Front MatterSource: Proceedings of the National Academy of Sciences of the United States of America,Vol. 86, No. 8 (Apr. 15, 1989), pp. iii-viiiPublished by: National Academy of SciencesStable URL: http://www.jstor.org/stable/34079 .

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Proceedings OF THE

National Academy of Sciences

OF THE UNITED STATES OF AMERICA

April 1989 Volume 86, Number 8 pp. 2521-2990

Table of Contents

CONDENSED INFORMATION FOR CONTRIBUTORS

AUTHOR INDEX

Physical Sciences

MATHEMATICS

Standard basis in supersymplectic algebras

Biological Sciences

BIOCHEMISTRY

Retroviral integration: Structure of the initial covalent product and its precursor, and a role for the viral IN protein

Multiple states of protein-DNA interaction in the assembly of transcription complexes on Saccharomyces cerevisiae 5S ribosomal RNA genes

A glucose transport protein expressed predominately in insulin-responsive tissues

Gian-Carlo Rota and Joel A. Stein

Patrick O. Brown, Bruce Bowerman, Harold E. Varmus, and J. Michael Bishop

Buckhard R. Braun, Daniel L. Riggs, George A. Kassavetis, and E. Peter Geiduschek

Maureen J. Charron, Frank C. Brosius III, Seth L. Alper, and Harvey F. Lodish

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Contents

Ubiquitin fusion augments the yield of cloned gene products in Escherichia coli

Amplification of the proto-neu oncogene facilitates oncogenic activation by a single point mutation

Transfer of the inducible lac repressor/operator system from Escherichia coli to a vaccinia virus expression vector

An erythroid-specific, developmental-stage-independent enhancer far upstream of the human "fl-like globin" genes

Reconstitution of purified brown adipose tissue mitochondria uncoupling protein: Demonstration of separate identity of nucleotide binding and proton translocation sites by chemical probes

Complete amino acid sequence of rat brain hexokinase, deduced from the cloned cDNA, and proposed structure of a mammalian hexokinase

Plasmin-mediated fibrinolysis by variant recombinant tissue plasminogen activators

Expression of the Ul RNA gene repeat during early sea urchin development: Evidence for a switch in Ul RNA genes during development

Pertussis toxin induces structural changes in Ga proteins independently of ADP-ribosylation

Molecular cloning and analysis of cDNA encoding a plant tryptophan decarboxylase: Comparison with animal dopa decarboxylases

Characterization of the human 5-lipoxygenase gene

Native and mutant 5-lipoxygenase expression in a baculovirus/insect cell system

Involvement of the proteasome in various degradative processes in mammalian cells

A simple high-resolution procedure to study DNA methylation and in vivo DNA-protein interactions on a single-copy gene level in higher eukaryotes

Trypanothione is the primary target for arsenical drugs against African trypanosomes

Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2

Illegitimate transcription: Transcription of any gene in any cell type

Structural basis for DNA bending

Identification and purification of a single-stranded-DNA-specific exonuclease encoded by the recJ gene of Escherichia coli

Tissue cooperation in a proteolytic cascade activating human interstitial collagenase

Filamentous hemagglutinin of Bordetella pertussis: Nucleotide sequence and crucial role in adherence

Activation of glucose uptake by insulin and insulin-like growth factor I in Xenopus oocytes

A double-stranded RNA unwinding activity introduces structural alterations by means of adenosine to inosine conversions in mammalian cells and Xenopus eggs

Yeast GCN4 transcriptional activator protein interacts with RNA polymerase II in vitro

Tauseef R. Butt, Sobhanaditya Jonnalagadda, Brett P. Monia, Edmund J. Sternberg, Jonathan A. Marsh, Jeffrey M. Stadel, David J. Ecker, and Stanley T. Crooke

