Alexanderwerk AG Kippdorfstraße 6–24 42857 Remscheid/Germany P +49 (0)2191 79 50 F +49 (0)2191 79 53 50 imaschinen@alexanderwerk.com www.alexanderwerk.comNo liability will be accepted for errors or omissions. Subject to change (246-9011)

Roller Compactors and GranulatorsWP 200 Pharma

Examples of Granules

Antibiotics Riboflavin Natrium Bicarbonate

Spice extract Lactose

Applications

For many years pharmaceutical corporations all over the world have been using roller compactors made by Alexanderwerk to produce granules, and to further process tablets or capsules, Life-Science products, flavours, instant powders, or intense sweeteners.

Flavours

Technical Data

Throughput, continuous operation 10 to 250 kg/hr

Granule size variable

Maximum compacting pressure 18.4 kN/cm of roller width

Installed power approx. 29 kVA

Weightapprox. 2,000 kg (complete unit, excluding control cabinet)

Material of construction 1.4571 (complete), 316 Ti

Material of construction: Rollers 1.4122

Material of construction: Product touching seals FDA approved materials

Machine control separate from the machine (not shown).

www.fa

berm

olde

nhau

er.de

Pharma Roller Compactor and Granulator WP200Pharma

The operator panel is designed as a touch panel.

The WP200 Pharma is the obvious choice of compactor and granulator for production. With a throughput of up to 400 kg/hr (Lactose), the WP200P-harma is ideal for situations of frequent product changes, special products, small batches, or for compacting and granulating of a mono product in continuous operation. The WP200Pharma comes with the Combi-Vent-Feeder® System patented by Alexanderwerk, as standard. This unique design of thefeed system facilitates the highly efficient operation of this unit. Due to the dedicated venting of the gas flow, larger quantities of material can be fed into the roller gap. The process equipment is completely separated from the drive equipment. As an option, the WP200Pharma is available in a “Through the Wall“design. With this special design, the access to the process equipment can be separated from the access to the drive equipment. For ultimate containment applica-tions, the WP200Pharma can be fitted with an Isolator. The machine‘s design meets all the require-ments of the pharmaceutical industry:

•spatialseparationofprocessanddriveequipment•Combi-Vent-Feeder® System•two-stagerotorfinegranulationinDdesign•patentedSuction-Cooling-System®

•cGMPdesign•completelymadeofstainlesssteel•allnon-metallicmaterialsaccordingtoFDAstandards•maybefittedwithIsolator•automatedPLC•optional:WIP(WashInPlace)•optional:ThroughtheWalldesign•optional:21CFRPart11•optional:PAT•designaccordingtoURS

Quality parameters can be easily scaled to larger or smaller production units. Quality parameters deter-mined by means of the WP120Pharma pilot plant and small-batch machine made by Alexanderwerk can be easily scaled to the WP200Pharma and vice versa.

CompactionThe basic process principle of roller compaction is simple. However, only the use of latest control tech-nology facilitates the efficient production of a high-quality granule.

The quality of the final granule is mainly determined by the quality of the flake. A constant compacting pressure and constant roller gap are required. The control equipment made by Alexanderwerk will compensate any physical fluctuations in the material (such as local inhomogenities). As a result, the process parameters (throughput, flake density, compacting pressure, speed or similar) can be precisely adjusted at highly repetitive accuracy.

With roller compactors made by Alexanderwerk, there is a clear, modular separation between the pro-cess steps of feed and compaction. The feed screw 3 alone is designed to feed the powder to the rollers 4 – intentionally, this process does not aim at a pre-

compaction by the feed screw system.

Granulation with Roller Compactors made by Alexanderwerk

7

4

5

3

2

1

6

8

Patented Combi-Vent-Feeder® System to boost Efficiency.The Combi-Vent-Feeder® System patented by Alexanderwerk offers an additional “chamber“next to the material hopper (which does not contain any material). Air, displaced from the material during com-paction, can freely escape through this second chamber. As a result of this configuration, the material can be fed to the screw, and thus to the rollers, more uniformly, there is less back pressure building up in the feed sec-tion, and the process, as such, runs smoother, faster and more uniformly.

Additionally, the Combi-Vent-Feeder® System can do more undersize or fines (e. g. side seal leakages) can be continuously recycled into the additional hopper cham-ber, blending with raw material to form a consistent feed quality.

Another option available is the vacuum station for the screw feeder. A vacuum is applied on the screw housing to force the return-flow air into a defined path. Thus, the processing of very light or heavily fluidizing materials is made possible.

GranulationGranulesarecharacterisedbydefinedparticlesizes,i.e.the size of the particles varies between fixed upper and lower limits (oversize, undersize). After feeding into the compacting unit, the course flakes are generally larger than the upper tolerance limit of the finished product. Only defined size reduction in the granulation unit will produce the finished granule.

