Front Matter

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JULY 1989 VOLUME 86 NUMBER 14

Proceedings OF THE

National Academy

OF THE UNITED STATES OF AMERICA



Proceedings OF THE

National Academy of Sciences OF THE UNITED STATES OF AMERICA

Officers FRANK PRESS, President of the JAMES D. EBERT, Vice President Academy PETER H. RAVEN, Home Secretary

WILLIAM E. GORDON, Foreign Secretary ELKAN R. BLOUT, Treasurer

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RONALD BRESLOW STUART A. KORNFELD SOLOMON H. SNYDER MICHAEL J. CHAMBERLIN DANIEL E. KOSHLAND, JR. HAROLD VARMUS MARY-DELL CHILTON PHILIP W. MAJERUS THOMAS A. WALDMANN

DANIEL NATHANS

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i



A-.

Proceedings OF THE

National Academy of Sclences

OF THE UNITED STATES OF AMERICA

July 1989 Volume 86, Number 14 pp. 5217-5670

Table of Contents

CONDENSED INFORMATION FOR CONTRIBUTORS i

AUTHOR INDEX ix

Biological Sciences

BIOCHEMISTRY

Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin Maria A. Soos, Richard M. O'Brien, 5217 but do not stimulate receptor autophosphorylation in transfected NIH 3T3 Nicholas P. J. Brindle, Jill M. Stigter, fibroblasts Annette K. Okamoto, Jonathan

Whittaker, and Kenneth Siddle

Physical association of the 2,6-diamino-4-hydroxy-5N-formamidopyrimidine- Timothy R. O'Connor and Jacques Laval 5222 DNA glycosylase of Escherichia coli and an activity nicking DNA at apurinic/apyrimidinic sites

Identification of a monocyte specific pre-interleukin 1,8 convertase activity Matthew J. Kostura, Michael J. Tocci, 5227 Guadalupe Limjuco, Jayne Chin, Patricia Cameron, Andrew G. Hillman, Nicole A. Chartrain, and John A. Schmidt

Labeling the peptidyltransferase center of the Eschernchia coili ribosome with Jacek Wower, Stephen S. Hixson, and 5232 photoreactive tRNAPbC derivatives containing azidoadenosine at the 3' end Robert A. Zimmermann of the acceptor arm: A model of the tRNA-ribosome complex

The (A)BC excinuclease of Eschernchia coili has only the UvrB and UvrC David K. Orren and Aziz Sancar 5237 subunits in the incision complex

iii



Contents Vasotocin and isotocin precursors from the white sucker, Catostomus Jorg Heierhorst, Steven D. Morley, 5242

commersoni: Cloning and sequence analysis of the cDNAs Jaime Figueroa, Christiane Krentler, Karl Lederis, and Dietmar Richter

Multiple enhancer-like sequences in the HLA-B7 gene Subinay Ganguly, Haren A. Vasavada, 5247 and Sherman M. Weissman

Human placenta protein-tyrosine-phosphatase: Amino acid sequence and Harry Charbonneau, Nicholas K. Tonks, 5252 relationship to a family of receptor-like proteins Santosh Kumar, Curtis D. Diltz, Maria

Harrylock, Deborah E. Cool, Edwin G. Krebs, Edmond H. Fischer, and Kenneth A. Walsh

cDNA isolated from a human T-cell library encodes a member of the Deborah E. Cool, Nicholas K. Tonks, 5257 protein-tyrosine-phosphatase family Harry Charbonneau, Kenneth A.

Walsh, Edmond H. Fischer, and Edwin G. Krebs

Altered membrane association of p60v-src and a murine 63-kDa N-myristoyl Robert 0. Heuckeroth and Jeffrey I. 5262 protein after incorporation of an oxygen-substituted analog of myristic acid Gordon

Cooperative activation of a eukaryotic transcription factor: Interaction between Peter Furst and Dean Hamer 5267 Cu(I) and yeast ACE1 protein

Hydrins, hydroosmotic neurohypophysial peptides: Osmoregulatory adaptation Y. Rouille, G. Michel, M. T. Chauvet, 5272 in amphibians through vasotocin precursor processing J. Chauvet, and R. Acher

Isolation of a rat liver Golgi mannosidase II clone by mixed Kelley W. Moremen 5276 oligonucleotide-primed amplification of cDNA

