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DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide Öncü,MD Istanbul Sisli Etfal Teaching Hospital [email protected] Arzu On,MD; Simin Hepguler,MD Ege University Medical Faculty [email protected]
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Page 1: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS

Juumllide OumlncuumlMDIstanbul Sisli Etfal Teaching Hospital

julideoncusislietfalgovtr

Arzu OnMD Simin HepgulerMDEge University Medical Faculty

arzuonegeedutr

What is osteoporosis

bull Skeletal disorder bull increased porositybull low bone mineral density

bull Bone fragility amp fracturesbull HİP FRACTURES-dangerousbull Wrist amp spine fractures

bull Early diagnosis and preventative treatment should be instituted before a possible fall or fracture occurs

NIH Consensus Development Panel on Osteoporosis JAMA 285 (2001) 785-95

NORMAL BONE

OSTEOPOROTIC BONE

Osteoporotic fracture is a problem

NIH Consensus Development Panel on Osteoporosis JAMA 285 (2001) 785-95

bull 20 of those who suffer a hip fracture will die within 1 year

bull 20 of the general population with a hip fracture will require nursing home care and will not be able to return to living independently

bull A 50-year-old woman has an estimated 16 to 54 risk of suffering a broken bone during her remaining lifetime bull The estimated risk for male is 6

What is disuse osteoporosis

bull Weight-bearing pressure helps to build bonendash Anything that keeps a person off his feet for any

amount of time can cause disuse osteoporosis

bull İmmobilization neuromuscular weakness are major risk factorsndash Bed rest for 1 week induced 1 loss of BMC

bull Disuse bone atrophy between is mainly seen in weight-bearing bones other than non-weight-bearing bones

Shinjiro Takata Natsuo Yasui Disuse Osteoporosis The Journal of Medical Investigation Vol 48 2001

ndash In patients with poliomyelitis

OUR AIM IS

bull To investigate the presence of osteoporosis at the hip and lumbar spine

bull To measure and compare the T-scores of affected amp non-affected hip on BMD

Study Design

bull Between 2010-2011bull 29 patients with poliomyelitis attending outpatient clinics in Ege

University and İstanbul Sisli Etfal Teaching Hospital

bull Inclusion criteriabull previous paralytic polio bull the subjects had an ambulatory potential in daily livingbull premenopousal women and men wo testosterone deficiencybull with lower extremity paralysis and one-side more prominently

affected

bull Bone density of the hip and lumbar spine were taken in the BMD laboratory and t-scores were assessed by a physiatrist

Osteoporosis is diagnosed by bone dansitometry

bull DEXA scans check bull the density of bones bull X-rays to show how strong bones are

bull Density means how much of something there is in a certain amount of space

bull The denser the tissue the less X-rays pass through

ldquo the more dense the bone the stronger it is and the less likely it is to break rdquo

wwwmayocliniccomhealthbone-density-testMY00304

How is a DEXA scan done

wwwmayocliniccomhealthbone-density-testMY00304

WHO osteoporosisscores

Understanding your DEXA result

Study design

bull We obtained total femur t scores

ndash It is most representative

ndash It contains both trabecular and cortical bone

Characteristics Number () Number ()

Sex 15 male (51) 14 female (49)

Paretic side Left (24) Right (76)

Minimum Maximum Mean

Age (years) 26 65 396

RESULTS

Age distribution of polio patients

20-30 years of age

30-40 years of age

40-50 years of age

over age of 50

RESULTS

Most of our patients at the middle age

-2

-15

-1

-05

0

05

1

Female Male All patients

total femur score-paretic side

total femur score-normal side

total lomber score

Mean of T-scores on BMD

Rate of osteoporosis on both sides

paretic hip

osteopenia

osteoporosis

normal

non-paretic hip

osteopenia

osteoporosis

normal

bull 3 non-paretic side

bull 21 paretic side respectivelyhellip

Disuse osteoporosis in POLIO SURVIVORS

Polio subjects are prone to hip fractures after even mildtrauma due to

1 Disuse osteoporosis ldquonot same with generalizedosteoporosisrdquo2 Muscle weakness

BMD of lumbar region is normal opposite to normal population may be due to scoliosis degenerative disease

Osteoporosis is an important issue for polio survivors

1 Many of them are over the age of 50

2 The polio-affected areas have less bone mass and weaker bones because of the lack of normal weight bearing

3 Many of them will fall more often than persons with normal neuromuscular function

If you break your good hip or fracture an arm that youdepend on to assist in walking with canes crutches or topropel a wheelchair or for transferring it makes atremendous impact on your lives and your independence

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 2: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

What is osteoporosis

bull Skeletal disorder bull increased porositybull low bone mineral density

bull Bone fragility amp fracturesbull HİP FRACTURES-dangerousbull Wrist amp spine fractures

bull Early diagnosis and preventative treatment should be instituted before a possible fall or fracture occurs

