=525 YBD=1806 YHG=1759>6-hourly " XBD=1011 XHG=749 YBD=1795 YHG=1761>intravenous " XBD=1218 XHG=1050 YBD=1795 YHG=1761>method " XBD=1306 XHG=1260 YBD=1795 YHG=1759>of" XBD=338 XHG=111 YBD=1846 YHG=1810>CRAFOORD " XBD=435 XHG=354 YBD=1845 YHG=1810>and JORPES " XBD=794 XHG=623 YBD=1856 YHG=1810>6 during " XBD=878 XHG=807 YBD=1845 YHG=1811>the " XBD=978 XHG=890 YBD=1846 YHG=1810>first " XBD=1040 XHG=991 YBD=1844 YHG=1811>24 " XBD=1176 XHG=1053 YBD=1845 YHG=1810>hours " XBD=1305 XHG=1188 YBD=1845 YHG=1810>while" XBD=180 XHG=109 YBD=1895 YHG=1860>the " XBD=448 XHG=196 YBD=1895 YHG=1860>dicoumarin " XBD=495 XHG=461 YBD=1895 YHG=1860>is " XBD=668 XHG=512 YBD=1906 YHG=1860>coming " XBD=771 XHG=683 YBD=1895 YHG=1860>into " XBD=935 XHG=787 YBD=1895 YHG=1860>action. " XBD=1093 XHG=989 YBD=1895 YHG=1860>How " XBD=1170 XHG=1107 YBD=1895 YHG=1860>far " XBD=1218 XHG=1184 YBD=1895 YHG=1860>is " XBD=1305 XHG=1233 YBD=1895 YHG=1861>the" XBD=621 XHG=110 YBD=1958 YHG=1910>haemorrhage-producing " XBD=856 XHG=664 YBD=1956 YHG=1913>property " XBD=944 XHG=900 YBD=1945 YHG=1909>of " XBD=1234 XHG=984 YBD=1945 YHG=1910>dicoumarin " XBD=1303 XHG=1278 YBD=1945 YHG=1922>a" XBD=435 XHG=109 YBD=2006 YHG=1960>disadvantage ? " XBD=555 XHG=490 YBD=1995 YHG=1959>All " XBD=701 XHG=586 YBD=2006 YHG=1972>agree " XBD=827 XHG=734 YBD=1995 YHG=1960>that " XBD=892 XHG=857 YBD=1995 YHG=1960>it " XBD=1032 XHG=923 YBD=1995 YHG=1963>must " XBD=1114 XHG=1065 YBD=1995 YHG=1960>be " XBD=1306 XHG=1146 YBD=1995 YHG=1960>treated" XBD=315 XHG=110 YBD=2057 YHG=2010>seriously. " XBD=551 XHG=370 YBD=2046 YHG=2010>WRIGHT " XBD=662 XHG=581 YBD=2045 YHG=2010>and " XBD=946 XHG=692 YBD=2045 YHG=2010>PRANDONI have " XBD=1305 XHG=1113 YBD=2046 YHG=2010>recorded" XBD=219 XHG=111 YBD=2096 YHG=2072>some " XBD=521 XHG=276 YBD=2107 YHG=2059>unpleasant |>" XBD=956 XHG=577 YBD=2106 YHG=2060>experiences-one " XBD=1184 XHG=1013 YBD=2106 YHG=2060>patient, " XBD=1305 XHG=1242 YBD=2095 YHG=2060>for" XBD=307 XHG=110 YBD=2157 YHG=2111>example, " XBD=426 XHG=343 YBD=2146 YHG=2111>had " XBD=650 XHG=459 YBD=2157 YHG=2122>purpura, " XBD=868 XHG=685 YBD=2156 YHG=2110>bleeding " XBD=1029 XHG=902 YBD=2156 YHG=2122>gums, " XBD=1304 XHG=1064 YBD=2145 YHG=2110>haematurla" XBD=192 XHG=111 YBD=2196 YHG=2161>and " XBD=527 XHG=222 YBD=2203 YHG=2160>haematemesis, " XBD=636 XHG=560 YBD=2196 YHG=2161>but " XBD=878 XHG=665 YBD=2196 YHG=2160>recovered " XBD=1012 XHG=908 YBD=2195 YHG=2160>after |>" XBD=1303 XHG=1042 YBD=2196 YHG=2160>transfusion." XBD=223 XHG=109 YBD=2257 YHG=2212>They " XBD=338 XHG=241 YBD=2246 YHG=2214>note " XBD=451 XHG=357 YBD=2246 YHG=2211>that " XBD=662 XHG=475 YBD=2256 YHG=2210>bleeding " XBD=723 XHG=678 YBD=2249 YHG=2213>at " XBD=766 XHG=742 YBD=2246 YHG=2222>a " XBD=1081 XHG=790 YBD=2257 YHG=2211>venipuncture " XBD=1177 XHG=1102 YBD=2245 YHG=2211>site " XBD=1231 XHG=1197 YBD=2245 YHG=2210>is " XBD=1304 XHG=1250 YBD=2245 YHG=2223>an" XBD=296 XHG=111 YBD=2296 YHG=2262>ominous " XBD=400 XHG=312 YBD=2306 YHG=2261>sign " XBD=496 XHG=416 YBD=2296 YHG=2261>and " XBD=657 XHG=513 YBD=2296 YHG=2259>should " XBD=723 XHG=672 YBD=2301 YHG=2260>be, " XBD=808 XHG=736 YBD=2295 YHG=2260>the " XBD=950 XHG=824 YBD=2306 YHG=2259>signal " XBD=1027 XHG=965 YBD=2295 YHG=2259>for " XBD=1303 XHG=1043 YBD=2296 YHG=2259>transfusion." XBD=256 XHG=109 YBD=2345 YHG=2311>ALLEN " XBD=361 XHG=279 YBD=2345 YHG=2311>and " XBD=443 XHG=381 YBD=2345 YHG=2311>his " XBD=686 XHG=466 YBD=2356 YHG=2310>colleagues " XBD=832 XHG=707 YBD=2345 YHG=2310>noted " XBD=1157 XHG=852 YBD=2356 YHG=2309>haemorrhages, " XBD=1207 XHG=1179 YBD=2349 YHG=2321>a " XBD=1304 XHG=1227 YBD=2345 YHG=2309>few" XBD=273 XHG=111 YBD=2402 YHG=2360>serious, " XBD=343 XHG=300 YBD=2395 YHG=2361>in " XBD=501 XHG=374 YBD=2395 YHG=2361>about " XBD=631 XHG=536 YBD=2407 YHG=2359>10% " XBD=700 XHG=655 YBD=2395 YHG=2358>of " XBD=917 XHG=728 YBD=2407 YHG=2360>patients. DAViDSON " XBD=1304 XHG=1222 YBD=2395 YHG=2360>and

