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Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King...

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Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy
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Page 1: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS

Associate Professor,Department of Neurology,King George’s Medical University, Lucknow

Epilepsy

Page 2: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-1

• When do you label a “seizure” as “epilepsy”?– Presence of family history– >1 unprovoked seizure– >1 provoked seizure– >2 provoked seizures

Page 3: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-1

• When do you label a “seizure” as “epilepsy”?– Presence of family history– >1 unprovoked seizure– >1 provoked seizure– >2 provoked seizures

Page 4: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-2

• All of the following are excitatory neurotransmitters except:– AMPA– NMDA– GABA– Glutamate

Page 5: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-2

• All of the following are excitatory neurotransmitters except:– AMPA– NMDA– GABA– Glutamate

Page 6: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-3

• Which of the following abnormality is associated with ‘Generalized Epilepsy & Febrile Seizures plus’ syndrome?– Sodium channel mutations– Calcium channel mutations– Potassium channel mutations– Chloride channel mutations

Page 7: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-3

• Which of the following abnormality is associated with ‘Generalized Epilepsy & Febrile Seizures plus’ syndrome?– Sodium channel mutations– Calcium channel mutations– Potassium channel mutations– Chloride channel mutations

Page 8: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-4

• Which of the following abnormality is associated with ‘Juvenile Myoclonic Epilepsy’?– Sodium channel mutations– Calcium channel mutations– Potassium channel mutations– Chloride channel mutations

Page 9: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-4

• Which of the following abnormality is associated with ‘Juvenile Myoclonic Epilepsy’?– Sodium channel mutations– Calcium channel mutations– Potassium channel mutations– Chloride channel mutations

Page 10: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-5

• Which of the following abnormality is associated with ‘Temporal lobe epilepsy’?– Sodium channel mutations– Calcium channel mutations– Potassium channel mutations– Chloride channel mutations

Page 11: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-5

• Which of the following abnormality is associated with ‘Temporal lobe epilepsy’?– Sodium channel mutations– Calcium channel mutations– Potassium channel mutations– Chloride channel mutations

Page 12: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-6

• Pathophysiologically, which is the most important reason for the precipitation of seizure?– Increased Glutamate, increased GABA– Increased AMPA, increased GABA– Increased Glutamate, decreased GABA– Decreased Glutamate, increased GABA

Page 13: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-6

• Pathophysiologically, which is the most important reason for the precipitation of seizure?– Increased Glutamate, increased GABA– Increased AMPA, increased GABA– Increased Glutamate, decreased GABA– Decreased Glutamate, increased GABA

Page 14: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-7

• Clinically, the most relevant epilepsy classification system is:– ILAE 1985– ILAE 1989– ILAE 1991– ILAE 2006

Page 15: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-7

• Clinically, the most relevant epilepsy classification system is:– ILAE 1985– ILAE 1989– ILAE 1991– ILAE 2006

Page 16: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-8

• Which of the following is not a localization-related epilepsy?– Benign childhood epilepsy with centrotemporal

spikes– Juvenile myoclonic epilepsy– Childhood epilepsy with occipital paroxysms– Primary reading epilepsy

Page 17: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-8

• Which of the following is not a localization-related epilepsy?– Benign childhood epilepsy with centrotemporal

spikes– Juvenile myoclonic epilepsy– Childhood epilepsy with occipital paroxysms– Primary reading epilepsy

Page 18: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-9

• Which of the following is not an idiopathic generalized epilepsy?– Juvenile absence epilepsy– Epilepsy with grand mal seizures on awakening– Childhood absence epilepsy– Lennox-Gastaut syndrome

Page 19: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-9

• Which of the following is not an idiopathic generalized epilepsy?– Juvenile absence epilepsy– Epilepsy with grand mal seizures on awakening– Childhood absence epilepsy– Lennox-Gastaut syndrome

Page 20: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-10

• Which is the most important differential diagnosis of ‘first seizure’?– Migraine without aura– Abdominal migraine– Syncope– Migraine with aura

Page 21: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

MCQ-10

• Which is the most important differential diagnosis of ‘first seizure’?– Migraine without aura– Abdominal migraine– Syncope– Migraine with aura

Page 22: Dr. Hardeep Singh Malhotra MD, DM, FIACM, MNAMS Associate Professor, Department of Neurology, King George’s Medical University, Lucknow Epilepsy.

THANK YOU


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