NIH Consensus Development Panel on Osteoporosis JAMA 285 (2001) 785-95

NORMAL BONE

OSTEOPOROTIC BONE

Osteoporotic fracture is a problem

NIH Consensus Development Panel on Osteoporosis JAMA 285 (2001) 785-95

bull 20 of those who suffer a hip fracture will die within 1 year

bull 20 of the general population with a hip fracture will require nursing home care and will not be able to return to living independently

bull A 50-year-old woman has an estimated 16 to 54 risk of suffering a broken bone during her remaining lifetime bull The estimated risk for male is 6

What is disuse osteoporosis

bull Weight-bearing pressure helps to build bonendash Anything that keeps a person off his feet for any

amount of time can cause disuse osteoporosis

bull İmmobilization neuromuscular weakness are major risk factorsndash Bed rest for 1 week induced 1 loss of BMC

bull Disuse bone atrophy between is mainly seen in weight-bearing bones other than non-weight-bearing bones

Shinjiro Takata Natsuo Yasui Disuse Osteoporosis The Journal of Medical Investigation Vol 48 2001

ndash In patients with poliomyelitis

OUR AIM IS

bull To investigate the presence of osteoporosis at the hip and lumbar spine

bull To measure and compare the T-scores of affected amp non-affected hip on BMD

Study Design

bull Between 2010-2011bull 29 patients with poliomyelitis attending outpatient clinics in Ege

University and İstanbul Sisli Etfal Teaching Hospital

bull Inclusion criteriabull previous paralytic polio bull the subjects had an ambulatory potential in daily livingbull premenopousal women and men wo testosterone deficiencybull with lower extremity paralysis and one-side more prominently

affected

bull Bone density of the hip and lumbar spine were taken in the BMD laboratory and t-scores were assessed by a physiatrist

Osteoporosis is diagnosed by bone dansitometry

bull DEXA scans check bull the density of bones bull X-rays to show how strong bones are

bull Density means how much of something there is in a certain amount of space

bull The denser the tissue the less X-rays pass through

ldquo the more dense the bone the stronger it is and the less likely it is to break rdquo

wwwmayocliniccomhealthbone-density-testMY00304

How is a DEXA scan done

wwwmayocliniccomhealthbone-density-testMY00304

WHO osteoporosisscores

Understanding your DEXA result

Study design

bull We obtained total femur t scores

ndash It is most representative

ndash It contains both trabecular and cortical bone

Characteristics Number () Number ()

Sex 15 male (51) 14 female (49)

Paretic side Left (24) Right (76)

Minimum Maximum Mean

Age (years) 26 65 396

RESULTS

Age distribution of polio patients

20-30 years of age

30-40 years of age

40-50 years of age

over age of 50

RESULTS

Most of our patients at the middle age

-2

-15

-1

-05

0

05

1

Female Male All patients

total femur score-paretic side

total femur score-normal side

total lomber score

Mean of T-scores on BMD

Rate of osteoporosis on both sides

paretic hip

osteopenia

osteoporosis

normal

non-paretic hip

osteopenia

osteoporosis

normal

bull 3 non-paretic side

bull 21 paretic side respectivelyhellip

Disuse osteoporosis in POLIO SURVIVORS

Polio subjects are prone to hip fractures after even mildtrauma due to

1 Disuse osteoporosis ldquonot same with generalizedosteoporosisrdquo2 Muscle weakness

BMD of lumbar region is normal opposite to normal population may be due to scoliosis degenerative disease

Osteoporosis is an important issue for polio survivors

1 Many of them are over the age of 50

2 The polio-affected areas have less bone mass and weaker bones because of the lack of normal weight bearing

3 Many of them will fall more often than persons with normal neuromuscular function

If you break your good hip or fracture an arm that youdepend on to assist in walking with canes crutches or topropel a wheelchair or for transferring it makes atremendous impact on your lives and your independence

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 3: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Osteoporotic fracture is a problem

NIH Consensus Development Panel on Osteoporosis JAMA 285 (2001) 785-95

bull 20 of those who suffer a hip fracture will die within 1 year

bull 20 of the general population with a hip fracture will require nursing home care and will not be able to return to living independently

bull A 50-year-old woman has an estimated 16 to 54 risk of suffering a broken bone during her remaining lifetime bull The estimated risk for male is 6

What is disuse osteoporosis

bull Weight-bearing pressure helps to build bonendash Anything that keeps a person off his feet for any

amount of time can cause disuse osteoporosis

bull İmmobilization neuromuscular weakness are major risk factorsndash Bed rest for 1 week induced 1 loss of BMC

bull Disuse bone atrophy between is mainly seen in weight-bearing bones other than non-weight-bearing bones