MACDONALD " XBD=552 XHG=404 YBD=2445 YHG=2410>have " XBD=719 XHG=580 YBD=2445 YHG=2410>shown " XBD=839 XHG=746 YBD=2445 YHG=2410>that " XBD=1117 XHG=868 YBD=2444 YHG=2409>dicoumarin " XBD=1179 XHG=1144 YBD=2444 YHG=2410>is " XBD=1304 XHG=1208 YBD=2455 YHG=2409>only" XBD=295 XHG=110 YBD=2495 YHG=2459>effective " XBD=434 XHG=318 YBD=2494 YHG=2459>when " XBD=491 XHG=456 YBD=2494 YHG=2459>it " XBD=586 XHG=513 YBD=2494 YHG=2459>has " XBD=782 XHG=609 YBD=2494 YHG=2459>reduced " XBD=1086 XHG=805 YBD=2505 YHG=2459>prothrombin " XBD=1153 XHG=1108 YBD=2494 YHG=2462>to " XBD=1305 XHG=1177 YBD=2494 YHG=2460>about" XBD=208 XHG=111 YBD=2555 YHG=2508>30% " XBD=269 XHG=223 YBD=2544 YHG=2508>of " XBD=448 XHG=280 YBD=2550 YHG=2509>normal, " XBD=543 XHG=462 YBD=2544 YHG=2508>and " XBD=654 XHG=553 YBD=2554 YHG=2508>they " XBD=764 XHG=664 YBD=2543 YHG=2520>were " XBD=966 XHG=778 YBD=2544 YHG=2508>troubled " XBD=1033 XHG=976 YBD=2554 YHG=2508>by " XBD=1114 XHG=1043 YBD=2544 YHG=2508>the " XBD=1305 XHG=1125 YBD=2544 YHG=2508>variable" XBD=228 XHG=109 YBD=2593 YHG=2558>effect " XBD=349 XHG=255 YBD=2593 YHG=2558>that " XBD=401 XHG=376 YBD=2593 YHG=2570>a " XBD=547 XHG=428 YBD=2603 YHG=2558>given " XBD=669 XHG=574 YBD=2593 YHG=2558>dose " XBD=779 XHG=696 YBD=2594 YHG=2558>had " XBD=858 XHG=806 YBD=2593 YHG=2570>on " XBD=1070 XHG=886 YBD=2593 YHG=2557>different " XBD=1303 XHG=1097 YBD=2604 YHG=2558>patients ;" XBD=209 XHG=109 YBD=2652 YHG=2608>they " XBD=369 XHG=232 YBD=2653 YHG=2611>report " XBD=417 XHG=392 YBD=2642 YHG=2611>a " XBD=530 XHG=441 YBD=2642 YHG=2618>case " XBD=596 XHG=553 YBD=2642 YHG=2608>in " XBD=749 XHG=619 YBD=2642 YHG=2607>which " XBD=1158 XHG=772 YBD=2643 YHG=2606>blood-transfusion " XBD=1304 XHG=1181 YBD=2643 YHG=2606>failed" XBD=155 XHG=110 YBD=2691 YHG=2660>to " XBD=375 XHG=178 YBD=2700 YHG=2656>influence " XBD=470 XHG=398 YBD=2691 YHG=2656>the " XBD=569 XHG=492 YBD=2692 YHG=2656>low " XBD=874 XHG=593 YBD=2702 YHG=2657>prothrombin " XBD=995 XHG=897 YBD=2692 YHG=2657>time " XBD=1224 XHG=1019 YBD=2703 YHG=2657>produced " XBD=1305 XHG=1248 YBD=2703 YHG=2657>by" XBD=373 XHG=110 YBD=2741 YHG=2706>dicoumarin. " XBD=540 XHG=428 YBD=2752 YHG=2706>They " XBD=688 XHG=587 YBD=2741 YHG=2718>were " XBD=1036 XHG=736 YBD=2753 YHG=2706>unfavourably " XBD=1304 XHG=1083 YBD=2753 YHG=2707>impressed" XBD=209 XHG=111 YBD=2790 YHG=2755>with " XBD=307 XHG=236 YBD=2790 YHG=2755>the " XBD=436 XHG=334 YBD=2801 YHG=2756>drug " XBD=526 XHG=463 YBD=2791 YHG=2755>for " XBD=623 XHG=552 YBD=2791 YHG=2755>the " XBD=792 XHG=650 YBD=2792 YHG=2768>reason " XBD=924 XHG=818 YBD=2799 YHG=2757>that, " XBD=993 XHG=950 YBD=2791 YHG=2757>in " XBD=1124 XHG=1019 YBD=2791 YHG=2756>their " XBD=1302 XHG=1151 YBD=2803 YHG=2757>experi-" XBD=219 XHG=110 YBD=2846 YHG=2816>ence, " XBD=416 XHG=254 YBD=2840 YHG=2804>reliable " XBD=608 XHG=453 YBD=2840 YHG=2804>control " XBD=687 XHG=641 YBD=2840 YHG=2805>of " XBD=889 XHG=717 YBD=2852 YHG=2806>possible " XBD=1193 XHG=922 YBD=2852 YHG=2805>haemorrhage " XBD=1304 XHG=1230 YBD=2841 YHG=2806>has" XBD=155 XHG=109 YBD=2889 YHG=2857>to " XBD=236 XHG=186 YBD=2889 YHG=2854>be " XBD=473 XHG=268 YBD=2888 YHG=2853>sacrificed " XBD=537 XHG=501 YBD=2888 YHG=2853>if " XBD=596 XHG=562 YBD=2888 YHG=2854>it " XBD=660 XHG=626 YBD=2889 YHG=2854>is " XBD=735 XHG=690 YBD=2889 YHG=2857>to " XBD=814 XHG=765 YBD=2890 YHG=2855>be " XBD=1054 XHG=845 YBD=2897 YHG=2855>effective ; " XBD=1168 XHG=1092 YBD=2890 YHG=2856>but " XBD=1304 XHG=1198 YBD=2890 YHG=2856>their" XBD=228 XHG=110 YBD=2938 YHG=2904>series " XBD=310 XHG=265 YBD=2937 YHG=2902>of " XBD=453 XHG=343 YBD=2937 YHG=2914>cases " XBD=522 XHG=487 YBD=2937 YHG=2903>is " XBD=685 XHG=558 YBD=2945 YHG=2902>small, " XBD=805 XHG=724 YBD=2939 YHG=2905>and " XBD=897 XHG=844 YBD=2940 YHG=2916>no " XBD=1082 XHG=934 YBD=2939 YHG=2905>serious " XBD=1304 XHG=1119 YBD=2950 YHG=2904>bleeding" XBD=300 XHG=109 YBD=2998 YHG=2953>occurred " XBD=467 XHG=319 YBD=2998 YHG=2963>among " XBD=599 XHG=485 YBD=2987 YHG=2953>them " XBD=763 XHG=620 YBD=2998 YHG=2957>except " XBD=824 XHG=781 YBD=2988 YHG=2953>in " XBD=868 XHG=843 YBD=2988 YHG=2965>a " XBD=1046 XHG=888 YBD=2999 YHG=2954>patient " XBD=1163 XHG=1065 YBD=2988 YHG=2953>with " XBD=1304 XHG=1184 YBD=2988 YHG=2954>endo-" XBD=274 XHG=110 YBD=3042 YHG=2993>carditis " XBD=416 XHG=293 YBD=3037 YHG=3002>lenta. " XBD=513 XHG=471 YBD=3036 YHG=3000>It " XBD=564 XHG=530 YBD=3037 YHG=3001>is " XBD=688 XHG=584 YBD=3038 YHG=3001>clear " XBD=799 XHG=706 YBD=3037 