Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 86, No. 1 (Jan. 1, 1989), pp. ix-xivPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/33043 .

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OF

Proceedings OF THE

National Academy of Sciences

OF THE UNITED STATES OF AMERICA

January 1989 Volume 86, Number 1 pp. 1-406

Table of Contents

INFORMATION FOR CONTRIBUTORS

AUTHOR INDEX xv

Editorial Igor B. Dawid 1

Biological Sciences

BIOCHEMISTRY

Esperamicins, a class of potent antitumor antibiotics: Mechanism of action Byron H. Long, Jerzy Golik, Salvatore 2 Forenza, Brian Ward, Robert Rehfuss, James C. Dabrowiak, Joseph J. Catino, Steve T. Musial, Kenneth W. Brookshire, and Terrence W. Doyle

Structure of human neutrophil elastase in complex with a peptide chloromethyl Manuel A. Navia, Brian M. McKeever, 7 ketone inhibitor at 1.84-A resolution James P. Springer, Tsau-Yen Lin,

Hollis R. Williams, Eugene M. Fluder, Conrad P. Dorn, and Karst Hoogsteen

RNA polymerase II is capable of pausing and prematurely terminating Orna Resnekow and Yosef Aloni 12 transcription at a precise location in vivo and in vitro

Structure and heterogeneity of the oligosaccharides from the Bradford W. Gibson, James W. Webb, 17 lipopolysaccharides of a pyocin-resistant Neisseria gonorrhoeae Ryohei Yamasaki, Susan J. Fisher,

A. L. Burlingame, Robert E. Mandrell, Herman Schneider, and J. McLeod Griffiss

ix

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Contents Processing at the carboxyl terminus of nascent placental alkaline phosphatase Carole A. Bailey, Louise Gerber, 22

in a cell-free system: Evidence for specific cleavage of a signal peptide Andrew D. Howard, and Sidney Udenfriend

Sequence investigation of the major gastrointestinal tumor-associated antigen Alban J. Linnenbach, Jacek 27 gene family, GA733 Wojcierowski, Shuang Wu, Janina J.

Pyrc, Alonzo H. Ross, Bernard Dietzschold, David Speicher, and Hilary Koprowski

Cloning and expression of the gene cluster encoding key proteins involved in David L. Roberts, Julie E. James- 32 acetyl-CoA synthesis in Clostridium thermoaceticum: CO dehydrogenase, Hagstrom, Denise K. Garvin, Carol M. the corrinoid/Fe-S protein, and methyltransferase Gorst, Jennifer A. Runquist,

Jacqueline R. Baur, F. Carl Haase, and Steve W. Ragsdale

High-level erythroid expression of human a-globin genes in transgenic mice Thomas M. Ryan, Richard R. Behringer, 37 Tim M. Townes, Richard D. Palmiter, and Ralph L. Brinster

Is there a relationship between DNA sequences encoding peptide ligands and Avram Goldstein and Douglas L. Brutlag 42 their receptors?

In the presence of CTP, UTP becomes an allosteric inhibitor of aspartate J. R. Wild, S. J. Loughrey-Chen, and 46 transcarbamoylase T. S. Corder

Enzymatic cleavage of a bacterial genome at a 10-base-pair recognition site Michael D. Weil and Michael McClelland 51

Negative control elements and cAMP responsive sequences in the tissue- Norifumi Nakamura, David W. Burt, 56 specific expression of mouse renin genes Martin Paul, and Victor J. Dzau

Specific protein-DNA interactions at a xenobiotic-responsive element: Janet Hapgood, Scott Cuthill, Marc 60 Copurification of dioxin receptor and DNA-binding activity Denis, Lorenz Poellinger, and Jan-Ake

Gustafsson

Copper-induced binding of cellular factors to yeast metallothionein upstream Jon M. Huibregtse, David R. Engelke, 65 activation sequences and Dennis J. Thiele

Sequence recognition protein for the 17-base-pair A+T-rich tract in the Linda H. Malkas and Earl F. Baril 70 replication origin of simian virus 40 DNA

Purification of Tetrahymena actin reveals some unusual properties Masafumi Hirono, Yasuko Kumagai, 75 Osamu Numata, and Yoshio Watanabe

Bioluminescence of the Ca2+-binding photoprotein aequorin after cysteine Kouichi Kurose, Satoshi Inouye, 80 modification Yoshiyuki Sakaki, and Frederick I.