Calf thymus histone Hi is a recombinase that catalyzes ATP-independent DNA Ichiro Kawasaki, Shoji Sugano, and 5281 strand transfer Hideo Ikeda

Unusually stable helix formation in short alanine-based peptides Susan Marqusee, Virginia H. Robbins, 5286 and Robert L. Baldwin

The v-sea oncogene of avian erythroblastosis retrovirus S13: Another member Douglas R. Smith, Peter K. Vogt, and 5291 of the protein-tyrosine kinase gene family Michael J. Hayman

Glutathione metabolism in the lung: Inhibition of its synthesis leads to lamellar Johannes MArtensson, Ajey Jain, William 5296 body and mitochondrial defects Frayer, and Alton Meister

Gene Q antiterminator proteins of Escherichia coli phages 82 and A suppress Xianjie Yang and Jeffrey W. Roberts 5301 pausing by RNA polymerase at a p-dependent terminator and at other sites

Identification of a transcriptional silencer in the 5'-flanking region of the human Shi Xian Cao, Pablo D. Gutman, Harish 5306 e-globin gene P. G. Dave, and Alan N. Schechter

A third human retinoic acid receptor, hRAR-y A. Krust, Ph. Kastner, M. Petkovich, A. 5310 Zelent, and P. Chambon

Genomic footprinting in mammalian cells with ultraviolet light Michael M. Becker, Zhou Wang, 5315 Gregory Grossmann, and Kathleen A. Becherer

Escherichia coli SecB protein associates with exported protein precursors in Carol A. Kumamoto 5320 vivo

Molecular cloning of rat homologues of the Drosophila melanogaster dunce Johannes V. Swinnen, David R. Joseph, 5325 cAMP phosphodiesterase: Evidence for a family of genes and Marco Conti

Characterization of cDNAs encoding human pyruvate dehydrogenase a subunit Lap Ho, Isaiah D. Wexler, Te-Chung 5330 Liu, Thomas J. Thekkumkara, and Mulchand S. Patel

Telomeric function of the tRNA-like structure of brome mosaic virus RNA A. L. N. Rao, T. W. Dreher, L. E. 5335 Marsh, and T. C. Hall

Characterization of the termini and transposition products of Tn4399, a David W. Hecht, Jeffrey S. Thompson, 5340 conjugal mobilizing transposon of Bacteroides fragilis and Michael H. Malamy

A set of lacZ mutations in Escherichia coli that allow rapid detection of each of Claire G. Cupples and Jeffrey H. Miller 5345 the six base substitutions

Involvement of the proteasome in various degradative processes in mammalian William Matthews, James Driscoll, Keiji 5350 cells (Correction) Tanaka, Akira Ichihara, and Alfred L.

Goldberg

BIOPHYSICS

Mechanism of spontaneous vesiculation Helmut Hauser 5351 Imaging of single uncoated DNA molecules by scanning tunneling microscopy David Keller, Carlos Bustamante, and 5356

Rebecca W. Keller

iv



Contents

Electrostatic fields in the active sites of lysozymes Sun Dao-pin, Der-Ing Liao, and Stephen 5361 J. Remington

Effect of negative mechanical stress on the orientation of myosin cross-bridges Thomas P. Burghardt and Katalin Ajtai 5366 in muscle fibers

Mechanical properties of sensory hair bundles are reflected in their Brownian W. Denk, W. W. Webb, and A. J. 5371 motion measured with a laser differential interferometer Hudspeth

Is there an excitonic interaction or antenna system in bacteriorhodopsin? M. A. El-Sayed, C. T. Lin, and W. R. 5376 Mason

Formation of hybrid cell-cell channels Rudolf Werner, Eric Levine, Cristina 5380 Rabadan-Diehl, and Gerhard Dahl

Direct measurement of interstitial convection and diffusion of albumin in Srikanth R. Chary and Rakesh K. Jain 5385 normal and neoplastic tissues by fluorescence photobleaching

CELL BIOLOGY

Drosophila ninaA gene encodes an eye-specific cyclophilin (cyclosporine A Stephan Schneuwly, Randall D. 5390 binding protein) Shortridge, Denis C. Larrivee, Toshiko

Ono, Mamiko Ozaki, and William L. Pak

Mouse Mos protooncogene product is present and functions during oogenesis Richard S. Paules, Roberto Buccione, 5395 Robert C. Moschel, George F. Vande Woude, and John J. Eppig