Mien-Chie Hung, Duen-Hwa Yan, and Xiaoyan Zhao

Thomas R. Fuerst, M. Pilar Fernandez, and Bernard Moss

Dorothy Y. H. Tuan, William B. Solomon, Irving M. London, and David P. Lee

Sarvagya S. Katiyar and Earl Shrago

David A. Schwab and John E. Wilson

Shoko Urano, Alan R. Metzger, and Francis J. Castellino

Carlos Santiago and William F. Marzluff

Fernando A. P. Ribeiro-Neto and Martin Rodbell

Vincenzo De Luca, Claude Marineau, and Normand Brisson

Colin D. Funk, Shigeru Hoshiko, Takashi Matsumoto, Olof Radmark, and Bengt Samuelsson

Colin D. Funk, Hans Gunne, Hakan Steiner, Takashi Izumi, and Bengt Samuelsson

William Matthews, James Driscoll, Keiji Tanaka, Akira Ichihara, and Alfred L. Goldberg

Hanspeter Saluz and Jean-Pierre Jost

Alan H. Fairlamb, Graeme B. Henderson, and Anthony Cerami

T. Kirchhausen, K. L. Nathanson, W. Matsui, A. Vaisberg, E. P. Chow, C. Burne, J. H. Keen, and A. E. Davis

Jamel Chelly, Jean-Paul Concordet, Jean-Claude Kaplan, and Axel Kahn

James G. Nadeau and Donald M. Crothers

Susan T. Lovett and Richard D. Kolodner

Chengshi He, Scott M. Wilhelm, Alice P. Pentland, Barry L. Marmer, Gregory A. Grant, Arthur Z. Eisen, and Gregory I. Goldberg

David A. Relman, Mario Domenighini, Elaine Tuomanen, Rino Rappuoli, and Stanley Falkow

Michel Janicot and M. Daniel Lane

Richard W. Wagner, Joseph E. Smith, Barry S. Cooperman, and Kazuko Nishikura

Christopher J. Brandl and Kevin Struhl

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Contents

Expression of apolipoprotein B mRNAs encoding higher- and lower-molecular Gregory E. Tennyson, Charles A. weight isoproteins in rat liver and intestine (Correction) Sabatos, Keiichi Higuchi, Nancy

Meglin, and H. Bryan Brewer, Jr.

BIOPHYSICS

In photosynthetic reaction centers, the free energy difference for electron transfer between quinones bound at the primary and secondary quinone-binding sites governs the observed secondary site specificity

Medium-chain fatty acid binding to albumin and transfer to phospholipid bilayers

Monte Carlo simulation of equilibrium globular protein folding: a-Helical bundles with long loops

BOTANY

Characterization of vacuolar and extracellular P(1,3)-glucanases of tobacco: Evidence for a strictly compartmentalized plant defense system

Nitrogen-dependent regulation of photosynthetic gene expression

CELL BIOLOGY

Acidic fibroblast growth factor mRNA is expressed by cardiac myocytes in culture and the protein is localized to the extracellular matrix

Constitutive endocytosis of HLA class I antigens requires a specific portion of the intracytoplasmic tail that shares structural features with other endocytosed molecules

Generation of fibrosarcomas in vivo by a retrovirus that expresses the normal B chain of platelet-derived growth factor and mimics the alternative splice pattern of the v-sis oncogene

Thymidine kinase obliteration: Creation of transgenic mice with controlled immune deficiency

c-myc gene amplification during hepatocarcinogenesis by a choline-devoid diet

Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions

Phagocytosis of aggregated lipoprotein by macrophages: Low density lipoprotein receptor-dependent foam-cell formation

Modulation of mitogenic stimuli by angiogenin correlates with in vitro phosphatidylinositol bisphosphate synthesis

Direct visualization of the interrelationship between intramembrane and extracellular structures

Cytosolic factor purified from Escherichia coli is necessary and sufficient for the export of a preprotein and is a homotetramer of SecB

DEVELOPMENTAL BIOLOGY

Ammonia and thermotaxis: Further evidence for a central role of ammonia in the directed cell mass movements of Dictyostelium discoideum

EVOLUTION

Allozymes of glucose-6-phosphate isomerase differentially modulate pentose-shunt metabolism in the sea anemone Metridium senile

