8 2013 EAS Final Program Technical Program Monday Morning, November 18, 2013 New York Section of the Society for Applied Spectroscopy Gold Medal Award Honoring Prof. Stephen P. Cramer, University of California – Lawrence Berkeley Lab Chair: Deborah A. Peru, Colgate-Palmolive Company Ballroom Center 9:00 1 Synchrotron X-Ray Spectroscopy - How 10 Orders of Magnitude Makes Hard Things Easy, Stephen P. Cramer, University of California - Lawrence Berke- ley Lab 9:30 2 X-Ray Emission Spectroscopy - A Powerful Tool to Study Biocatalysts, Uwe Bergmann, SLAC National Accelerator Laboratory 10:00 Break 10:20 3 Coherent and Inelastic Resonant X-Ray Scattering, Esen E. Alp, Argonne National Laboratory 10:50 4 The Good, the Bad and the Ugly: Understanding the Roles of Metals in Biology Using Synchrotron Radiation, Graham N. George, University of Saskatchewan American Microchemical Society Benedetti-Pichler Award Honoring Dr. Mark A. Hayes, Arizona State University Chair: Joseph Sneddon, McNeese University Ballroom East 9:00 5 Analysis of Vesicle Contents with Electrochemistry and Mass Spectrometry, Andrew G. Ewing, Chalm- ers and Gothenburg Universities 9:30 6 Autophagy from an Individual Organelle Perspec- tive, Edgar A. Arriaga, Chad P. Satori, University of Minnesota 10:00 Break 10:20 7 Microscale Separations Applied to Studies of Pro- tein Aggregation, Doug Gilman, Suresh C. Regmi, Indu Kheterpal, Louisiana State University 10:50 8 Punctuated Microgradients for Bioanalysis, Mark A. Hayes, Arizona State University Recent Advances and Novel Applications of uHPLC Chair: Yan Ma, Bristol-Myers Squibb Ballroom West 9:00 9 Monolith Versus Core Shell - Which One is Better?, Egidijus Machtejevas, Karin Cabrera, EMD Millipore 9:20 10 Performance Advantages of Monodispersed Porous Particles in UHPLC, Richard Henry, William H. Campbell, David S. Bell, Gaurang Parmar, Wayne K. Way, Supelco Division of Sigma-Aldrich Technical Program 2013 Eastern Analytical Symposium & Exposition 9:40 11 Superficially Porous Particles Offer a Complete Solution for LC Analyses, Anne E. Mack, William J. Long, Agilent Technologies 10:00 Break 10:20 12 Speed vs. Sensitivity: Compatibility of Ultra High- Performance Liquid Chromatography Coupled to Electrospray Ionization High-Resolution Mass Spec- trometry (ESI-HRMS), Samantha M. Mahmoud, Dil Ramanathan, Kean University 10:40 13 The Impact of Acquity UPLC on Dissolution Method Development: A Case Study, Dante Pillon, Xiaoxuan (Jason) Shen, Yali Sun, Celgene Corporation 11:00 14 Determination of Carbohydrates Using a New Integrated Capillary High-Performance Ion Chroma- tography System with Electrochemical Detection, Jun Chen, Petr Jandik, Yan Liu, Chris Pohl, Michael Hvizd, Thermo Fisher Scientific 11:20 15 Oligonucleotide Analysis with Different Liquid Chromatography Methods, Mirlinda Biba, Bing Mao, Christopher J. Welch, Merck, Joe P. Foley, Drexel University 11:40 16 Using Chaotropic Anions for Optimizing the Reten- tion of Basic Pharmaceutical Compounds in HPLC Method Development for Complex Sample Matrix in OTC Drug Products, Hugh V. Ta, Gail Reed, McNeil Analytical Inhalation Session: Bringing Patients into the Lab Chair: Jennifer Wylie, Merck Bridgewater 9:00 17 Improving Cascade Impaction Return on Invest- ment, Adrian Goodey, Buchilingam Bupathi, Xiuhua Fang, Henry Tat, Kathleen Hogan, John Jekonski, Jennifer Loria, Maya George, Kuriakose Jacob, Antonio Macaluso, Ying Li, Merck 9:30 18 Assessment of Nasal Drug Deposition Using Ana- tomical Models, Samiran De, Next Breath 10:00 Break 10:20 19 Development and Validation of an HPLC-MS Meth- od for Tobramycin in Isolated Perfused Rat Lung (IPRL) Perfusate: Applicability to Pulmonary Kinetic Studies, Min Li, Virginia Commonwealth University 10:50 20 Bringing Patients into the Lab, Benoit Adamo, Chad Smutney, Spencer Kinsey, Mannkind Manufacturing, Pharmaceutical and Environmental Applications of GC and GC/MS Chair: Daryl Cobranchi, DuPont Bernardsville 9:00 21 Ultrafast GC for Residual Solvents in Drug Sub- stance Scale-Up and Manufacturing Using a Low Thermal Mass GC, Yuwen Wang, Boehringer Ingelheim New this year we are excited to announce our award winner of the EAS Award for Outstanding Achievements in the Fields of Analytical Chemistry, Dr. Irving Wainer from the NIH, will present a plenary lecture for all of EAS registrants, on Monday, Nov. 18th at 4:30pm in the Ballroom at the DoubleTree Hotel. This presentation will be followed by a time of networking and complimentary refreshments. We encourage all registrants of EAS to attend this special event.
Transcript
8
2013 EAS Final Program Technical Program
Monday Morning, November 18, 2013
New York Section of the Society for Applied Spectroscopy Gold Medal AwardHonoring Prof. Stephen P. Cramer, University of California – Lawrence Berkeley LabChair: Deborah A. Peru, Colgate-Palmolive Company
Ballroom Center
9:00 1 Synchrotron X-Ray Spectroscopy - How 10 Orders of Magnitude Makes Hard Things Easy, Stephen P. Cramer, University of California - Lawrence Berke-ley Lab
9:30 2 X-Ray Emission Spectroscopy - A Powerful Tool to Study Biocatalysts, Uwe Bergmann, SLAC National Accelerator Laboratory
10:00 Break
10:20 3 Coherent and Inelastic Resonant X-Ray Scattering, Esen E. Alp, Argonne National Laboratory
10:50 4 The Good, the Bad and the Ugly: Understanding the Roles of Metals in Biology Using Synchrotron Radiation, Graham N. George, University of Saskatchewan
American Microchemical Society Benedetti-Pichler AwardHonoring Dr. Mark A. Hayes, Arizona State UniversityChair: Joseph Sneddon, McNeese University
Ballroom East
9:00 5 Analysis of Vesicle Contents with Electrochemistry and Mass Spectrometry, Andrew G. Ewing, Chalm-ers and Gothenburg Universities
9:30 6 Autophagy from an Individual Organelle Perspec-tive, Edgar A. Arriaga, Chad P. Satori, University of Minnesota
10:00 Break
10:20 7 Microscale Separations Applied to Studies of Pro-tein Aggregation, Doug Gilman, Suresh C. Regmi, Indu Kheterpal, Louisiana State University
10:50 8 Punctuated Microgradients for Bioanalysis, Mark A. Hayes, Arizona State University
Recent Advances and Novel Applications of uHPLCChair: Yan Ma, Bristol-Myers Squibb
Ballroom West
9:00 9 Monolith Versus Core Shell - Which One is Better?, Egidijus Machtejevas, Karin Cabrera, EMD Millipore
9:20 10 Performance Advantages of Monodispersed Porous Particles in UHPLC, Richard Henry, William H. Campbell, David S. Bell, Gaurang Parmar, Wayne K. Way, Supelco Division of Sigma-Aldrich
9:40 11 Superficially Porous Particles Offer a Complete Solution for LC Analyses, Anne E. Mack, William J. Long, Agilent Technologies
10:00 Break
10:20 12 Speed vs. Sensitivity: Compatibility of Ultra High-Performance Liquid Chromatography Coupled to Electrospray Ionization High-Resolution Mass Spec-trometry (ESI-HRMS), Samantha M. Mahmoud, Dil Ramanathan, Kean University
10:40 13 The Impact of Acquity UPLC on Dissolution Method Development: A Case Study, Dante Pillon, Xiaoxuan (Jason) Shen, Yali Sun, Celgene Corporation
11:00 14 Determination of Carbohydrates Using a New Integrated Capillary High-Performance Ion Chroma-tography System with Electrochemical Detection, Jun Chen, Petr Jandik, Yan Liu, Chris Pohl, Michael Hvizd, Thermo Fisher Scientific
11:20 15 Oligonucleotide Analysis with Different Liquid Chromatography Methods, Mirlinda Biba, Bing Mao, Christopher J. Welch, Merck, Joe P. Foley, Drexel University
11:40 16 Using Chaotropic Anions for Optimizing the Reten-tion of Basic Pharmaceutical Compounds in HPLC Method Development for Complex Sample Matrix in OTC Drug Products, Hugh V. Ta, Gail Reed, McNeil
Analytical Inhalation Session: Bringing Patients into the LabChair: Jennifer Wylie, Merck
Bridgewater
9:00 17 Improving Cascade Impaction Return on Invest-ment, Adrian Goodey, Buchilingam Bupathi, Xiuhua Fang, Henry Tat, Kathleen Hogan, John Jekonski, Jennifer Loria, Maya George, Kuriakose Jacob, Antonio Macaluso, Ying Li, Merck
9:30 18 Assessment of Nasal Drug Deposition Using Ana-tomical Models, Samiran De, Next Breath
10:00 Break
10:20 19 Development and Validation of an HPLC-MS Meth-od for Tobramycin in Isolated Perfused Rat Lung (IPRL) Perfusate: Applicability to Pulmonary Kinetic Studies, Min Li, Virginia Commonwealth University
10:50 20 Bringing Patients into the Lab, Benoit Adamo, Chad Smutney, Spencer Kinsey, Mannkind
Manufacturing, Pharmaceutical and Environmental Applications of GC and GC/MSChair: Daryl Cobranchi, DuPont
Bernardsville
9:00 21 Ultrafast GC for Residual Solvents in Drug Sub-stance Scale-Up and Manufacturing Using a Low Thermal Mass GC, Yuwen Wang, Boehringer Ingelheim
New this year we are excited to announce our award winner of the EAS Award for Outstanding Achievements in the Fields of Analytical Chemistry, Dr. Irving Wainer from the NIH, will present a plenary lecture for all of EAS registrants, on Monday, Nov. 18th at 4:30pm in the Ballroom at the DoubleTree Hotel. This presentation will be followed by a time of networking and complimentary refreshments. We encourage all registrants of EAS to attend this special event.
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2013 EAS Final Program Technical Program
9:20 22 Chiral Constituents and Enantiomeric Composition in the Essential Oil Obtained from Artemisia Vulgaris L. Using Selectable 1-D/2-D Gas Chromatography/Mass Spectrometry, Jack D. Williams, Tianyue Xie, Mercyhurst University, Michael A. Campbell, Michael C. Jaskolka, The Behrand College
9:40 23 Identification of Impurities and Recovery of Start-ing Material from Industrial Distillation Bottom from y-Butyroactone Production, Bala Balasanmugam, Joycelyn Yapchulay, Maria Diss, Ashland Inc.
10:00 Break
10:20 24 Ionic Liquid Submerged Single Drop Microextraction and Static Headspace Single Drop Microextraction of Aromatic Hydrocarbons from Water, Ramkumar Dhandapani, Nicholas H. Snow, Seton Hall Univer-sity
10:40 25 Extending the Hydrocarbon Range above Naphtha-lene for Soil Vapor and Air Samples Using Automat-ed Thermal Desorption-Gas Chromatography-Mass Spectrometry, Bill Hahn, Lee D. Marotta, Cindy Liang, Perkin Elmer Instruments
11:00 26 Petroleum Biomarker Analysis by Atmospheric Pres-sure Gas Chromatography Tandem Mass Spectrom-etry (APGC-MS-MS) and Electron-Impact Ionization Tandem Mass Spectrometry (EI-MSMS), Chang S. Hsu, Florida State University, Quan Shi, China Uni-versity of Petroleum, Douglas M. Stevens, Waters
11:20 27 An Approach to Quantifying Petroleum Ether in Active Pharmaceutical Ingredients, Jana Stavova, Curtis Tinker, Michelle Kubin, William Fish, Bristol-Myers Squibb
Carbon Dioxide-Based HPLC: Modern SFCChair: Larry Taylor, University of Virginia Tech
Hillsborough
9:00 28 Evaluation of Non-Conventional Polar Modifiers on Immobilized Chiral Stationary Phases with Supercritical Fluid Chromatography (SFC), Jimmy DaSilva, Merck
9:30 29 Development of a Strategy to Transfer SFC Meth-ods from Analytical to Preparative Scale, Christo-pher J. Hudalla, Abhijit Tarafder, Kenneth J. Foun-tain, Waters
10:00 Break
10:20 30 Use of Supercritical Fluid Chromatography to Im-prove Efficiency of Medicinal Chemistry Purification, Larry Miller, Amgen
10:50 31 Supercritical Fluid Chromatography: Breaking out of the Pharmaceutical and Chiral Paradigm, Terry A. Berger, SFC Solutions, Inc.