Regulated expression of foreign genes in mammalian cells under the control of Ulrich Deuschle, Rainer Pepperkok, 5400 coliphage T3 RNA polymerase and lac repressor Fubao Wang, Thomas J. Giordano,

William T. McAllister, Wilhelm Ansorge, and Hermann Bujard

Identification of a vitamin D-responsive protein on the surface of human Susan Shull, Russell P. Tracy, and 5405 osteosarcoma cells Kenneth G. Mann

Lung surfactant apoprotein SP-A (26-36 kDa) binds with high affinity to Jo Rae Wright, Jenny D. Borchelt, and 5410 isolated alveolar type II cells Samuel Hawgood

An alternative cytoplasmic domain of the integrin f3 subunit Toin H. M. S. M. van Kuppevelt, Lucia 5415 R. Languino, James 0. Gailit, Shintaro Suzuki, and Erkki Ruoslahti

Isolation of peroxisome-deficient mutants of Saccharomyces cerevisiae Ralf Erdmann, Marten Veenhuis, 5419 Daphne Mertens, and Wolf-H. Kunau

Functional inhibition of endogenously produced urokinase decreases cell Johannes C. Kirchheimer, Johann Wojta, 5424 proliferation in a human melanoma cell line Gunter Christ, and Bernd R. Binder

Subtypes of intercalated cells in rat kidney collecting duct defined by S. L. Alper, J. Natale, S. Gluck, H. F. 5429 antibodies against erythroid band 3 and renal vacuolar H+-ATPase Lodish, and D. Brown

DEVELOPMENTAL BIOLOGY

Activation of muscle-specific genes in pigment, nerve, fat, liver, and fibroblast Harold Weintraub, Stephen J. Tapscott, 5434 cell lines by forced expression of MyoD Robert L. Davis, Mathew J. Thayer,

Mohammed A. Adam, Andrew B. Lassar, and A. Dusty Miller

Molecular analysis of the human p-globin locus activation region William C. Forrester, Ulrike Novak, 5439 Richard Gelinas, and Mark Groudine

Abnormal development and dye coupling produced by antisense RNA to gap Arturo Bevilacqua, Rita Loch-Caruso, 5444 junction protein in mouse preimplantation embryos and Robert P. Erickson

Identification of a developmentally regulated protein-tyrosine kinase by using Elena B. Pasquale and S. J. Singer 5449 anti-phosphotyrosine antibodies to screen a cDNA expression library

EVOLUTION

Cloning and sequencing of cDNA encoding baboon liver alcohol Ann E. 0. Trezise, Elizabeth A. 5454 dehydrogenase: Evidence for a common ancestral lineage with the human Godfrey, Roger S. Holmes, and Ifor R. alcohol dehydrogenase j3 subunit and for class I ADH gene duplications Beacham predating primate radiation

Two steps in the evolution of Antennapedia-class vertebrate homeobox genes Claudia Kappen, Klaus Schughart, and 5459 Frank H. Ruddle

Genetics of sexual isolation between two sibling species, Drosophila simulans Jerry A. Coyne 5464 and Drosophila mauritiana

v



Contents GENETICS

Evidence for diploidy in metacyclic forms of African trypanosomes R. F. Kooy, H. Hirumi, S. K. Moloo, 5469 V. M. Nantulya, P. Dukes, P. M. Van der Linden, W. A. L. Duijndam, C. J. Janse, and J. P. Overdulve

Multiplex gene regulation: A two-tiered approach to transgene regulation in G. W. Byrne and F. H. Ruddle 5473 transgenic mice

Shuttle vectors for the archaebacterium Halobacterium volcanii Wan L. Lam and W. Ford Doolittle 5478 The homeotic gene spalt (sal) evolved during Drosophila speciation Dirk Reuter, Reinhard Schuh, and 5483

Herbert Jackle Activation of the Mlvi-1/misl/pvt-1 locus in Moloney murine leukemia Philip N. Tsichlis, Barbara M. Shepherd, 5487

virus-induced T-cell lymphomas and Susan E. Bear UV induction of coliphage 186: Prophage induction as an SOS function Iain Lamont, Anthony M. Brumby, and 5492

J. Barry Egan Dysfunction of chromosomal loop attachment sites: Illegitimate recombination Ann 0. Sperry, Veronica C. Blasquez, 5497

linked to matrix association regions and topoisomerase II and William T. Garrard Structure of the human retinoblastoma gene Frank D. Hong, Huei-Jen S. Huang, 5502