Tsuji

Regulation of methionine synthesis in Escherichia coli: Effect of the MetR Mary E. Maxon, Betty Redfield, 85 protein on the expression of the metE and metR genes Xiao-Yan Cai, Robert Shoeman, Kenji

Fujita, Wolfgang Fisher, George Stauffer, Herbert Weissbach, and Nathan Brot

Purification of tropomyosin from Saccharomyces cerevisiae and identification Haoping Liu and Anthony Bretscher 90 of related proteins in Schizosaccharomyces and Physarum

Chiral syntheses of D- and L-myo-inositol 1,4,5-trisphosphate Werner Tegge and Clinton E. Ballou 94

Heme oxygenase is the major 32-kDa stress protein induced in human skin Stephen M. Keyse and Rex M. Tyrrell 99 fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite

Prolactin and glucocorticoid hormones synergistically induce expression of Wolfgang Doppler, Bernd Groner, and 104 transfected rat 13-casein gene promoter constructs in a mammary epithelial Roland K. Ball cell line

Identification and purification of a Saccharomyces cerevisiae protein with the Young-Sun Lin and Michael R. Green 109 DNA binding specificity of mammalian activating transcription factor

Structure of the human insulin receptor gene and characterization of its Susumu Seino, Mitsuko Seino, Shigeo 114 promoter Nishi, and Graeme I. B3ell

Rate, origin, and bidirectionality of Caulobacter chromosome replication as Andrew Dingwall and Lucille Shapiro 119 determined by pulsed-field gel electrophoresis

Regulation of thromboxane receptor activation in human platelets Rosemary Murray and Garret A. 124 FitzGerald

A translational enhancer derived from tobacco mosaic virus is functionally D. R. Gallie and C. I. Kado 129 equivalent to a Shine-Dalgarno sequence

x

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Contents Site-directed mutagenesis of the catalytic residues Asp-52 and Glu-35 of Bruce A. Malcolm, Steven Rosenberg, 133

chicken egg white lysozyme Michael J. Corey, Judith S. Allen, Annie de Baetselier, and Jack F. Kirsch

Characterization of hydrogen-uptake activity in the hyperthermophile Todd D. Pihl, Richard N. Schicho, 138 Pyrodictium brockii Robert M. Kelly, and Robert J. Maier

BIOPHYSICS

Limit-cycle oscillations and chaos in reaction networks subject to conservation Enrico Di Cera, Paul E. Phillipson, and 142 of mass Jeffries Wyman

Evidence for selenocysteine coordination to the active site nickel in the Marly K. Eidsness, Robert A. Scott, 147 [NiFeSe]hydrogenases from Desulfovibrio baculatus Benet C. Prickril, Daniel V.

DerVartanian, Jean Legall, Isabel Moura, Jose J. G. Moura, and Harry D. Peck, Jr.

Protein secondary structure prediction with a neural network L. Howard Holley and Martin Karplus 152

BOTANY

Cloned avirulence genes from the tomato pathogen Pseudomonas syringae pv. Donald Y. Kobayashi, Stanley J. 157 tomato confer cultivar specificity on soybean Tamaki, and Noel T. Keen

CELL BIOLOGY

Detection of genes with a potential for suppressing the transformed phenotype Makoto Noda, Hitoshi Kitayama, 162 associated with activated ras genes Tomoko Matsuzaki, Yoshikazu

Sugimoto, Hiroto Okayama, Robert H. Bassin, and Yoji Ikawa

Physiological localization of an agonist-sensitive pool of Ca2+ in parotid acinar J. Kevin Foskett, Pamela J. Gunter- 167 cells Smith, James E. Melvin, and R. James

Turner Circadian regulation of bioluminescence in Gonyaulax involves translational David Morse, Patrice M. Milos, Etienne 172

control Roux, and J. Woodland Hastings Chromatin architecture and nuclear RNA Jeffrey A. Nickerson, Gabriela 177

Krochmalnic, Katherine M. Wan, and Sheldon Penman

Cytolysis by tumor necrosis factor is preceded by a rapid and specific Mary Scanlon, Scott M. Laster, John G. 182 dissolution of microfilaments Wood, and Linda R. Gooding

Malignant transformation of human fibroblasts caused by expression of a Peter J. Hurlin, Veronica M. Maher, and 187 transfected T24 HRAS oncogene J. Justin McCormick