11:20 32 Unattended Method Development for Optimizing Selective Supercritical Fluid Extraction, Jeffrey Wright, John A. MacKay, Waters
NMR of Molecules: Small and LargeChair: Tatyana Polenova, University of Delaware
Westfield
9:00 33 Utility of NMR in the Development of Protein Drugs, Luciano Mueller, Brian O’Mara, Matt Conover, James Tamura, Yongmi An, Nelly Aranibar, Sam Bo-
nacorsi, John Devincentis, Kai Cao, Brad Maxwell, Bristol Myers Squibb
9:30 34 Regulation of Protein Tyrosine Kinase Signaling in Bacteria, Ranajeet Ghose, The City College of New York
10:00 35 Molecular Dynamics Revealed: A 2H Solid-State NMR Investigation, Bernie O’Hare, Bruker Biospin
10:20 Break
10:40 36 Anisotropic Interactions in MAS Solid-State NMR Spectroscopy: Methodology Development and Applications in Protein Assemblies, Guangjin Hou, Alexander J. Vega, Sivakumar Paramasivam, Si Yan, Christopher L. Suiter, Huilan Zhang, Tatyana Polenova, University of Delaware, Ago Samoson, Tallinn University of Technology, In-Ja L. Byeon, Jinwoo Ahn, Angela M. Gronenborn, University of Pittsburgh School of Medicine
11:00 37 Molecular Insights into the Recognition of Cellular Membrane Geometry, Fang Tian, Penn State-Her-shey
11:20 38 The Electronic Structure of Manganese Catalysts for Hydroxo- and Peroxo-Splitting Reactions, LV Lakshmi, Sergey Milikisiyants, Christopher Coates, Ruchira Chatterjee, James Whittaker, Faisal Koua, Jian-Ren Shen, Rensselaer Polytechnic Institute
Spectroscopy for Surface Science, Nano Materials and Fiber AnalysisChair: Andrew Teplyakov, University of Delaware
Tewksbury
9:00 39 Reaction of Hydrazine with Cl-Terminated Si(111) Surfaces, Fei Gao, Andrew Teplyakov, University of Delaware
9:20 40 Towards Formation of Oxygen-Free Interface by Cy-clocondensation on H-Terminated Si(111) Surface, Yuexing Cui, Fangyuan Tian, Andrew Teplyakov, University of Delaware
9:40 41 Probing the Orientation of 2,3-Dichloro-1,4-Naph-thoquinone on Gold Nano-Rods and Ag Colloids, Maraizu Ukaegbu, Oladapo Bakare, Charles Hosten, Howard University, Alberto Vivoni, Inter America University
10:00 Break
10:20 42 Ultrafast Microscopy of Single CdSSe Nanowires, Peter S. Eldridge, Jolie C. Blake, Lars Gundlach, University of Delaware
10:40 43 Merging Methods - Correlating Structure and Chem-istry with Light Microscopy (LM), SEM and XPS Imaging, Peter Eastman, Michaeleen Pacholski, The Dow Chemical Company
11:00 44 Polarized Raman Spectra of Single Isolated Strained Fibers of Cellulose, Fran Adar, HORIBA Scientific, Craig Clemons, Umesh Agarwal, USDA
11:20 45 Terahertz Spectroscopy Advancement to a Broad-band Source: Pushing the Limits of Vibrational Spectroscopy and Time-of-Flight Analysis, David A. Heaps, Eiji Kato, Edward E. King, Richard R. McKay, Mark J. Sullivan, Akiyoshi Irisawa, Motoki Imamura, Advantest America
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2013 EAS Final Program Technical Program
11:20 46 Sequential Electrochemical Reduction Analyses as a Tool for Surface Evaluation, Peter Bratin, Michael Pavlov, Eugene Shalyt, ECI Technology
Environmental Analysis for Cultural Heritage Part I, organized in cooperation with New York Conservation FoundationChair: John Scott, New York Conservation Foundation
Bedminster
9:00 47 Environmental Analysis for Cultural Heritage, John Scott, New York Conservation Foundation
9:30 48 ATP Testing to Determine if Cultural Artifacts are Contaminated with Active Biological Materials, Jessica Keister, Jessica Silverman, Conservation Center for Art & Historic Artifacts
10:00 Break
10:20 49 The Influence of Select Pigments and Aging on the Detection of Proteinaceous Materials with ELISA, Natalya Atlasevich, Julie Arslanoglu, Metropolitan Museum of Art, Brian Baade, University of Dela-ware, Caroline Tokarski, Université de Lille, John Loike, Columbia University
10:50 50 Determining the Kinetics of Paper Degradation in Reduced Oxygen Environments, Ami L. Pass, Be-linda J. Colston, University of Lincoln, Barry Knight, British Library
Practical Trace Analysis in Forensic and Environmental ApplicationsChair: Matthew Wood, Ocean County Sheriff Department
Princeton
9:00 51 Spectroscopic Document Analysis - In Pursuit of a “Forensic Scanner,” John Allison, Kelly Wisnewski, The College of New Jersey
9:20 52 Effect of Orientation on the Dichroism of Dyed Fibers, Dale K. Purcell, Chaminade University of Honolulu, John A. Reffner, Thomas A. Kubic, John Jay College, Fran Adar, HORIBA Scientific
9:40 53 Luminol for Blood Detection - Should It Be an Instrumental Method?, John Allison, Nicole Renkel, Samantha Nowak, The College of New Jersey
10:00 Break
10:20 54 Rapid Quantification of DOSS Oil Dispersant in White Pelican Bill Knobs Inhabiting the Shores of the Gulf of Mexico Using QuEChERS Extraction and UPLC-MS/MS Analysis, Aliaksandr V. Yeuda-kimau, Anthony A. Provatas, Brianna M. Galos, Christopher R. Perkins, James D. Stuart, University of Connecticut
10:40 55 Automating the Fractionation of Extractable Petro-leum Hydrocarbons with a Scaled Down Silica-Gel Cartridge, Brian LaBrecque, Alicia J. Cannon, Wil-liam R. Jones, Horizon Technology
11:00 56 Double Lab Productivity Overnight: Extract PAHs and PCBs Simultaneously from Tissue and Soil Samples Using a New Accelerated Solvent Extrac-tion (ASE) Procedure, Greg Malek, Peter Bodsky, Art W. Fitchett, Michael G. Hvizd, Thermo Fisher Scientific
11:20 57 Comparison of Methods for the Determination of As-bestos Soil Surface Contamination; Pretoria, South Africa, Frank Ehrenfeld, Raymond Kennedy, Kristen Goedde, Thomas Barkley, International Asbestos Testing Laboratories
Monday Poster Session:Pharmaceutical Analysis: Quality-by-Design, Inhalation, Solid State Techniques
Poster Area of the Exhibit Hall
12:00-2:00 58 Development, Validation and Application of a New HPTLC Method for the Simultaneous Determination of Alfuzosin, Terazosin, Prazo-sin Doxazosin and Finasteride in Pharmaceuti-cal Formulations, Mona M. Khamis, Hoda G. Daabees, Mohamed S. Mahrous, Magdi M. Abdel-Khalek, Tarek S. Belal, University of Alexandria
12:00-2:00 59 In-Situ Monitoring of Form Change as a Func-tion of Relative Humidity in the Solid State by VTIRaman, Candice Choi, Duohai Pan, Den-ette Murphy, Anisha Patel, Roxana Schlam, Shawn Yin, Bristol-Myers Squibb, Sruthi Jana-kiraman, Drexel University
12:00-2:00 60 The Correlation Between Actuation Profile and Dose Content Uniformity: Design and Implementation of a Non-Invasive Meter Dose Inhaler Actuation Profiler, Jagruti A. Patel, Francisco Alberto, Paul Bjorndal, Justin Pen-nington, Merck
12:00-2:00 61 AIM (Abbreviated Impaction) for Success: Streamlining Inhaler Characterization, Buchilingam Bupathi, Xiuhua Fang, Kathleen Hogan, Kuriakose Jacob, John Jekonski, Jen-nifer Loria, Adrian Goodey, Ying Li, Merck
12:00-2:00 62 Relating Surface Wettability Measured by IGC to Dissolution Properties of Dry Powder Inhaler Formulations, Daniel J. Burnett, Armando R. Garcia, Majid Naderi, Manaswini Acharya, Surface Measurement Systems
12:00-2:00 63 Automated Analysis of In-Vitro Nasal Spray Deposition Patterns to Guide Formulation Development, Xiuhua Fang, Elaine Pu, Adrian Goodey, Kuriakose Jacob, Julianne Berry, Merck
12:00-2:00 64 A PCA Model of Atypical Andersen Cascade Data, Lauren Seabrooks, Merck
12:00-2:00 65 ELS Detectors: A Simplified Approach to Mathematic Modeling of Dry Powder Inhaler Blend Uniformity, John Lena, Justin Pennington, Merck
12:00-2:00 66 Design of Experiments (DoE) and Response Surface Methodology (RSM) to Improve the Robustness of a Particle Size Method, Shasad Sharif, Mario Hubert, Beth Sarsfield, Bristol-Myers Squibb
12:00-2:00 67 A Quality-by-Design (QbD) Based LC-CAD Method for Oleic Acid in Metered-Dose Inhalers(MDI), Honggen Zhang, Zhenyu Wang, Merck
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2013 EAS Final Program Technical Program
12:00-2:00 68 Design of Experiment Studies of the Robust-ness of a Chiral Method Using a Modeling Software, Hui (Viviane) Zhao, Xin (Amy) Bu, John Castoro, Bristol-Myers Squibb
12:00-2:00 69 Quality-by-Design (QbD): A Life Cycle Ap-proach for Analytical Method Development, Prasad Panzade, Aditya Birla Science and Technology
12:00-2:00 70 Scientific Instrument Regulation and Qualifica-tion, Alex White, Anton Paar
12:00-2:00 71 Pesticides in My Beverage - Screening (and Subsequent Quantification) of Pesticides in Beverages Originating from Leaves, Grapes, Grasses, and the Hydrologic Cycle (Tea, Wine, Milk, and Water) Using Automated SPE, Peter Bodsky, Jennifer Peterson, Thermo Fisher Scientific
12:00-2:00 72 Development of an In-Vitro Assay for Assess-ing the Anti-Inflammatory Drug Effects Based on Human Airway Epithelium, Antonio Macaluso, Ivy Hamill, Jason Ehrick, Merck, Song Huang, Ludovic Wiszniewski, Samuel Constant, Epithelix Sàrl
12:00-2:00 73 Quantifying the Effect of Powder Caking by Powder Rheometry, Mike Delancy, Tim Free-man, Brian Armstrong, Katrina Brockbank, Freeman Technology
12:00-2:00 74 The Characterization of Granulation Wet Masses Using Powder Rheometry, Mike Delancy, Tim Freeman, Brian Armstrong, Freeman Technology
Monday Poster Session:HPLC/UHPLC Techniques
Poster Area of the Exhibit Hall
12:00-2:00 75 Stability Studies of a Novel Silica-Based Diol-Bonded 3-μm Particle Size 30nm Pore Size-Exclusion Chromatography Analytical Column Especially Designed for the Separation of Ag-gregates, Justin Steve, Atis Chakrabarti, Tosoh Bioscience
`12:00-2:00 76 Separation Improvements with 2-D Liquid Chromatography, William J. Long, Anne E. Mack, Agilent Technologies
12:00-2:00 77 HPLC Separations of Highly Polar Compounds and Isomers Using Reliasil Polychrom Column, Xuejun Zang, Dipali Parikh, Anil Oroskar, Asha Oroskar, Orochem Technologies
12:00-2:00 78 Statistical Comparison of Unique Chemically Modified Carbohydrate Based Chiral Station-ary Phases to Improve Chiral Separations, Matthew Przybyciel, ES Industries
12:00-2:00 79 Thermodynamics and Multivariate Analysis of HPLC Stationary and Mobile Phase Behavior, Wilmer R. Barndt, Eric J. Williamsen, Ursinus College
12:00-2:00 80 Characterization and Resolution of the Deteriorative Effects of Hydroxypropyl Meth-ylcellulose on UHPLC Column Performance, Karthik Jayaraman, Frank Tomasella, Bristol-Myers Squibb, Hutton Chapman, University of Virginia, Thomas Hooker, Gilead Sciences
12:00-2:00 81 Particle Size Considerations of Superficially Porous Particles, Stephanie A. Schuster, Joseph J. DeStefano, Robert S. Bichlmeir, Wil-liam L. Johnson, Advanced Materials Technol-ogy
12:00-2:00 82 Efficient and Rapid Method Development with Hybrid Silica Based Material by Utilizing Par-ticle Size, Temperature and Bonded Chemis-try, Ernest J. Sobkow, Noriko Shoji, Takatomo Takai, Takashi Sato, Naohiro Kuriyama, YMC Co.
12:00-2:00 83 Efficient Method Development for Polar Compounds Analysis on Hybrid Silica Based Particle Column, Ernest J. Sobkow, Noriko Shoji, Takatomo Takai, Takashi Sato, Naohiro Kuriyama, YMC Co.
12:00-2:00 84 Increased Throughput and Purity of Combi-natorial Libraries Utilizing a Targeted Gradient Profile Based on Method Scouting Software, Todd M. Anderson, Shimadzu Scientific
12:00-2:00 85 Determination of Organic Acids in Electroless Nickel, Silver, and Gold Plating Solutions Us-ing High Performance Liquid Chromatography, Peter P. Yeh, Shelby Hale, MacDermid
12:00-2:00 86 Evaporative Light Scattering Detection - Improved Detector Design for the Detection of Semi-Volatile Compounds, Graham M. Cleaver, Stephen Bullock, Agilent echnologies
12:00-2:00 87 Preparative Isolation of Active Components from Natural Products Using Low-Pressure Gradient Preparative High Performance Liquid Chromatography, Kenichiro Tanaka, William Hedgepeth, Lincoln Grimes, Tsutomu Wata-nabe, Takaei Kitagawa, Yosuke Iwata, Shi-madzu Scientific Instruments
12:00-2:00 88 Exploring Low and High pH Eluents Using a New Silica-Based Extended pH Range C18 Column for Analysis of Amphetamines and Opiates from Urine by LC-MS-MS, Geoffrey Faden, MACMOD Analytical, Alan P. McKe-own, Advanced Chromatography Technologies
12:00-2:00 89 Exploring the Power 0f Chromatographic Selectivity for Polar and Non-Polar Analytes with a Unique HPLC-UHPLC Polar Embedded Stationary Phase, Geoffrey Faden, MACMOD Analytical, Alan P. McKeown, Advanced Chro-matography Technologies
12:00-2:00 90 Determination of the Average Volumetric Flow Rate in Supercritical Fluid Chromatography, Peter Vajda, Georges Guiochon, University of Tennessee
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2013 EAS Final Program Technical Program
Monday Poster Session:Chromatography: Coupled Methods of Analysis
Poster Area of the Exhibit Hall
12:00-2:00 91 High Performance Ion Mobility Spectrometry-Liquid Chromatography: An Integrated Tool for 2-D Separation, Carol Moraff, Ching Wu, Clinton Krueger, Anthony Midey, Excellims Corporation
12:00-2:00 92 Studying Stability and Degradation Pattern for Sunscreens Containing TiO2 Nanoparticles and Other 93Sunscreen Agents Under UV Light Exposure Through Universal LC-ESI-MS, Michael M. Puppolo, Siddharth Shah, Temple University
12:00-2:00 93 Identification of Purified Flavonoids (Proan-thocyanidins and Flavonols) from American Cranberry, Yifei Wang, Ajay P. Singh, Nicholi Vorsa, Rutgers University
12:00-2:00 94 Selectivity of Chloride Ion Attachment in Negative-Ion Atmospheric-Pressure Chemical Ionization LC-MS with Applications to Phar-maceutical Development, Keith B. McKellop, Scott Pennino, Shirley A. Rodriguez, Daniel Norwood, Boehringer Ingelheim
12:00-2:00 95 Novel SFC Additives and Modifiers for Separating Drug Candidates in Discovery Chemistry, Peng Li, Dawn Sun, Yip Shiuhang, Wu Dauh-Rurng, Arvind Mathur, Joel Barrish, Bristol-Myers Squibb
12:00-2:00 96 Analytical Challenges in Residual Chlorobuta-nol Analysis in the Presence of Trace Amount of THF, Vera Leshchinskaya, Yande Huang, Yun Ye, Bristol-Myers Squibb
12:00-2:00 97 GC-MS Study of the Composition of Satu-rated Hydrocarbons in High-Boiling Fractions of Georgian Oils, Elza N. Topuria, Natela T. Khetsuriani, Melikishvili Institute of Physical & Organic Chemistry, Kirill V. Tretyakov, Carlos A. Gonzalez, Anzor I. Mikaia, National Institute of Standards & Technology
12:00-2:00 98 GC-MS Study of Polycyclic Aromatic Hydrocar-bons in High-Boiling Fractions of Norio Oil, Na-tela T. Khetsuriani, Elza N. Topuria, Melikishvili Institute of Physical & Organic Chemistry, Nino G. Todua, Carlos A. Gonzalez, Anzor I. Mikaia, National Institute of Standards & Technology
12:00-2:00 99 Evolved Gas Analysis of Biomass Derived Rigid Polyurethane Foam by Pyrolysis GC-MS, Courtney Taylor, Shimadzu Scientific Instru-ments
12:00-2:00 100 Characterizing Copolymer Compositional Heterogeneity by GPC-FTIR Combined Sys-tem, Tracy Phillpott, William Carson, Spectra Analysis Instruments
12:00-2:00 101 Extraction of 22 Pain Management Drugs from Human Urine Using Supported Liquid Extrac-tion (ISOLUTE® SLE+) in 96-Well Plate Prior to LC-MS-MS Analysis, Victor E. Vandell, Brad Nolt, Biotage
12:00-2:00 102 Use of Sorbent Coated Metal Probes with Direct Analysis in Real Time (DART) Ioniza-tion for Rapid Analysis of Herbal Supplements, Joseph LaPointe, Brian Musselman, Robert Goguen, Ionsense Inc.