Hoang To, Lih-Jiuan S. Young, Anthony Oro, Robert Bookstein, Eva Y.-H. P. Lee, and Wen-Hwa Lee

A general method for detecting rearrangements in a bacterial genome Lo-Chun Au and Paul 0. P. Ts'o 5507 Molecular cloning of a mouse DNA repair gene that complements the defect of Kiyoji Tanaka, Ichiro Satokata, 5512

group-A xeroderma pigmentosum Zenzaburo Ogita, Tsuyoshi Uchida, and Yoshio Okada

Analysis of mammalian cell genetic regulation in situ by using Daniel G. Brenner, Sue Lin-Chao, and 5517 retrovirus-derived "portable exons" carrying the Escherichia coli lacZ gene Stanley N. Cohen

Intracellular methicillin selection of Listenia monocytogenes mutants unable to Andrew Camilli, Christine R. Paynton, 5522 replicate in a macrophage cell line and Daniel A. Portnoy

IMMUNOLOGY

Diversity in T-cell receptor y gene usage in intestinal epithelium Susan Kyes, Elizabeth Carew, Simon R. 5527 Carding, C. A. Janeway, Jr., and Adrian Hayday

Significant structural and functional change of an antigen-binding site by a Nadine C. Chien, Victoria A. Roberts, 5532 distant amino acid substitution: Proposal of a structural mechanism Angela M. Giusti, Matthew D. Scharff,

and Elizabeth D. Getzoff Development of biologically active peptides based on antibody structure William V. Williams, David A. Moss, 5537

Thomas Kieber-Emmons, Jeffrey A. Cohen, Jeffrey N. Myers, David B. Weiner, and Mark I. Greene

Interleukin 3 activates human blood basophils via high-affinity binding sites P. Valent, J. Besemer, M. Muhm, 0. 5542 Majdic, K. Lechner, and P. Bettelheim

Cell proliferation and thymocyte subset reconstitution in sublethally irradiated Claude Penit and Sophie Ezine 5547 mice: Compared kinetics of endogenous and intrathymically transferred progenitors

Immunoglobulin A light-chain-related genes 14.1 and 16.1 are expressed in Gregory F. Hollis, Robert J. Evans, 5552 pre-B cells and may encode the human immunoglobulin w light-chain Jeannine M. Stafford-Hollis, Stanley J. protein Korsmeyer, and John P. McKearn

Loss of HLA-A,B,C allele products and lymphocyte function-associated Mark E. F. Smith, Steven G. E. Marsh, 5559 antigen 3 in colorectal neoplasia Julia G. Bodmer, Keith Gelsthorpe,

and Walter F. Bodmer Human homologue of mouse lymph node homing receptor: Evolutionary Mark H. Siegelman and Irving L. 5562

conservation at tandem cell interaction domains Weissman Complete physical map of the human immunoglobulin heavy chain constant Marten H. Hofker, Michael A. Walter, 5567

region gene complex and Diane W. Cox Monoclonal antibody against interferon y can prevent experimental cerebral Georges E. Grau, Hubertine Heremans, 5572

malaria and its associated overproduction of tumor necrosis factor Pierre-Fransois Piguet, Pascal Pointaire, Paul-Henri Lambert, Alfons Billiau, and Pierre Vassalli

vi



Contents Murine complement component C4 and sex-limited protein: Identification of Ronald T. Ogata, Neil R. Cooper, 5575

amino acid residues essential for C4 function Bonnie M. Bradt, Patricia Mathias, and Maria A. Picchi

IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is George Thyphronitis, George C. Tsokos, 5580 stimulated by interleukin 4 and suppressed by interferon y Carl H. June, Alan D. Levine, and

Fred D. Finkelman

MEDICAL SCIENCES

Early estrogen-induced metabolic changes and their inhibition by actinomycin M. Neeman and H. Degani 5585 D and cycloheximide in human breast cancer cells: 31P and 13C NMR studies

Retinoid receptor antisense DNAs inhibit alkaline phosphatase induction and Frederick 0. Cope and John J. Wille 5590 clonogenicity in malignant keratinocytes

Megakaryocytes of human immunodeficiency virus-infected individuals express Dorothea Zucker-Franklin and Yunzhen 5595 viral RNA Cao

Difluorothromboxane A2 and stereoisomers: Stable derivatives of thromboxane Thomas A. Morinelli, Anselm K. Okwu, 5600 A2 with differential effects on platelets and blood vessels Dale E. Mais, Perry V. Halushka,

Varghese John, Chien-Kuang Chen, and Josef Fried

Wavelength dependence of pyrimidine dimer formation in DNA of human skin S. E. Freeman, H. Hacham, R. W. 5605 irradiated in situ with ultraviolet light Gange, D. J. Maytum, J. C.