EVOLUTION

Evolution of the genome and the genetic code: Selection at the dinucleotide Ernest Beutler, Terri Gelbart, Jiahuai 192 level by methylation and polyribonucleotide cleavage Han, James A. Koziol, and Bruce

Beutler

GENETICS

At least two mutant alleles of ornithine &-aminotransferase cause gyrate Grant A. Mitchell, Lawrence C. Brody, 197 atrophy of the choroid and retina in Finns Ilkka Sipila, James E. Looney,

Corinne Wong, John F. Engelhardt, Achyut S. Patel, Gary Steel, Cassandra Obie, Muriel Kaiser- Kupfer, and David Valle

Macromolecular organization of human centromeric regions reveals high- Ethylin Wang Jabs, Corintha A. Goble, 202 frequency, polymorphic macro DNA repeats and Garry R. Cutting

Expression and replication of hepatitis B virus genome in transgenic mice Kimi Araki, Jun-ichi Miyazaki, Okio 207 Hino, Naohiro Tomita, Osamu Chisaka, Kenichi Matsubara, and Ken-ichi Yamamura

Rapid typing of tandemly repeated hypervariable loci by the polymerase chain Eric Boerwinkle, Weijun Xiong, Eric 212 reaction: Application to the apolipoprotein B 3' hypervariable region Fourest, and Lawrence Chan

xi

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Contents Functional substitution of mouse ribosomal protein L27' for yeast ribosomal Geraldine Fleming, Pierre Belhumeur, 217

protein L29 in yeast ribosomes Daniel Skup, and Howard M. Fried

Mapping to molecular resolution in the T to H-2 region of the mouse genome Thomas R. King, William F. Dove, 222 with a nested set of meiotic recombinants Bernhard Herrmann, Amy R. Moser,

and Alexandra Shedlovsky

Positive genetic selection for gene disruption in mammalian cells by John M. Sedivy and Phillip A. Sharp 227 homologous recombination

Attachment of a 40-base-pair G+C-rich sequence (GC-clamp) to genomic DNA Val C. Sheffield, David R. Cox, Leonard 232 fragments by the polymerase chain reaction results in improved detection of S. Lerman, and Richard M. Myers single-base changes

IMMUNOLOGY

Mercuric chloride induces autoantibodies against U3 small nuclear Rolf Reuter, Gabriela Tessars, Hans- 237 ribonucleoprotein in susceptible mice Werner Vohr, Ernst Gleichmann, and

Reinhard Luhrmann

Identification of murine complement receptor type 2 Joyce D. Fingeroth, Mary A. Benedict, 242 David N. Levy, and Jack L. Strominger

Cloning, analysis, and expression of murine perforin 1 cDNA, a component of David Lowrey, Tony Aebischer, Kristin 247 cytolytic T-cell granules with homology to complement component C9 Olsen, Mathias Lichtenheld, Fabio

Rupp, Hans Hengartner, and Eckhard R. Podack

Isolation and characterization of a cDNA and gene coding for a fourth CD1 Steven P. Balk, Paul A. Bleicher, and 252 molecule Cox Terhorst

cDNA sequence for the aM subunit of the human neutrophil adherence Dennis D. Hickstein, Mark J. Hickey, 257 receptor indicates homology to integrin a subunits Juris Ozols, Dianne M. Baker,

Anthony L. Back, and Gerald J. Roth

Insect immunity: Isolation from immune blood of the dipteran Phormia Jean Lambert, Elisabeth Keppi, 262 terranovae of two insect antibacterial peptides with sequence homology to Jean-Luc Dimarcq, Claude Wicker, rabbit lung macrophage bactericidal peptides Jean-Marc Reichhart, Bryan Dunbar,

Pierre Lepage, Alain Van Dorsselaer, Jules Hoffmann, John Fothergill, and Daniele Hoffman

Rearrangement by inversion of a T-cell receptor 8 variable region gene located Alan J. Korman, Junichi Maruyama, and 267 3' of the 6 constant region gene David H. Raulet

Transplantation tolerance correlates with high levels of T- and B-lymphocyte A. Bandeira, A. Coutinho, C. Carnaud, 272 activity F. Jacquemart, and L. Forni

Class I major histocompatibility complex-restricted cytolytic T lymphocytes Thomas J. Braciale, Marianne T. 277 recognize a limited number of sites on the influenza hemagglutinin Sweetser, Lynda A. Morrison, David