Kathleen M. Giangiacomo and P. Leslie Dutton

James A. Hamilton

Andrzej Sikorski and Jeffrey Skolnick

M. Van den Bulcke, G. Bauw, C. Castresana, M. Van Montagu, and J. Vandekerckhove

F. Gerald Plumley and Gregory W. Schmidt

Henry L. Weiner and Judith L. Swain

Miguel A. Vega and Jack L. Strominger

M. Pech, A. Gazit, P. Arnstein, and S. A. Aaronson

Richard A. Heyman, Emiliana Borrelli, Jayne Lesley, Deborah Anderson, Douglas D. Richman, Stephen M. Baird, Robert Hyman, and Ronald M. Evans

Nalini Chandar, Benito Lombardi, and Joseph Locker

Juan C. Sdez, John A. Connor, David C. Spray, and Michael V. L. Bennett

Arthur G. Suits, Alan Chait, Michael Aviram, and Jay W. Heinecke

William F. Heath, Jr., Frances Moore, Roy Bicknell, and Bert L. Vallee

James B. Wade and Richard A. Coleman

Makato Watanabe and Guinter Blobel

J. T. Bonner, D. Har, and H. B. Suthers

William E. Zamer and Richard J. Hoffman

GENETICS

Two-dimensional DNA fingerprinting of human individuals Andre G. Uitterlinden, P. Eline Slagboom, Dick L. Knook, and Jan Vijg

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Involvement of vimentin in the reverse transformation reaction

UACUAAC is the preferred branch site for mammalian mRNA splicing

Allele-specific enzymatic amplification of 8-globin genomic DNA for diagnosis of sickle cell anemia

Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity

Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms

Variant translocation of the bcl-2 gene to immunoglobulin A light chain gene in chronic lymphocytic leukemia

Mutation and selection in bacterial populations: Alternatives to the hypothesis of directed mutation

3-Hydroxy-3-methylglutaryl-coenzyme A reductase from Arabidopsis thaliana is structurally distinct from the yeast and animal enzymes

Yeast translation initiation suppressor sui2 encodes the a subunit of eukaryotic initiation factor 2 and shares sequence identity with the human a subunit

Gene-controlled cytosine demethylation in the promoter region of the Ac transposable element in maize

Mutations in RNA polymerase II enhance or suppress mutations in GAL4

Daniel Chan, Alison Goate, and Theodore T. Puck

Yuan Zhuang, Allan M. Goldstein, and Alan M. Weiner

Dan Y. Wu, Luis Ugozzoli, Bijay K. Pal, and R. Bruce Wallace

John P. Phillips, Shelagh D. Campbell, Denise Michaud, Marc Charbonneau, and Arthur J. Hilliker

Masato Orita, Hiroyuki Iwahana, Hiroshi Kanazawa, Kenshi Hayashi, and Takao Sekiya

Masaaki Adachi, Jeffrey Cossman, Dan Longo, Carlo M. Croce, and Yoshihide Tsujimoto

Richard E. Lenski, Montgomery Slatkin, and Francisco J. Ayala

R. Marc Learned and Gerald R. Fink

A. Mark Cigan, Edward K. Pabich, Lan Feng, and Thomas F. Donahue

Drew Schwartz

Lori A. Allison and C. James Ingles

IMMUNOLOGY

Structural homology of complement protein C6 with other channel-forming proteins of complement

Cytolytic T-cell clones against an autologous human melanoma: Specificity study and definition of three antigens by immunoselection

Fluorinated 4-quinolones induce hyperproduction of interleukin 2

Characterization of a presecretory phase in B-cell differentiation

Molecular characterization of sialophorin (CD43), the lymphocyte surface sialoglycoprotein defective in Wiskott-Aldrich syndrome

Oligodendrocyte-specific autoreactive T cells using an a/,3 T-cell receptor kill their target without self restriction

Synthesis of germ-line yl immunoglobulin heavy-chain transcripts in resting B cells: Induction by interleukin 4 and inhibition by interferon y

Deb N. Chakravarti, Bulbul Chakravarti, Carlos A. Parra, and Hans J. Muller-Eberhard

Alexander Knuth, Thomas Wolfel, Eva Klehmann, Thierry Boon, and Karl-Hermann Meyer zum Buischenfelde