12:00-2:00 103 Extraction of Caffeine from Tea and Water Using QuEChERS with Gas Chromatography-Mass Spectrometry Detection, Michelle L. Schmidt, Nicholas H. Snow, Seton Hall Univer-sity
12:00-2:00 104 Measuring Estrogens by Automated On-Line Extraction, Derivatization and Cleanup Coupled to LC-MS-MS, Heather L. Heilman, Joseph M. Di Bussolo, Thermo Fisher Scientific
12:00-2:00 105 Evaluation of Centroid and Profile Mode Data Collection Methods, for High-Resolution Ac-curate Mass Spectrometry (HRMS) Based In-tegrated Qualitative and Quantitative Analysis, Eldho Raju, Kean University
12:00-2:00 106 Rapid Separation of Anthocyanins in Bil-berry and Cranberry Extract using Core Shell Columns, Peter Bodsky, Pranathi Perati, Art W. Fitchett, Michael G. Hvizd, Thermo Fisher Scientific
Monday Afternoon, November 18, 2013
EAS Award for Outstanding Achievements in the Fields of Analytical ChemistryHonoring Dr. Irving Wainer, National Institutes of HealthSponsored by Bristol-Myers SquibbChair: Ruin Moaddel, National Institutes of Health
Ballroom West
2:00 107 Ramp Up the Pressure, Turn Up the Heat: Second-ary Effects in Chromatographic Method Scaling, David Lloyd, Holly M. Shackman, Wei Wang, Xujin Lu, Zhen Wu, Bristol-Myers Squibb, Samantha Mahmoud, Kean University, Hannah Lo, Rutgers University
2:30 108 Chiral Bioanalysis and Metabolite Monitoring in the Era of Enantiomerically Pure Drugs, Anne- Françoise Aubry, Michael T. Furlong, Jian Wang, Bristol-Myers Squibb, Daria Wentzel, Tandem Labs, Song Zhao, Moucun Yuan, William R. Mylott Jr., PPD
3:00 Break
3:20 109 High-Performance Affinity Microcolumns: Recent Developments in Clinical Testing, Pharmaceutical Analysis and Biointeraction Studies, David Hage, University of Nebraska
3:50 110 Biochromatography: An Endless Frontier, Gabriella Massolini, University of Pavia
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2013 EAS Final Program Technical Program
Plenary LectureEAS Award for Outstanding Achievements in the Fields of Analytical ChemistryHonoring Dr. Irving Wainer, National Institutes of HealthWe invite all attendees to join us in honoring Dr. Irving Wainer at this special event. Complimentary refreshments to follow.
Ballroom West
4:30 Presentation of the EAS Award for Outstanding Achievements in the Fields of Analytical Chemistry
4:35 111 Plenary Lecture When Someone Says “Everybody Knows That ...” Stop Listening! Adventures in Basic and Translational Research, Irving Wainer, National Institutes of Health
Spectroscopic Applications in Biologics, organized by the Coblentz SocietySponsored by the SAS New EnglandChair: Brandye Smith-Goettler, Coblentz Society
Bridgewater
2:00 112 Deep UV Resonance Raman Spectroscopy of Bio-pharmaceuticals, Sergey Arzhantsev, Liwei Yuan, Vincent Vilker, John Kauffman, United States Food and Drug Administration
2:30 113 Characterization and Spectroscopic Applications in Pulmonary Delivery and Advanced Dry Powder Inhalers, Heidi M. Mansour, University of Arizona-Tucson
3:00 Break
3:20 114 Application of In-Line Raman for Real-time Mea-surement of Carbon Source in Mammalian Cell Culture Fermentation, Louis Obando, Daniel C. Johnson, Merck
3:50 115 Challenges and Issues of Spectroscopy and Chemometric Applications in Protein Therapeutics Development and Manufacturing, Seongkyu Yoon, Nicholas A. Trunfio, HaeWoo Lee, University of Massachusetts-Lowell
High Resolution Mass Spectrometry For Small and Large Molecule Characterization and DetectionChair: Dil Ramanathan, Kean University
Bernardsville
2:00 116 Analysis of Tetracycline Transformation and Deg-radation Using Vetiver Grass by Ultra High-Perfor-mance Liquid Chromatography/High-Resolution Mass Spectrometry, Chinmayi Parikh, Dil Ramana-than, Kean University, Aparupa Sengupta, Rupali Datta, Michigan Technological University
2:20 117 Electrospray Ionization Mass Spectrometry of Didodecylpolysulfides Using Silver(I) Complexation, Christie Bowden, Sriraj Srinivasan, Gary S. Smith, Arkema
2:40 118 Rapid Disulfide-Containing Protein Structure Analy-sis Using Combined Electrochemistry and Mass Spectrometry, Hao Chen, Ohio University
3:00 Break
3:20 119 Process Mass Spectrometers - Now a PAT Tool for Cell Culture, Todd B. Colin, Peter J. Traynor, Thermo Fisher Scientific
3:40 120 Evaluation of Centroid and Profile Mode Data Col-lection Methods for High-Resolution Accurate Mass Spectrometry, (HRMS) Based Integrated Qualitative and Quantitative Analysis, Eldho Raju, Dil Ramana-than, Kean University
4:00 121 Elucidation of Polysaccharide Structures, Contain-ing Charged Polysulfated/Polycarboxylated Moi-eties, Using Exact-Mass ESI Negative Ionization MSMS Data and the MASSPEC Algorithm, Marshall M. Siegel, Gary Walker, MS Mass Spec Consul-tants, Lingyun Li, Robert J. Linhardt, Rensselaer Polytechnic Institute
Supercritical Fluid Chromatography (SFC) as an Analytical and Preparative ToolChair: Chris Hudalla, ProVerde Laboratories
Hillsborough
2:00 122 Chromatographic Method Development Strategies for Convergence Chromatography, Paula Hong, Michael D. Jones, Patricia McConville, Waters
2:20 123 Novel Supercritical Carbon Dioxide Enhanced Chromatography Method for the Comprehensive Analysis of Fatty Acid Methyl Esters (FAMEs) and FAMEs Containing Materials, François J. Huby, Robert M. Campbell, The Dow Chemical Company
2:40 124 Overloaded Chiral Separations on an Analytical and Preparatory (with Collection) Scale in SFC, John Whelan, II, John Baugher, Waters
3:00 Break
3:20 125 Targeted Isolation of Impurities in Pharmaceutical Compounds Using SFC (Strategy Development for Pharmaceutical Impurity Isolation), Mikey Rego, Paul Lefebvre, John H. Tipping, Jeff P. Kiplinger, Averica Discovery Services
3:40 126 Improved Chiral SFC Screening for Separation of Complex Mixtures, Erik L. Regalado, Wes Schafer, Tilak Chandrasekaran, Zainab Pirzada, Chaowei Zhang, Xiaoyi Gong, Mirlinda Biba, Christopher J. Welch, Merck
Applications of NMR Spectroscopy from Small Molecules to Large AssembliesChair: Bernie O’Hare, Bruker Biospin
Westfield
2:00 127 Comparison of Two-Dimensional 1H-19F NMR Scalar Coupling Experiments in Small Molecules, Alexander Marchione, Elizabeth F. McCord, Re-becca J. Dooley, DuPont
2:20 128 Spectroscopic and Computational Analyses of Poly-morphic Organic Materials, Sean T. Holmes, Fahri Alkan, Cecil Dybowski, University of Delaware
2:40 129 Characterization of Polymer Electrolyte Membranes by Gel-State MAS NMR, Haiming Liu, Dave Mountz, Tao Zhang, Wensheng He, Arkema
3:00 Break
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2013 EAS Final Program Technical Program
3:20 130 Investigating the Molecular Framework and Assem-bly of Synthetic and Fungal Melanins by Solid-State NMR, Subhasish Chatterjee, Sindy Tan, Hsin Wang, Ruth E. Stark, CUNY Institute for Macromolecu-lar Assemblies, Rafael Prados-Rosales, Susana Frases, Arturo Casadevall, Albert Einstein College of Medicine, Boris Itin, New York Structural Biology Center
3:40 131 NMR Relaxation Method to Detect Small Dynamical Differences in Proteins, Rieko Ishima, University of Pittsburgh
4:00 132 Exploring Amyloid Structure by Quenched Hydrogen Exchange Solution NMR, Andrei T. Alexandrescu, University of Connecticut
Spectroscopy at Surfaces and InterfacesChair: Lars Gundlac, University of Delaware
Tewksbury
2:00 133 Two-Dimensional IR and Two-Dimensional SFG Spectroscopies: New Techniques for the Analytical Sciences, Martin Zanni, University of Wisconsin-Madison
2:40 134 Photoexcited Excitons in Single Walled Carbon Nanotubes, Todd Krauss, Michael Odoi, Julie Smyder, Lisa Nogaj, Andrea Lee, Xiaoyong Wang, University of Rochester
3:00 Break
3:20 135 Quadrupole Enhanced Raman Scattering of Spiky Gold Nanoshells, Zahra Fakhraai, Simon P Hast-ings, Zhaoxia Qian, So-Jung Park, Nader Engheta, University of Pennsylvania, Pattanawit Swanglap, Ying Fang, Stephan Link, Rice University
3:50 136 Using Ultrafast Pump-Probe Microscopy to Image Carrier Migration and Carrier Recombination in Si and ZnO Nanowires, John Papanikolas, University of North Carolina - Chapel Hill
Environmental Analysis for Cultural Heritage Part II, organized in cooperation with New York Conservation FoundationChair: John Scott, New York Conservation Foundation
Bedminster
2:00 137 Evaluating Exposure During Cleaning and Con-servation of Metallic Lead, Shaundree T. Davis, Princeton University
2:30 138 Long Term Environmental Monitoring: Museum Size Strategies and Wooden Objects Hygro-Mechanical Reactivity to Temperature and Relative Humidity Fluctuations, Paolo Dionisi-Vici, Masahiko Tsukada, Lucretia Kargère, Marco Leona, Metropolitan Mu-seum of Art, Hendrik F Hamann, Sergio A Ramirez Bermudez, Levente Klein, Vanessa Lopez, Alejan-dro G Schrott, IBM Research Thomas J. Watson Center
3:00 Break
3:20 139 Environment Monitoring in Developing Countries and Remote Assessment of Cultural Materials Through Nano-scale Weight Monitoring, Henoc Agbota, University College, London
3:50 140 Evaluating the use of Agricultural Moisture Probes in the Historic Built Environment, Nicole Fielding, Belinda J. Colston, Adrian M. Goodman, University of Lincoln
Women in Chromatography: Solving Real Life Problems
Sponsored by Chromatography Forum of the Delaware ValleyChair: Mary Ellen McNally, DuPont Crop Protection
Princeton
2:00 141 Supercritical Fluid Chromatography (SFC), a Widely Applicable Technique Used in Industries from Pharmaceutical to Food, Jennifer Van Anda, Agilent Technologies, Terry A. Berger, SFC Solutions
2:30 142 Keeping Our Food Safe: Detection of Veterinary Drug Residues, Marilyn J. Schneider, United States Department of Agriculture
3:00 Break
3:20 143 Analytical Development in Over-the-Counter Drugs – Straddling Pharmaceutical and Consumer Prod-ucts, Mary Selman, The Mentholatum Company
3:50 144 Systematic Investigation of Factors that Affect Preci-sion in HPLC, Mary Ellen McNally, Steven Hansen, DuPont Crop Protection, Karyn Usher, West Ches-ter University
Tuesday Morning, November 19, 2013
EAS Award for Outstanding Achievements in ChemometricsHonoring Dr. Olav Martin Kvalheim, University of BergenSponsored by Eigenvector ResearchChair: Svante Wold, Umeå University
Hillsborough
9:00 145 Endogenous Metabolic Profiling as a Fundament in Personalized Theranostics, Torbjörn Lundtstedt, Katrin Lundstedt-Enkel, Uppsala University, Thomas Moritz, Swedish University of Agricultural Science, Frida Troell, Johan Trygg, Umeå University, Kate Bennett, AcureOmics AB
9:30 146 Multivariate Approach to Reveal Biomarker Sig-natures for Disease Classification, Tarja Rajalahti Kvalheim, Haukeland University Hospital
10:00 Break
10:20 147 The OPLS Approach for Multi-Block Data Integra-tion, Johan Trygg, Umeå University 10:50 148 Latent Variables - What are they?, Svante Wold, Umeå University
11:20 Presentation of the EAS Award for Outstanding Achievements in Chemometrics
11:25 149 Interpretation and Measures of Variable Importance in Multivariate Data by Latent Variable Modeling, Olav Martin Kvalheim, University of Bergen
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2013 EAS Final Program Technical Program
EAS Award for Outstanding Achievements in Separation ScienceHonoring Dr. Mark R. Schure, Kroungold Analytical, Inc.Sponsored by Agilent TechnologiesChair: J. Ilja Siepmann, University of Minnesota
Ballroom Center
9:00 Presentation of the EAS Award for Outstanding Achievements in Separation Science
9:05 150 Orthogonal Separations, Mark R. Schure, Kroun-gold Analytical, Inc., Joe M. Davis, Southern Illinois University – Carbondale
9:30 151 Adventures in Two-Dimensional Liquid Chromatog-raphy, Dwight Stoll, Gustavus Adolphus College, Peter W. Carr, University of Minnesota
10:00 Break
10:20 152 Resolution of Transport and Kinetic Limitations in Protein Exchange in Polymer-Functionalized Adsor-bents, Abraham M. Lenhoff, University of Delaware
10:50 153 Understanding Retention in Reversed-Phase Liquid Chromatography: Insights from Molecular Simula-tion, J. Ilja Siepmann, University of Minnesota, Mark R. Schure, Kroungold Analytical, Jake L. Rafferty, North Hennepin Community College
Challenges of Impurity Quantitation in Pharmaceutical AnalysisChair: Fenghe Qiu, Boehringer Ingelheim
Ballroom East
9:00 154 ASAP (Accelerated Stability Assessment Program): Opportunities and Challenges, Fenghe Qiu, Madhuri Jerfy, Lisa Hernandez, Zeena Williams, Prince Ko-rah, Boehringer Ingelheim
9:20 155 The Material Mass Balance Investigation of API in Orlistat Drug Product Stored at Accelerated Condition: Where is the Missing Orlistat?, Zbigniew Marcinow, GlaxoSmithKline
9:40 156 The Impact of Extractable Materials from Plastic Sample Preparation Devices on Formulation Analy-sis, Jigna Patel, William Fish, Anne Kelly, Bristol-Myers Squibb
10:00 Break
10:20 157 A Complete Solution for Sample Prep Technique for New USP<232> and <233>, Arshad Kokardekar, David Gunn, Milestone Inc.