Shinjiro Takata Natsuo Yasui Disuse Osteoporosis The Journal of Medical Investigation Vol 48 2001

ndash In patients with poliomyelitis

OUR AIM IS

bull To investigate the presence of osteoporosis at the hip and lumbar spine

bull To measure and compare the T-scores of affected amp non-affected hip on BMD

Study Design

bull Between 2010-2011bull 29 patients with poliomyelitis attending outpatient clinics in Ege

University and İstanbul Sisli Etfal Teaching Hospital

bull Inclusion criteriabull previous paralytic polio bull the subjects had an ambulatory potential in daily livingbull premenopousal women and men wo testosterone deficiencybull with lower extremity paralysis and one-side more prominently

affected

bull Bone density of the hip and lumbar spine were taken in the BMD laboratory and t-scores were assessed by a physiatrist

Osteoporosis is diagnosed by bone dansitometry

bull DEXA scans check bull the density of bones bull X-rays to show how strong bones are

bull Density means how much of something there is in a certain amount of space

bull The denser the tissue the less X-rays pass through

ldquo the more dense the bone the stronger it is and the less likely it is to break rdquo

wwwmayocliniccomhealthbone-density-testMY00304

How is a DEXA scan done

wwwmayocliniccomhealthbone-density-testMY00304

WHO osteoporosisscores

Understanding your DEXA result

Study design

bull We obtained total femur t scores

ndash It is most representative

ndash It contains both trabecular and cortical bone

Characteristics Number () Number ()

Sex 15 male (51) 14 female (49)

Paretic side Left (24) Right (76)

Minimum Maximum Mean

Age (years) 26 65 396

RESULTS

Age distribution of polio patients

20-30 years of age

30-40 years of age

40-50 years of age

over age of 50

RESULTS

Most of our patients at the middle age

-2

-15

-1

-05

0

05

1

Female Male All patients

total femur score-paretic side

total femur score-normal side

total lomber score

Mean of T-scores on BMD

Rate of osteoporosis on both sides

paretic hip

osteopenia

osteoporosis

normal

non-paretic hip

osteopenia

osteoporosis

normal

bull 3 non-paretic side

bull 21 paretic side respectivelyhellip

Disuse osteoporosis in POLIO SURVIVORS

Polio subjects are prone to hip fractures after even mildtrauma due to

1 Disuse osteoporosis ldquonot same with generalizedosteoporosisrdquo2 Muscle weakness

BMD of lumbar region is normal opposite to normal population may be due to scoliosis degenerative disease

Osteoporosis is an important issue for polio survivors

1 Many of them are over the age of 50

2 The polio-affected areas have less bone mass and weaker bones because of the lack of normal weight bearing

3 Many of them will fall more often than persons with normal neuromuscular function

If you break your good hip or fracture an arm that youdepend on to assist in walking with canes crutches or topropel a wheelchair or for transferring it makes atremendous impact on your lives and your independence

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 4: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

What is disuse osteoporosis

bull Weight-bearing pressure helps to build bonendash Anything that keeps a person off his feet for any

amount of time can cause disuse osteoporosis

bull İmmobilization neuromuscular weakness are major risk factorsndash Bed rest for 1 week induced 1 loss of BMC

bull Disuse bone atrophy between is mainly seen in weight-bearing bones other than non-weight-bearing bones

Shinjiro Takata Natsuo Yasui Disuse Osteoporosis The Journal of Medical Investigation Vol 48 2001

ndash In patients with poliomyelitis

OUR AIM IS

bull To investigate the presence of osteoporosis at the hip and lumbar spine

bull To measure and compare the T-scores of affected amp non-affected hip on BMD

Study Design

bull Between 2010-2011bull 29 patients with poliomyelitis attending outpatient clinics in Ege

University and İstanbul Sisli Etfal Teaching Hospital

bull Inclusion criteriabull previous paralytic polio bull the subjects had an ambulatory potential in daily livingbull premenopousal women and men wo testosterone deficiencybull with lower extremity paralysis and one-side more prominently

affected

bull Bone density of the hip and lumbar spine were taken in the BMD laboratory and t-scores were assessed by a physiatrist

Osteoporosis is diagnosed by bone dansitometry

bull DEXA scans check bull the density of bones bull X-rays to show how strong bones are

bull Density means how much of something there is in a certain amount of space

bull The denser the tissue the less X-rays pass through

ldquo the more dense the bone the stronger it is and the less likely it is to break rdquo

wwwmayocliniccomhealthbone-density-testMY00304

How is a DEXA scan done

wwwmayocliniccomhealthbone-density-testMY00304

WHO osteoporosisscores

Understanding your DEXA result

Study design

bull We obtained total femur t scores

ndash It is most representative

ndash It contains both trabecular and cortical bone

Characteristics Number () Number ()

Sex 15 male (51) 14 female (49)

Paretic side Left (24) Right (76)