YHG=3002>that " XBD=853 XHG=817 YBD=3037 YHG=3001>if " XBD=1119 XHG=868 YBD=3038 YHG=3003>dicoumarin " XBD=1170 XHG=1136 YBD=3038 YHG=3003>is " XBD=1304 XHG=1189 YBD=3037 YHG=3000>to be" XBD=221 XHG=110 YBD=3094 YHG=3047>used, " XBD=281 XHG=247 YBD=3087 YHG=3052>it |>|>" XBD=420 XHG=305 YBD=3087 YHG=3055>must " XBD=536 XHG=431 YBD=3097 YHG=3050>only " XBD=611 XHG=560 YBD=3086 YHG=3051>be " XBD=760 XHG=630 YBD=3087 YHG=3051>where " XBD=970 XHG=786 YBD=3087 YHG=3051>facilities " XBD=1056 XHG=993 YBD=3088 YHG=3051>for " XBD=1191 XHG=1080 YBD=3098 YHG=3052>daily " XBD=1304 XHG=1214 YBD=3098 YHG=3064>pro-" XBD=317 XHG=109 YBD=3137 YHG=3102>thrombin " XBD=466 XHG=346 YBD=3136 YHG=3102>times " XBD=566 XHG=495 YBD=3146 YHG=3101>by - " XBD=605 XHG=580 YBD=3136 YHG=3113>a " XBD=778 XHG=634 YBD=3147 YHG=3108>proper " XBD=1027 XHG=812 YBD=3147 YHG=3102>technique " XBD=1188 XHG=1057 YBD=3143 YHG=3102>exist ; " XBD=1306 XHG=1235 YBD=3137 YHG=3102>the" XBD=266 XHG=109 YBD=3197 YHG=3150>halting " XBD=333 XHG=288 YBD=3186 YHG=3151>of " XBD=374 XHG=349 YBD=3186 YHG=3163>a " XBD=607 XHG=395 YBD=3196 YHG=3150>spreading " XBD=869 XHG=626 YBD=3185 YHG=3150>thrombosis " XBD=1144 XHG=889 YBD=3196 YHG=3151>threatening " XBD=1244 XHG=1164 YBD=3186 YHG=3151>loss " XBD=1311 XHG=1264 YBD=3186 YHG=3150>of" XBD=136 XHG=110 YBD=3234 YHG=3212>a " XBD=250 XHG=152 YBD=3235 YHG=3200>limb " XBD=314 XHG=270 YBD=3236 YHG=3212>or " XBD=456 XHG=330 YBD=3235 YHG=3212>worse " XBD=506 XHG=472 YBD=3234 YHG=3200>is " XBD=653 XHG=524 YBD=3235 YHG=3201>worth " XBD=780 XHG=672 YBD=3234 YHG=3210>some " XBD=879 XHG=796 YBD=3234 YHG=3200>risk " XBD=941 XHG=897 YBD=3234 YHG=3199>of " XBD=1240 XHG=955 YBD=3245 YHG=3200>haemorrhage, " XBD=1305 XHG=1261 YBD=3235 YHG=3212>so" XBD=203 XHG=109 YBD=3295 YHG=3249>long " XBD=273 XHG=228 YBD=3284 YHG=3261>as " XBD=436 XHG=298 YBD=3284 YHG=3261>means " XBD=523 XHG=461 YBD=3284 YHG=3249>for " XBD=692 XHG=548 YBD=3295 YHG=3260>proper " XBD=872 XHG=718 YBD=3283 YHG=3248>control " XBD=942 XHG=898 YBD=3283 YHG=3248>of " XBD=1111 XHG=964 YBD=3294 YHG=3249>dosage " XBD=1217 XHG=1136 YBD=3283 YHG=3250>and " XBD=1305 XHG=1242 YBD=3283 YHG=3249>for" XBD=301 XHG=110 YBD=3344 YHG=3299>stopping " XBD=507 XHG=322 YBD=3344 YHG=3298>bleeding " XBD=595 XHG=528 YBD=3333 YHG=3310>are " XBD=661 XHG=617 YBD=3333 YHG=3302>at " XBD=803 XHG=681 YBD=3333 YHG=3298>hand. " XBD=908 XHG=858 YBD=3332 YHG=3298>In " XBD=999 XHG=928 YBD=3332 YHG=3298>the " XBD=1242 XHG=1020 YBD=3332 YHG=3298>discussion " XBD=1310 XHG=1264 YBD=3332 YHG=3298>of" XBD=179 XHG=108 YBD=3382 YHG=3347>the " XBD=405 XHG=192 YBD=3382 YHG=3348>American " XBD=574 XHG=416 YBD=3389 YHG=3347>results, " XBD=791 XHG=589 YBD=3383 YHG=3348>OCHSNER " XBD=817 XHG=804 YBD=3369 YHG=3351>9 " XBD=877 XHG=832 YBD=3381 YHG=3347>of " XBD=983 XHG=885 YBD=3382 YHG=3347>New " XBD=1162 XHG=997 YBD=3381 YHG=3346>Orleans " XBD=1306 XHG=1175 YBD=3381 YHG=3347>raised

5. Lehmann, J. Lancet, 1943, i, 458.6. Crafoord, C. and Jorpes, E. J. Amer. med. Ass. 1941, 116, 2831.7. Wright, I. S. and Prandoni, A. Ibid, p. 1015.8. Davidson, C. S., MacDonald, H. Amer. J. med. Sci. 1943, 205, 24.9. J. Amer. med. Ass. 1942, 120, 1025.

" XBD=1416 XHG=1363 YBD=264 YHG=242>an " XBD=1666 XHG=1430 YBD=276 YHG=230>interesting " XBD=1821 XHG=1682 YBD=276 YHG=231>point : " XBD=1888 XHG=1854 YBD=264 YHG=230>if " XBD=1958 XHG=1900 YBD=265 YHG=241>we " XBD=2055 XHG=1974 YBD=275 YHG=242>pay " XBD=2139 XHG=2070 YBD=264 YHG=234>too " XBD=2469 XHG=2155 YBD=264 YHG=208>much attention " XBD=2520 XHG=2483 YBD=265 YHG=235>to" XBD=1698 XHG=1363 YBD=325 YHG=279>anticoagulants, " XBD=1768 XHG=1718 YBD=313 YHG=279>he " XBD=1926 XHG=1790 YBD=320 YHG=279>asked, " XBD=2013 XHG=1946 YBD=313 YHG=290>are " XBD=2150 XHG=2039 YBD=312 YHG=278>these " XBD=2346 XHG=2175 YBD=323 YHG=278>patients " XBD=2466 XHG=2362 YBD=324 YHG=279>going " XBD=2519 XHG=2481 YBD=314 YHG=282>to" XBD=1532 XHG=1364 YBD=374 YHG=328>develop " XBD=1740 XHG=1561 YBD=363 YHG=329>emboli ? " XBD=2041 XHG=1797 YBD=373 YHG=328>Experience " XBD=2111 XHG=2069 YBD=361 YHG=327>in " XBD=2327 XHG=2139 YBD=362 YHG=327>subacute " XBD=2518 XHG=2353 YBD=362 YHG=327>bacterial" XBD=1632 XHG=1364 YBD=413 YHG=378>endocarditis " XBD=1712 XHG=1639 YBD=412 YHG=378>has " XBD=1861 XHG=1724 YBD=412 YHG=377>shown " XBD=1965 XHG=1872 YBD=412 YHG=378>that " XBD=2058 XHG=1977 YBD=411 YHG=377>this " XBD=2098 XHG=2065 YBD=411 YHG=377>is " XBD=2134 XHG=2110 YBD=410 YHG=389>a " XBD=2338 XHG=2141 YBD=421 YHG=376>pertinent " XBD=2515 XHG=2345 YBD=420 YHG=377>question," XBD=1445 XHG=1364 YBD=462 YHG=428>and " XBD=1558 XHG=1477 YBD=461 YHG=427>this " XBD=1671 XHG=1589 YBD=461 YHG=427>and " XBD=1817 XHG=1703 YBD=461 YHG=427>other " XBD=1950 XHG=1848 YBD=461 YHG=426>risks " XBD=2091 XHG=1982 YBD=460 YHG=429>must " XBD=2172 XHG=2124 YBD=460 YHG=426>be " XBD=2309 XHG=2203 YBD=459 YHG=436>more " XBD=2518 XHG=2339 YBD=469 YHG=423>definitely" XBD=1579 XHG=1364 YBD=511 YHG=476>evaluated " XBD=1730 XHG=1596 YBD=510 YHG=475>before " XBD=1995 XHG=1747 YBD=510 YHG=475>dicoumarin " XBD=2088 XHG=2013 YBD=508 YHG=486>can " XBD=2154 XHG=2105 YBD=509 YHG=475>be " XBD=2455 XHG=2171 YBD=508 YHG=473>recommended " XBD=2522 XHG=2470 YBD=508 YHG=473>for

" XBD=1520 XHG=1363 YBD=570 YHG=524>general |>" XBD=1620 XHG=1539 YBD=580 YHG=536>use.Annotations

SUCCESS IN TREATMENT OF PNEUMONIA

" XBD=1528 XHG=1412 YBD=811 YHG=780>FROM " XBD=1624 XHG=1558 YBD=810 YHG=779>the " XBD=1754 XHG=1654 YBD=811 YHG=788>mass " XBD=1823 XHG=1783 YBD=810 YHG=779>of " XBD=1987 XHG=1850 YBD=819 YHG=788>papers " XBD=2065 XHG=2016 YBD=810 YHG=789>on " XBD=2159 XHG=2094 YBD=810 YHG=769>the " XBD=2466 XHG=2188 YBD=819 YHG=778>chemotherapy " XBD=2524 XHG=2491 YBD=810 YHG=779>of" XBD=1656 XHG=1363 YBD=865 YHG=823>pneumococcal " XBD=1915 XHG=1686 YBD=863 YHG=824>pneumonia " XBD=2033 XHG=1947 YBD=855 YHG=824>that " XBD=2164 XHG=2065 YBD=855 YHG=824>have " XBD=2376 XHG=2195 YBD=863 YHG=823>appeared " XBD=2440 XHG=2403 YBD=855 YHG=823>in " XBD=2523 XHG=2468 YBD=856 YHG=823>the" XBD=1451 XHG=1363 YBD=909 YHG=871>past " XBD=1565 XHG=1490 YBD=900 YHG=868>five " XBD=1713 XHG=1590 YBD=908 YHG=861>’years " XBD=1828 XHG=1752 YBD=900 YHG=869>two " XBD=2078 XHG=1867 YBD=908 YHG=869>important " XBD=2347 XHG=2119 YBD=900 YHG=868>conclusions " XBD=2521 XHG=2383 YBD=910 YHG=877>emerge." XBD=1470 XHG=1364 YBD=945 YHG=914>With " XBD=1562 XHG=1497 YBD=944 YHG=913>the " XBD=1724 XHG=1587 YBD=952 YHG=922>proper " XBD=1815 XHG=1749 YBD=945 YHG=922>use " XBD=1881 XHG=1842 YBD=943 YHG=913>of " XBD=2226 XHG=1907 YBD=953 YHG=913>sulphapyridine, " XBD=2522 XHG=2253 YBD=953 YHG=912>sulphathiazole" XBD=1406 XHG=1365 YBD=988 YHG=967>or " XBD=1717 XHG=1434 YBD=997 YHG=956>sulphadiazine " XBD=1809 XHG=1745 YBD=988 YHG=956>the " XBD=1941 XHG=1838 YBD=996 YHG=966>gross " XBD=2221 XHG=1968 YBD=997 YHG=958>fatality-rate " XBD=2278 XHG=2247 YBD=988 YHG=957>is " XBD=2384 XHG=2304 YBD=989 YHG=967>now " XBD=2444 XHG=2408 YBD=997 YHG=957>ip " XBD=2524 XHG=2468 YBD=990 YHG=958>the" XBD=1492 XHG=1364 YBD=1043 YHG=1002>region " XBD=1557 XHG=1518 YBD=1033 YHG=1002>of " XBD=1628 XHG=1586 YBD=1033 YHG=1003>10 " XBD=1720 XHG=1652 YBD=1042 YHG=1011>per " XBD=1868 XHG=1744 YBD=1039 YHG=1004>cent. ; " XBD=1980 XHG=1904 YBD=1032 YHG=1001>and " XBD=2037 XHG=1998 YBD=1033 YHG=1002>of " XBD=2121 XHG=2056 YBD=1033 YHG=1002>the " XBD=2243 XHG=2138 YBD=1033 YHG=1002>three " XBD=2368 XHG=2260 YBD=1043 YHG=1001>drugs " XBD=2522 XHG=2390 YBD=1043 YHG=1002>sulpha-" XBD=1511 XHG=1366 YBD=1078 YHG=1046>diazine " XBD=1580 XHG=1549 YBD=1077 YHG=1046>is " XBD=1657 XHG=1617 YBD=1077 YHG=1048>to " XBD=1742 XHG=1695 YBD=1077 YHG=1046>be " XBD=1967 XHG=1776 YBD=1087 YHG=1046>preferred " XBD=2161 XHG=2003 YBD=1078 YHG=1047>because " XBD=2246 XHG=2190 YBD=1079 YHG=1047>its " XBD=2379 XHG=2280 YBD=1079 YHG=1047>toxic " XBD=2525 XHG=2411 YBD=1080 YHG=1046>effects" XBD=1427 XHG=1365 YBD=1122 YHG=1100>are " XBD=1563 XHG=1456 YBD=1123 YHG=1091>least. " XBD=1693 XHG=1615 YBD=1122 YHG=1090>But " XBD=1903 XHG=1721 YBD=1132 YHG=1090>although " XBD=1999 XHG=1927 YBD=1122 YHG=1091>the " XBD=2162 XHG=2026 YBD=1123 YHG=1092>results " XBD=2229 XHG=2190 YBD=1123 YHG=1091>of " XBD=2526 XHG=2256 YBD=1133 YHG=1091>chemotherapy" XBD=1427 XHG=1365 YBD=1166 YHG=1144>are " XBD=1725 XHG=1461 YBD=1176 YHG=1135>undoubtedly " XBD=2005 XHG=1760 YBD=1175 YHG=1135>spectacular, " XBD=2088 XHG=2045 YBD=1167 YHG=1137>10 " XBD=2187 