J. Kittlesen, and Vivian L. Braciale

B-lymphoma cells process and present their endogenous immunoglobulin to Siegfried Weiss and Bjarne Bogen 282 major histocompatibility complex-restricted T cells

Chimeric cytotoxin IL2-PE40 delays and mitigates adjuvant-induced arthritis in John P. Case, Haya Lorberboum-Galski, 287 rats Robert Lafyatis, David FitzGerald,

Ronald L. Wilder, and Ira Pastan

Identification of receptor-binding residues in the inflammatory complement Karl W. Mollison, Wlodek Mandecki, 292 protein C5a by site-directed mutagenesis Erik R. P. Zuiderweg, Lisbeth Fayer,

Thomas A. Fey, Ruth A. Krause, Richard G. Conway, Loan Miller, Rohinton P. EdaUji, Mary Ann Shallcross, Benjamin Lane, J. Lawrence Fox, Jonathan Greer, and George W. Carter

Common acute lymphoblastic leukemia antigen (CALLA) is active neutral Margaret A. Shipp, Jayanthi 297 endopeptidase 24.11 ("enkephalinase"): Direct evidence by cDNA Vijayaraghavan, Emmett V. Schmidt, transfection analysis Emma L. Masteller, Luciano

D'Adamio, Louis B. Hersh, and Ellis L. Reinherz

xii

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Contents

Human interleukin 7: Molecular cloning and growth factor activity on human Raymond G. Goodwin, Stephen Lupton, 302 and murine B-lineage cells Ann Schmierer, Kathryn J. Hjerrild,

Rita Jerzy, William Clevenger, Steve Gillis, David Cosman, and Anthony E. Namen

MEDICAL SCIENCES

Lymphocyte antigen Leu-19 as a molecular marker of regeneration in human Walter Schubert, Katrin Zimmerman, 307 skeletal muscle Matthias Cramer, and Anna

Starzinski-Powitz

Detection of serum hepatitis B virus DNA in patients with chronic hepatitis Shuichi Kaneko, Roger H. Miller, 312 using the polymerase chain reaction assay Stephen M. Feinstone, Masashi

Unoura, Kenichi Kobayashi, Nobu Hattori, and Robert H. Purcell

Protection of rhesus monkeys from fatal Lassa fever by vaccination with a S. P. Fisher-Hoch, J. B. McCormick, D. 317 recombinant vaccinia virus containing the Lassa virus glycoprotein gene Auperin, B. G. Brown, M. Castor, G.

Perez, S. Ruo, A. Conaty, L. Brammer, and S. Bauer

Human anti-endoplasmic reticulum antibodies in sera of patients with H. Satoh, B. M. Martin, A. H. Schulick, 322 halothane-induced hepatitis are directed against a trifluoroacetylated D. D. Christ, J. G. Kenna, and L. R. carboxylesterase Pohl

Characterization and expression of a cDNA encoding the human androgen Wayne D. Tilley, Marco Marcelli, Jean 327 receptor D. Wilson, and Michael J. McPhaul

Marked in vivo antiretrovirus activity of 9-(2-phosphonylmethoxyethyl)adenine, Jan Balzarini, Lieve Naesens, Piet 332 a selective anti-human immunodeficiency virus agent Herdewijn, Ivan Rosenberg, Antonin

H6ly, Rudi Pauwels, Masanori Baba, David G. Johns, and Erik De Clercq

Overexpression of amyloid precursor protein A4 (/3-amyloid) immunoreactivity Charles A. Marotta, Wen-Gang Chou, 337 in genetically transformed cells: Implications for a cellular model of Ronald E. Majocha, Richard Watkins, Alzheimer amyloidosis Carol LaBonne, and Sayeeda B. Zain

Isolation and characterization of human defensin cDNA clones (Correction) Kathleen A. Daher, Robert I. Lehrer, 342 Tomas Ganz, and Mitchell Kronenberg

MICROBIOLOGY

Cloned diphtheria toxin within the periplasm of Escherichia coli causes lethal Donald 0. O'Keefe and R. John Collier 343 membrane damage at low pH

NEUROBIOLOGY

Phenylethanolamine N-methyltransferase-containing neurons in the limbic tva Mezey 347 system of the young rat

Consequences of stochastic release of neurotransmitters for network Y. Burnod and H. Korm 352 computation in the central nervous system