Minimum Maximum Mean

Age (years) 26 65 396

RESULTS

Age distribution of polio patients

20-30 years of age

30-40 years of age

40-50 years of age

over age of 50

RESULTS

Most of our patients at the middle age

-2

-15

-1

-05

0

05

1

Female Male All patients

total femur score-paretic side

total femur score-normal side

total lomber score

Mean of T-scores on BMD

Rate of osteoporosis on both sides

paretic hip

osteopenia

osteoporosis

normal

non-paretic hip

osteopenia

osteoporosis

normal

bull 3 non-paretic side

bull 21 paretic side respectivelyhellip

Disuse osteoporosis in POLIO SURVIVORS

Polio subjects are prone to hip fractures after even mildtrauma due to

1 Disuse osteoporosis ldquonot same with generalizedosteoporosisrdquo2 Muscle weakness

BMD of lumbar region is normal opposite to normal population may be due to scoliosis degenerative disease

Osteoporosis is an important issue for polio survivors

1 Many of them are over the age of 50

2 The polio-affected areas have less bone mass and weaker bones because of the lack of normal weight bearing

3 Many of them will fall more often than persons with normal neuromuscular function

If you break your good hip or fracture an arm that youdepend on to assist in walking with canes crutches or topropel a wheelchair or for transferring it makes atremendous impact on your lives and your independence

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 5: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

ndash In patients with poliomyelitis

OUR AIM IS

bull To investigate the presence of osteoporosis at the hip and lumbar spine

bull To measure and compare the T-scores of affected amp non-affected hip on BMD

Study Design

bull Between 2010-2011bull 29 patients with poliomyelitis attending outpatient clinics in Ege

University and İstanbul Sisli Etfal Teaching Hospital

bull Inclusion criteriabull previous paralytic polio bull the subjects had an ambulatory potential in daily livingbull premenopousal women and men wo testosterone deficiencybull with lower extremity paralysis and one-side more prominently

affected

bull Bone density of the hip and lumbar spine were taken in the BMD laboratory and t-scores were assessed by a physiatrist

Osteoporosis is diagnosed by bone dansitometry

bull DEXA scans check bull the density of bones bull X-rays to show how strong bones are

bull Density means how much of something there is in a certain amount of space

bull The denser the tissue the less X-rays pass through

ldquo the more dense the bone the stronger it is and the less likely it is to break rdquo

wwwmayocliniccomhealthbone-density-testMY00304

How is a DEXA scan done

wwwmayocliniccomhealthbone-density-testMY00304

WHO osteoporosisscores

Understanding your DEXA result

Study design

bull We obtained total femur t scores

ndash It is most representative

ndash It contains both trabecular and cortical bone

Characteristics Number () Number ()

Sex 15 male (51) 14 female (49)

Paretic side Left (24) Right (76)

Minimum Maximum Mean

Age (years) 26 65 396

RESULTS

Age distribution of polio patients

20-30 years of age

30-40 years of age

40-50 years of age

over age of 50

RESULTS

Most of our patients at the middle age

-2

-15

-1

-05

0

05

1

Female Male All patients

total femur score-paretic side

total femur score-normal side

total lomber score

Mean of T-scores on BMD

Rate of osteoporosis on both sides

paretic hip

osteopenia

osteoporosis

normal

non-paretic hip

osteopenia

osteoporosis

normal

bull 3 non-paretic side

bull 21 paretic side respectivelyhellip

Disuse osteoporosis in POLIO SURVIVORS

Polio subjects are prone to hip fractures after even mildtrauma due to

1 Disuse osteoporosis ldquonot same with generalizedosteoporosisrdquo2 Muscle weakness

BMD of lumbar region is normal opposite to normal population may be due to scoliosis degenerative disease

Osteoporosis is an important issue for polio survivors

1 Many of them are over the age of 50

2 The polio-affected areas have less bone mass and weaker bones because of the lack of normal weight bearing

3 Many of them will fall more often than persons with normal neuromuscular function

If you break your good hip or fracture an arm that youdepend on to assist in walking with canes crutches or topropel a wheelchair or for transferring it makes atremendous impact on your lives and your independence

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 6: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Study Design

bull Between 2010-2011bull 29 patients with poliomyelitis attending outpatient clinics in Ege

University and İstanbul Sisli Etfal Teaching Hospital

bull Inclusion criteriabull previous paralytic polio bull the subjects had an ambulatory potential in daily livingbull premenopousal women and men wo testosterone deficiencybull with lower extremity paralysis and one-side more prominently

affected

bull Bone density of the hip and lumbar spine were taken in the BMD laboratory and t-scores were assessed by a physiatrist