Kristian Riesbeck, Jan Andersson, Martin Gullberg, and Arne Forsgren

Leslie B. King and Ronald B. Corley

C. Simon Shelley, Eileen Remold-O'Donnell, Alvin E. Davis III, Gail A. P. Bruns, Fred S. Rosen, Michael C. Carroll, and Alexander S. Whitehead

Voahangy Jewtoukoff, Ren6 Lebar, and Marie-Anne Bach

Michael T. Berton, Jonathan W. Uhr, and Ellen S. Vitetta

MEDICAL SCIENCES

Gastrin releases a blood calcium-lowering peptide from the acid-producing part of the rat stomach

Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque

GLQ223: An inhibitor of human immunodeficiency virus replication in acutely and chronically infected cells of lymphocyte and mononuclear phagocyte lineage

Per Persson, Rolf Hakanson, Jan Axelson, and Frank Sundler

Josiah N. Wilcox, Kathleen M. Smith, Stephen M. Schwartz, and David Gordon

Michael S. McGrath, Kou M. Hwang, Susan E. Caldwell, Isabelle Gaston, Ka-Cheung Luk, Paul Wu, Valerie L. Ng, Suzanne Crowe, Jan Daniels, Jane Marsh, Tracy Deinhart, Patricia V. Lekas, Joann C. Vennari, Hin-Wing Yeung, and Jeffrey D. Lifson

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Contents

Induction of megakaryocytic differentiation and modulation of protein kinase gene expression by site-selective cAMP analogs in K-562 human leukemic cells

Amyloid protein and neurofibrillary tangles coexist in the same neuron in Alzheimer disease

Mitotic recombination of chromosome 17 in astrocytomas

The human endothelin family: Three structurally and pharmacologically distinct isopeptides predicted by three separate genes

Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects

Characterization of a cDNA encoding a 34-kDa Purkinje neuron protein recognized by sera from patients with paraneoplastic cerebellar degeneration

Detection of sequences homolbgous to human retroviral DNA in multiple sclerosis by gene amplification

Establishment of a human T-cell clone cytotoxic for both autologous and allogeneic hepatocytes from chronic hepatitis patients with type non-A, non-B virus

In vitro duplication and in vivo cure of mast-cell deficiency of Sl/Sld mutant mice by cloned 3T3 fibroblasts

MICROBIOLOGY

Isolation of human immunodeficiency virus-related simian immunodeficiency viruses from African green monkeys

Alterations of amino acid repeats in the Escherichia coli hemolysin affect cytolytic activity and secretion (Correction)

NEUROBIOLOGY

Relationship of insulin-like growth factor II gene expression in muscle to synaptogenesis

Membrane docosahexaenoate is supplied to the developing brain and retina by the liver

Isolation and characterization of an olfactory mutant in Drosophila with a chemically specific defect

Purification and sequencing of neuropeptides contained in neuron R15 of Aplysia californica

Voltage dependence of adaptation and active bundle movement in bullfrog saccular hair cells

Brain phospholipase C isozymes: Differential mRNA localizations by in situ hybridization

Differential expression of acetylcholine receptor mRNA in nuclei of cultured muscle cells

Giampaolo Tortora, Timothy Clair, Dionyssios Katsaros, Shamsia Ally, Oscar Colamonici, Leonard M. Neckers, Pierosandro Tagliaferri, Tore Jahnsen, Roland K. Robins, and Yoon Sang Cho-Chung

Inge Grundke-Iqbal, Khalid Iqbal, Lalu George, Yunn-Chyn Tung, Kwang Soo Kim, and Henry M. Wisniewski

C. bavid James, Elisabeth Carlbom, Magnus Nordenskjold, V. Peter Collins, and Webster K. Cavenee

Akihiro Inoue, Masashi Yanagisawa, Sadao Kimura, Yoshitoshi Kasuya, Takashi Miyauchi, Katsutoshi Goto, and Tomoh Masaki

Hans-Peter Guler, Christoph Schmid, Jiirgen Zapf, and E. Rudolf Froesch

Henry M. Furneaux, Edward J. Dropcho, Denise Barbut, Yao-Tserig Chen, Marc K. Rosenblum, Lloyd J. Old, and Jerome B. Posner