10:40 158 A System to Perform Autocalibration, Automated Sample Dilution, and Auto-Spiking for Analyzing Pharmaceuticals by ICP and ICP-MS, Kyle Uhlmeyer, Paul Field, Dan Wiederin, Elemental Scientific
11:00 159 Determination of Polymeric Impurities in Pharma-ceutical Products by Reversed Phase Chromatog-raphy, Zongyun Huang, Yan Zha, Yue Hu, Zuguang Tian, Robert Perrone, Robert Francis, Joan Ruan, Bristol-Myers Squibb
11:20 160 New Aspects in Drug Development Using (U)HPLC Methods and Robustness Evaluation According to Quality-by-Design Principles with the Help of Modeling Techniques, Imre L. Molnar, Hans-Jürgen Rieger, Molnar-Institute, Alexander H. Schmidt, Steiner & Co.
Innovations in Forensic Drug AnalysisSponsored by New Jersey Association of Forensic ScientistsChair: Thomas Blackwell, DEA Northeast Laboratory
Princeton
9:00 161 DART-MS Collision Induced Dissociation (CID) for Structural Analysis of Designer Drugs, Jason Shepard, Rabi Musah, Ashton Lesiak, University at Albany, Marek Domin, Boston College, Robert Cody, John Dane, JEOL, USA Inc.
9:30 162 A Study of Positional Isomers Using Linear Ion Trap LCMS/MS and Q-TOF LC/MS, Ada Kong, DEA Northeast Laboratory
10:00 Break
10:20 163 Forensic Applications of Comprehensive GC with TOF/MS, Frank Dorman, Pennsylvania State Uni-versity
10:50 164 Development of a Surface-Enhanced Raman Spectroscopy Method for the Detection of Benzodi-azepines in Urine, Erika L. Doctor, Bruce McCord, Florida International University
Spectroscopic Applications in Biomedical Sensing, organized by the Coblentz SocietyChair: Brandye Smith-Goettler, Coblentz Society
Bridgewater
9:00 165 Semi-Conductor Compatible Plasmonic Materials: The Next Wave of Optical Sensing Technology, Stefan Franzen, North Carolina State University
9:30 166 Modeling Spectroscopic Imaging Optical Paths for New Biomedical Sensing Opportunities, Rohit Bhargava, Thomas van Dijk, Rohith Reddy, Paul S. Carney, University of Illinois at Urbana-Champaign
10:00 Break
10:20 167 Surface Enhanced Raman Scattering (SERS): New Pathways for Rapid, Parallel and Low-Level Analyte Detection, Jennifer H. Granger, Marc D. Porter, Nano Institute of Utah
10:50 168 An Atypical Query about the Subjectivity of “Objec-tive” Spectroscopy-Based Cancer Recognition, Ishan Barman, Massachusetts Institute of Technology
New Technology for Quantitation of Intracellular Drugs in Transporter StudiesChair: Mingshe Zhu, Bristol-Myers Squibb
Bernardsville
9:00 169 Tailor-Made Transporter Assays for Stage-Specific Drug Discovery and Development, Imad Hanna, Novartis
9:30 170 Leveraging High-Throughput Mass Spectrometry-Based Transporter Assays to Drive Decision-Making and Enhance ADMET Knowledge, Andrew Wagner, Wilson Shou, Matt G Soars, Bristol-Myers Squibb
10:00 Break
10:20 171 High-Throughput LC/MS/MS Based Permeability and Transporter Assays in Early Drug Discovery, Hui Zhang, John P. Umland, Carrie Funk, Michael West, Matthew D. Troutman, Pfizer
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2013 EAS Final Program Technical Program
10:50 172 A Generic Mass Spectrometry-Based Methodology for Sensitive and Fast Analysis of Non-Radiolabeled Substrates or Test Compounds in Transporter Study, Ming Yao, Hong Shen, William G. Hum-phreys, Mingshe Zhu, Bristol-Myers Squibb
Structural Studies by Magnetic Resonance SpectroscopyChair: Patrick van der Wel, University of Pittsburgh
Westfield
9:00 173 EPR and NMR Studies of Membrane Proteins, Gary A. Lorigan, Miami University
9:30 174 Structural Basis for Disruption by Model Amyloid Peptides from Solid State NMR, Simon Sharpe, The Hospital for Sick Children
10:00 Break
10:20 175 Mechanism of Transient Sequential Domain Interac-tions in Nonribosomal Peptide Synthetases Re-vealed by NMR, Dominique Frueh, Johns Hopkins School of Medicine
10:40 176 Stochastic Dipolar Recoupling NMR Spectroscopy for the Structural Studies of Biological Solids, Wei Qiang, Robert Tycko, National Institutes of Health
11:00 177 Investigating the Structure, Oligomerization, and Topology of Caveolin-1, Jebrell Glover, Lehigh Uni-versity
11:20 178 Application of NMR Crystallography to Drug Development, Heather Frericks Schmidt, Yuriy A. Abramov, Linda L. Lohr, Pfizer
Environmental Surface ChemistryChair: John Newberg, University of Delaware
Tewksbury
9:00 179 Scenes from the Edge: Atmospheric Chemistry of Environmental Interfaces, V. Faye McNeil, Columbia University
9:30 180 Interactions of Oxalic Acid on Ice, Liang Chu, Wad-sworth Center-SUNY
10:00 Break
10:20 181 Photolysis of Pollutants at Ice Surfaces in the Presence of Environmental Contaminants, Tara F. Kahan, Syracuse University
10:50 182 Heterogeneous Reactions on Ice and Metal Oxide Surfaces Studied In-Situ by X-Ray Photoelectron Spectroscopy, Hendrik Bluhm, Lawrence Berkeley National Laboratory
Analytical Imaging for Cultural Heritage Part I, organized in cooperation with the New York Conservation FoundationChair: John Scott, New York Conservation Foundation
Bedminster
9:00 183 Diverse Spectroscopy on Modern and Traditional Materials at the Library of Congress, Fenella G. France, Eric Breitung, Lynn Brostoff, Library of Congress
9:30 184 Scientific and Computational Imaging: Research & Conservation of Smithsonian Collections, E. Keats Webb, Melvin Wachowiak, Smithsonian Museum Conservation Institute
10:00 Break
10:20 185 Structure from Motion/Photogrammetry and the Long-term, Archival Survival of 3-D Information, Mark Mudge, Cultural Heritage Imaging
10:50 186 Computed Tomography meets Archaeology – Virtual Excavation and Reconstruction, Nicole Ebinger-Rist, Landesamt für Denkmalpflege Baden-Würt-temberg
Mass Spectrometry – A Powerful Technology for the Biotech and Pharmaceutical Scientist, organized by AmericanChemical Society North Jersey Mass Spectrometry Discussion GroupChair: Robert Iannucci, ACS North Jersey Mass Spectrometry Discussion Group
Ballroom West
9:00 187 Measuring Dysregulation of Kynurenine Metabo-lites in Mouse Models of Inflammation Associated Depression, David Budac, Lundbeck
9:30 188 A Chemical Derivatization Approach for the Quantifi-cation of Genotoxic Impurities HOPO and EDACHCl at Sub-ppm Level by LC-MS/MS, Wei Ding, Yande Huang, Jeff Dai, Jonathan Marshall, Scott Miller, Bristol-Myers Squibb
10:00 Break
10:20 189 Enabling Rapid, Sensitive Peptide Quantitation Through Automation and Nano/LC/MS, Weixun Wang, Merck
10:50 190 Data Independent High Resolution Mass Spec-trometry Methods to Integrate Drug Metabolism and Pharmacokinetics Studies, Ragu Ramanathan, QPS
Tuesday Poster Session:Spectroscopy
Poster Area of the Exhibit Hall
12:00-2:00 191 Atomic Emission Beacons for Long-Distance Chemical Signaling, Christopher N. LaFratta, Ian Pelse, Jose Luis Ffalla, Yi Liu, Bard Col-lege, Manuel A. Palacios, David R. Walt, Tufts University, George M. Whitesides, Harvard University
12:00-2:00 192 Mass Spectrometry in RIC ROC Applications - Part 01 in Theory and Practice, Srivas R. Srinivas, Anadams
12:00-2:00 193 Mass Spectrometry in RIC ROC Applications - Part 02 Pharmaceutical Analysis, Srivas R. Srinivas, Anadams
12:00-2:00 194 On the Fermentation of Cabbage by NMR, Kenith M. Conover, Princeton University
12:00-2:00 195 The Determination of Silicon Concentration on Hair Tresses Using FTIR, Alex J. Augatis, Ray-mond Bret Clark, Chi-san Wu, Osama Musa, Eugene W. Oldham, James E. Brady, Ashland Specialty Ingredients
12:00-2:00 196 Spectroelectrochemical Study of the Redox Activity of 2, 3-Dichloro-1, 4-Naphthoquinone, Maraizu Ukaegbu, Oladapo Bakare, Charles Hosten, Howard University
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2013 EAS Final Program Technical Program
12:00-2:00 197 Combined Headspace Karl Fischer and NIR System Makes NIR Modeling of Lyophilized Products Quicker, Safer and More Reliable, George E. Porter III, Hari Narayanan, Denise Root, Metrohm
12:00-2:00 198 Label-Free Imaging and Characterization of Cancer Cell Responses to Polymethoxyfla-vones Using Raman Microscopy, Hua Zhang, Hang Xiao, Lili He, University of Massachu-setts-Amherst
12:00-2:00 199 Elemental Analysis of Ancient Pottery by Inductively Coupled Plasma-Optical Emission Spectroscopy (ICP-OES) to Better Understand Provenance, Erika Portero, Astrid Castillo, Molly W. Crowther, Jon Kettenring, Carl Sav-age, Drew University
12:00-2:00 200 Trace Metal Screening of Barium Sulfate Raw Ores by ICP-OES, Gregory W. White, Nishit Gandhi, Thomas Katona, Bracco Research USA
12:00-2:00 201 FT-Raman Mapping of Multi-Component Solid Dosage Forms, Ronald L. Rubinovitz, Thermo Fisher Scientific
12:00-2:00 202 PMMA/PLA Blends Compositional Analysis. ATR-FT-IR Coupled with Chemometrics Meth-ods, Dana Garcia, Susan Pirollo, Florence Mehlmann, Thomas Richards, Arkema
12:00-2:00 203 FT-NIR Applications in Tablet API Analysis and Tablet Coating Process Monitoring, Herman He, Thermo Fisher Scientific
12:00-2:00 204 SEC-IR Coupled Technology to Characterize Polymer Grafting and Polymer Degradation, Ming Zhou, Tom Kearney, Spectra Analysis Instruments
12:00-2:00 205 Coupling Raman Spectroscopy and Gravimet-ric Vapor Sorption Methods to Monitor Vapor-Induced Phase Transitions, Daniel J. Burnett, Armando R. Garcia, Majid Naderi, Manaswini Acharya, Surface Measurement Systems
12:00-2:00 206 Modifying Gold Nanoparticles for Analysis of Lipophilic Food Components, Michael Driver, Yue Li, Lili He, University of Massachusetts-Amherst
12:00-2:00 207 SERS Characterization of Hydrophobic Com-pounds by Silver Dendrites, Yue Li, Michael Driver, Eric Decker, Lili He, University of Massachusetts-Amherst
12:00-2:00 208 Use of Surface Dissolution Imaging to Deter-mine the Effect of Counter Ions on Dissolution Rate of Several Standard Drugs, Jun Yin, Jon Mole, Rebeca Ruiz, Karl J. Box, John Comer, Sirius Analytical
12:00-2:00 209 On the Interpretability of O-PLS Filtered Mod-els, Barry M. Wise, Jeremy M Shaver, Eigen-vector Research
12:00-2:00 210 Classification Using Fused Data: Selectivity Enhancement and Simplification Using a Hi-erarchical Approach, Michael Dotlich, Eli Lilly, Bob Roginski, Jeremy Shaver, Eigenvector Research
12:00-2:00 211 Effect of a Fluorophore on Bovine Serum Albu-min Using Molecular Imprinting Process, Anne E. Okafor, Enju Wang, Neil Jespersen, Viviana Scocco, Mustafa Sadoqi, St John’s University
12:00-2:00 212 SARA – A Software Environment for the Analy-sis of Relaxation Data Acquired with Accordion Spectroscopy, Bradley J. Harden, Dominique P. Frueh, Johns Hopkins University
12:00-2:00 213 Dual-optimized 1JCC-Edited 1,n-ADEQUATE: A Novel NMR Structure Elucidation Technique, Gary E. Martin, Mikhail Reibarkh, Mary Senior, R. Thomas Williamson, Merck, Wolfgang Ber-mel, Bruker BioSpin
12:00-2:00 214 Dynamic NMR Characterization of the Flux-ional Rearrangement at an Eight-Coordinate Metal Center, Heather Siebert, Harpreet Sodhi, Gregory A. Moehring, Monmouth University
12:00-2:00 215 Progress Towards a Mid-Infrared Noninvasive In-Vivo Glucose Sensor, Sabbir Liakat, Kevin A. Bors, Laura Xu, Claire F. Gmachl, Princeton University, Jessica Doyle, Hunterdon Regional Central High School
12:00-2:00 216 Cell Culture Media Identification with Handheld 1064 Nanometer Raman, Claire Dentinger, Mark Mabry, Alyssa Knightly, Rigaku Raman Technologies
12:00-2:00 217 Reprogrammable Multi-Species Gas Moni-tors Based on Fourier Transform Millimeter-Wave Spectroscopy, Justin L. Neill, Matthew T. Muckle, Robin L. Pulliam, Brent J. Harris, BrightSpec, Brooks H. Pate, University of Virginia
12:00-2:00 218 Analysis of Produced Water Samples: A Comparison of Techniques, Helen M. Boylan, Danielle Murtagh, Tyler Umstead, Westminster College
12:00-2:00 219 Measurement of Molecular Structure with Low Frequency Raman Spectroscopy, James T. Carriere, Randy A. Heyler, Frank Havermeyer, Ondax
Tuesday Poster Session:Pharmaceutical Analysis, Dissolution and Other Techniques
Poster Area of the Exhibit Hall
12:00-2:00 220 Development of a Sensitive Analytical Method to Characterize Polymer and API Release from Solid Dispersion Formulations - Linking Bioavailability to In-Vitro Dissolution, Jagdish A. Prajapati, Zheng Zhao, Joshua Hoerner, Merck
12:00-2:00 221 Development of a Discriminatory Dissolution Method for a BCS Class II Tablet Formulation Containing a Basic Active Ingredient, Himanshu Gandhi, Peter Tattersall, Amy Bu, Huang Zongyun, Bristol-Myers Squibb
12:00-2:00 222 Monitoring the Hydrolysis of Aspirin During the Dissolution Testing of Aspirin by In-Situ IR Spectroscopy, Vrushali Bhawtankar, Seton Hall University
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2013 EAS Final Program Technical Program
12:00-2:00 223 The Effect of In-Situ pH Change on a Biphasic Dissolution Model in the Presence of Simu-lated Intestinal Fluids, Jon Mole, Karl J. Box, Robert Taylor, John Comer, Sirius Analytical
12:00-2:00 224 Super Saturation and Precipitation Behavior of Ionizable Drugs in the Presence of Cellu-lose Polymers, Jon Mole, Karl J. Box, Robert Taylor, John Comer, Rebeca Ruiz, Sirius Analytical
12:00-2:00 225 Withdrawn by the author.