Osteoporosis is diagnosed by bone dansitometry

bull DEXA scans check bull the density of bones bull X-rays to show how strong bones are

bull Density means how much of something there is in a certain amount of space

bull The denser the tissue the less X-rays pass through

ldquo the more dense the bone the stronger it is and the less likely it is to break rdquo

wwwmayocliniccomhealthbone-density-testMY00304

How is a DEXA scan done

wwwmayocliniccomhealthbone-density-testMY00304

WHO osteoporosisscores

Understanding your DEXA result

Study design

bull We obtained total femur t scores

ndash It is most representative

ndash It contains both trabecular and cortical bone

Characteristics Number () Number ()

Sex 15 male (51) 14 female (49)

Paretic side Left (24) Right (76)

Minimum Maximum Mean

Age (years) 26 65 396

RESULTS

Age distribution of polio patients

20-30 years of age

30-40 years of age

40-50 years of age

over age of 50

RESULTS

Most of our patients at the middle age

-2

-15

-1

-05

0

05

1

Female Male All patients

total femur score-paretic side

total femur score-normal side

total lomber score

Mean of T-scores on BMD

Rate of osteoporosis on both sides

paretic hip

osteopenia

osteoporosis

normal

non-paretic hip

osteopenia

osteoporosis

normal

bull 3 non-paretic side

bull 21 paretic side respectivelyhellip

Disuse osteoporosis in POLIO SURVIVORS

Polio subjects are prone to hip fractures after even mildtrauma due to

1 Disuse osteoporosis ldquonot same with generalizedosteoporosisrdquo2 Muscle weakness

BMD of lumbar region is normal opposite to normal population may be due to scoliosis degenerative disease

Osteoporosis is an important issue for polio survivors

1 Many of them are over the age of 50

2 The polio-affected areas have less bone mass and weaker bones because of the lack of normal weight bearing

3 Many of them will fall more often than persons with normal neuromuscular function

If you break your good hip or fracture an arm that youdepend on to assist in walking with canes crutches or topropel a wheelchair or for transferring it makes atremendous impact on your lives and your independence

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 7: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Osteoporosis is diagnosed by bone dansitometry

bull DEXA scans check bull the density of bones bull X-rays to show how strong bones are

bull Density means how much of something there is in a certain amount of space

bull The denser the tissue the less X-rays pass through

ldquo the more dense the bone the stronger it is and the less likely it is to break rdquo

wwwmayocliniccomhealthbone-density-testMY00304

How is a DEXA scan done

wwwmayocliniccomhealthbone-density-testMY00304

WHO osteoporosisscores

Understanding your DEXA result

Study design

bull We obtained total femur t scores

ndash It is most representative

ndash It contains both trabecular and cortical bone

Characteristics Number () Number ()

Sex 15 male (51) 14 female (49)

Paretic side Left (24) Right (76)

Minimum Maximum Mean

Age (years) 26 65 396

RESULTS

Age distribution of polio patients

20-30 years of age

30-40 years of age

40-50 years of age

over age of 50

RESULTS

Most of our patients at the middle age

-2

-15

-1

-05

0

05

1

Female Male All patients

total femur score-paretic side

total femur score-normal side

total lomber score

Mean of T-scores on BMD

Rate of osteoporosis on both sides

paretic hip

osteopenia

osteoporosis

normal

non-paretic hip

osteopenia

osteoporosis

normal

bull 3 non-paretic side

bull 21 paretic side respectivelyhellip

Disuse osteoporosis in POLIO SURVIVORS

Polio subjects are prone to hip fractures after even mildtrauma due to

1 Disuse osteoporosis ldquonot same with generalizedosteoporosisrdquo2 Muscle weakness

BMD of lumbar region is normal opposite to normal population may be due to scoliosis degenerative disease

Osteoporosis is an important issue for polio survivors

1 Many of them are over the age of 50

2 The polio-affected areas have less bone mass and weaker bones because of the lack of normal weight bearing

3 Many of them will fall more often than persons with normal neuromuscular function

If you break your good hip or fracture an arm that youdepend on to assist in walking with canes crutches or topropel a wheelchair or for transferring it makes atremendous impact on your lives and your independence

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 8: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

How is a DEXA scan done

wwwmayocliniccomhealthbone-density-testMY00304

WHO osteoporosisscores

Understanding your DEXA result

Study design

bull We obtained total femur t scores

ndash It is most representative

ndash It contains both trabecular and cortical bone

Characteristics Number () Number ()

Sex 15 male (51) 14 female (49)

Paretic side Left (24) Right (76)