Visual responses of neurons in somatosensory cortex of hamsters with Christine Metin and Douglas 0. Frost 357 experimentally induced retinal projections to somatosensory thalamus

Decrease in plasminogen activator correlates with synapse elimination during Daniel Hantal, Jasti S. Rao, Cheryl 362 neonatal development of mouse skeletal muscle Kahler, and Barry W. Festoff

Change in desensitization of cat muscle acetylcholine receptor caused by K. Sumikawa and R. Miledi 367 coexpression of Torpedo acetylcholine receptor subunits in Xenopus oocytes

Botulinum toxin type A blocks the morphological changes induced by chemical J. Marsal, G. Egea, C. Solsona, X. 372 stimulation on the presynaptic membrane of Torpedo synaptosomes Rabasseda, and J. Blasi

Structure of the NGFI-A gene and detection of upstream sequences responsible Paul S. Changelian, Ping Feng, Timothy 377 for its transcriptional induction by nerve growth factor C. King, and Jeffrey Milbrandt

Sex- and hormone-dependent antigen immunoreactivity in developing rat S. A. Tobet and T. 0. Fox 382 hypothalamus

Functional role of spines in the retinal horizontal cell network Raimond L. Winslow, Robert F. Miller, 387 and Thomas E. Ogden

Neuropeptide K potently stimulates salivary gland secretion and potentiates Yasuo Takeda and James E. Krause 392 substance P-induced salivation

xiii

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Contents

PHYSIOLOGICAL SCIENCES

Aldosterone stimulates K secretion across mammalian colon independent of Na Gerhard Rechkemmer and Dan R. Halm 397 absorption

Crustacean peptidergic neurons in culture show immediate outgrowth in simple I. Cooke, R. Graf, S. Grau, B. Haylett, 402 medium D. Meyers, and P. Ruben

xiv

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JANUARY 1989

VOLUME 86

NUMBER 1

"~~~ 0

Proceedings O)F THE

1Natilonal Academ y of Sciences OF THE UNITED STATES OF AMERICA

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Proceedings OF THE

National Academy of Sciences OF THE UNITED STATES OF AMERICA

Officers FRANK PRESS, President of the JAMES D. EBERT, Vice President Academy PETER H. RAVEN, Home Secretary

WILLIAM E. GORDON, Foreign Secretary ELKAN R. BLOUT, Treasurer

Editorial Board of the Proceedings

ROBERT H. ABELES GORDON A. BAYM WILLIAM F. BRACE RONALD BRESLOW MICHAEL J. CHAMBERLIN

IGOR B. DAWID, Chairman MARY-DELL CHILTON EDWARD E. DAVID, JR. STUART A. KORNFELD DANIEL E. KOSHLAND, JR. PETER D. LAX DANIEL NATHANS

HERBERT E. SCARF MAXINE F. SINGER SOLOMON H. SNYDER HAROLD VARMUS THOMAS A. WALDMANN

Managing Editor: FRANCES R. ZWANZIG Senior Associate Editor: GARY T. COCKS Associate Editor: CAY BUTLER Associate Editor: JOHN M. MALLOY Associate Editor: MARILYN J. MASON Associate Editor: JANET L. MORGAN Associate Editor: T. PEARSON Associate Editor: DOROTHY P. SMITH Associate Editor: COLENE RUCH WALDEN Assistant Managing Editor: JOANNE D'AMICo

Senior Production Editor: LYNN A. WASSYNG Production Editors: BARBARA A. BACON, DEBORAH G. CHLEBOVE, RUTH E. CROSSGROVE,

SCOTT C. HERMAN, MARGARET M. MADELEINE, KATHLEEN RUBY, DON C. TIPPMAN, DEBORAH 1. WEINER

Proofreader: MARY E. MCLAUGHLIN Administrative Assistants: DELORES BANKS, BRENDA L. MCCOY Manuscript Coordinators: JACQUELINE PERRY, SHEILA W. POWERS Circulation: JULIA LITTLE, CYNDY MATHEWS, VIRGINIA TREADWAY

Editorial correspondence: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, 2101 Constitution Avenue, Washing- ton, DC 20418.

Business correspondence: Circulation Office of the PROCEEDINGS, National Academy of Sciences, 2101 Constitution Ave- nue, Washington, DC 20418.

Information for Contributors: See pp. i-viii of this issue, January 1989.

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