Downstream further processing of the granule, such as in tableting machines, requires a tight tolerance and for this reason the granulation unit of the WP200 Pharma is of a two-stage diagonal design. The first stage is pre-granulation, and the second stage is designed as a fine granulator.

Modular DesignFrom the consumer’s point of view, porosity is the most critical requirement of pharmaceutical products. From the user‘s point of view, flexibility is a decisive characte-ristic of a pharmaceutical machine, specifically in a time of ever tighter markets. The WP200Pharma meets both requirements – definedporosity of the final product, and flexible use of the ma-chine. Due to its consistent modular design, the WP200 Pharma can be dismantled practically without special tools.

The process equipment of the WP200 Pharma can be completely dismantled without any special tools.

Rollers 4 (protective shroud removed) and flake crusher 5 .Cantilever bearing design of rollers for easy replacement or cleaning.

Two-stage granulating unit in diagonal design 7 (protective shroud removed).

The granulator screens are exchangeable, and the particle size of the final granule is determined by the mesh size and screen design.

Feed hopper in Combi-Vent-Feeder® design as standard.

3

2

1 Vent for displaced air and feed hopper for undersize and oversize at the same time

Material feed hopper

Socket for level probe

3

2

1

Material feed

Feed hopper in Combi-Vent-Feeder® design

Feed screw system

Compacting unit: Roller Unit

Pre-crushing

Sampling

Two-stage granulating unit

Granule outlet

Numerous special or customized designs available upon request.

2

1

3

4

5

7

6

8

Pharma Roller Compactor and Granulator WP200Pharma

The operator panel is designed as a touch panel.

The WP200 Pharma is the obvious choice of compactor and granulator for production. With a throughput of up to 400 kg/hr (Lactose), the WP200P-harma is ideal for situations of frequent product changes, special products, small batches, or for compacting and granulating of a mono product in continuous operation. The WP200Pharma comes with the Combi-Vent-Feeder® System patented by Alexanderwerk, as standard. This unique design of thefeed system facilitates the highly efficient operation of this unit. Due to the dedicated venting of the gas flow, larger quantities of material can be fed into the roller gap. The process equipment is completely separated from the drive equipment. As an option, the WP200Pharma is available in a “Through the Wall“design. With this special design, the access to the process equipment can be separated from the access to the drive equipment. For ultimate containment applica-tions, the WP200Pharma can be fitted with an Isolator. The machine‘s design meets all the require-ments of the pharmaceutical industry:

•spatialseparationofprocessanddriveequipment•Combi-Vent-Feeder® System•two-stagerotorfinegranulationinDdesign•patentedSuction-Cooling-System®

•cGMPdesign•completelymadeofstainlesssteel•allnon-metallicmaterialsaccordingtoFDAstandards•maybefittedwithIsolator•automatedPLC•optional:WIP(WashInPlace)•optional:ThroughtheWalldesign•optional:21CFRPart11•optional:PAT•designaccordingtoURS

Quality parameters can be easily scaled to larger or smaller production units. Quality parameters deter-mined by means of the WP120Pharma pilot plant and small-batch machine made by Alexanderwerk can be easily scaled to the WP200Pharma and vice versa.

CompactionThe basic process principle of roller compaction is simple. However, only the use of latest control tech-nology facilitates the efficient production of a high-quality granule.

The quality of the final granule is mainly determined by the quality of the flake. A constant compacting pressure and constant roller gap are required. The control equipment made by Alexanderwerk will compensate any physical fluctuations in the material (such as local inhomogenities). As a result, the process parameters (throughput, flake density, compacting pressure, speed or similar) can be precisely adjusted at highly repetitive accuracy.

With roller compactors made by Alexanderwerk, there is a clear, modular separation between the pro-cess steps of feed and compaction. The feed screw 3 alone is designed to feed the powder to the rollers 4 – intentionally, this process does not aim at a pre-

compaction by the feed screw system.

Granulation with Roller Compactors made by Alexanderwerk

7

4

5

3

2

1

6

8

Patented Combi-Vent-Feeder® System to boost Efficiency.The Combi-Vent-Feeder® System patented by Alexanderwerk offers an additional “chamber“next to the material hopper (which does not contain any material). Air, displaced from the material during com-paction, can freely escape through this second chamber. As a result of this configuration, the material can be fed to the screw, and thus to the rollers, more uniformly, there is less back pressure building up in the feed sec-tion, and the process, as such, runs smoother, faster and more uniformly.

Additionally, the Combi-Vent-Feeder® System can do more undersize or fines (e. g. side seal leakages) can be continuously recycled into the additional hopper cham-ber, blending with raw material to form a consistent feed quality.

