Cell mediated immunity

By:- Dinesh Kumar student of M.Sc. Zoology Govt. Science college Gwalior(M.P.)

Introduction

Human life is a battle field in human beings.

Dinesh Kumar

History of immunology

1. Thucididas (430 BC.)Plague The foundation of immunity

2. Variolation (15th Century)Base on the practical and understanding that the immunity

Dinesh Kumar

Dinesh Kumar

Karl landsteiner (1868-1943)Discovered of primary blood group and 1940Discovered antigen system Rh 1901 nobel prize for blood grouping

Alexander Fleming(1881-1955)Fleming is a British bacteriologist antibacterial1945 For his discovered penicillin

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Antigen is a foreign substance which binds to antibody.

Dinesh Kumar

Ability of the body to fight against infectious agents .

Dinesh Kumar

Innate immunity Adaptive immunity

Dinesh Kumar

Immune Response › Immune response is the response

of the body against an › Infectious agent.

Dinesh Kumar

First line of defense – innate immunity

Second line of defense – adaptive immunity

Physical barrier Cell Mediated (IR)

Phagocytosis

Anti microbial substance

Inflammation

Humoral (IR)

Fever

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Types Component Physical barriers skin, Mucous membrane bacteriaAntimicrobial substances complement, interferons, lysozymes, lactenins acid

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Phagocytosis Neutrophils

Monocyts Inflammation

Macrophages

Fever

Dinesh Kumar

Dinesh Kumar

Tissue damage

Vasodilation--------------- Tissue redness

EdemaMigration of at the injury

Phagocytosis invandingmicrobes

Tissue Repair

Tissue damage

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Target cell Target cell

VirusVirus Interferon

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Target cell Target cell

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TranscriptionTranscriptionTranslationTranslation

Host cell Host cell

Viral protein

Target cell Target cell

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TranscriptionTranscriptionTranslationTranslation

Host cell Host cell

Viral protein

Viral protein

Dinesh Kumar

TranscriptionTranscriptionTranslationTranslation

Host cell Host cell

Viral protein

Viral protein

Dinesh Kumar

TranscriptionTranscriptionTranslationTranslation

Host cell Host cell

Viral protein

Viral proteinVirusVirus Destyoy Destyoy

Dinesh Kumar

Dinesh Kumar

The are two components of adaptative immunity

Humoral Immunity Cell – Mediated immunity

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Humoral immunity refers to the immunity brought about by antibodies

Dinesh Kumar

Cell-mediated immunity involves T lymphocytes which recognize an antigen kill by different ways.

Dinesh Kumar

Dinesh Kumar

Cell Function

B-lymphocytes Antibody formation

T-lymphocytes Release of cytokines

Natural killer cells Cytotoxis

Dendrite cells Phagocytosis, antigen presenting cell

Mononuclear Phagcytic cells

Phagocytosis

Mast cells Allerigic rection

Neutrophils Phagocytosis, inflamestion

Eosinophils Allerigic rection

Basophils Hypersensitivity Dinesh Kumar

Acknowledgment of Dr. D.K. Sharma ,Dr. Trapti Sharma

Dinesh Kumar

Faculty of Zoology DepartmentS.M.S. Govt. Science college Gwalior (M.P.)

Dinesh Kumar