XHG=2120 YBD=1175 YHG=1145>per " XBD=2315 XHG=2220 YBD=1168 YHG=1138>cent. " XBD=2378 XHG=2348 YBD=1169 YHG=1136>is " XBD=2477 XHG=2408 YBD=1169 YHG=1137>still " XBD=2526 XHG=2506 YBD=1168 YHG=1147>a" XBD=1525 XHG=1366 YBD=1212 YHG=1180>sizeable " XBD=1791 XHG=1537 YBD=1220 YHG=1180>fatality-rate " XBD=1880 XHG=1805 YBD=1211 YHG=1180>and " XBD=1927 XHG=1897 YBD=1212 YHG=1180>it " XBD=1978 XHG=1945 YBD=1211 YHG=1180>is " XBD=2146 XHG=1994 YBD=1212 YHG=1180>natural " XBD=2203 XHG=2162 YBD=1212 YHG=1182>to " XBD=2362 XHG=2221 YBD=1220 YHG=1180>inquire " XBD=2525 XHG=2376 YBD=1214 YHG=1180>whether" XBD=1396 XHG=1365 YBD=1256 YHG=1225>it " XBD=1580 XHG=1440 YBD=1256 YHG=1225>cannot " XBD=1671 XHG=1623 YBD=1255 YHG=1224>be " XBD=1861 XHG=1712 YBD=1255 YHG=1224>further " XBD=2078 XHG=1902 YBD=1256 YHG=1224>reduced. " XBD=2272 XHG=2132 YBD=1256 YHG=1224>Recent " XBD=2439 XHG=2313 YBD=1265 YHG=1234>papers " XBD=2523 XHG=2477 YBD=1266 YHG=1226>by" XBD=1528 XHG=1365 YBD=1313 YHG=1269>Flippin, " XBD=1750 XHG=1562 YBD=1301 YHG=1268>Schwartz " XBD=1857 XHG=1782 YBD=1300 YHG=1269>and " XBD=2056 XHG=1888 YBD=1300 YHG=1269>Domin and " XBD=2244 XHG=2192 YBD=1309 YHG=1270>by " XBD=2431 XHG=2273 YBD=1302 YHG=1269>Meakins " XBD=2525 XHG=2459 YBD=1303 YHG=1271>and

McKenna " XBD=1816 XHG=1578 YBD=1346 YHG=1313>2 illustrate " XBD=1930 XHG=1854 YBD=1345 YHG=1314>this " XBD=2147 XHG=1969 YBD=1346 YHG=1313>attitude. " XBD=2276 XHG=2198 YBD=1346 YHG=1313>The " XBD=2459 XHG=2311 YBD=1346 YHG=1314>chances " XBD=2527 XHG=2493 YBD=1347 YHG=1316>of" XBD=1533 XHG=1365 YBD=1391 YHG=1359>survival " XBD=1616 XHG=1554 YBD=1389 YHG=1368>are " XBD=1898 XHG=1638 YBD=1399 YHG=1358>considerably " XBD=2081 XHG=1919 YBD=1390 YHG=1359>reduced " XBD=2131 XHG=2102 YBD=1389 YHG=1359>if " XBD=2219 XHG=2152 YBD=1390 YHG=1358>the " XBD=2306 XHG=2239 YBD=1400 YHG=1368>age " XBD=2355 XHG=2325 YBD=1391 YHG=1359>is " XBD=2457 XHG=2375 YBD=1391 YHG=1368>over " XBD=2552 XHG=2472 YBD=1398 YHG=1362>40," XBD=1393 XHG=1363 YBD=1435 YHG=1404>if " XBD=1516 XHG=1409 YBD=1436 YHG=1404>there " XBD=1565 XHG=1533 YBD=1435 YHG=1404>is " XBD=1821 XHG=1581 YBD=1435 YHG=1403>bacteraemia " XBD=1880 XHG=1839 YBD=1435 YHG=1413>or " XBD=1926 XHG=1896 YBD=1435 YHG=1404>if " XBD=2007 XHG=1942 YBD=1435 YHG=1403>the " XBD=2205 XHG=2024 YBD=1435 YHG=1403>infection " XBD=2253 XHG=2221 YBD=1435 YHG=1403>is " XBD=2357 XHG=2269 YBD=1436 YHG=1403>with " XBD=2457 XHG=2372 YBD=1445 YHG=1405>type " XBD=2523 XHG=2474 YBD=1437 YHG=1395>III" XBD=1584 XHG=1367 YBD=1489 YHG=1449>organisms. " XBD=1714 XHG=1636 YBD=1479 YHG=1448>The " XBD=1935 XHG=1737 YBD=1480 YHG=1448>combined " XBD=2023 XHG=1957 YBD=1480 YHG=1458>use " XBD=2085 XHG=2046 YBD=1479 YHG=1448>of " XBD=2238 XHG=2115 YBD=1480 YHG=1458>serum " XBD=2340 XHG=2268 YBD=1480 YHG=1449>and " XBD=2523 XHG=2368 YBD=1489 YHG=1449>sulphon-" XBD=1509 XHG=1366 YBD=1525 YHG=1493>amides " XBD=1618 XHG=1529 YBD=1533 YHG=1503>may " XBD=1774 XHG=1637 YBD=1525 YHG=1493>reduce " XBD=1863 XHG=1797 YBD=1525 YHG=1493>the " XBD=2084 XHG=1889 YBD=1533 YHG=1494>mortality " XBD=2148 XHG=2109 YBD=1523 YHG=1493>in |>" XBD=2401 XHG=2173 YBD=1525 YHG=1493>bactersemic " XBD=2523 XHG=2424 YBD=1532 YHG=1503>cases," XBD=1436 XHG=1365 YBD=1569 YHG=1538>but " XBD=1535 XHG=1469 YBD=1570 YHG=1538>the " XBD=1764 XHG=1568 YBD=1578 YHG=1538>discovery " XBD=1837 XHG=1797 YBD=1569 YHG=1538>of " XBD=1891 XHG=1869 YBD=1569 YHG=1547>a " XBD=2211 XHG=1924 YBD=1578 YHG=1537>sulphonamide " XBD=2342 XHG=2244 YBD=1570 YHG=1547>more " XBD=2525 XHG=2372 YBD=1571 YHG=1538>effective" XBD=1514 XHG=1365 YBD=1624 YHG=1583>against " XBD=1641 XHG=1548 YBD=1623 YHG=1584>type " XBD=1736 XHG=1676 YBD=1614 YHG=1583>III " XBD=1979 XHG=1773 YBD=1623 YHG=1583>organisms " XBD=2132 XHG=2013 YBD=1614 YHG=1592>seems " XBD=2206 XHG=2165 YBD=1614 YHG=1585>to " XBD=2330 XHG=2242 YBD=1614 YHG=1582>offer " XBD=2422 XHG=2361 YBD=1614 YHG=1582>the " XBD=2525 XHG=2452 YBD=1615 YHG=1583>best" XBD=1507 XHG=1366 YBD=1660 YHG=1628>chance " XBD=1560 XHG=1520 YBD=1659 YHG=1628>of " XBD=1748 XHG=1571 YBD=1668 YHG=1628>lowering " XBD=1826 XHG=1760 YBD=1659 YHG=1628>the " XBD=1956 XHG=1838 YBD=1668 YHG=1626>figure " XBD=2092 XHG=1973 YBD=1659 YHG=1627>below " XBD=2155 XHG=2113 YBD=1658 YHG=1629>10 " XBD=2234 XHG=2167 YBD=1667 YHG=1636>per " XBD=2344 XHG=2251 YBD=1659 YHG=1629>cent. " XBD=2525 XHG=2392 YBD=1669 YHG=1627>Flippin" XBD=1443 XHG=1365 YBD=1704 YHG=1673>and " XBD=1520 XHG=1461 YBD=1704 YHG=1672>his " XBD=1749 XHG=1541 YBD=1713 YHG=1673>colleagues " XBD=1981 XHG=1770 YBD=1712 YHG=1672>emphasise " XBD=2160 XHG=2001 YBD=1704 YHG=1671>another " XBD=2287 XHG=2179 YBD=1711 YHG=1672>point " XBD=2388 XHG=2306 YBD=1704 YHG=1672>that " XBD=2526 XHG=2407 YBD=1704 YHG=1672>should" XBD=1412 XHG=1365 YBD=1748 YHG=1717>be " XBD=1547 XHG=1430 YBD=1748 YHG=1707>taken " XBD=1607 XHG=1566 YBD=1748 YHG=1719>to " XBD=1733 XHG=1624 YBD=1748 YHG=1717>heart " XBD=1803 XHG=1753 YBD=1757 YHG=1717>by " XBD=1873 XHG=1823 YBD=1748 YHG=1716>all " XBD=2166 XHG=1891 YBD=1756 YHG=1716>practitioners. " XBD=2264 XHG=2219 YBD=1748 YHG=1717>In " XBD=2374 XHG=2281 YBD=1748 YHG=1716>their " XBD=2526 XHG=2390 YBD=1758 YHG=1716>opinion" XBD=1390 XHG=1368 YBD=1775 YHG=1762>&dquo; " XBD=1471 XHG=1405 YBD=1793 YHG=1761>the " XBD=1624 XHG=1493 YBD=1802 YHG=1761>length " XBD=1687 XHG=1648 YBD=1793 YHG=1762>of " XBD=1801 XHG=1709 YBD=1793 YHG=1762>time " XBD=1912 XHG=1825 YBD=1793 YHG=1761>that " XBD=2078 XHG=1935 YBD=1801 YHG=1761>elapses " XBD=2270 XHG=2102 YBD=1793 YHG=1761>between " XBD=2355 XHG=2291 YBD=1793 YHG=1762>the " XBD=2473 XHG=2376 YBD=1793 YHG=1763>onset " XBD=2527 XHG=2494 YBD=1793 YHG=1762>of" XBD=1431 XHG=1365 YBD=1838 YHG=1806>the " XBD=1640 XHG=1459 YBD=1838 YHG=1806>infection " XBD=1747 XHG=1671 YBD=1838 YHG=1806>and " XBD=1841 XHG=1775 YBD=1838 YHG=1806>the " XBD=2072 XHG=1870 YBD=1847 YHG=1805>beginning " XBD=2140 XHG=2101 YBD=1838 YHG=1806>of " XBD=2314 XHG=2168 YBD=1846 YHG=1805>specific " XBD=2525 XHG=2340 YBD=1838 YHG=1807>treatment" XBD=1396 XHG=1364 YBD=1883 YHG=1851>is " XBD=1486 XHG=1420 YBD=1882 YHG=1850>the " XBD=1610 XHG=1511 YBD=1883 YHG=1852>most " XBD=1845 XHG=1634 YBD=1891 YHG=1851>important " XBD=1986 XHG=1869 YBD=1892 YHG=1851>single " XBD=2253 XHG=2010 YBD=1882 YHG=1850>controllable " XBD=2392 XHG=2276 YBD=1882 YHG=1851>factor " XBD=2449 XHG=2413 YBD=1882 YHG=1851>in " XBD=2526 XHG=2470 YBD=1882 YHG=1850>the" XBD=1560 XHG=1364 YBD=1937 YHG=1896>prognosis " XBD=1639 XHG=1601 YBD=1927 YHG=1895>of " XBD=1966 XHG=1679 YBD=1936 YHG=1896>pneumococcic " XBD=2273 XHG=2007 YBD=1937 YHG=1895>pneumonia.&dquo; " XBD=2396 XHG=2322 YBD=1927 YHG=1895>The " XBD=2525 XHG=2432 YBD=1927 YHG=1897>onset" XBD=1405 XHG=1366 YBD=1972 YHG=1941>of " XBD=1647 XHG=1416 YBD=1981 YHG=1940>pneumonia " XBD=1693 XHG=1661 YBD=1972 YHG=1940>is " XBD=1813 XHG=1708 YBD=1980 YHG=1941>quite " XBD=2107 XHG=1827 YBD=1973 YHG=1940>characteristic " XBD=2159 XHG=2120 YBD=1972 YHG=1941>in " XBD=2238 XHG=2173 YBD=1972 YHG=1940>the " XBD=2353 XHG=2251 YBD=1982 YHG=1941>great " XBD=2525 XHG=2367 YBD=1981 YHG=1939>majority" XBD=1405 XHG=1366 YBD=2017 YHG=1985>of " XBD=1539 XHG=1423 YBD=2022 YHG=1995>cases, " XBD=1637 XHG=1560 YBD=2017 YHG=1986>and " XBD=1721 XHG=1656 YBD=2017 YHG=1985>the " XBD=1873 XHG=1742 YBD=2018 YHG=1986>doctor " XBD=1976 XHG=1891 YBD=2017 YHG=1985>who " XBD=2105 XHG=1995 YBD=2017 YHG=1986>waits " XBD=2181 XHG=2122 YBD=2017 YHG=1986>for " XBD=2264 XHG=2200 YBD=2017 YHG=1985>the " XBD=2525 XHG=2283 YBD=2026 YHG=1984>confirmatory" XBD=1544 XHG=1366 YBD=2062 YHG=2031>evidence " XBD=1758 XHG=1572 YBD=2070 YHG=2030>provided " XBD=1840 XHG=1787 YBD=2071 YHG=2030>by " XBD=1995 XHG=1857 YBD=2071 YHG=2031>-X-ray " XBD=2280 XHG=2023 YBD=2062 YHG=2030>examination " XBD=2350 XHG=2310 YBD=2068 YHG=2039>or " XBD=2468 XHG=2377 YBD=2071 YHG=2030>signs " XBD=2526 XHG=2493 YBD=2061 YHG=2029>of" XBD=1639 XHG=1365 YBD=2107 YHG=2075>consolidation " XBD=1790 XHG=1662 YBD=2107 YHG=2075>before " XBD=2029 XHG=1810 YBD=2117 YHG=2075>instituting " XBD=2342 XHG=2051 YBD=2115 YHG=2075>chemotherapy " XBD=2391 XHG=2362 YBD=2107 YHG=2075>is " XBD=2569 XHG=2411 YBD=2115 YHG=2083>expos-" XBD=1428 XHG=1364 YBD=2162 YHG=2121>ing " XBD=1502 XHG=1443 YBD=2152 YHG=2120>his " XBD=1667 XHG=1516 YBD=2161 YHG=2121>patient " XBD=1723 XHG=1682 YBD=2152 YHG=2123>to " XBD=1907 XHG=1740 YBD=2153 YHG=2121>needless " XBD=2010 XHG=1922 YBD=2152 YHG=2120>risk.