Sutherland, and B. M. Sutherland Antibiotic proteins of human polymorphonuclear leukocytes Joelle E. Gabay, Randy W. Scott, David 5610

Campanelli, Joe Griffith, Craig Wilde, Marian N. Marra, Mary Seeger, and Carl F. Nathan

Transgenic mouse model for human gastric carcinoma Kazuhiko Koike, Steven H. Hinrichs, 5615 Kurt J. Isselbacher, and Gilbert Jay

Detection of mRNA for the taxl/rex1 gene of human T-cell leukemia virus type Tomohiro Kinoshita, Masanori 5620 I in fresh peripheral blood mononuclear cells of adult T-cell leukemia Shimoyama, Kensei Tobinai, Mizuko patients and viral carriers by using the polymerase chain reaction Ito, Shin-ichiro Ito, Shuichi Ikeda,

Kazuo Tajima, Kunitada Shimotohno, and Takashi Sugimura

Molecular basis of adult-onset and chronic GM2 gangliosidoses in patients of Barry H. Paw, Michael M. Kaback, and 5625 Ashkenazi Jewish origin: Substitution of serine for glycine at position 269 of Elizabeth F. Neufeld the a-subunit of 8-hexosaminidase (Correction)

Aminosugar derivatives as potential anti-human immunodeficiency virus agents Abraham Karpas, George W. J. Fleet, 5625 (Correction) Raymond A. Dwek, Sigthor Petursson,

Sung K. Namgoong, Nigel G. Ramsden, Gary S. Jacob, and Thomas W. Rademacher

MICROBIOLOGY

Coronavirus subgenomic minus-strand RNAs and the potential for mRNA Phiroze B. Sethna, Shan-Ling Hung, and 5626 replicons David A. Brian

NEUROBIOLOGY

Synthesis and characterization of a series of diarylguanidines that are John F. W. Keana, Robert N. 5631 noncompetitive N-methyl-D-aspartate receptor antagonists with McBurney, Michael W. Scherz, James neuroprotective properties B. Fischer, Philip N. Hamilton,

Stephen M. Smith, Alfred C. Server, Steven Finkbeiner, Charles F. Stevens, Craig Jahr, and Eckard Weber

Adrenalectomy decreases nerve growth factor in young adult rat hippocampus Luigi Aloe 5636 Adenylate cyclase mediates olfactory transduction for a wide variety of Graeme Lowe, Tadashi Nakamura, and 5641

odorants Geoffrey H. Gold Identification and localization of a X peptide to paired helical filaments of Khalid Iqbal, Inge Grundke-Iqbal, Alan 5646

Alzheimer disease J. Smith, Lalu George, Yunn-Chyn Tung, and Tanweer Zaidi

Molecular cloning of a neuron-specific transcript and its regulation during Lakshmi Sangameswaran, James 5651 normal and aberrant cerebellar development Hempstead, and James I. Morgan

vii



Contents ATP-dependent directional movement of rat synaptic vesicles injected into the R. Llinds, M. Sugimori, J.-W. Lin, P. L. 5656

presynaptic terminal of squid giant synapse Leopold, and S. T. Brady Restoration of myelin formation by a single type of myelin basic protein in Minoru Kimura, Masahiro Sato, Akira 5661

transgenic shiverer mice Akatsuka, Shiari Nozawa-Kimura, Riichi Takahashi, Minesuke Yokoyama, Tatsuji Nomura, and Motoya Katsuki

Evidence that brain prostaglandin E2 is involved in physiological sleep-wake Hitoshi Matsumura, Kazuki Honda, Wan 5666 regulation in rats Sung Choi, Shojiro Inoue, Toshiaki

Sakai, and Osamu Hayaishi Topology of cell adhesion molecules (Correction) Joseph W. Becker, Harold P. Erickson, 5670

Stanley Hoffman, Bruce A. Cunningham, and Gerald M. Edelman

viii



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