Steven J. Greenberg, Garth D. Ehrlich, Mark A. Abbott, Barrie J. Hurwitz, Thomas A. Waldmann, and Bernard J. Poiesz

Michio Imawari, Masayuki Nomura, Takeji Kaieda, Takashi Moriyama, Kazuo Oshimi, Ikuo Nakamura, Toshiaki Gunji, Shin Ohnishi, Takashi Ishikawa, Hitoshi Nakagama, and Fumimaro Takaku

Jun Fujita, Hitoshi Onoue, Yoshitaka Ebi, Hiroki Nakayama, and Yuzuru Kanakura

G. Kraus, A. Werner, M. Baier, D. Binniger, F. J. Ferdinand, S. Norley, and R. Kurth

T. Felmlee and R. A. Welch

Douglas N. Ishii

Burton L. Scott and Nicolas G. Bazan

Stephen L. Helfand and John R. Carlson

K. R. Weiss, H. Bayley, P. E. Lloyd, R. Tenenbaum, M. A. Gawinowicz Kolks, L. Buck, E. C. Cropper, S. C. Rosen, and I. Kupfermann

John A. Assad, Nir Hacohen, and David P. Corey

Christopher A. Ross, Mathew W. MacCumber, Charles E. Glatt, Solomon H. Snyder

S. Bursztajn, S. A. Berman, and W. Gilbert

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Ontogenesis and localization of Ca2+ channels in mammalian skeletal muscle in culture and role in excitation-contraction coupling

cAMP and forskolin decrease y-aminobutyric acid-gated chloride flux in rat brain synaptoneurosomes

Protein kinase C is not necessary for peptide-induced suppression of M current or for desensitization of the peptide receptors

Elevated dynorphin in the hippocampal formation of aged rats: Relation to cognitive impairment on a spatial learning task

Georges Romey, Luis Garcia, Violetta Dimitriadou, Martine Pincon-Raymond, Francois Rieger, and Michel Lazdunski

Giinter Heuschneider and Rochelle D. Schwartz

Martha M. Bosma and Bertil Hille

Hann-Kuang Jiang, Vivian Owyang, Jau-Shyong Hong, and Michela Gallagher

PHYSIOLOGICAL SCIENCES

Water intake in rats subjected to hypothalamic immunoneutralization of angiotensin II, atrial natriuretic peptide, vasopressin, or oxytocin

Bone remodeling signaled by a dihydropyridine- and phenylalkylamine-sensitive calcium channel

Modulation of 3-methylcholanthrene toxicity in cultured neoplastic keratinocytes by glucocorticoids and retinoids is not accounted for by macromolecular adduct formation

Regulation of myocardial Ca2+-ATPase and phospholamban mRNA expression in response to pressure overload and thyroid hormone

Regulation of ATP-sensitive K+ channels in insulinoma cells: Activation by somatostatin and protein kinase C and the role of cAMP

Isolation and identification of a diuretic hormone from the tobacco hornworm, Manduca sexta

Monitoring cytosolic free magnesium in cultured chicken heart cells by use of the fluorescent indicator Furaptra

PSYCHOLOGY

Two motion perception mechanisms revealed through distance-driven reversal of apparent motion

C. R. Franci, G. P. Kozlowski, and S. M. McCann

Sandra E. Guggino, Daniel Lajeunesse, John A. Wagner, and Solomon H. Snyder

Andrew L. Rubin and Robert H. Rice

Ryozo Nagai, Angel Zarain-Herzberg, Christopher J. Brandl, Junichi Fujii, Michihiko Tada, David H. MacLennan, Norman R. Alpert, and Muthu Periasamy

Jan R. de Weille, Heidy Schmid-Antomarchi, Michel Fosset and Michael Lazdunski

Hiroshi Kataoka, Ruth G. Troetschler, Jorge P. Li, Steven J. Kramer, Robert L. Carney, and David A. Schooley

Elizabeth Murphy, Craig C. Freudenrich, Louis A. Levy, Robert E. London, and Melvyn Lieberman

Charles Chubb and George Sperling

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