PYRIDOXINE DEFICIENCIES" XBD=1447 XHG=1413 YBD=2296 YHG=2265>A " XBD=1559 XHG=1474 YBD=2296 YHG=2273>FEW " XBD=1695 XHG=1586 YBD=2305 YHG=2274>years " XBD=1792 XHG=1722 YBD=2305 YHG=2274>ago " XBD=1849 XHG=1818 YBD=2296 YHG=2265>it " XBD=2011 XHG=1875 YBD=2296 YHG=2264>looked " XBD=2079 XHG=2038 YBD=2296 YHG=2274>as " XBD=2250 XHG=2106 YBD=2304 YHG=2264>though " XBD=2380 XHG=2276 YBD=2296 YHG=2264>Dean " XBD=2523 XHG=2404 YBD=2296 YHG=2263>Swift’s" XBD=1556 XHG=1364 YBD=2341 YHG=2309>witticism " XBD=1698 XHG=1579 YBD=2341 YHG=2309>about " XBD=1787 XHG=1721 YBD=2341 YHG=2304>the " XBD=1900 XHG=1808 YBD=2341 YHG=2309>fleas " XBD=2044 XHG=1922 YBD=2350 YHG=2309>might " XBD=2145 XHG=2066 YBD=2341 YHG=2309>also " XBD=2257 XHG=2168 YBD=2340 YHG=2310>turn " XBD=2343 XHG=2280 YBD=2341 YHG=2310>out " XBD=2403 XHG=2365 YBD=2341 YHG=2310>to " XBD=2523 XHG=2424 YBD=2350 YHG=2308>apply" XBD=1405 XHG=1364 YBD=2386 YHG=2357>to " XBD=1501 XHG=1434 YBD=2386 YHG=2355>the " XBD=1605 XHG=1528 YBD=2391 YHG=2354>B’s, " XBD=1736 XHG=1634 YBD=2386 YHG=2354>since " XBD=1855 XHG=1763 YBD=2395 YHG=2355>they " XBD=2032 XHG=1883 YBD=2386 YHG=2353>seemed " XBD=2216 XHG=2060 YBD=2395 YHG=2353>capable " XBD=2282 XHG=2243 YBD=2385 YHG=2353>of " XBD=2522 XHG=2307 YBD=2394 YHG=2353>subdividing" XBD=1415 XHG=1366 YBD=2431 YHG=2400>ad " XBD=1639 XHG=1435 YBD=2431 YHG=2398>infinitum. " XBD=1770 XHG=1691 YBD=2431 YHG=2399>The " XBD=1947 XHG=1791 YBD=2432 YHG=2399>outlook " XBD=1999 XHG=1968 YBD=2432 YHG=2399>is " XBD=2106 XHG=2020 YBD=2431 YHG=2409>now " XBD=2229 XHG=2127 YBD=2431 YHG=2408>more " XBD=2442 XHG=2248 YBD=2440 YHG=2398>promising " XBD=2522 XHG=2460 YBD=2429 YHG=2397>and" XBD=1493 XHG=1365 YBD=2476 YHG=2446>recent " XBD=1614 XHG=1510 YBD=2476 YHG=2444>work " XBD=1719 XHG=1631 YBD=2485 YHG=2452>goes " XBD=1778 XHG=1738 YBD=2476 YHG=2446>to " XBD=1901 XHG=1797 YBD=2476 YHG=2444>show " XBD=2005 XHG=1918 YBD=2475 YHG=2443>that " XBD=2183 XHG=2023 YBD=2476 YHG=2444>animals " XBD=2271 XHG=2202 YBD=2475 YHG=2453>can " XBD=2333 XHG=2288 YBD=2475 YHG=2443>be " XBD=2467 XHG=2350 YBD=2476 YHG=2444>reared " XBD=2523 XHG=2484 YBD=2473 YHG=2451>on" XBD=1463 XHG=1367 YBD=2519 YHG=2489>diets " XBD=1519 XHG=1480 YBD=2519 YHG=2488>in " XBD=1656 XHG=1533 YBD=2520 YHG=2488>which " XBD=1723 XHG=1673 YBD=2519 YHG=2488>all " XBD=1803 XHG=1739 YBD=2519 YHG=2488>the " XBD=1852 XHG=1820 YBD=2520 YHG=2489>B " XBD=2052 XHG=1870 YBD=2521 YHG=2488>vitamins " XBD=2165 XHG=2066 YBD=2520 YHG=2488>have " XBD=2274 XHG=2180 YBD=2519 YHG=2488>been " XBD=2406 XHG=2291 YBD=2520 YHG=2487>added " XBD=2454 XHG=2419 YBD=2519 YHG=2488>in " XBD=2522 XHG=2469 YBD=2519 YHG=2487>the" XBD=1463 XHG=1364 YBD=2564 YHG=2533>form " XBD=1534 XHG=1495 YBD=2563 YHG=2533>of " XBD=1637 XHG=1562 YBD=2564 YHG=2532>fine " XBD=1878 XHG=1668 YBD=2564 YHG=2532>chemicals. " XBD=2132 XHG=1930 YBD=2573 YHG=2533>Naturally " XBD=2237 XHG=2162 YBD=2564 YHG=2532>this " XBD=2333 XHG=2266 YBD=2564 YHG=2532>has " XBD=2416 XHG=2361 YBD=2565 YHG=2532>led " XBD=2478 XHG=2443 YBD=2564 YHG=2534>to " XBD=2521 XHG=2502 YBD=2561 YHG=2541>a" XBD=1473 XHG=1365 YBD=2617 YHG=2577>rapid " XBD=1662 XHG=1492 YBD=2608 YHG=2577>advance " XBD=1718 XHG=1680 YBD=2608 YHG=2577>in " XBD=1805 XHG=1738 YBD=2608 YHG=2586>our " XBD=2041 XHG=1823 YBD=2618 YHG=2577>knowledge " XBD=2099 XHG=2059 YBD=2610 YHG=2578>of " XBD=2181 XHG=2116 YBD=2609 YHG=2577>the " XBD=2366 XHG=2199 YBD=2609 YHG=2577>function " XBD=2418 XHG=2383 YBD=2609 YHG=2577>of " XBD=2520 XHG=2434 YBD=2607 YHG=2576>these" XBD=1598 XHG=1366 YBD=2658 YHG=2622>substances, " XBD=1724 XHG=1648 YBD=2652 YHG=2621>and " XBD=1996 XHG=1772 YBD=2661 YHG=2621>pyridoxine " XBD=2262 XHG=2046 YBD=2654 YHG=2621>deficencies " XBD=2346 XHG=2308 YBD=2653 YHG=2622>in " XBD=2519 XHG=2390 YBD=2653 YHG=2621>various" XBD=1505 XHG=1365 YBD=2706 YHG=2666>species " XBD=1590 XHG=1527 YBD=2697 YHG=2675>are " XBD=1697 XHG=1613 YBD=2697 YHG=2675>now " XBD=1922 XHG=1720 YBD=2707 YHG=2666>beginning " XBD=1985 XHG=1944 YBD=2698 YHG=2668>to " XBD=2056 XHG=2008 YBD=2698 YHG=2666>be " XBD=2359 XHG=2079 YBD=2701 YHG=2666>characterised. " XBD=2440 XHG=2406 YBD=2697 YHG=2666>It " XBD=2522 XHG=2458 YBD=2698 YHG=2664>will" XBD=1412 XHG=1364 YBD=2742 YHG=2710>be " XBD=1581 XHG=1422 YBD=2743 YHG=2710>recalled " XBD=1681 XHG=1594 YBD=2742 YHG=2710>that " XBD=1810 XHG=1695 YBD=2742 YHG=2710>Chick " XBD=1899 XHG=1824 YBD=2742 YHG=2711>and " XBD=1976 XHG=1909 YBD=2743 YHG=2711>her " XBD=2199 XHG=1992 YBD=2752 YHG=2710>colleagues " XBD=2250 XHG=2211 YBD=2743 YHG=2711>in 1938 " XBD=2521 XHG=2363 YBD=2743 YHG=2709>3 showed" XBD=1451 XHG=1365 YBD=2787 YHG=2755>that " XBD=1551 XHG=1468 YBD=2796 YHG=2756>pigs " XBD=1631 XHG=1566 YBD=2788 YHG=2755>fed " XBD=1697 XHG=1648 YBD=2786 YHG=2765>on " XBD=1746 XHG=1723 YBD=2787 YHG=2765>a " XBD=1986 XHG=1771 YBD=2796 YHG=2755>selectively " XBD=2162 XHG=2001 YBD=2796 YHG=2755>purified " XBD=2257 XHG=2180 YBD=2788 YHG=2756>diet " XBD=2466 XHG=2277 YBD=2796 YHG=2755>developed " XBD=2521 