Minimum Maximum Mean

Age (years) 26 65 396

RESULTS

Age distribution of polio patients

20-30 years of age

30-40 years of age

40-50 years of age

over age of 50

RESULTS

Most of our patients at the middle age

-2

-15

-1

-05

0

05

1

Female Male All patients

total femur score-paretic side

total femur score-normal side

total lomber score

Mean of T-scores on BMD

Rate of osteoporosis on both sides

paretic hip

osteopenia

osteoporosis

normal

non-paretic hip

osteopenia

osteoporosis

normal

bull 3 non-paretic side

bull 21 paretic side respectivelyhellip

Disuse osteoporosis in POLIO SURVIVORS

Polio subjects are prone to hip fractures after even mildtrauma due to

1 Disuse osteoporosis ldquonot same with generalizedosteoporosisrdquo2 Muscle weakness

BMD of lumbar region is normal opposite to normal population may be due to scoliosis degenerative disease

Osteoporosis is an important issue for polio survivors

1 Many of them are over the age of 50

2 The polio-affected areas have less bone mass and weaker bones because of the lack of normal weight bearing

3 Many of them will fall more often than persons with normal neuromuscular function

If you break your good hip or fracture an arm that youdepend on to assist in walking with canes crutches or topropel a wheelchair or for transferring it makes atremendous impact on your lives and your independence

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 9: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

WHO osteoporosisscores

Understanding your DEXA result

Study design

bull We obtained total femur t scores

ndash It is most representative

ndash It contains both trabecular and cortical bone

Characteristics Number () Number ()

Sex 15 male (51) 14 female (49)

Paretic side Left (24) Right (76)

Minimum Maximum Mean

Age (years) 26 65 396

RESULTS

Age distribution of polio patients

20-30 years of age

30-40 years of age

40-50 years of age

over age of 50

RESULTS

Most of our patients at the middle age

-2

-15

-1

-05

0

05

1

Female Male All patients

total femur score-paretic side

total femur score-normal side

total lomber score

Mean of T-scores on BMD

Rate of osteoporosis on both sides

paretic hip

osteopenia

osteoporosis

normal

non-paretic hip

osteopenia

osteoporosis

normal

bull 3 non-paretic side

bull 21 paretic side respectivelyhellip

Disuse osteoporosis in POLIO SURVIVORS

Polio subjects are prone to hip fractures after even mildtrauma due to

1 Disuse osteoporosis ldquonot same with generalizedosteoporosisrdquo2 Muscle weakness

BMD of lumbar region is normal opposite to normal population may be due to scoliosis degenerative disease

Osteoporosis is an important issue for polio survivors

1 Many of them are over the age of 50

2 The polio-affected areas have less bone mass and weaker bones because of the lack of normal weight bearing

3 Many of them will fall more often than persons with normal neuromuscular function

If you break your good hip or fracture an arm that youdepend on to assist in walking with canes crutches or topropel a wheelchair or for transferring it makes atremendous impact on your lives and your independence

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 10: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Study design

bull We obtained total femur t scores

ndash It is most representative

ndash It contains both trabecular and cortical bone

Characteristics Number () Number ()

Sex 15 male (51) 14 female (49)

Paretic side Left (24) Right (76)

Minimum Maximum Mean

Age (years) 26 65 396

RESULTS

Age distribution of polio patients

20-30 years of age

30-40 years of age

40-50 years of age

over age of 50

RESULTS

Most of our patients at the middle age

-2

-15

-1

-05

0

05

1

Female Male All patients

total femur score-paretic side

total femur score-normal side

total lomber score

Mean of T-scores on BMD

Rate of osteoporosis on both sides

paretic hip

osteopenia

osteoporosis

normal

non-paretic hip

osteopenia

osteoporosis

normal

bull 3 non-paretic side

bull 21 paretic side respectivelyhellip

Disuse osteoporosis in POLIO SURVIVORS

Polio subjects are prone to hip fractures after even mildtrauma due to

1 Disuse osteoporosis ldquonot same with generalizedosteoporosisrdquo2 Muscle weakness

BMD of lumbar region is normal opposite to normal population may be due to scoliosis degenerative disease

Osteoporosis is an important issue for polio survivors

1 Many of them are over the age of 50

2 The polio-affected areas have less bone mass and weaker bones because of the lack of normal weight bearing

3 Many of them will fall more often than persons with normal neuromuscular function

If you break your good hip or fracture an arm that youdepend on to assist in walking with canes crutches or topropel a wheelchair or for transferring it makes atremendous impact on your lives and your independence

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 11: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Characteristics Number () Number ()

Sex 15 male (51) 14 female (49)

Paretic side Left (24) Right (76)

Minimum Maximum Mean

Age (years) 26 65 396

RESULTS

Age distribution of polio patients

20-30 years of age

30-40 years of age

40-50 years of age

over age of 50

RESULTS

Most of our patients at the middle age

-2

-15

-1

-05

0

05

1

Female Male All patients

total femur score-paretic side

total femur score-normal side

total lomber score

Mean of T-scores on BMD

Rate of osteoporosis on both sides

paretic hip

osteopenia

osteoporosis

normal

non-paretic hip

osteopenia

osteoporosis

normal

bull 3 non-paretic side

bull 21 paretic side respectivelyhellip

Disuse osteoporosis in POLIO SURVIVORS

Polio subjects are prone to hip fractures after even mildtrauma due to

1 Disuse osteoporosis ldquonot same with generalizedosteoporosisrdquo2 Muscle weakness

BMD of lumbar region is normal opposite to normal population may be due to scoliosis degenerative disease