12:00-2:00 226 Spectrofluorimetric Determination of Two Phar-maceutical Mixtures Containing the Antihyper-tensive Drug Amlodipine Besylate Together with either Candesartan Cilexetil or Telmisar-tan, Mona M. Khamis, Hoda G. Daabees, Mo-hamed S. Mahrous, Magdi M. Abdel-Khalek, Tarek S. Belal, University of Alexandria
12:00-2:00 227 Development and Validation of an Oven Karl Fischer Titration for Testing Water Content in Thiohydrazide Derivative Pharmaceutical Active Ingredient, Chumang Zhao, Jinghua Lu, Jianhua Shen, Suresh Babu, Synta Pharma-ceuticals
12:00-2:00 228 Approaching USP Method 233 - Results of Sample Preparation and Analysis of Several Pharmaceutical Sample Types, Jason Keith, Daniel Iversen, Elaine Hasty, Tina Restivo, Ivana Mrvalj, CEM Corporation
12:00-2:00 229 Pressure Decay Pneumatic Integrity Testing of Medical Device Tubing Components, Peter J. Oehlberg, Irene K. Ropiak, Julius P. Zodda, Bracco Research USA
12:00-2:00 230 Association Study of Serum Biomarkers (Alpha-fetoprotein and PIVKA-II) for Prognosis of Hepatocellular Carcinoma, Mi-Ran Kim, Asan Medical Center
12:00-2:00 231 Comparison Between Theoretical and Experi-mental Retention Times of Prostanoids and Sex Hormones, Guoxiu Wei, Susan Jansen-Varnum, Temple University
12:00-2:00 232 An LC-MS-MS Method for Quantitation of Hydrocodone and Hydromorphone in Rat Plasma, Yuexin Su, Steve Gorman, Teva Pharmaceuticals
12:00-2:00 233 Rapid Determination of Polysorbate 80 Content in Therapeutic Monoclonal Antibody Products by a Sensitive Fluorescence-Based Method, Songyan Zheng, Pedro Smith, Monica Adams, Bristol-Myers Squibb
12:00-2:00 234 A Novel Approach to Greener and Healthier Medical Chemicals Purifications, Matthew Przybyciel, Dave Kohler, ES Industries, Joe Stefkovic, Xenosep, Rolf Schlake, Martin Fet-ner, Applied Separations
12:00-2:00 235 Improving Peptide Mapping of a Therapeutic Monoclonal Antibody (mAb) and Consider-ations for Enhancing Analysis, James Martosella, Alex Zhu, Ning Tang, Agilent Technologies
12:00-2:00 236 Rapid Counter Ion/Residual Ion Analysis using LC-MS, Holly M. Shackman, Mark S. Bolgar, Xujin Lu, Bristol-Myers Squibb
12:00-2:00 237 Rapid Determination of Water Content in Sodium Chloride Salt Using Portable NIR Spectrometer, Ravi Kalyanaraman, Sibylle Herzer, Judith Punzalan, Abdelhady Elkhouga, Nisha Patel, Bristol-Myers Squibb
12:00-2:00 238 Screening Herbal Supplements Using Statisti-cal Modeling to Find and Identify Adulterants and Contaminants Using Direct Analysis in Real-Time (DART)-MS, Robert Goguen, Brian Musselman, Joseph LaPointe, IonSense
12:00-2:00 239 Withdrawn by the author.
12:00-2:00 240 Overcoming Challenges in Particle Size Mea-surement by Laser Diffraction Technique, Kalyan Potluri, Noel Hamill, Linda McCaus-land, Catherine McClorey, Almac
12:00-2:00 241 Statistical Evaluation using Design of Experi-ments of Total Organic Carbon (TOC) Analysis to Combine Cleaning Agent Methods with Drug Product Methods, Peter A. Walsh, Stevens In-stitute of Technology, Nikunj Vasoya, Mariann Neverovitch, Antonio Fernandez, Bristol-Myers Squibb
12:00-2:00 242 High Sensitivity Glycan Profiling in Antibody Drugs Using the RF-20Axs Fluorescence Detector, Kenichiro Tanaka, William Hedge-peth, Ayako Nomura, Tadayuki Yamaguchi, Yuki Sato, Shimadzu Scientific Instruments, Kenichiro Todoroki, University of Shizuoka
12:00-2:00 243 Development of a Novel Fingerprint Scan-ner Capable of Detecting Drug Metabolites in Sweat, Karol F. Alvarez, Marcel Roberts, John Jay College
12:00-2:00 244 Overcoming USP Chapter <233> Challenges: Introducing a Novel Microwave Combustion Sample Digestion Technique for Complex Pharmaceutical Matrices, Reynhardt Klopper, Anton Paar USA
12:00-2:00 245 Quantitative Application of Cyclic Voltammetry to Superoxide Radical Scavenging by Anti-oxidants, Stuart L. Belli, Francesco Caruso, Casey Bartow-McKenney, Charles Caldwell, Grace Lee, Miriam Rossi, Vassar College
12:00-2:00 246 Filter Filtration Suitability for Sample Prepa-ration in Drug Assay Testing, William Long, Limian Zhao, Agilent Technologies
Tuesday Poster Session:Gas Chromatography + Gas Chromatography + Mass Spectrometry
Poster Area of the Exhibit Hall
12:00-2:00 247 Automated Extraction of Phthalates in Con-sumer Products for Analysis by GC-MS, Fredrick D. Foster, John R. Stuff, Jacqueline A. Whitecavage, Edward A. Pfannkoch, Gerstel
12:00-2:00 248 From Helium to Hydrogen: Case Study in GC-MS Analysis of VOCs and SVOCs in Water, Alexander Semyonov, Jessie Butler, Thermo Fisher Scientific
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2013 EAS Final Program Technical Program
12:00-2:00 249 Enhancing Efficiency of Generic Residual Solvent Methods in API, James Girotti, C.J. Venkatramani, Larry Wigman, Nik Chetwyn, Genentech
12:00-2:00 250 Headspace Single-Drop Microextration for the Detection of Jasmine Flowers Essential Oil Content, Sevgi Kocaoba, Ozge Erdogmus, Yildiz Technical University
12:00-2:00 251 Analysis of Steroids in Water Using SPME with GC-MS-MS and GCxGC-ToFMS, Shilpi Chopra, Nicholas H. Snow, Seton Hall University
12:00-2:00 252 Thermodynamic and Kinetic Performance of Ionic Liquids as Gas Chromatographic Station-ary Phases, Ramkumar Dhandapani, Nicholas H. Snow, Seton Hall University
12:00-2:00 253 Analysis of Synthetic Controlled Substances; Cannabinoids, Cathinones, Phenethylamines and Related Isomers by GC-IR, Thomas M. Kearney, Bill Carson, Spectra Analysis Instru-ments
12:00-2:00 254 Withdrawn by the author.
12:00-2:00 255 Analysis of Caffeine in Coffee and Tea Prod-ucts Using ChromatoProbe and GC-MS, Viv-ian Xianyu Chen, Bruker Daltonics
12:00-2:00 256 Nitrogen Carrier Gas for GC-MS, Adam J. Patkin, Andrew Tipler, Ruben Garnica, PerkinElmer
12:00-2:00 257 A Design of Experiment (DoE) Approach to Develop and Optimize a GC Method for Residual Pivalic Acid in Amoxicillin, Richard Desmangles, Marie Di Maso, Yves Mouget, Corealis Pharma
12:00-2:00 258 Analysis of Oxygenated Compounds in Jet Fuel Using Solid-Phase Extraction and Com-prehensive 2-Dimensional Gas Chromatog-raphy, Raymond Yoder, Rory McAloon, Mark Heininger, Jim Dudek Virent, Inc.
12:00-2:00 259 Influence of Alkyl Spacer on Properties of L-Phenylalanine Ester Chiral Ionic Liquids, Lydia R. Morris, Nicole J. Savage, Irene Kimaru, St. John Fisher College
12:00-2:00 260 The Application of a HS Trap with GC Olfac-tometry and Mass Spectrometry for the Analy-sis and Aroma Characterization of Perfumes, David J. Scott, Andrew Tipler, Sheila Eletto, PerkinElmer
Tuesday Poster Session:Surface Science and Education
Poster Area of the Exhibit Hall
12:00-2:00 261 Structure Sensitivity in Adsorption and Desorp-tion of Hydrogen on Iridium Surfaces, Wenhua Chen, Robert A. Bartynski, Rutgers University, Payam Kaghazchi, Timo Jacob, Ulm University
12:00-2:00 262 Tuning Re(11-21) Surface Morphology by Kinetic Control of Adsorbate, Hao Wang, Grant Junno, Wenhua Chen, Robert A. Bartynski, Rutgers University, Xiaofang Yang, Bruce E. Koel, Princeton University, Payam Kaghazchi, Timo Jacob, Ulm University
12:00-2:00 263 Analysis of Surface Chemistry and Optical Properties in Post Synthesis Treated CdSe Quantum Dots, Daniel J. Asunskis, Saman-tha R. Brush, Wick D. Carr, Black Hills State University
12:00-2:00 264 Incorporating Application Based Service Learning into an Instrumental Methods of Analysis Course, L. Jay Deiner, New York City College of Technology, Gregory Galford, Cha-tham University, Gail Rowe, La Roche College, Nancy Trun, Duquesne University
Tuesday Poster Session:Student Awards
Poster Area of the Exhibit Hall
12:00-2:00 265 Sample Preparation Optimization for GC-MS Characterization of Cell Culture Media, Christina Johnson, Christine M. Ingersoll, Muhlenberg College, John Cunningham, Adam M. Fermier, Janssen Pharmaceutical
12:00-2:00 266 Identifying Crossover Points between Particle Sizes in the Optimization of Liquid Chromatog-raphy, Adam Matula, Peter Carr, University of Minnesota
12:00-2:00 267 Development of a Method for a Compara-tive Study of the Microbial Dehalogenation of PCBs and PBBs, Kathleen Naccarato, Alison Holliday, Swarthmore College
12:00-2:00 268 Exploring the Heterogeneity of Oil in Sand Patties from the Gulf of Mexico, Patrick Williams, Helen K. White, Haverford College
Tuesday Afternoon, November 19, 2013
EAS Award for Outstanding Achievements in Mass SpectrometryHonoring Dr. Michael L. Gross, Washington University - St. LouisSponsored by Thermo Fisher ScientificChair: David Russell, Texas A&M University
Ballroom West
2:00 269 Mass Spectrometry for Assessing the Occur-rence and Biological Consequences of Oxidatively Induced Tandem DNA Lesions, Yinsheng Wang, University of California-Riverside
2:30 270 Mass Spectrometry as a Tool for Structural Biology, Lisa M. Jones, Indiana University-Purdue University Indianapolis
3:00 Break
3:20 271 Metal-Induced Structural Changes of Human Metallothionein-2A: A Combined Theoretical and Experimental Structural Analysis of Metal-Free and Partially Metallated Intermediates, David Russell, Shu-Hua Chen, Texas A&M University
3:50 Presentation of the EAS Award for Outstanding Achievements in Mass Spectrometry
3:55 272 Mass Spectrometry-Based Protein Footprinting: A Tool for Biophysics, Michael L. Gross, Washington University – St. Louis
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2013 EAS Final Program Technical Program
EAS New Faculty Award in NMR SpectroscopyHonoring Dr. Patrick van der Wel, University of PittsburghSponsored by Agilent TechnologiesChair: Tatyana Polenova, University of Delaware
Westfield
2:00 273 Insight into the Structure and Formation of Polyglu-tamine Amyloid Aggregates from Solid-State NMR Spectroscopy, Patrick van der Wel, University of Pittsburgh
2:30 274 Structural and Dynamic Studies of Membrane Proteins by Oriented-Sample NMR, Alexander Nevzorov, North Carolina State University
3:00
3:20 275 Transmembrane Allosteric Coupling Between the Inner and Outer Gates of a K+ Channel in Lipid Bilayers Revealed by Solid-State NMR, Benjamin J. Wylie, Manasi P. Bhate, Ann E. McDermott, Colum-bia University
3:50 276 Structure Studies of Amyloid Fibrils in Alzheimer’s Diseases, from Test Tube to Human Brain, Wei Qiang, Robert Tycko, National Institutes of Health
4:20 Presentation of the EAS New Faculty Award in NMR Spectroscopy
What’s New in NIR Analysis?Chair: David Hopkins, NIR Consultant
Ballroom East
2:00 277 Using the Fourth Derivative to Understand Changes in NIR Spectra, Karl H. Norris, NIR Consultant
2:30 278 Are Non-Linear Regression Techniques Useful for NIR Pharmaceutical Applications? A Pharmaceutical Tablet Assay Example, Benoit Igne, James K. Dren-nen III, Carl A. Anderson, Duquesne University
3:00 Break
3:20 279 Addressing THE Problem with NIR, Howard Mark, Mark Electronics
3:50 280 NIR Methods for Health Assessment: New Eyes on an Old Problem, David Burns, University New Brunswick
Multidimensional ChromatographySponsored by the ACS Analytical DivisionChairs: Neil Danielson, Miami University Ohio and Irena Maksimovic, Bristol Myers Squibb
Ballroom Center
2:00 281 Comprehensive GC x GC Separation of Petroleum and Alternative Navy Mobility Fuels, Thomas N. Loegel, Kristina M. Myers, NOVA Research, Robert E. Morris, Jeffrey A. Cramer, Mark H. Hammond, U.S. Naval Research Laboratory
2:30 282 A Comparison of Heartcutting, Selective Compre-hensive, and Fully Comprehensive Two-Dimen-sional Liquid Chromatography, with an Emphasis on Practical Factors Important for Success, Dwight Stoll, Eric Talus, David Harmes, Gustavus Adolphus College, Kelly Zhang, Genentech
3:00 Break
3:20 283 Can Multidimensional-Like Separations Be Achieved in Liquid Chromatography via a Sequen-tial Use of Orthogonal Mobile Phases?, Joe P. Foley, Adam Socia, Drexel University
3:50 284 Two-Dimensional Liquid Chromatography in Phar-maceutical Analysis: An Industry Perspective, Kelly Zhang, Yi Li, Genentech Inc.