Another option available is the vacuum station for the screw feeder. A vacuum is applied on the screw housing to force the return-flow air into a defined path. Thus, the processing of very light or heavily fluidizing materials is made possible.

GranulationGranulesarecharacterisedbydefinedparticlesizes,i.e.the size of the particles varies between fixed upper and lower limits (oversize, undersize). After feeding into the compacting unit, the course flakes are generally larger than the upper tolerance limit of the finished product. Only defined size reduction in the granulation unit will produce the finished granule.

Downstream further processing of the granule, such as in tableting machines, requires a tight tolerance and for this reason the granulation unit of the WP200 Pharma is of a two-stage diagonal design. The first stage is pre-granulation, and the second stage is designed as a fine granulator.

Modular DesignFrom the consumer’s point of view, porosity is the most critical requirement of pharmaceutical products. From the user‘s point of view, flexibility is a decisive characte-ristic of a pharmaceutical machine, specifically in a time of ever tighter markets. The WP200Pharma meets both requirements – definedporosity of the final product, and flexible use of the ma-chine. Due to its consistent modular design, the WP200 Pharma can be dismantled practically without special tools.

The process equipment of the WP200 Pharma can be completely dismantled without any special tools.

Rollers 4 (protective shroud removed) and flake crusher 5 .Cantilever bearing design of rollers for easy replacement or cleaning.

Two-stage granulating unit in diagonal design 7 (protective shroud removed).

The granulator screens are exchangeable, and the particle size of the final granule is determined by the mesh size and screen design.

Feed hopper in Combi-Vent-Feeder® design as standard.

3

2

1 Vent for displaced air and feed hopper for undersize and oversize at the same time

Material feed hopper

Socket for level probe

3

2

1

Material feed

Feed hopper in Combi-Vent-Feeder® design

Feed screw system

Compacting unit: Roller Unit

Pre-crushing

Sampling

Two-stage granulating unit

Granule outlet

Numerous special or customized designs available upon request.

2

1

3

4

5

7

6

8

Pharma Roller Compactor and Granulator WP200Pharma

The operator panel is designed as a touch panel.

The WP200 Pharma is the obvious choice of compactor and granulator for production. With a throughput of up to 400 kg/hr (Lactose), the WP200P-harma is ideal for situations of frequent product changes, special products, small batches, or for compacting and granulating of a mono product in continuous operation. The WP200Pharma comes with the Combi-Vent-Feeder® System patented by Alexanderwerk, as standard. This unique design of thefeed system facilitates the highly efficient operation of this unit. Due to the dedicated venting of the gas flow, larger quantities of material can be fed into the roller gap. The process equipment is completely separated from the drive equipment. As an option, the WP200Pharma is available in a “Through the Wall“design. With this special design, the access to the process equipment can be separated from the access to the drive equipment. For ultimate containment applica-tions, the WP200Pharma can be fitted with an Isolator. The machine‘s design meets all the require-ments of the pharmaceutical industry:

•spatialseparationofprocessanddriveequipment•Combi-Vent-Feeder® System•two-stagerotorfinegranulationinDdesign•patentedSuction-Cooling-System®

•cGMPdesign•completelymadeofstainlesssteel•allnon-metallicmaterialsaccordingtoFDAstandards•maybefittedwithIsolator•automatedPLC•optional:WIP(WashInPlace)•optional:ThroughtheWalldesign•optional:21CFRPart11•optional:PAT•designaccordingtoURS

Quality parameters can be easily scaled to larger or smaller production units. Quality parameters deter-mined by means of the WP120Pharma pilot plant and small-batch machine made by Alexanderwerk can be easily scaled to the WP200Pharma and vice versa.

CompactionThe basic process principle of roller compaction is simple. However, only the use of latest control tech-nology facilitates the efficient production of a high-quality granule.

The quality of the final granule is mainly determined by the quality of the flake. A constant compacting pressure and constant roller gap are required. The control equipment made by Alexanderwerk will compensate any physical fluctuations in the material (such as local inhomogenities). As a result, the process parameters (throughput, flake density, compacting pressure, speed or similar) can be precisely adjusted at highly repetitive accuracy.

With roller compactors made by Alexanderwerk, there is a clear, modular separation between the pro-cess steps of feed and compaction. The feed screw 3 alone is designed to feed the powder to the rollers 4 – intentionally, this process does not aim at a pre-

compaction by the feed screw system.

Granulation with Roller Compactors made by Alexanderwerk

7

4

5

3

2

1

6

8

Patented Combi-Vent-Feeder® System to boost Efficiency.The Combi-Vent-Feeder® System patented by Alexanderwerk offers an additional “chamber“next to the material hopper (which does not contain any material). Air, displaced from the material during com-paction, can freely escape through this second chamber. As a result of this configuration, the material can be fed to the screw, and thus to the rollers, more uniformly, there is less back pressure building up in the feed sec-tion, and the process, as such, runs smoother, faster and more uniformly.