Osteoporosis is an important issue for polio survivors

1 Many of them are over the age of 50

2 The polio-affected areas have less bone mass and weaker bones because of the lack of normal weight bearing

3 Many of them will fall more often than persons with normal neuromuscular function

If you break your good hip or fracture an arm that youdepend on to assist in walking with canes crutches or topropel a wheelchair or for transferring it makes atremendous impact on your lives and your independence

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 12: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Age distribution of polio patients

20-30 years of age

30-40 years of age

40-50 years of age

over age of 50

RESULTS

Most of our patients at the middle age

-2

-15

-1

-05

0

05

1

Female Male All patients

total femur score-paretic side

total femur score-normal side

total lomber score

Mean of T-scores on BMD

Rate of osteoporosis on both sides

paretic hip

osteopenia

osteoporosis

normal

non-paretic hip

osteopenia

osteoporosis

normal

bull 3 non-paretic side

bull 21 paretic side respectivelyhellip

Disuse osteoporosis in POLIO SURVIVORS

Polio subjects are prone to hip fractures after even mildtrauma due to

1 Disuse osteoporosis ldquonot same with generalizedosteoporosisrdquo2 Muscle weakness

BMD of lumbar region is normal opposite to normal population may be due to scoliosis degenerative disease

Osteoporosis is an important issue for polio survivors

1 Many of them are over the age of 50

2 The polio-affected areas have less bone mass and weaker bones because of the lack of normal weight bearing

3 Many of them will fall more often than persons with normal neuromuscular function

If you break your good hip or fracture an arm that youdepend on to assist in walking with canes crutches or topropel a wheelchair or for transferring it makes atremendous impact on your lives and your independence

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 13: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

-2

-15

-1

-05

0

05

1

Female Male All patients

total femur score-paretic side

total femur score-normal side

total lomber score

Mean of T-scores on BMD

Rate of osteoporosis on both sides

paretic hip

osteopenia

osteoporosis

normal

non-paretic hip

osteopenia

osteoporosis

normal

bull 3 non-paretic side

bull 21 paretic side respectivelyhellip

Disuse osteoporosis in POLIO SURVIVORS

Polio subjects are prone to hip fractures after even mildtrauma due to

1 Disuse osteoporosis ldquonot same with generalizedosteoporosisrdquo2 Muscle weakness

BMD of lumbar region is normal opposite to normal population may be due to scoliosis degenerative disease

Osteoporosis is an important issue for polio survivors

1 Many of them are over the age of 50

2 The polio-affected areas have less bone mass and weaker bones because of the lack of normal weight bearing

3 Many of them will fall more often than persons with normal neuromuscular function

If you break your good hip or fracture an arm that youdepend on to assist in walking with canes crutches or topropel a wheelchair or for transferring it makes atremendous impact on your lives and your independence

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 14: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Rate of osteoporosis on both sides

paretic hip

osteopenia

osteoporosis

normal

non-paretic hip

osteopenia

osteoporosis

normal

bull 3 non-paretic side

bull 21 paretic side respectivelyhellip

Disuse osteoporosis in POLIO SURVIVORS

Polio subjects are prone to hip fractures after even mildtrauma due to

1 Disuse osteoporosis ldquonot same with generalizedosteoporosisrdquo2 Muscle weakness

BMD of lumbar region is normal opposite to normal population may be due to scoliosis degenerative disease

Osteoporosis is an important issue for polio survivors

1 Many of them are over the age of 50

2 The polio-affected areas have less bone mass and weaker bones because of the lack of normal weight bearing

3 Many of them will fall more often than persons with normal neuromuscular function

If you break your good hip or fracture an arm that youdepend on to assist in walking with canes crutches or topropel a wheelchair or for transferring it makes atremendous impact on your lives and your independence

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 15: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Disuse osteoporosis in POLIO SURVIVORS

Polio subjects are prone to hip fractures after even mildtrauma due to

1 Disuse osteoporosis ldquonot same with generalizedosteoporosisrdquo2 Muscle weakness

BMD of lumbar region is normal opposite to normal population may be due to scoliosis degenerative disease

Osteoporosis is an important issue for polio survivors

1 Many of them are over the age of 50

2 The polio-affected areas have less bone mass and weaker bones because of the lack of normal weight bearing

3 Many of them will fall more often than persons with normal neuromuscular function

If you break your good hip or fracture an arm that youdepend on to assist in walking with canes crutches or topropel a wheelchair or for transferring it makes atremendous impact on your lives and your independence