Advanced Vibrational Spectroscopy: Instrumentation and Applications, organized by the Coblentz SocietyChair: Ian Lewis, Kaiser Optical Systems
Bridgewater
2:00 285 Standardization of Raman Spectrometer Systems to Facilitate Data Comparison and Exchange, Aaron Urbas, Steven Choquette, National Institute of Stan-dards and Technology
2:30 286 Quality-by-Design and Spectroscopy: The Perfect Pair, John Wasylyk, Daniel Hallow, Ming Huang, Douglas McLeod, Robert Wethman, Bristol-Myers Squibb
3:00 Break
3:20 287 Handheld Spectrometers: Providing Answers in the Field, Richard A. Crocombe, Thermo Fisher Scientific
3:50 288 High Spatial Resolution Infrared Spectroscopy and Imaging Using AFM Detection, Curtis Marcott, Light Light Solutions, Michael Lo, Qichi Hu, Kevin Kjoller, Anasys Instruments
Analytical Imaging for Cultural Heritage Part II, organized in cooperation with New York Conservation FoundationChair: John Scott, New York Conservation Foundation
Bedminster
2:00 289 The Emergence of Computational Photography: Interpretation, Measurement, and the Quantifica-tion of Surface and Material Property Change, Mark Mudge, Carla Schroer, Cultural Heritage Imaging
2:30 290 Advanced Spectral Imaging for Noninvasive Pres-ervation of Cultural Heritage Materials, Fenella G. France, Library of Congress
3:00 Break
3:20 291 Watching Paint Age I, Melinda H. Keefe, Michael Linsen, The Dow Chemical Company
3:50 292 Watching Paint Age II, Michael Linsen, Melinda H. Keefe The Dow Chemical Company
Drug, Biomarkers and Cellular BioanalysisChair: Nanda Subbarao, Biologics Consulting Group
Bernardsville
2:00 293 Quantitation of an Adenine Adduct of the Cytotoxin of an Antibody Drug Conjugate BMS-936561 in Urine as Potential Pharmacodynamic Biomarker of DNA Binding, John Lute, Jian Wang, Anne-Fran-çoise Aubry, Bristol-Myers Squibb
2:20 294 Detection of Fentanyl Analogs and Metabolites in Four Biological Matrices; Urine, Plasma, Dried Urine Spots, and Dried Blood Spots, Rebecca L. Shaner, Pearl Kaplan, Courtney T. Callahan, Eliza-beth I. Hamelin, Rudolph C. Johnson, Centers for Disease Control and Prevention
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2013 EAS Final Program Technical Program
2:40 295 Universal LC-MS/MS Assays for Bioanalysis of Human Monoclonal Antibody Drug Candidates in Pharmacokinetic / Toxicokinetic Studies, Michael T. Furlong, Bristol-Myers Squibb
3:00 Break
3:20 296 Quantitative LC-MS/MS Analysis of NanoRNAs in Escherichia Coli, Landon Greene, Jeehiun Lee, Mu Chen, Rutgers University
3:40 297 Characterization of Curcumin-Nicotine Interaction in Cetyltrimethyammonium Bromide Micelle, Yongchao Zhang, Maurice O. Iwunze, Morgan State University
4:00 298 Determination of Phthalate Metabolites, Bisphenol A Glucuronide, 1-Hydroxypyrene Glucuronide, Per-fluorinated Chemicals and Leukotriene E4 in Urine, Chia-Yang Chen, Shin-Hung Liu, National Taiwan University
Special Topics in Chemometrics and Quality-by-DesignChair: Dongsheng Bu, Bristol-Myers Squibb
Hillsborough
2:00 299 Imputation of Incomplete Data in Classification Analysis, Yushan Liu, Steven D. Brown, University of Delaware
2:20 300 Geospatial Pattern Recognition: Geographical Pat-tern Knowledge Discovered from Surface Water Data, Liyuan Chen, Steven D. Brown, University of Delaware
2:40 301 Examination and Dating of Silver Gelatin Fiber Based Photographic Papers Using Infrared Spec-troscopy and PLS-GLSW Modeling, Donald B. Dahlberg, Lebanon Valley College, Ana Martins, Museum of Modern Art
3:00 Break
3:20 302 Raw Material Characterization for Mammalian Cell-Cultures Using Spectral Technologies, Nicolas A. Trunfio, Haewoo Lee, Seongkyu Yoon, University of Massachusetts-Lowell
3:40 303 A “Built-in-Quality” Analytical Separation Method Obtained through QbD concepts: Method Develop-ment, NDA Validation and Technique Transfer, Li Li, Peter Tattersall, Bristol-Myers Squibb
4:00 304 Determining Particle Size Distribution Effects on Acoustic Emission, Shikhar Mohan, Benoit Igne, Carla A. Anderson, James K. Drennen III, Duquesne University
4:20 305 Characterizing and Optimizing the use of Flow Addi-tives in Powders and Powder Formulations, Michael Delancy, Tim C. Freeman, John Yin, Brian Arm-strong, Katrina Brockbank, Freeman Technology
Forensic Toxicology: From Sample to InterpretationSponsored by New Jersey Association of Forensic ScientistsChair: Jeffery Hackett, United Chemical Technologies
Princeton
2:00 306 Survey of Practices and Recommendations for Toxi-cological Investigation of Drug-Impaired Driving and Motor Vehicle Fatalities, Kayla J. Lowrie, Jennifer Turri, Jillian Yeakel, Center for Forensic Science Re-search and Education, Barry K. Logan, NMS Labs,
Jennifer Limoges, New York State Police Forensic Investigation Center, Amy Miles, Wisconsin State Laboratory of Hygiene, Colleen Scarneo, New Hampshire State Police Forensic Laboratory, Sarah Kerrigan, Sam Houston State University, Laurel Far-rell, Toxicologist Consultant
2:30 307 SPE in Forensic Toxicology, Michael J. Telepchak, United Chemical Technologies
3:00 Break
3:20 308 Simultaneous Quantification of Opiates and Polar Metabolites in Urine and Blood by SPE and HILIC/MS/MS, James N. Anasti, Thomas A. Brettell, Cedar Crest College
3:50 309 Case Reports in the Analysis of Designer Drugs, Jeffery Hackett, United Chemical Technologies, Albert A. Elian, Massachusetts State Police Crime Laboratory
Keeping Water Safe: Analysis of Aqueous SystemsChair: Liang Chu, SUNY- Albany
Tewksbury
2:00 310 The Analysis of Challenging Samples Using Ion Analysis Techniques, Art Fitchett, Peter Bodsky, Rong Lin, Sheetal Bhardwaj, Kannan Srinivasan, Chris Pohl, Thermo Fisher Scientific
2:20 311 Improved Determination of Trace Concentrations of Perchlorate in Drinking Water with Analytical/Capil-lary Two-Dimensional Ion Chromatography, Peter Bodsky, Art W. Fitchett, Lillian Chen, Thermo Fisher Scientific
2:40 312 Determination of 100 Pesticides in Water Using Ultra-Performance Liquid Chromatography/Tandem Mass Spectrometry with Electrospray Ionization, Ming-Tsung Lu, Chia-Yang Chen, National Taiwan University
3:00 313 Fracking, Boldly Going where no Ion Analysis has Gone Before, Stuart J. Procter, Jay Gandhi, John-son Matthew, Metrohm USA
3:20 Break
3:40 314 Environmental Impact and Testing Requirements Required in the Process of “Fracking” with a Focus on the Analysis of Methane, Ethylene, and Ethane in Water by Headspace/Gas Chromatography (HS/GC) with Flame Ionization Detection (FID), Bill Hahn, Lee D. Marotta, Cindy Liang, Perkin Elmer Instruments
4:00 315 Withdrawn by the author.
4:20 316 Preconcentration and Quantitative Determination of Venlafaxine HCl Present in Water, Prakash B. Samnani, The Maharaja Sayajirao University of Baroda, Santosh K. Koppula, Navrachna University
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2013 EAS Final Program Technical Program
Wednesday Morning, November 20, 2013
EAS Award for Outstanding Achievements in Near-Infrared SpectroscopyHonoring Ms. Susan Foulk, Guided WaveSponsored by Metrohm USAChair: Katherine Bakeev, B&W Tek, Inc.
Ballroom East
9:00 Presentation of the EAS Award for Outstanding Achievements in Near-Infrared Spectroscopy
9:05 317 Online Implementation of NIR – Lessons Learned (or not), Susan Foulk, Guided Wave
9:30 318 Monitoring, Online and in Real Time, the Coating of an Active Solution onto Tablets by Near-Infrared Spectroscopy, Benoit Igne, Hiroaki Arai, Hanzhou Feng, James K. Drennen III, Carl A. Anderson, Duquesne University
10:00 Break
10:20 319 Multivariate Optical Computing in Oilfield Explora-tion, Michael Myrick, University of South Carolina
10:50 320 Near Infrared Spectroscopy for Assessment of Fetal, Maternal and Infant Health, David Burns, University of New Brunswick
Advances in Fast and High Performance Bio-Analytical Separation TechniquesSponsored by the Chromatography Forum of the Delaware ValleyChairs: William Barber and Xiaoli Wang, Agilent Technologies
Ballroom Center
9:00 321 High Resolution LC/MS Peptide Separations with Formic Acid Mobile Phases Using Charge Sur-face Modified C18 Columns, Matthew A. Lauber, Stephan M Koza, Kenneth J. Fountain, Waters
9:30 322 Advances in Sample Preparation and Chromato-graphic Separations in Bioanalytical Analyses, David S. Bell, Craig R. Aurand, Gaurang Parmar, Supelco Division of Sigma-Aldrich
10:00 Break
10:20 323 Recent Innovations in Core Shell HPLC Columns for the Separation of Biomolecules, Jason Anspach, Michael McGinley, Lawrence Loo, Jeff Layne, Phe-nomenex
10:50 324 Challenges and Rewards for Fast and High-Per-formance Techniques for Protein Separations: An Application Point of View, Phu T. Duong, James Martosella, Andrew Coffey, Keeley Mapp, Agilent Technologies
USP Compendial Standards: Recent and Future UpdatesChairs: Leonel M. Santos, United States Pharmacopeia (USP) and Kim Huynh-Ba, Pharmalytik
Ballroom West
9:00 325 Impurities in Drug Products: Recent Updates, Antonio Hernandez-Cardoso, USP
10:20 327 USP Packaging Standards - Recent Changes and those to Come, Desmond G. Hunt, USP
10:50 328 Revision to Spectroscopy Chapter - Recent Propos-als, Horacio N. Pappa, USP
Spectroscopic Imaging for Dissolution and Pharmaceutical DevelopmentChair: Xujin Lu, Bristol-Myers Squibb
Bridgewater
9:00 329 UV Surface Imaging Studies of Dissolution Behav-iors of an Extended Release Drug Formulation, Christopher A. Zordan, Bristol-Myers Squibb
9:30 330 Spatially Resolved Quantitative Magnetic Reso-nance Imaging Studies of API Behavior during In-Vitro Dissolution of Solid Dosage Forms, Michael D. Mantle, University of Cambridge
10:00 Break
10:20 331 A Miniaturized Instrument for Rapid In-Vitro Release Testing, David M. Goodall, Paraytec
10:50 332 Understanding Dissolution Inconsistency Through In-Situ Study of Disintegration Mechanisms Using FBRM, Jack Shu, Des O’Grady, Mettler Toledo
LC/IC/HILIC with Alternative Detection TechniquesChair: Judy Lin, Bristol-Myers Squibb
Bernardsville
9:00 333 Platform Technologies for Pharmaceutical Coun-terion Analysis, Michael W. Dong, Ross Woods, Genentech
9:20 334 Determination of Anions in Dried Distillers Grains with Solubles (DDGS), Art W. Fitchett, Peter Bod-sky, Kassandra Oates, Thermo Fisher Scientific
9:40 335 Mixed-Mode Chromatography for Pharmaceutical Analysis, Peter Bodsky, Xiaodong Liu, Chris Pohl, Michael G. Hvizd, Art W. Fitchett, Thermo Fisher Scientific
10:00 Break
10:20 336 HILIC (Hydrophilic Interaction Chromatography) Chromatography-ELSD (Evaporative Light Scat-tering Detection) Detection for the Quantitative Analysis of Amino Acids, Nicolas J. Hauser, Andy Ommen, Sigma-Aldrich, Carmen T. Santasania, Supelco Division of Sigma-Aldrich
10:40 337 Resolution of Antibody Charge Variants by Ion Exchange Chromatography, Hillel Brandes, Dave S. Bell, Roy Eksteen, Supelco Division of Sigma-Aldrich
11:00 338 Assaying Gentamicin Sulfate by HPLC-Charged Aerosol Detection with an Ion-Pairing Reagent Gra-dient, Michael Hvizd, Peter Bodsky, Lipika Basumal-lick, Jeff Rohrer, Thermo Fisher Scientific
11:20 339 HPLC Column “Standardization” Process for Pharmaceutical Analysis, Michael W. Dong, Midco Tsang, Dawen Lou, Roberto Garcia, Genentech
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2013 EAS Final Program Technical Program
PAT for Continuous Manufacturing and Real-Time Release Testing (RTRT)Chair: Joseph Medendorp, Vertex Pharmaceuticals
Hillsborough
9:00 340 PAT Options for Measuring Induction Seals and Blister Packs, Robert A. Lodder, Jarred Williams, University of Kentucky
9:30 341 A Look at RTRT Nearly One Decade Following Ap-proval, Steven M. Short, Nathan C Pixley, Mono-haran Ramasamy, Gert Thurau, Busolo Wabuyele, Merck
10:00 Break
10:20 342 Method Development, Method Validation, Specifica-tions and Data Reporting for RTRT, Henrik T. Rasmussen, Kelly A. Swinney, David E. Nadig, Vertex Pharmaceuticals
10:50 343 Application of an Advanced Process Controller to a Continuous Mixing / Direct Compression Process, Daniel Blackwood, Salvador Garcia-Munoz, Yang A Liu, Koji Muteki, Pfizer, John N. Mack, Perceptive Engineering Ltd
Applications of NMR in the Pharmaceutical IndustryChair: Gary Martin, Merck
Westfield
9:00 344 Why Small is Good: Selected Applications of Small Volume NMR Probes in Pharmaceutical R&D, Michael D. Riley, Bristol-Myers Squibb
9:30 345 NMR Analysis of [3H]Radiopharmaceuticals, Peter G. Dormer, David J. Schenk, Merck
10:00 Break
10:20 346 Small Molecule Applications of Optimized Acqui-sition-Based Sensitivity Enhancement, David A. Rovnyak, Bucknell University
10:50 347 Online NMR Reaction Monitoring in Pharmaceutical Process Development, Brian Marquez, David Foley, Pfizer