Additionally, the Combi-Vent-Feeder® System can do more undersize or fines (e. g. side seal leakages) can be continuously recycled into the additional hopper cham-ber, blending with raw material to form a consistent feed quality.

Another option available is the vacuum station for the screw feeder. A vacuum is applied on the screw housing to force the return-flow air into a defined path. Thus, the processing of very light or heavily fluidizing materials is made possible.

GranulationGranulesarecharacterisedbydefinedparticlesizes,i.e.the size of the particles varies between fixed upper and lower limits (oversize, undersize). After feeding into the compacting unit, the course flakes are generally larger than the upper tolerance limit of the finished product. Only defined size reduction in the granulation unit will produce the finished granule.

Downstream further processing of the granule, such as in tableting machines, requires a tight tolerance and for this reason the granulation unit of the WP200 Pharma is of a two-stage diagonal design. The first stage is pre-granulation, and the second stage is designed as a fine granulator.

Modular DesignFrom the consumer’s point of view, porosity is the most critical requirement of pharmaceutical products. From the user‘s point of view, flexibility is a decisive characte-ristic of a pharmaceutical machine, specifically in a time of ever tighter markets. The WP200Pharma meets both requirements – definedporosity of the final product, and flexible use of the ma-chine. Due to its consistent modular design, the WP200 Pharma can be dismantled practically without special tools.

The process equipment of the WP200 Pharma can be completely dismantled without any special tools.

Rollers 4 (protective shroud removed) and flake crusher 5 .Cantilever bearing design of rollers for easy replacement or cleaning.

Two-stage granulating unit in diagonal design 7 (protective shroud removed).

The granulator screens are exchangeable, and the particle size of the final granule is determined by the mesh size and screen design.

Feed hopper in Combi-Vent-Feeder® design as standard.

3

2

1 Vent for displaced air and feed hopper for undersize and oversize at the same time

Material feed hopper

Socket for level probe

3

2

1

Material feed

Feed hopper in Combi-Vent-Feeder® design

Feed screw system

Compacting unit: Roller Unit

Pre-crushing

Sampling

Two-stage granulating unit

Granule outlet

Numerous special or customized designs available upon request.

2

1

3

4

5

7

6

8

Alexanderwerk AG Kippdorfstraße 6–24 42857 Remscheid/Germany P +49 (0)2191 79 50 F +49 (0)2191 79 53 50 imaschinen@alexanderwerk.com www.alexanderwerk.comNo liability will be accepted for errors or omissions. Subject to change (246-9011)

Roller Compactors and GranulatorsWP 200 Pharma

Examples of Granules

Antibiotics Riboflavin Natrium Bicarbonate

Spice extract Lactose

Applications

For many years pharmaceutical corporations all over the world have been using roller compactors made by Alexanderwerk to produce granules, and to further process tablets or capsules, Life-Science products, flavours, instant powders, or intense sweeteners.

Flavours

Technical Data

Throughput, continuous operation 10 to 250 kg/hr

Granule size variable

Maximum compacting pressure 18.4 kN/cm of roller width

Installed power approx. 29 kVA

Weightapprox. 2,000 kg (complete unit, excluding control cabinet)

Material of construction 1.4571 (complete), 316 Ti

Material of construction: Rollers 1.4122

Material of construction: Product touching seals FDA approved materials

Machine control separate from the machine (not shown).

www.fa

berm

olde

nhau

er.de

Alexanderwerk AG Kippdorfstraße 6–24 42857 Remscheid/Germany P +49 (0)2191 79 50 F +49 (0)2191 79 53 50 imaschinen@alexanderwerk.com www.alexanderwerk.comNo liability will be accepted for errors or omissions. Subject to change (246-9011)

Roller Compactors and GranulatorsWP 200 Pharma

Examples of Granules

Antibiotics Riboflavin Natrium Bicarbonate

Spice extract Lactose

Applications

For many years pharmaceutical corporations all over the world have been using roller compactors made by Alexanderwerk to produce granules, and to further process tablets or capsules, Life-Science products, flavours, instant powders, or intense sweeteners.

Flavours

Technical Data

Throughput, continuous operation 10 to 250 kg/hr

Granule size variable

Maximum compacting pressure 18.4 kN/cm of roller width

Installed power approx. 29 kVA

Weightapprox. 2,000 kg (complete unit, excluding control cabinet)

Material of construction 1.4571 (complete), 316 Ti

Material of construction: Rollers 1.4122

Material of construction: Product touching seals FDA approved materials

Machine control separate from the machine (not shown).

www.fa

berm

olde

nhau

er.de