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 16: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Osteoporosis is an important issue for polio survivors

1 Many of them are over the age of 50

2 The polio-affected areas have less bone mass and weaker bones because of the lack of normal weight bearing

3 Many of them will fall more often than persons with normal neuromuscular function

If you break your good hip or fracture an arm that youdepend on to assist in walking with canes crutches or topropel a wheelchair or for transferring it makes atremendous impact on your lives and your independence

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 17: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Eur Neurol 200962(6)369-74 Epub 2009 Oct 1

High incidence of osteoporosis and fractures in an aging post-polio populationMohammad AF Khan KA Galvin L Hardiman O OConnell PG

High incidence of fractures in an aging postpolio population

bull 41 PPS subject included in this study

bull Based on the bone mineral density data 28 (56) of the patients were diagnosed with OP and 20 (40) had osteopenia

bull Eight out of 9 fractures of the neck of femur occurred in the weaker leg

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 18: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

bull

If a DEXA scan shows that you have osteoporosis

then you may be given advice and treatment to help strengthen your bones

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 19: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Can further bone loss be slowed

bull Diet modificationbull Pharmacologic treatmentbull Exercisebull Life style modification

bull Avoid immobilizationbull Regular bone mineral density

measurement

wwwmayocliniccomhealthosteoporosis-treatment

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 20: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Can bone loss be prevented or slowed

Calciumbull Most people get about 700 or 800 milligrams day bull recommended is 1000 to 1500 mgm

Vitamin Dbull Adequate amounts of (between 400 and 800 units per day) are also needed bull One glass of milk is fortified with 100 units of Vitamin Dbull You can get enough Vitamin D by a daily 15-minute exposure to sunlight which is possible even in wintertime when you are fully clothed because your hands or face are exposed

wwwmayocliniccomhealthosteoporosis-treatment

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 21: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Pharmacological Treatment

Hormone replacementbull for women (estrogen with or without progesterone) can slow bone loss preserve bone strength and decrease fractures by approximately 50bull A new drug raloxifene (Evista) can be used in women who have had breast or uterine cancer or those at high risk for these forms of cancer

Bisphosphonatesbull The biphosphonates have been shown to decrease fractures by 50 and are recommended for women who cannot take estrogen

Calcitoninbull It increases bone density and prevents further mineral loss for at least one or two years but the studies to date have not shown a decrease in fractures

wwwmayocliniccomhealthosteoporosis-treatment

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 22: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Exercise is important for maintaining strength to prevent osteoporosis both in normal and polio subjects

bull Exercise is definitely an area that should require input from a polio specialist so you do not overuse or overstress extremities that have already been weakened by polio bull However you may have unaffected or stronger muscles that can be safely used for exercise

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 23: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Exercise is a little bit confusing issue

Weight-bearing activities WALKING amp WEIGHT-LIFTING

bull Walking is better than non-weight bearing activities such as swimming

bull Heavy Weight-lifting for lower extremities is not recommended for PPS

subjects butsubmaximal resistive program may be planned individually

bullWeightlifting with upper extremities for axial loading while sitting can be

done for PPS subjects

So to help maintain bone density we need to keep the muscles working as well as they can and exercise them

But this means within their capabilities without getting fatigue or overuse which can cause further muscle damage and so will end up with even less muscle pull

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 24: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Exercise for osteoporosis in polio subjects

bull Gentle back extension exercises can be given

bullFlexion exercises are not suitable for posture

bull Mobility is important- absolute bedrest results in very rapid skeletal loss This

is seen in patients with spinal cord injury- Wheelchair users also under the risk of hip fracture- However as little exercise as going to the bathroom is

sufficient to prevent the rapid loss

wwwarthritisnsworgauuploadsanswosteo-fact

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 25: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Fall Prevention

RECOMMENDATIONS TO PREVENT FALLS

- Bars and other safety devices in bathroom (Or are you using a towel bar that is just attached to the wallboard) - handrails on all the stairs in your home- keep bathroom lights on- avoid loose rugs- remove clutter- keep wires behind furniture - hip protection cushions- Gait amp Balance training

wwwarthritisnsworgauuploadsanswosteo-fact

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 26: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

bull all poliomyelitis patients should be evaluated for osteoporosis at both hips and at the lumbar spine even if they are younger than 50

bull Diet modification exercise and mobilization are important for prevention of further bone loss

bull There are many pharmacological options for treatment of osteoporosis

bull Fall prevention is extremely important to prevent fractures

Clinical messages

Warm wishes fromİstanbulhellip

Page 27: DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITISpolioconference.com/2011/Powerpoint presentations/pdf/thursday/J… · DISUSE OSTEOPOROSIS IN PATIENTS WITH POLIOMYELITIS Jülide

Warm wishes fromİstanbulhellip


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