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Natalia Zuleta Rendón
Medicine Student
3rd Semester
NER and repair
of mismatches
is the principal
defense
against UV rays
These
factors may
lead to incorrect
addition of
bases during
replication
TARGETING PTEN MAY PREVENT
SKIN CANCER
Phosphatase and tensin
homolog ( PTEN ) is
a protein that, in
humans, is encoded by
the PTEN gene .
Regulate of the cell
cycle , preventing cells
from growing and
dividing too rapidly
TARGETING PTEN MAY PREVENT
SKIN CANCER
The degree
of inactivation is
proportional to the
aggressiveness of
the disease, that is, the
less work the worse the
prognosis gene for the
patient.
TARGETING PTEN MAY PREVENT
SKIN CANCER Plays a role as a key modulator of the AKT-
mTOR signaling pathway controlling the
tempo of the process of newborn neurons
integration during adult neurogenesis. May
be a negative regulator of insulin signaling
and glucose metabolism in adipose tissue.
With the discovery of this gene could prevent
several types of cancer since its action is to
prevent cells from multiplying rapidly. Also
important to note that if there is a good
diet can increase your activity. This gene will
be a challenge to modern science as if it
can increase its activity was abolished many
cancers. (endometrial cancer, prostate and
breast)
ULTRAVIOLET LIGHT AFFECTS FUNCTION
OF PROTEIN IN EWING’S SARCOMA
The genetic circuitsaltered in cancerprocesses include theactivation or inhibitionof various genes andproteins.
In the case of Ewing'ssarcoma, EWS proteinalterations inducechanges in theexpression of variousgenes, thus affecting theability to detect andcorrect DNA damage.
ULTRAVIOLET LIGHT AFFECTS FUNCTION
OF PROTEIN IN EWING’S SARCOMA
The EWS protein stops being joined to the
genes it regulates and relocates to structures
located within the cell nucleus known as
nucleoli. The relocation results in changes in
the expression of the genes regulated by
EWS, and these changes are important for an
appropriate response to DNA damage.
ULTRAVIOLET LIGHT AFFECTS FUNCTION
OF PROTEIN IN EWING’S SARCOMA
UV radiation can also
produce pyrimidine
dimers (TT)
block transcription
which also leads to skin
cancer.
The DNA repair mechanisms are the most
active response to UV light. Without them we
could not expose any type
of radiation (solar or conventional light)
because it would be fatal for the skin. This
study can conclude that these
mechanisms should be preserved to
prevent many diseases and have a good
quality of life.
Through recentadvances humanitycould prevent andcure many diseases thatare deadly and havehigh prevalence.
With the manipulationof genetic material, DNAanalysis could knowthat disease willdevelop each person andwhat is the best way tocure them.
If they are
created more consistent treatment to
genetic damage, medicine could increase the
quality of life of patients, always
seeking wellness and cure disease with few
adverse effects.
For medicine is
very important to be hand
in hand with
advances genetic
Nothing
less eradicated multiple
cancers, congenital
diseases and diseases
caused by bad DNA repair
mechanisms.
MARTINEZ S., Lina Maria. Biología Molecular. 6 ed.
Medellín: UPB. Facultad de Medicina, 2011. 56 p.
Cancer Research (July 26, 2011). Targeting PTEN May
Prevent Skin Cancer. Science Daily. Retrieved August 11,
2011, from
http://www.sciencedaily.com/releases/2011/07/11072613
2351.htm
Journal Molecular Cell (August 3, 2011). Ultravioler Light
Affects Function of Protein Involved in Ewing’s Sarcoma,
Study Finds. Science Daily. Retrieved August 11, 2011,
from
http://www.sciencedaily.com/releases/2011/08/11080413
3444.htm