XHG=2481 YBD=2787 YHG=2764>an|>" XBD=1525 XHG=1366 YBD=2831 YHG=2800>anaemia " XBD=1618 XHG=1542 YBD=2831 YHG=2800>and " XBD=1712 XHG=1635 YBD=2831 YHG=2799>had " XBD=1905 XHG=1729 YBD=2840 YHG=2799>epileptic " XBD=1997 XHG=1921 YBD=2837 YHG=2799>fits, " XBD=2094 XHG=2016 YBD=2831 YHG=2801>and " XBD=2307 XHG=2111 YBD=2844 YHG=2800>that both " XBD=2420 XHG=2323 YBD=2832 YHG=2801>these " XBD=2521 XHG=2436 YBD=2841 YHG=2800>signs" XBD=1477 XHG=1366 YBD=2876 YHG=2844>could " XBD=1551 XHG=1504 YBD=2875 YHG=2844>be " XBD=1741 XHG=1578 YBD=2876 YHG=2844>relieved " XBD=1861 XHG=1768 YBD=2875 YHG=2843>with " XBD=2057 XHG=1889 YBD=2876 YHG=2846>extracts " XBD=2125 XHG=2086 YBD=2876 YHG=2844>of |>" XBD=2244 XHG=2151 YBD=2876 YHG=2842>liver " XBD=2343 XHG=2271 YBD=2876 YHG=2845>and " XBD=2405 XHG=2370 YBD=2876 YHG=2844>of " XBD=2521 XHG=2429 YBD=2885 YHG=2845>yeast" XBD=1487 XHG=1365 YBD=2919 YHG=2888>which " XBD=1609 XHG=1511 YBD=2920 YHG=2897>were " XBD=1770 XHG=1632 YBD=2920 YHG=2888>known " XBD=1835 XHG=1794 YBD=2919 YHG=2890>to " XBD=2015 XHG=1861 YBD=2920 YHG=2889>contain " XBD=2273 XHG=2039 YBD=2929 YHG=2888>pyridoxine. " XBD=2416 XHG=2323 YBD=2929 YHG=2889>Dogs " XBD=2481 XHG=2439 YBD=2920 YHG=2898>on " XBD=2522 XHG=2502 YBD=2918 YHG=2897>a" XBD=1444 XHG=1367 YBD=2963 YHG=2932>diet " XBD=1643 XHG=1469 YBD=2965 YHG=2932>deficient " XBD=1705 XHG=1666 YBD=2964 YHG=2933>in " XBD=1806 XHG=1729 YBD=2964 YHG=2932>this " XBD=1992 XHG=1829 YBD=2964 YHG=2933>vitamin " XBD=2114 XHG=2015 YBD=2964 YHG=2933>have " XBD=2216 XHG=2138 YBD=2965 YHG=2933>also " XBD=2330 XHG=2238 YBD=2965 YHG=2933>been " XBD=2467 XHG=2351 YBD=2965 YHG=2933>shown " XBD=2521 XHG=2487 YBD=2964 YHG=2935>to" XBD=1523 XHG=1368 YBD=3017 YHG=2977>develop " XBD=1564 XHG=1541 YBD=3009 YHG=2986>a " XBD=1798 XHG=1581 YBD=3017 YHG=2977>microcytic " XBD=1998 XHG=1814 YBD=3015 YHG=2977>anaemia ; " XBD=2101 XHG=2029 YBD=3008 YHG=2977>but " XBD=2345 XHG=2116 YBD=3018 YHG=2975>pyridoxine, " XBD=2522 XHG=2362 YBD=3018 YHG=2976>although" XBD=1611 XHG=1365 YBD=3061 YHG=3021>temporarily " XBD=1865 XHG=1643 YBD=3057 YHG=3021>efficaoious, " XBD=1961 XHG=1892 YBD=3053 YHG=3020>has " XBD=2063 XHG=1995 YBD=3053 YHG=3023>not " XBD=2132 XHG=2092 YBD=3052 YHG=3030>so " XBD=2218 XHG=2159 YBD=3052 YHG=3021>far " XBD=2334 XHG=2244 YBD=3053 YHG=3015>been |>" XBD=2464 XHG=2357 YBD=3056 YHG=3021>found " XBD=2521 XHG=2485 YBD=3052 YHG=3023>to" XBD=1477 XHG=1366 YBD=3097 YHG=3064>effect " XBD=1517 XHG=1495 YBD=3097 YHG=3075>a " XBD=1720 XHG=1535 YBD=3106 YHG=3065>complete " XBD=1813 XHG=1737 YBD=3097 YHG=3065>and " XBD=2054 XHG=1829 YBD=3105 YHG=3067>permanent " XBD=2186 XHG=2071 YBD=3097 YHG=3065>cure.4" XBD=1494 XHG=1415 YBD=3140 YHG=3109>The " XBD=1783 XHG=1523 YBD=3150 YHG=3105>experiments " XBD=1845 XHG=1805 YBD=3140 YHG=3110>of Wtntrobe " XBD=2223 XHG=2084 YBD=3141 YHG=3109>5 have " XBD=2342 XHG=2252 YBD=3143 YHG=3110>been " XBD=2413 XHG=2370 YBD=3141 YHG=3119>on " XBD=2520 XHG=2438 YBD=3152 YHG=3111>pigs." XBD=1472 XHG=1367 YBD=3193 YHG=3154>They " XBD=1575 XHG=1496 YBD=3185 YHG=3154>find " XBD=1686 XHG=1600 YBD=3185 YHG=3154>that " XBD=1732 XHG=1710 YBD=3185 YHG=3164>a " XBD=1849 XHG=1756 YBD=3193 YHG=3163>pure " XBD=2097 XHG=1871 YBD=3194 YHG=3154>pyridoxine " XBD=2314 XHG=2113 YBD=3194 YHG=3154>deficiency " XBD=2422 XHG=2329 YBD=3186 YHG=3154>leads " XBD=2480 XHG=2443 YBD=3186 YHG=3156>to " XBD=2520 XHG=2500 YBD=3185 YHG=3164>a" XBD=1494 XHG=1368 YBD=3229 YHG=3207>severe " XBD=1684 XHG=1525 YBD=3229 YHG=3198>anaemia " XBD=1754 XHG=1714 YBD=3229 YHG=3199>of " XBD=1849 XHG=1782 YBD=3229 YHG=3198>the " XBD=2098 XHG=1880 YBD=3238 YHG=3198>microcytic " XBD=2231 XHG=2127 YBD=3238 YHG=3199>type, " XBD=2284 XHG=2261 YBD=3229 YHG=3207>a " XBD=2378 XHG=2312 YBD=3229 YHG=3198>rise " XBD=2439 XHG=2403 YBD=3229 YHG=3198>in " XBD=2521 XHG=2465 YBD=3230 YHG=3198>the" XBD=1491 XHG=1367 YBD=3273 YHG=3251>serum " XBD=1596 XHG=1514 YBD=3272 YHG=3242>iron " XBD=1695 XHG=1620 YBD=3273 YHG=3242>and " XBD=1768 XHG=1719 YBD=3273 YHG=3251>an " XBD=2071 XHG=1791 YBD=3274 YHG=3241>accumulation " XBD=2133 XHG=2095 YBD=3273 YHG=3242>of " XBD=2236 XHG=2155 YBD=3272 YHG=3242>iron " XBD=2297 XHG=2259 YBD=3273 YHG=3242>in " XBD=2379 XHG=2318 YBD=3274 YHG=3242>the " XBD=2519 XHG=2398 YBD=3282 YHG=3242>spleen," XBD=1459 XHG=1366 YBD=3316 YHG=3286>liver " XBD=1550 XHG=1475 YBD=3316 YHG=3286>and " XBD=1849 XHG=1566 YBD=3317 YHG=3286>bone-marrow. " XBD=1939 XHG=1903 YBD=3316 YHG=3286>It " XBD=1986 XHG=1955 YBD=3317 YHG=3286>is " XBD=2222 XHG=2001 YBD=3326 YHG=3286>interesting " XBD=2319 XHG=2236 YBD=3316 YHG=3285>that " XBD=2412 XHG=2333 YBD=3317 YHG=3286>here " XBD=2520 XHG=2426 YBD=3327 YHG=3287>again

1. Flippin, H. W., Schwartz, L. and Domm, A. H. J. Amer. med.Ass. 1943, 121, 230.

2. Meakins, J. C. and McKenna, R. D. Canad. med. Ass. J. 1943,48, 104.

3. Chick, H. et al. Biochem. J. 1938, 32, 2207.4. McKibbin, J. M. et al. J. Biol. Chem. 1942, 142, 77.5. Wintrobe, M. M. et al. Bull. Johns Hopk. Hosp. 1943, 72, 1.