The Key to a Successful Lab: Work Smarter, organized by ALMAChair: Dennis Swijter, International Flavors and Fragrances
Tewksbury
9:00 349 Coaching your Team to Improved Performance, Stephanie Olexa, Lead to the Future
9:30 350 S.M.A.R.T. Laboratory Practices, Julius Neil C. Buenconsejo, Keppel Seghers Engineering
10:00 Break
10:20 351 Managing for Increased Productivity in a Rapidly Evolving Analytical Landscape, Richard Durand, Sun Chemical
10:50 352 Tools for Knowledge Retention and Transfer, Scott Hanton, Intertek
What’s in the Cabinet? Looking at Everyday Items in a New LightChair: Christina Robb, Connecticut Agricultural Experiment Station
Bedminster
9:00 353 Determination of Choline in Infant Formula and Other Food Samples by IC, Ken Kirkbride, Pe-ter Bodsky, Michael G. Hvizd, Kassandra Oates, Thermo Fisher Scientific
9:20 354 Rapid Measurement of Pomegranate Juice Adulter-ation with Minimal Sample Preparation Using DSA/TOF, Avinash Dalmia, Perkin Elmer
9:40 355 Determining Flavors and “Defects” in Beer by Head-space Trap/Gas Chromatography/Mass Spectrom-etry (HS Trap/GC/MS), Bill Hahn, Lee D. Marotta, Andrew Tipler, Cindy Liang, Perkin Elmer
10:00 Break
10:20 356 Rapid Detection of Food Contaminants Using Sur-face Enhanced Raman Spectroscopy (SERS), Lili He, University of Massachusetts
10:40 357 Rapid Phthalate Screening Techniques for Envi-ronmental and Consumer Product Samples, Ken Kirkbride, Peter Bodsky, Jennifer Peterson, Thermo Fisher Scientific
11:00 358 Preparation and Analysis of Imported Children’s Toys for Toxic Metals, Patricia L. Atkins, SPEX Cer-tiPrep
11:20 359 Analysis of Terpene Hydroperoxides Related to Al-lergic Contact Dermatitis Caused by Fragrance Use, Michael J. Calandra, John A. Impellizzeri, Firmenich
Forensic Microscopy VII “What is it? Who does it?”Sponsored by the New York Microscopical SocietyChair: Thomas Kubic, John Jay College
Princeton
9:00 360 Firearms and Fabric, Peter Diaczuk, John Jay Col-lege, Jack Hietpas, Pedico Research Institute
9:30 361 Microanalysis of Environmental Particulates, Randy Boltin, MVA Scientific Consultants
10:00 Break
10:20 362 Does Your UV-Visible Microspectrometer Have Intrinsic Polarization?, Dale K. Purcell, Chaminade University of Honolulu, John A. Reffner, Thomas A. Kubic, John Jay College, Fran Adar, HORIBA Scien-tific
10:50 363 The Statistical Significance of the Aggregate Trace Evidence found in Household Dust Specimens, Nick Petraco, John Jay College, Nicholas D. K. Petraco, Petraco Forensic Consulting, Anna Duggar, Loyola University, Mary Eng, New York Police Department Forensic Investigation
Wednesday Poster Session:Pharmaceutical Analysis and Separation Sciences
Poster Area of the Exhibit Hall
12:00-2:00 364 Fast Two-Column Initial Screening in HPLC Method Development, Ken Tseng, Toshi Ono, Tsunehisa Hirose, Kazuhiro Kimata, Nacalai USA
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2013 EAS Final Program Technical Program
12:00-2:00 365 Optimization of Reversed-Phase HPLC Sepa-rations of Biomolecules, Stephanie A. Schuster, Barry E. Boyes, Brian M. Wagner, Joseph J. Kirkland, Advanced Materials Technology
12:00-2:00 366 Larger Superficially Porous Particles: The “Long and Short of It” for HPLC Separations, Joseph J. DeStefano, Stephanie A. Schus-ter, William L. Johnson, Joseph J. Kirkland, Advanced Materials Technology, Thomas J. Waeghe, Mac-Mod Analytical
12:00-2:00 367 Application of Fusion AE™ and DryLab® Soft-ware in HPLC Method Development on a New Drug Substance (DS), Lily Du, Fenghe Qiu, Boehringer Ingelheim
12:00-2:00 368 Very High-Pressure Liquid Chromatography (vHPLC) Method Development for the De-termination of Purity and Impurities of Drug Substance A by Utilizing Computer Simulation, Rushin Jadawala, Mohan Kanhasamy, Yan Ma, Harshad Patel, Bristol-Myers Squibb
12:00-2:00 369 Development of a 2-Butanol Background Electrolyte for Non-Aqueous Chiral Capil-lary Electrophoresis and the Separation of Charged Pharmaceutical Enantiomers, Erin J. Ennis, Joe P. Foley, Drexel University
12:00-2:00 370 Identification of Ephedrine Analogs in Lipo-drene Products Using Capillary Electrophore-sis, Michael Fletcher, Joe P. Foley, Drexel University
12:00-2:00 371 Development of a Trace Level LC-MS Method for the Direct Quantitation of EDC (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide) in Pharmaceutical Compounds, Timothy Nowak, Ryan Cohen, Yong Liu, Renee Dermenjian, Merck
12:00-2:00 372 Direct Observation of Dissociation Behavior of Organic Salts in Preparative SFC, Mickey Rego, Paul Lefebvre, John H. Tipping, Jeffrey P. Kiplinger, Averica Discovery Services
12:00-2:00 373 Investigation of an Unknown Degradation Product Found in a Drug Product Batch Release Test, Frances F. Liu, Sung Yoon-Kim, Novartis
12:00-2:00 374 HPLC Method Development for Analysis and Release of a Multi-Component Drug Product, Kalyan Potluri, John Wood, Abul Kalam Azad, Almac
12:00-2:00 375 The Importance of Thresholding in Imaging Analysis of Protein Aggregates, Josh Geib, Lew Brown, Fluid Imaging Technologies
12:00-2:00 376 Evaluation and Application of Hybrid Quadru-pole-Time-of-Flight Mass Spectrometry in Dis-covery Quantitative and Qualitative Analysis, Hongwei Zhang, Baomin Xin, Timothy Olah, Bristol-Myers Squibb
12:00-2:00 377 Evaluation of Non-Conventional Polar Modi-fiers on Immobilized Chiral Stationary Phases for Improved Resolution of Enantiomers by Supercritical Fluid Chromatography (SFC), Jimmy O. DaSilva, Brandyce Coes, Lisa Frey, Ingrid Mergelsberg, Ray McClain, Lisa Nogle, Christopher J. Welsh, Merck
12:00-2:00 378 Extraction of β-blockers from Small Volume Biological Fluid Samples using a new Versatile SPE 96-well Plate Format, Matthew Cleeve, Kinesis Ltd.
12:00-2:00 379 Simplifying Safety Inspections in Chemistry Laboratories through an iPAD Application, Tilak Chandrasekaran, David Waterhouse, Roy Helmy, Gabriel Graffius, Shaun Vandoren, Merck, Girish Rao, Sivadasan Plakote, Ashish Das, Real Soft Inc.
12:00-2:00 380 New Wide Pore C18 Phase for Fast and Effi-cient Purification of Peptides by Flash Chro-matography, Ben Hayes, Chitra Sundararajan, Melissa Wilcox, Grace Discovery Sciences
12:00-2:00 381 Improved Isolation and Purification of Natural Products by Automated Flash Chromatogra-phy, Ben Hayes, Chitra Sundararajan, Melissa Wilcox, Grace Discovery Sciences
12:00-2:00 382 Measurement of Density/Porosity in Pharma-ceutical Tablets Using Terahertz Pulsed Spec-troscopy, Wiphusanee Dendamrongvit, Mark J. Sullivan, Advantest America
Wednesday Poster Session:Environmental Analysis
Poster Area of the Exhibit Hall
12:00-2:00 383 Detecting Trace Amounts of Impurity in Methy-lene Chloride - Sample Preparation Matters, Subhra Bhattacharya, Eric Oliver, Chad Gold-man, Apollo Quezada, Mark Jasko, Deva H. Puranam, Stephen C. Roemer, Thermo Fisher Scientific
12:00-2:00 384 High-Throughput Microwave Assisted Solvent Extraction of Semi-Volatile Organic Com-pounds Using US EPA Method 3546, Jason Keith, Daniel Iversen, Michael Karney, CEM Corporation
12:00-2:00 385 Determination of Aflatoxins in Dried Fig, Dried Apricot and Red Pepper in Turkey, Sevgi Kocaoba, Omer Ozcan, Yildiz Technical University
12:00-2:00 386 A New NIST Standard Reference Material to Support Unbiased Perchlorate Measurements in Drinking Water and Other Matrices, Therese Butler, Michaele Winchester, Lee Yu, Rabia Oflaz, National Institute of Standards and Technology
12:00-2:00 387 Withdrawn by the author.
12:00-2:00 388 Nutrients and Dissolved Oxygen in Monmouth County Coastal Waters: Sustainability Con-cerns, Ellen Rubinstein, Sarah-Pearl Siganporia, Monmouth University
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2013 EAS Final Program Technical Program
12:00-2:00 389 UPLC-UV Analysis of PAHs in Avian Egg Samples Collected after the Crude Oil Spill in the Gulf of Mexico with Rapid QuEChERS Extraction and Novel 96-Well Phospholipid Cleanup, Anthony A. Provatas, Aliaksnadr V. Yeudakimau, Gina M. Guerrera, Christopher R. Perkins, James D. Stuart, University of Connecticut
12:00-2:00 390 Methods for Determining Sugars and Hydroxy-methyl Furfural in Biomass, Michael G. Hvizd, Peter Bodsky, Lipika Basumallick, Jeffrey Rohrer, Thermo Fisher Scientific
12:00-2:00 391 Expanding the Capabilities of Direct Mercury Analysis: A Look into Evolution, Detection Ranges and Sample Types, Sumedh P. Phatak, Milestone Inc.
12:00-2:00 392 Novel Extraction and Analysis of 18 EPA PAHs from Mussel Tissue: Baseline Resolution of All PAHs in 6 Minutes with No Post Extraction Clean-up, Ken Kirkbride, Peter Bodsky, Art W. Fitchett, Michael G. Hvizd, Thermo Fisher Scientific, Michael Martin, Kodak Corp
12:00-2:00 393 Chromium (III) and Chromium (VI) Content in Agricultural Products in Vicinity of Chromium Smelters, Isiaka Alade Owolabi, Tshwane University of Technology
12:00-2:00 394 A Preliminary Examination: Historical Records of Polycyclic Aromatic Hydrocarbons in Cor-als from the South China Sea, Carolyn M. Poutasse, Helen K. White, Haverford College, Nathalie F. Goodkin, Nanyang Technological Institute
12:00-2:00 395 A Regional Academic, Biodiesel Testing Labo-ratory Following ASTM Methods, James D. Stuart, Joseph S. Impellizeri, Robert D. Morrin, Anthony A. Provatas, Christopher R. Perkins, University of Connecticut
12:00-2:00 396 Nanopore Stochastic Detection of an Anthrax Biomarker, Yujing Han, Shuo Zhou, Illinois Institute of Technology
12:00-2:00 397 Nanopore Detection of Copper and Zinc Ions, Shuo Zhou, Xiyun Guan, Liang Wang, Illinois Institute of Technology
12:00-2:00 398 Isolation and Quantification of DOSS from Deep-Sea Sediments, Shelby L. Lyons, Sarah J. Harrison, Helen K. White, Haverford Col-lege, Elizabeth B. Kujawinski, Woods Hole Oceanographic Institution
12:00-2:00 399 High Throughput Analysis of Harmful Algal Toxins in Freshwater Samples Utilizing Simple Preparation Followed by UPLC Tandem Mass Spectrometry, Anthony A. Provatas, Eliza-beth R. Guerrera, Syed U. Ali, Aliaksandr V. Yeudakimau, James D. Stuart, Christopher R. Perkins, University of Connecticut
12:00-2:00 400 The Determination of Organophosphate Degradation Products in Water, Soil and Wipe Samples by LC-MS-MS, Anthony G. Gug-liotta, Alexander E. Bleich, Julia Capri, CSS-Dynamac, Lawrence Kaelin, United States Environmental Protection Agency
Wednesday Poster Session:Applications of HPLC and UHPLC
Poster Area of the Exhibit Hall
12:00-2:00 401 HPLC Separation of 10 Fat-Soluble Vitamins in a Single Run, Ken Tseng, Toshi Ono, Tsune-hisa Hirose, Kazuhiro Kimata, Nacalai USA
12:00-2:00 402 Migration of USEPA Method 8270 from Helium Carrier Gas to Hydrogen Carrier Gas, Paul V. Macek, Cindy Burkhardt, Shimadzu Scientific Instruments
12:00-2:00 403 Impurity Analysis Using a New High Sensitiv-ity UHPLC Detector, William Hedgepeth, Ken Tanaka, Shimadzu Scientific Instruments
12:00-2:00 404 Examining the Capabilities and Benefits of a UHPLC Method Development Scouting System, William Hedgepeth, Ken Tanaka, Shimadzu Scientific Instruments
12:00-2:00 405 Quantitation of Surfactants in Products by High-Performance Liquid Chromatography and Corona Charged Aerosol Detection, Marc A. Plante, David H. Thomas, Bruce A. Bailey, Ian N. Acworth, Qi Zhang, Thermo Fishe Scientific
12:00-2:00 406 Fast Ion Determinations and Efficient Sepa-rations of Complex Samples Using Smaller Particle-Size Ion Exchange Columns, Greg Malek, Peter Bodsky, Terri Christison, Thermo Fisher Scientific
12:00-2:00 407 Improved Universal Approach to Measure Natural Products in a Variety of Botanicals and Supplements, Marc Plante, David Thomas, Ian N. Acworth, Bruce A. Bailey, Qi Zhang, Marc Plante, Thermo Fisher Scientific
12:00-2:00 408 A Fast and Easy Way for Determining the Level of Oxidative Stress Using UHPLC with Boron Doped Diamond Electrochemical Detection, Bruce A. Bailey, Marc Plante, David Thomas, Qi Zhang, Ian N. Acworth, Thermo Fisher Scientific
12:00-2:00 409 Evaluation of Herb and Fruit Juice Adultera-tion and Authenticity by Coulometric Array Detection and Pattern Recognition Analysis, Qi Zhang, Bruce A. Bailey, Marc Plante, David Thomas, Ian N. Acworth, Thermo Fisher Sci-entific
12:00-2:00 410 Development of a Hybrid Thin Layer Chroma-tography (TLC)-Near-Infrared Spectroscopy (NIRS) for OTC Pharmaceuticals, Emil W. Ciurczak, Doramaxx Consulting, Sunghee Lee, Safiat Ayinde, Jaclyn Robustelli, Iona College
12:00-2:00 411 HPLC Method Optimization for Large Mol-ecule in an Inhalation Dosage Form, Craig D. Oakum, Eugene R. Reynolds, MicroDose Therapeutx
12:00-2:00 412 Solubility of a Drug Unstable to Buffer, John H. Tipping, Jeffrey P. Kiplinger, Paul M. Lefebvre, Mickey Rego, Averica Discovery Services
12:00-2:00 413 Withdrawn by the author.
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2013 EAS Final Program Technical Program
12:00-2:00 414 Comparing Electrochemical Detection and De-rivatization-Photometric Detection in Analyzing Sulfur-Containing Compounds Using Cation Exchange Chromatography, Jinmo Huang, Sa-mantha Mascetti, The College of New Jersey
12:00-2:00 415 Development and Validation of a Stability-Indicating UHPLC Method for Determination of Anastrozole and Anastrozole Related Com-pounds in Pharmaceutical Dosage Forms, Tatiana Kim, Alex Schwarz, Scot Thorough-man, Joemon Varughese, ENDO Pharmaceuticals
12:00-2:00 416 Development of Low Extractables Syringe Filters for Liquid Chromatography-Mass Spec-trometry Applications, Gilbert Tumambac, Pall Corporation
12:00-2:00 417 Understanding the Health Safety and Environ-mental Implication of Formulating Solutions in the Laboratory Environment, Anthony R. Kemperman, Jeremy N. Diringer, Honeywell, Burdick and Jackson
12:00-2:00 418 Advantages of Reduced Surface Activity (RSA) Glass Autosampler Vials for Basic Solutes, Josh E. Young, William Ciccone, MicroSolv Technology, Joseph J. Pesek, Maria T. Ma-tyska, San Jose State University
12:00-2:00 419 Separation of 1,3-Dimethylamylamine and Other Polar Compounds in Dietary Supple-ment Formulation Using Aqueous Normal Phase Chromatography with Mass Spectrom-etry, Josh E. Young, MicroSolv Technology, Rosie Le, Maria T. Matyska, Joseph J. Pesek, San Jose State University
12:00-2:00 420 Undergraduate Students in a Microfluidics Lab: Harnessing the Versatility of the Microchip to Tailor Individual Research Projects, James M. Karlinsey, Pennsylvania State University
12:00-2:00 421 Inline Dialysis of Acrylate Polymers Prior to Residual Monomer Analysis, Fan Wu, Andrew R. Falls, Nigel Crabtree, Ashland Specialty Ingredients
Wednesday Afternoon, November 20, 2013
EAS Award for Outstanding Achievements in Magnetic ResonanceHonoring Dr. Dennis A. Torchia, National Institutes of HealthSponsored by Bruker Biospin and New Era EnterprisesChair: Edwin D. Becker, National Institutes of Health
Westfield
2:00 Presentation of the EAS Award for Outstanding Achievements in Magnetic Resonance
2:05 422 NMR in Structural Biology: Synergy of Solid- and Solution-State Approaches, Dennis A. Torchia, Na-tional Institutes of Health
2:30 423 High Frequency Dynamic Nuclear Polarization, Robert G. Griffin, Massachusetts Institute of Technology
3:00 Break
3:20 424 Seeing the Invisible by Solution NMR Spectroscopy, Lewis Kay, University of Toronto
3:50 425 Can a Static Ubiquitin Structure “Out Score” a Dynamic Ensemble?, Ad Bax, National Institutes of Health
Advancements in HPLC Stationary Phase and GC Carrier GasesChair: Landon Greene, Bristol-Myers Squibb
Ballroom Center
2:00 426 Developments in Particles, Columns and Phases for HPLC and UHPLC, Richard Henry, Consultant 2013 Eastern Analytical Symposium & Exposition
2:30 427 Carbon-Based Phases Revisited: New Chemis-tries, and a Fresh Perspective on Old Chemistries, Dwight Stoll, Tuan Tran, Ian Gibbs-Hall, Paul Young, John Danforth, Gustavus Adolphus College, Jonathan Thompson, United Science
3:00 Break
3:20 428 The Development and Utilization of Sub-2 Micron Chromatography Columns, Matthew Przybyciel, ES Industries
3:50 429 An Evaluation of Alternative Carrier Gases for GC-MS analysis in the Flavor & Fragrance Industry, Stephen Toth, Sharon Brown, International Flavors & Fragrances
Analytical, Process, Regulatory Perspectives in Quality-by-Design for Biologics DevelopmentChair: Jianmei Kochling, Genzyme
2:30 431 Quality-by-Design: Specifications Setting for Biologi-cal Drug Development, Nanda Subbarao, Biologics Consulting Group
3:00 Break
3:20 432 Analytical Methods Life Cycle Management in Quality-by-Design Paradigm for Biological Drug Development and Commercialization, Robert W. Donaldson, Genzyme
3:50 433 Case Study on Application of DOE to Formulation Development for Biologics, Vishal C. Nashine, Aas-tha Puri, Jose Tabora, Monica Adams, Bristol-Myers Squibb
Physical Measurements of Pharmaceutical ProductsChair: Lydia Breckenridge, Bristol-Myers Squibb
Ballroom East
2:00 434 Best Practice in Cascade Impactor Measurements, Volker Glaab, Terrence Tougas, Boehringer Ingel-heim, Jolyon P. Mitchell, Trudell Medical Interna-tional, Svetlana Lyapustina, Drinker Biddle & Reath
2:20 435 Physical Characterization of Drug Product Interme-diates Using Confocal Raman Imaging and Spec-troscopy, Duohai Pan, Bristol-Myers Squibb
2:40 436 Physical Stability of Nanoparticle Dispersion, Jonathan B. Denis, Formulaction Inc.
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2013 EAS Final Program Technical Program
3:00 437 A Rapid, Nondestructive Method to Measure Layer Thickness in Pharmaceutical Beads Using Tera-hertz Waves, Richard R. McKay, Edward E. King, Eiji Kato, Mark J. Sullivan, David Heaps, Akiyoshi Irisawa, Motoki Imamura, Advantest America
3:20 Break
3:40 438 Clustering, Visualization and Data Management as Applied to Preformulation, Michael Boruta, Ad-vanced Chemistry Development
4:00 439 Pulsed Terahertz Time-Domain and FT Spec-troscopy for the Molecular, Microscopic and Bulk Characterization of Pharmaceutical Tablets, Mark J. Sullivan, Edward E. King, Richard R. McKay, David Heaps, Eiji Kato, Advantest America
4:20 440 Applications of Differential Scanning Calorimetry High-Pressure Crucibles, Richard S. Kwasny, Ken-neth Kurko, Zachary Hackmeister, Fauske & Associ-ates
4:40 441 The Use of Natural-Abundance Stable Isotopes in the Characterization of Bio/Pharmaceutical Compounds and Synthetic Pathways, John P. Jasper, Nature’s Fingerprint, Martin B. Pavane, Cozen O’Connor, Dean Eyler, Gray Plant Mooty, Ila Sharma, Albert C. Lee, Chemir EAG Labs
Consumer Products - Challenges & StrategiesChair: Susan Friedman, Colgate Palmolive Company
Bernardsville
2:00 442 Challenges in Developing Robust Analytical Meth-ods for Consumer Products, Jacqueline Erickson, GlaxoSmithKline
2:30 443 Modernization of the USP Monograph with a Focus on the Consumer Products, Leonel M. Santos, Clydewyn M. Anthony, United States Pharmacopeia
3:00 Break
3:20 444 Method and Application of Using a Flow Cell Appa-ratus for Visualizing Additive Deposition on Con-sumer-Relevant Substrates, Ian D. Henry, Dirk W. Domaschko, Renee D. Bolden, Procter & Gamble
3:50 445 Implementation Challenges of Near IR Analysis in the Consumer Products Industry, Ramon Santana, Colgate-Palmolive Company
Advancements in Chemometric Data TreatmentChair: Benoit Igne, Duquesne University
Hillsborough
2:00 446 The Role of Chemometrics in Chromatography, Brian G. Rohrback, Infometrix 2:30 447 TBA, Karl Booksh, University of Delaware
3:00 Break
3:20 448 On the Relationship Between Whitened Principal Components Analysis and Maximum Autocorrela-tion Factors, Neal Gallagher, Jeremy M. Shaver, Eigenvector Research
3:50 449 Implementation of Out-of-Scope Diagnostic Tools in a Pharmaceutical Environment, Dongsheng Bu, Gary McGeorge, Douglas Both, Bristol-Myers Squibb
American Chemical Society Certification - How, When, WhyChair: Cecil Dybowski, University of Delaware
Tewksbury
2:00 450 The ACS Approval Process - A Preview of Coming Attractions, Cynthia K. Larive, University of Califor-nia - Riverside
2:30 451 The Role of Research in the ACS Certified Degree, Thomas Wenzel, Bates College
3:00 Break
3:20 452 Boots on the Ground: The Role of the Visiting Associate in the ACS Approval Program, Richard Dallinger, Wabash College
3:50 453 ACS Guidelines as a Catalyst for Institutional and Curricular Change, Kimberley A. Woznack, Califor-nia University of PA
Vibrate or Rotate - Techniques for Solving Problems with SpectroscopyChair: Shirley Fischer Drowos, Widener University
Bridgewater
2:00 454 Chirped-Pulse Millimeter Wave Spectroscopy of EPA TCL Volatiles Mix 5 Standard: Advantages of Coherent, Pure Rotational Spectroscopy for Trace Level Volatile Mixture Analysis, Brent J. Harris, Mat-thew Muckle, BrightSpec, Amanda Steber, Brooks H. Pate, University of Virginia
2:20 455 VOC Mixture Composition Analysis: Quantification of an EPA VOC Standard Mixture Using the Bright-Spec Chirped-Pulse Fourier Transform Spectrom-eter, Robin L. Pulliam, Brent J. Harris, Matthew Muckle, Dave McDaniel, BrightSpec, Brooks H. Pate, University of Virginia
2:40 456 GPC-IR Deformulation of Complex Polymer Mix-tures with IR Spectral Database Search, Ming Zhou, Tracy Phillpott, Spectra Analysis Instruments, Dana Garcia, Arkema, Farrel N. Borden, Bio Rad Labora-tories
3:00 457 USP Spectral Library Pilot, Michael Dotlich, Eli Lilly, Bei Ma, United States Pharmacopeia
3:20 Break
3:40 458 Quantitative Analysis of Feed and Agricultural Samples Using a Portable NIR Instrument, Suzanne Schreyer, Lin Zhang, Thermo Fisher Scientific
4:00 459 Measurements of Key Cotton Fiber Properties Us-ing a Small Portable NIR Analyzer, James Rodgers, Chris Delhom, Xiaoliang Cui, United States Depart-ment of Agriculture
4:20 460 A New Truly Easy-to-Use Dedicated Infrared Micro-scope, Thomas J. Tague, Jr., Bruker Optics
4:40 461 Handheld Vibrational Spectrometers: Novel De-velopments and Applications, Heinz W. Siesler, University of Duisburg-Essen
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2013 EAS Final Program Technical Program/Student Awards
Speeding Up Sample PreparationChair: Richard Nguyen, Merial Ltd.
Bedminster
2:00 462 Reducing Sample Extraction Time While Increasing Sample Throughput, Khanh Ha, Martin Schwalm, Bristol-Myers Squibb
2:20 463 Class-Selective Extraction of Streptomycin and Re-lated Drugs from Cell Culture and Peptide Solutions Using Moleculalrly-Imprinted Polymer SPE and LC/MS/MS, Emily Barrey, Olga Shimelis, Michael Ye, Supelco Division of Sigma-Aldrich
2:40 464 Investigating Matrix Interference in Bioanalysis of Antiarrhythmic Cardiac Drugs, Craig Aurand, Dave S. Bell, Lori Fields, Supelco Division of Sigma-Aldrich
3:40 466 Simplifying Complex Robotic Methods Using Visual Basic, Sam Abdelhamid, Purdue Pharma
4:00 467 Robotic Rheometry: A Novel Approach to High-Throughput Material Research, James P. Eickhoff, Jr., Prajakta Kamerkar, Maxine Quitaro, Anton Paar USA
4:20 468 Gel Point Determination Thanks to Microrheology, Jonathan B. Denis, Formulaction Inc.
4:40 469 A Novel Engineered Carbon Intended for Pigmented Sample Cleanup, Dwight Stoll, Conor Smith, Jona-than Thompson, Gustavus Adolphus College
2013 EAS Student Awards
Sponsored by Pfizer, Inc.EAS continues to actively support a Student Awards program to recognize scientific research by undergraduates. In the
spring of each year, we encourage professors to identify Juniors in college who are already involved in research in the broad field of analytical chemistry. Nominations include appraisals of how the students handle the investigations, approach the problems, and get involved in the projects.
In 2013, four outstanding undergraduates have been selected to receive EAS Student Awards. Based on the recommen-dations from their professors, the following have been chosen from a very worthy field of candidates:
The Governing Board of the 2013 EAS congratulatesthese awardees for their outstanding achievements.
The Student Awardees’ posters will be presented on Tuesday, November 19, 2013 in the Poster Area in the Exhibit Hall from 12:00 PM - 1:30 PM
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